基本信息

万林  男  博导  中国科学院数学与系统科学研究院
电子邮件: lwan@amss.ac.cn
通信地址: 北京市海淀区中关村东路55号
邮政编码: 100190

个人主页: http://lsc.amss.ac.cn/~lwan/

研究领域

计算与系统生物学
统计学、数据科学
机器学习、人工智能

招生信息

   
招生专业
070103-概率论与数理统计
071101-系统理论
071400-统计学
招生方向
计算与系统生物学
统计学、数据科学
机器学习、人工智能

教育背景

2003-09--2009-07   北京大学   理学博士
1999-09--2003-07   南京大学   理学学士
学历
-- 研究生
学位
-- 博士

工作经历

   
工作简历
2021-04~现在, 中国科学院数学与系统科学研究院, 研究员
2014-03~2021-04,中国科学院数学与系统科学研究院, 副研究员
2011-08~2014-02,中国科学院数学与系统科学研究院, 助理研究员
2009-04~2011-08,中国科学院数学与系统科学研究院, 博士后
社会兼职
2020-12-01-今,中国自动化学会智能健康与生物信息专业委员会, 委员
2015-01-01-今,中国运筹学会计算系统生物学分会, 理事

教授课程

系统估计
概率论与数理统计习题课-01
概率论与数理统计
概率论与数理统计习题课-02

专利与奖励

   
奖励信息
(1) APBC2019国际会议最佳论文, 特等奖, 其他, 2019
(2) Early Career Award, 研究所(学校), 2016
(3) 关肇直青年研究奖, 研究所(学校), 2014
(4) 中国科学院数学与系统科学研究院优秀教师奖, 研究所(学校), 2014
专利成果
( 1 ) 用于多个分子信号的数据处理方法与装置, 发明, 2018, 第 3 作者, 专利号: ZL201510061908.8

