基本信息
罗敏华  女  博导  中国科学院武汉病毒研究所
电子邮件: luomh@wh.iov.cn
通信地址: 湖北省武汉市小洪山44号
邮政编码: 430071

研究领域

1. 人巨细胞病毒感染和神经损伤:
    (1) 先天性感染致新生儿神经发育异常及其机制研究;
    (2) 持续性 / 潜伏感染和神经胶质瘤的相关性研究。

2. 嗜神经病毒改造与神经示踪:
    (1) 筛选新型神经示踪工具;
    (2) 改造病毒发展新型神经示踪工具病毒;
    (3) 利用新型工具病毒进行神经示踪研究。

招生信息

   
招生专业
071005-微生物学
招生方向
神经病毒学:(1) HCMV感染和神经损伤;(2)嗜神经病毒改造与神经环路示踪

教育背景

1983-09--1999-07   湖南医科大学(现中南大学湘雅医学院)   临床医学学士,硕士,博士
学历
博士
学位
博士

工作经历

2009/07-至今:中科院武汉病毒研究所,研究员

2004/12-2009/06:美国爱达荷大学,助理研究教授

2002/08-2004/11:湖南医科大学(现中南大学湘雅医学院),副教授、教授

1999/07-2002/08:美国哈佛大学医学院附属西莱弗研究中心,博士后

1988/07-1999/07:湖南医科大学(现中南大学湘雅医学院),见习助教,助教,讲师
社会兼职
2019-01-01-今,J Virol 编委,
2011-12-01-今,病毒所伦理委员会主任,
2010-06-01-今,湖北省遗传学会理事,

教授课程

病毒病与监控
病毒与病毒病
分子病毒学
Microbiology and Infectious Disease
医学微生物学,临床微生物学(病毒)

专利与奖励

奖励信息
(1) 中国科学院朱李月华优秀教师奖, , 院级, 2015
(2) 湖南省科技进步一等奖, 一等奖, 省级, 2015
(3) 自然科学奖, 二等奖, 部委级, 2013
(4) Outstanding Research Scientist, , 研究所(学校), 2008
(5) 湖南省长沙市优秀论文1等奖, 一等奖, 市地级, 2000
专利成果
[1] 罗敏华, 曾文波, 杨虹, 熊锋, 赵非. 调控给K蛋白功能的顺行跨单级神经示踪系统. 2021092200817280, 2021-09-26.

[2] 罗敏华, 段莹亮, 伊丽莎白福尔图那托. 一种基于细胞爬片的快速经济的免疫荧光方法. CN: CN109374883A, 2019-02-22.

[3] LUO, Minhua, ZENG, Wenbo, JIANG, Haifei, ZHAO, Fei, YANG, Hong, SONG, Yige, SHEN, Zhangzhou. ANTEROGRADE MULTI-SYNAPTIC TRANSNEURONAL TRACER. CN: US20180371467(A1), 2018-12-27.

[4] 罗敏华, 曾文波, 江海飞, 赵非, 杨虹, 宋一舸, 谌章舟. 顺行跨多级突触、跨神经元的示踪系统. CN: CN106544326A, 2017-03-29.

[5] 罗敏华, 曾文波, 江海飞, 赵非, 杨虹, 宋一舸, 谌章舟. 顺行跨单级突触神经示踪系统. CN: CN106520709A, 2017-03-22.

[6] 罗敏华, 谌章舟, 柳中洋, 赵非, 阮强, 朱桦. 人巨细胞病毒感染性克隆及其构建方法和应用. CN: CN105713866A, 2016-06-29.

[7] 罗敏华, 曾文波, 江海飞, 赵非, 谌章舟. HSV1-H129-BAC及其变体的构建方法与应用. CN: CN105567618A, 2016-05-11.

