General

LIU Xiongxiong

Associate Professor

The Department of Medical Physics 

Institute of Modern Physics,Chinese Academy of Sciences

509 Nanchang Road, Lanzhou, 730000, P.R.China

Tel: +86-931-4969173

E-mail:lxx002@impcas.ac.cn


Research Areas

Radiobiology


Education

2013/09-2017/06  Doctoral student,   Institute of Modern Physics, Chinese Academy of Sciences,  China

2008/09-2011/06  Postgraduate Student,  Northwest Normal University,   China

2004/09-2008/06  Undergraduate,  Northwest Normal University,   China


Experience

   
Work Experience

2016.11  now, Institute of Modern Physics,Chinese Academy of Sciences, associate professor

2014.07 2016.10, Institute of Modern Physics,Chinese Academy of Sciences, research assistant


Publications


Papers

1. Liu Xiongxiong, Sun Chao, Jin Xiaodong, Li Ping, Zheng Xiaogang, Zhao Ting, Li Qiang. Genistein sensitizes sarcoma cells in vitro and in vivo by enhancing apoptosis and by inhibiting DSB repair pathways. J Radiat Res. 2016; 57(3): 227-37.

2. Liu Xiongxiong, Sun Chao, Jin Xiaodong, Li Ping, Ye Fei, Zhao Ting, Gong Li, Li Qiang. Genistein enhances the radiosensitivity of breast cancer cells via G/M cell cycle arrest and apoptosis. Molecules. 2013; 18(11):13200-17.

3. Liu Xiongxiong, Sun Chao, Liu Bingtao, Jin Xiaodong, Li Ping, Zheng Xiaogang, Zhao Ting, Li Feifei, Li Qiang. Genistein mediates the selective radiosensitizing effect in NSCLC A549 cells via inhibiting methylation of the keap1 gene promoter region. Oncotarget. 2016; 7(19): 27267-79.

4. Liu Xiongxiong, Li Ping, Hirayama Ryoichi, Niu Yuzhen, Chen Weiqiang, Jin Xiaodong, Zhang Pengcheng, Ye Fei, Zhao Ting, Liu Bingtao, Li Qiang. Genistein sensitizes glioblastoma cells to carbon ions via inhibiting DNA-PKcs phosphorylation and subsequently repressing NHEJ and delaying HR repair pathways. Radiother Oncol. 2018;129(1):84-94.

5. Sun Chao, Liu Xiongxiong, Di Cuixia, Wang Zhenhua, Mi Xiangquan, Liu Yang, Zhao Qiuyue, Mao Aihong, Chen Weiqiang, Gan Lu, Zhang Hong. MitoQ regulates autophagy by inducing a pseudo-mitochondrial membrane potential. Autophagy. 2017;13(4):730-8.

6. Sun Chao, Wang Zhenhua, Liu Xiongxiong, Yang Lina, Wang Yali, Liu Yang, Mao Aihong, Liu Yuanyuan, Zhou Xin, Di Cuixia, Gan Lu, Zhang Hong. Disturbance of redox status enhances radiosensitivity of hepatocellular carcinoma. Am J Cancer Res. 2015; 5(4):1368-81.

7. Li Ping, Zhou Libin, Liu Xiongxiong, Jin Xiaodong, Zhao Ting, Ye Fei, Liu Xinguo, Hirayama Ryoichi, Li Qiang. Mitotic DNA damages induced by carbon-ion radiation incur additional chromosomal breaks in polyploidy. Toxicol Lett. 2014; 230(1):36-47.

8. Li Ping, Zhou Libin, Zhao Ting, Liu Xiongxiong, Zhang Pengcheng, Liu Yan, Zheng Xiaogang, Li Qiang. Caspase-9: structure, mechanisms and clinical application. Oncotarget. 2017; 8(14):23996-4008.

9. Jin Xiaodong, Liu Yan, Ye Fei, Liu Xiongxiong, Furusawa Yoshiya, Wu Qingfeng, Li Feifei, Zheng Xiaogang, Dai Zhongying, Li Qiang. Role of autophagy in high linear energy transfer radiation-induced cytotoxicity to tumor cells. Cancer Sci. 2014; 105(7):770-8.

10. Jin Xiaodong, Li Feifei, Zheng Xiaogang, Liu Yan, Hirayama Ryoichi, Liu Xiongxiong, Li Ping, Zhao Ting, Dai Zhongying, Li Qiang. Carbon ions induce autophagy effectively through stimulating the unfolded protein response and subsequent inhibiting Akt phosphorylation in tumor cells. Sci Rep. 2015; 5: 13815.

11. Zheng Xiaogang, Jin Xiaodong, Li Feifei, Liu Xiongxiong, Liu Yan, Ye Fei,  Li Ping, Zhao Ting, Li Qiang. Inhibiting autophagy with chloroquine enhances the anti-tumor effect of high-LET carbon ions via ER stress-related apoptosis. Med Oncol. 2017; 34(2):25.

12. Li Feifei, Zheng Xiaogang, Liu Yan, Li Ping, Liu Xiongxiong, Ye Fei, ZhaoTing, Wu Qingfeng, Jin Xiaodong, Li Qiang. Different Roles of CHOP and JNK in Mediating Radiation-Induced Autophagy and Apoptosis in Breast Cancer Cells. Radiat Res. 2016;185(5):539-48.

13. Ye Fei, Zhao Ting, Liu Xiongxiong, Jin Xiaodong, Liu Xinguo, Wang Tieshan, Li Qiang. Long-term Autophagy and Nrf2 Signaling in the Hippocampi of Developing Mice after Carbon Ion Exposure. Sci Rep. 2015;5:18636.

14. Jin Xiaodong, Zheng Xiaogang, Li Feifei, Liu Bingtao, Li Hongbin, Hirayama Ryoichi, Li Ping, Liu Xiongxiong, Shen Guosheng, Li Qiang. Fragmentation level determines mitochondrial damage response and subsequently the fate of cancer cells exposed to carbon ions. Radiother Oncol. 2018;129(1):75-83.



Research Interests

Biological effects induced by ionizing radiation