出版信息

   
发表论文
[1] Kai Cao, Yiguang Hong, Lin Wan. Manifold alignment for heterogeneous single-cell multi-omics data integration using Pamona. Bioinformatics[J]. 2021, 38(1): 211-219, [2] An, Shaokun, Huang, Jizu, Wan, Lin. D-EE: Distributed software for visualizing intrinsic structure of large-scale single-cell data. GIGASCIENCE[J]. 2020, 9(11): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657844/.
[3] Chen, Ziwei, Bai, Xiangqi, Ma, Liang, Wang, Xiawei, Liu, Xiuqin, Liu, Yuting, Chen, Luonan, Wan, Lin. A Branch Point on Differentiation Trajectory is the Bifurcating Event Revealed by Dynamical Network Biomarker Analysis of Single-Cell Data. IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS[J]. 2020, 17(2): 366-375, https://www.webofscience.com/wos/woscc/full-record/WOS:000524236800001.
[4] Chen, Ziwei, Gong, Fuzhou, Wan, Lin, Ma, Liang. RobustClone: a robust PCA method for tumor clone and evolution inference from single-cell sequencing data. BIOINFORMATICS[J]. 2020, 36(11): 3299-3306, http://dx.doi.org/10.1093/bioinformatics/btaa172.
[5] Cao, Kai, Bai, Xiangqi, Hong, Yiguang, Wan, Lin. Unsupervised topological alignment for single-cell multi-omics integration. BIOINFORMATICS[J]. 2020, 36(Suppl 1): 48-56, https://www.webofscience.com/wos/woscc/full-record/WOS:000579894600007.
[6] Xiong, Jiankang, Gong, Fuzhou, Wan, Lin, Ma, Liang. NeuralEE: A GPU-Accelerated Elastic Embedding Dimensionality Reduction Method for Visualizing Large-Scale scRNA-Seq Data. FRONTIERS IN GENETICS[J]. 2020, 11: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7587292/.
[7] Chen, Ziwei, An, Shaokun, Bai, Xiangqi, Gong, Fuzhou, Ma, Liang, Wan, Lin. DensityPath: an algorithm to visualize and reconstruct cell state-transition path on density landscape for single-cell RNA sequencing data. BIOINFORMATICS[J]. 2019, 35(15): 2593-2601, http://ir.amss.ac.cn/handle/2S8OKBNM/35572, http://www.irgrid.ac.cn/handle/1471x/6869820, http://ir.amss.ac.cn/handle/2S8OKBNM/35573, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000484378200009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=3a85505900f77cc629623c3f2907beab.
[8] Bai, Xiangqi, Ma, Liang, Wan, Lin. Statistical test of structured continuous trees based on discordance matrix. BIOINFORMATICS[J]. 2019, 35(23): 4962-4970, [9] An, Shaokun, Ma, Liang, Wan, Lin. TSEE: an elastic embedding method to visualize the dynamic gene expression patterns of time series single-cell RNA sequencing data. BMC Genomics[J]. 2019, 20(S2): 77-92, https://doaj.org/article/e317474d0c2d4765a67f55dc78ea637b.
[10] Li, Shuo, Dou, Xialiang, Gao, Ruiqi, Ge, Xinzhou, Qian, Minping, Wan, Lin. A remark on copy number variation detection methods. PLOS ONE[J]. 2018, 13(4): https://doaj.org/article/73c805e7cf894d14b96ac87b95e0ee42.
[11] Gong, Weikang, Wan, Lin, Lu, Wenlian, Ma, Liang, Cheng, Fan, Cheng, Wei, Grunewald, Stefan, Feng, Jianfeng. Statistical testing and power analysis for brain-wide association study. MEDICAL IMAGE ANALYSIS[J]. 2018, 47: 15-30, http://dx.doi.org/10.1016/j.media.2018.03.014.
[12] Zhang, Sheng, Wang, Bo, Wan, Lin, Li, Lei M. Estimating Phred scores of Illumina base calls by logistic regression and sparse modeling. BMC BIOINFORMATICS[J]. 2017, 18(1): http://dx.doi.org/10.1186/s12859-017-1743-4.
[13] Rolls, Edmund T, Lu, Wenlian, Wan, Lin, Yan, Hao, Wang, Chuanyue, Yang, Fude, Tan, Yunlong, Li, Lingjiang, Yu, Hao, Liddle, Peter F, Palaniyappan, Lena, Zhang, Dai, Yue, Weihua, Feng, Jianfeng, Chinese Schizophrenia Collabor. Individual differences in schizophrenia. BJPSYCH OPEN[J]. 2017, 3(6): 265-+, http://dx.doi.org/10.1192/bjpo.bp.117.005058.
[14] Wang, Bo, Wan, Lin, Wang, Anqi, Li, Lei M. An adaptive decorrelation method removes Illumina DNA base-calling errors caused by crosstalk between adjacent clusters. SCIENTIFIC REPORTS[J]. 2017, 7: https://www.webofscience.com/wos/woscc/full-record/WOS:000394330600001.
[15] Cheng, Wei, Rolls, Edmund T, Zhang, Jie, Sheng, Wenbo, Ma, Liang, Wan, Lin, Luo, Qiang, Feng, Jianfeng. Functional connectivity decreases in autism in emotion, self, and face circuits identified by Knowledge-based Enrichment Analysis. NEUROIMAGE[J]. 2017, 148: 169-178, http://dx.doi.org/10.1016/j.neuroimage.2016.12.068.