出版信息

   
发表论文
(1) A congenital CMV infection model for follow-up studies of neurodevelopmental disorders, neuroimaging abnormalities, and treatment, JCI Insight, 2022, 通讯作者
(2) Hearing Loss Caused by HCMV Infection through Regulating the Wnt and Notch Signaling Pathways, Viruses, 2021, 第 6 作者
(3) Concerns on Vaccine against Varicella Caused by Varicella-Zoster Virus Infection, Concerns on Vaccine against Varicella Caused by Varicella-Zoster Virus Infection, VIROLOGICA SINICA, 2021, 通讯作者
(4) Hearing Loss Caused by HCMV Infection through Regulating the Wnt and Notch Signaling Pathways, VIRUSES-BASEL, 2021, 通讯作者
(5) Human cytomegalovirus DNA and immediate early protein 1/2 are highly associated with glioma and prognosis (vol 11, pg 525, 2020), PROTEIN & CELL, 2021, 通讯作者
(6) Localization of the WD Repeat-Containing Protein 5 to the Virion Assembly Compartment Facilitates Human Cytomegalovirus Assembly, JOURNAL OF VIROLOGY, 2021, 通讯作者
(7) Anterograde Neuronal Circuit Tracers Derived from Herpes Simplex Virus 1: Development, Application, and Perspectives, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 通讯作者
(8) Does SARS‐CoV‐2 has a longer incubation period than SARS and MERS?, Journal of Medical Virology, 2020, 第 3 作者
(9) Viral Vectors for Neural Circuit Mapping and Recent Advances in Trans-synaptic Anterograde Tracers, NEURON, 2020, 第 3 作者
(10) 人类疱疹病毒6B与难治性颞叶内侧癫痫的相关性研究, Correlation study on human herpesvirus 6B and intractable mesial temporal lobe epilepsy, 癫痫杂志, 2020, 第 3 作者
(11) HSV-1 H129-Derived Anterograde Neural Circuit Tracers: Improvements, Production, and Applications, Neuroscience Bulletin, 2020, 第11作者
(12) Cryo-EM structure of the varicella-zoster virus A-capsid, NATURE COMMUNICATIONS, 2020, 通讯作者
(13) A PILOT CLINICAL TRIAL OUTCOME OF BIOSAFETY SYSTEM EVALUATION FOR PERV-C FREE PORCINE ISLET XENOTRANSPLANTATION BASED ON PRINCIPLE OF WHO "CHANGSHA COMMUNIQUE", TRANSPLANTATION, 2020, 第11作者
(14) Pathogenic Effects and Pathogenesis Processes in Vitro & in Vivo in Murine Cytomegalovirus Infected Rat Corneal Endothelial Cells, OCULAR IMMUNOLOGY AND INFLAMMATION, 2020, 通讯作者
(15) Human cytomegalovirus DNA and immediate early protein 1/2 are highly associated with glioma and prognosis, Human cytomegalovirus DNA and immediate early protein 1/2 are highly associated with glioma and prognosis, PROTEIN & CELL, 2020, 通讯作者
(16) Human Cytomegalovirus Protein UL94 Targets MITA to Evade the Antiviral Immune Response, JOURNAL OF VIROLOGY, 2020, 第 6 作者
(17) Anterograde Viral Tracer Herpes Simplex Virus 1 Strain H129 Transports Primarily as Capsids in Cortical Neuron Axons, JOURNAL OF VIROLOGY, 2020, 第11作者
(18) A Conditioning-Strengthened Circuit From CA1 of Dorsal Hippocampus to Basolateral Amygdala Participates in Morphine-Withdrawal Memory Retrieval, FRONTIERS IN NEUROSCIENCE, 2020, 第11作者
(19) The Susceptibility of Primary Dermis Fibroblasts from the Chinese Tree Shrew to Human Cytomegalovirus Infection, VIROLOGICA SINICA, 2019, 通讯作者
(20) Prion dimer is heterogenous and is modulated by multiple negative and positive motifs, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 第 4 作者