[16] 李雷. Achieving Accurate and Fast Base-calling by a Block Model of the Illumina Sequencing Data. IFAC-PapersOnLine. 2015, [17] 万林. Tracking the Evolving Spatial-Temporal Gene Networks. IFAC-PapersOnLine. 2015, [18] 王琳, 李诗卉, 张先闻, 张春崧, 李交, 赵思宇, 邓跃毅, 田建辉, 钱敏平, 万林, 陈以平. 应用全基因组拷贝数变异方法探索参芪膜肾方治疗特发膜性肾病基因水平机制的研究. 中国中西医结合肾病杂志. 2014, 329-332, http://lib.cqvip.com/Qikan/Article/Detail?id=49727178.
[19] Wang, Quan, Peng, Peichao, Qian, Minping, Wan, Lin, Deng, Minghua. Hybridization and amplification rate correction for affymetrix SNP arrays. BMC MEDICAL GENOMICS[J]. 2012, 5(1): 24-24, https://doaj.org/article/274df2763c7c4a42bfcb941ee3ac2602.
[20] Wan, Lin, Sun, Fengzhu. CEDER: Accurate Detection of Differentially Expressed Genes by Combining Significance of Exons Using RNA-Seq. IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS[J]. 2012, 9(5): 1281-1292, https://www.webofscience.com/wos/woscc/full-record/WOS:000307299200004.
[21] Wan, Lin, Yan, Xiting, Chen, Ting, Sun, Fengzhu. Modeling RNA degradation for RNA-Seq with applications. BIOSTATISTICS[J]. 2012, 13(4): 734-747, https://www.webofscience.com/wos/woscc/full-record/WOS:000308885800013.
[22] Liu, Xuemei, Wan, Lin, Li, Jing, Reinert, Gesine, Waterman, Michael S, Sun, Fengzhu. New powerful statistics for alignment-free sequence comparison under a pattern transfer model. JOURNAL OF THEORETICAL BIOLOGY[J]. 2011, 284(1): 106-116, http://dx.doi.org/10.1016/j.jtbi.2011.06.020.
[23] Wang, Quan, Qu, Jianghan, Cheng, Xiaoxing, Kang, Yongjian, Wan, Lin, Qian, Minping, Deng, Minghua. A study of biases of DNA copy number estimation based on PICR model. FRONTIERS OF MATHEMATICS IN CHINA[J]. 2011, 6(6): 1203-1216, https://www.webofscience.com/wos/woscc/full-record/WOS:000297647000011.
[24] Wang, Ying, Mehta, Gaurang, Mayani, Rajiv, Lu, Jingxi, Souaiaia, Tade, Chen, Yangho, Clark, Andrew, Yoon, Hee Jae, Wan, Lin, Evgrafov, Oleg V, Knowles, James A, Deelman, Ewa, Chen, Ting. RseqFlow: workflows for RNA-Seq data analysis. BIOINFORMATICS[J]. 2011, 27(18): 2598-2600, https://www.webofscience.com/wos/woscc/full-record/WOS:000294755400017.
[25] Wan, Lin, Reinert, Gesine, Sun, Fengzhu, Waterman, Michael S. Alignment-Free Sequence Comparison (II): Theoretical Power of Comparison Statistics. JOURNAL OF COMPUTATIONAL BIOLOGY[J]. 2010, 17(11): 1467-+, http://dx.doi.org/10.1089/cmb.2010.0056.
[26] 万林. The biases of copy numbers from Affymetrix SNP arrays and their corrections. Communications in Information and Systems. 2010, [27] Wang, Quan, Wan, Lin, Li, Dayong, Zhu, Lihuang, Qian, Minping, Deng, Minghua. Searching for bidirectional promoters in Arabidopsis thaliana. BMC BIOINFORMATICS[J]. 2009, 10(Suppl 1): S29-S29, https://www.webofscience.com/wos/woscc/full-record/WOS:000265601900029.
[28] 万林. Nonlinear cooperation between p53 and ING1 induces bax expression in mouse thymocyte apoptosis: A quantitative approach with cross-platform validation. Apoptosis. 2009, [29] Wan, Lin, Sun, Kelian, Ding, Qi, Cui, Yuehua, Li, Ming, Wen, Yalu, Elston, Robert C, Qian, Minping, Fu, Wenjiang J. Hybridization modeling of oligonucleotide SNP arrays for accurate DNA copy number estimation. NUCLEIC ACIDS RESEARCH[J]. 2009, 37(17): e117-e117, https://www.webofscience.com/wos/woscc/full-record/WOS:000271569100039.
[30] Wan, Lin, Li, Dayong, Zhang, Donglei, Liu, Xue, Fu, Wenjiang J, Zhu, Lihuang, Deng, Minghua, Sun, Fengzhu, Qian, Minping. Conservation and implications of eukaryote transcriptional regulatory regions across multiple species. BMC GENOMICS[J]. 2008, 9(1): 623-623, https://doaj.org/article/266cbfefec474f1f91c7be1f48f714bb.
[31] Wang, CJ, Huang, YN, Wan, L, Yin, HC, Wang, YN, Riande, E. Relaxation dynamics and glass transition in glassy materials. SYNTHETIC METALS[J]. 2003, 135(1-3): 495-496, http://dx.doi.org/10.1016/S0379-6779(02)00708-7.

科研活动

   
科研项目
( 1 ) 动物复杂形状的进化解析与调控, 参与, 部委级, 2014-07--2019-06
( 2 ) 中国科学院青年创新促进会, 主持, 部委级, 2016-01--2019-12
( 3 ) 生物/医学时空型数据的建模、计算与系统综合研究, 主持, 国家级, 2016-01--2019-12
( 4 ) 重大脑精神疾病的遗传影像学分析理论与计算方法, 参与, 国家级, 2017-01--2019-12
( 5 ) 非完整、异构材料数据关联统计分析与挖掘技术, 参与, 国家级, 2018-07--2022-06
( 6 ) 几何与拓扑型数据分析的理论与方 法及其在高维异质生物数据中的应 用, 主持, 国家级, 2021-01--2024-12
( 7 ) 大脑计算同化平台与新一代类脑智能算法理论, 参与, 国家级, 2020-06--2025-05

指导学生

已指导学生

白向琦  博士研究生  071101-系统理论  

现指导学生

易健平  硕士研究生  070103-概率论与数理统计  

陈紫薇  博士研究生  071101-系统理论  

蒋淇  硕士研究生  071101-系统理论  

安少坤  博士研究生  071101-系统理论