(21) Human cytomegalovirus protein UL42 antagonizes cGAS/MITA-mediated innate antiviral response, PLOS PATHOGENS, 2019, 第 7 作者
(22) USP20 Promotes Cellular Antiviral Responses via Deconjugating K48-Linked Ubiquitination of MITA, JOURNAL OF IMMUNOLOGY, 2019, 第 8 作者
(23) Basolateral amygdala input to the medial prefrontal cortex controls obsessive-compulsive disorder-like checking behavior, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 第 14 作者
(24) Human Cytomegalovirus DNA Polymerase Subunit UL44 Antagonizes Antiviral Immune Responses by Suppressing IRF3-and NF-kappa B-Mediated Transcription, JOURNAL OF VIROLOGY, 2019, 第 7 作者
(25) Direct auditory cortical input to the lateral periaqueductal gray controls sound-driven defensive behavior, PLoS Biology, 2019, 第 7 作者
(26) Proteomic Analysis of Zika Virus Infected Primary Human Fetal Neura Progenitors Suggests a Role for Doublecortin in the Pathological Consequences of Infection in the Cortex, FRONTIERS IN MICROBIOLOGY, 2018, 通讯作者
(27) Proteomic Analysis of Zika Virus Infected Primary Human Fetal Neural Progenitors Suggests a Role for Doublecortin in the Pathological Consequences of Infection in the Cortex, Frontiers in Microbiology, 2018, 第 10 作者
(28) Expression of Human Cytomegalovirus IE1 Leads to Accumulation of Mono-SUMOylated PML That Is Protected from Degradation by Herpes Simplex Virus 1 ICP0, JOURNAL OF VIROLOGY, 2018, 第 6 作者
(29) Serologic and viral genome prevalence of HSV, EBV, and HCMV among healthy adults in Wuhan, China, JOURNAL OF MEDICAL VIROLOGY, 2018, 通讯作者
(30) Human Cytomegalovirus Immediate Early 1 Protein Causes Loss of SOX2 from Neural Progenitor Cells by Trapping Unphosphorylated STAT3 in the Nucleus, JOURNAL OF VIROLOGY, 2018, 通讯作者
(31) Tick-borne encephalitis virus nonstructural protein ns5 induces rantes expression dependent on the rna-dependent rna polymerase activity, JOURNAL OF IMMUNOLOGY, 2018, 第11作者
(32) WDR5 Facilitates Human Cytomegalovirus Replication by Promoting Capsid Nuclear Egress, JOURNAL OF VIROLOGY, 2018, 通讯作者
(33) Human Cytomegalovirus Protein UL31 Inhibits DNA Sensing of cGAS to Mediate Immune Evasion, CELL HOST & MICROBE, 2018, 第 8 作者
(34) Impaired glutamatergic projection from the motor cortex to the subthalamic nucleus in 6-hydroxydopamine-lesioned hemi-parkinsonian rats, EXPERIMENTAL NEUROLOGY, 2018, 第 8 作者
(35) Molecular cloning and characterization of the genes encoding the proteins of Zika virus, GENE, 2017, 第 7 作者
(36) The central amygdala controls learning in the lateral amygdala, NATURE NEUROSCIENCE, 2017, 第 9 作者
(37) Human cytomegalovirus IE1 downregulates Hes1 in neural progenitor cells as a potential E3 ubiquitin ligase, PLOS PATHOGENS, 2017, 通讯作者
(38) Orf7 of varicella-zoster virus is required for viral cytoplasmic envelopment in differentiated neuronal cells, JOURNAL OF VIROLOGY, 2017, 通讯作者
(39) Anterograde monosynaptic transneuronal tracers derived from herpes simplex virus 1 strain H129, MOLECULAR NEURODEGENERATION, 2017, 通讯作者
(40) Herpesviruses: epidemiology, pathogenesis, and interventions, Herpesviruses: epidemiology, pathogenesis, and interventions, 中国病毒学:英文版, 2017, 第 2 作者
(41) Human cytomegalovirus infection dysregulates neural progenitor cell fate by disrupting Hes1 rhythm and down-regulating its expression, VIROLOGICA SINICA, 2017, 通讯作者
(42) Anterograde Trans-Synaptic Tagging Mediated by Adeno-Associated Virus, NEUROSCIENCE BULLETIN, 2017, 通讯作者
(43) Infected T98G glioblastoma cells support human cytomegalovirus reactivation from latency, VIROLOGY, 2017, 通讯作者
(44) Tick-borne encephalitis virus induces chemokine RANTES expression via activation of IRF-3 pathway, JOURNAL OF NEUROINFLAMMATION, 2016, 第 8 作者
(45) Identification and BAC construction of Han, the first characterized HCMV clinical strain in China, JOURNAL OF MEDICAL VIROLOGY, 2016, 通讯作者
(46) Later passages of neural progenitor cells from neonatal brain are more permissive for human cytomegalovirus infection (vol 87, pg 10968, 2013), JOURNAL OF VIROLOGY, 2016, 第 21 作者
(47) Multipotent mesenchymal stromal cells are fully permissive for human cytomegalovirus infection, VIROLOGICA SINICA, 2016, 通讯作者
(48) Human Cytomegalovirus Infection Dysregulates the Localization and Stability of NICD1 and Jag1 in Neural Progenitor Cells, JOURNAL OF VIROLOGY, 2015, 通讯作者
(49) MicroRNA miR-21 Attenuates Human Cytomegalovirus Replication in Neural Cells by Targeting Cdc25a, JOURNAL OF VIROLOGY, 2015, 通讯作者
(50) Natural antisense transcripts of UL123 packaged in human cytomegalovirus virions, ARCHIVES OF VIROLOGY, 2014, 第 8 作者
(51) Genotypic Analysis of Kaposi's Sarcoma-Associated Herpesvirus from Patients with Kaposi's Sarcoma in Xinjiang, China, VIRUSES-BASEL, 2014, 通讯作者
(52) Maintenance of Large Numbers of Virus Genomes in Human Cytomegalovirus-Infected T98G Glioblastoma Cells, JOURNAL OF VIROLOGY, 2014, 第 9 作者
(53) Comprehensive Analysis of Human Cytomegalovirus MicroRNA Expression during Lytic and Quiescent Infection, PLOS ONE, 2014, 通讯作者
(54) Later Passages of Neural Progenitor Cells from Neonatal Brain Are More Permissive for Human Cytomegalovirus Infection, JOURNAL OF VIROLOGY, 2013, 通讯作者
(55) A faster immunofluorescence assay for tracking infection progress of human cytomegalovirus, ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2012, 第 9 作者
(56) Comprehensive characterization of human cytomegalovirus infection in the long-term infected t98g cell model, NEURO-ONCOLOGY, 2011, 第 7 作者
(57) Human Cytomegalovirus Infection Causes Premature and Abnormal Differentiation of Human Neural Progenitor Cells ▿ †, JOURNAL OF VIROLOGY, 2010, 第 1 作者
(58) Neonatal Neural Progenitor Cells and Their Neuronal and Glial Cell Derivatives Are Fully Permissive for Human Cytomegalovirus Infection ▿, JOURNAL OF VIROLOGY, 2008, 第 1 作者
(59) Tau Protects Microtubules in the Axon from Severing by Katanin, JOURNAL OF NEUROSCIENCE, 2006, 
(60) Novel isoforms of tau that lack the microtubule-binding domain, JOURNAL OF NEUROCHEMISTRY, 2004, 
(61) Tau isoforms which contain the domain encoded by exon 6 and their role in neurite elongation, JOURNAL OF CELLULAR BIOCHEMISTRY, 2004, 
发表著作
(1) 医学微生物学(教材), Medical Microbiology, 吉林科学出版社, 2005-07, 第 1 作者
(2) 普通病毒学(第二版), 科学出版社, 2019-11, 第 其他 作者

科研活动

   
科研项目
( 1 ) HCMV感染致胎儿神经发育畸形机制, 负责人, 中国科学院计划, 2010-07--2013-06
( 2 ) 病毒潜伏感染与神经病变, 负责人, 国家任务, 2011-01--2015-12
( 3 ) HCMV感染致神经发育畸形机制-潜伏机制, 负责人, 国家任务, 2011-01--2013-12
( 4 ) HCMV下调神经干细胞SOX2表达机制, 负责人, 国家任务, 2012-01--2015-12
( 5 ) 武汉市学科带头人, 负责人, 地方任务, 2012-01--2014-12
( 6 ) 持续性感染病毒拮抗细胞凋亡机制, 负责人, 国家任务, 2012-01--2016-12
( 7 ) HCMV感染对神经前体细胞调控NOTCH通路的调控, 负责人, 国家任务, 2013-01--2016-12
( 8 ) 基于荧光分子纳米分辨定位的超分辨定位成像仪器, 负责人, 国家任务, 2015-01--2019-12
( 9 ) 特定脑功能联接图谱, 参与, 中国科学院计划, 2014-01--2016-12
( 10 ) 灵长类神经回路精细结构成像的新方法和新工具/灵长类动物脑细胞和神经回路的特异性光学标记, 参与, 国家任务, 2015-01--2019-08
( 11 ) 先天性巨细胞病毒感染下调Sox2影响胎脑发育的机制, 负责人, 国家任务, 2017-01--2021-12
( 12 ) 人巨细胞病毒感染对胶质瘤的影响, 负责人, 地方任务, 2016-01--2018-12
( 13 ) 情感与记忆的神经环路基础重大研究计划, 参与, 国家任务, 2018-01--2019-12
( 14 ) 脑联结图谱绘制新技术, 参与, 中国科学院计划, 2018-01--2022-12
( 15 ) Genetically engineered anterograde monosynaptic viral tracers for multi-species neural circuit analysis, 负责人, 其他任务, 2019-08--2022-07
( 16 ) 新型水痘疫苗合作开发项目, 负责人, 企业委托, 2020-01--2023-12
( 17 ) HCMV-IE1下调Cx43致听力损伤机制, 负责人, 国家任务, 2022-01--2025-12
参与会议
(1)A congenital CMV infection model for long-term follow-up studies:neurodevelopmental disorders, neuroimaging abnormalities, and brain damage from CMV-induced neuroinflammation and calcification   第十四届全国病毒学学术研讨会   2021-09-28
(2)Anterograde Trans-neuronal Tracers Derived from Herpes Simplex Virus 1 Strain 129   第44届国际疱疹病毒年会   2019-07-22
(3)Congenital CMV infection and fetal brain development disorders   第7届先天性疱疹病毒病会议   2019-04-07
(4)Human Cytomegalovirus Upregulates Cellular WDR5 Protein to Facilitate Viral Replication   2018-07-21
(5)WDR5 Facilitates Human Cytomegalovirus Replication by Promoting Capsid Nuclear Egress   2018-07-14
(6)Human Cytomegalovirus IE1 Downregulates Hes1 in Neural Progenitor Cells as a potential E3 Ubiquitin Ligase   2017细胞研讨会:新发和再发病毒会议   2017-10-01
(7)Human Cytomegalovirus Infection Alters miRNAs Associated with Perturbation of Neural Progenitor Cell Fate   第41届国际疱疹病毒会议   2016-07-23
(8)Human Cytomegalovirus Infection Dysregulates the Localization and Stability of NICD1 and Jag1 in Neural Progenitor Cells   第40届国际疱疹病毒会议   Li, Xiao-jun   2015-07-23
(9)Neural Models for HCMV Infection   Ying Liang Duan   2011-05-14

指导学生

已指导学生

杨翠青  硕士研究生  071010-生物化学与分子生物学  

段莹亮  博士研究生  071010-生物化学与分子生物学  

谌章舟  博士研究生  071010-生物化学与分子生物学  

潘杏  硕士研究生  071010-生物化学与分子生物学  

付亚茹  博士研究生  071005-微生物学  

乔冠华  博士研究生  071005-微生物学  

吴琮琮  硕士研究生  071005-微生物学  

李小军  博士研究生  071005-微生物学  

江海飞  博士研究生  071005-微生物学  

刘喜娟  博士研究生  071005-微生物学  

温乐  博士研究生  071005-微生物学  

杨波  博士研究生  071005-微生物学  

杨虹  博士研究生  100103-病原生物学  

周晶  硕士研究生  071005-微生物学  

熊锋  博士研究生  071005-微生物学  

周月鹏  博士研究生  071005-微生物学  

贾玉萍  硕士研究生  100103-病原生物学  

李栋  硕士研究生  085238-生物工程  

马雪慧  硕士研究生  085238-生物工程  

现指导学生

王冼章  博士研究生  071005-微生物学  

黄胜男  博士研究生  100103-病原生物学  

秦海滨  博士研究生  100103-病原生物学  

张清杨  硕士研究生  086000-生物与医药  

潘雨婷  硕士研究生  071005-微生物学  

梅梦杰  博士研究生  100103-病原生物学  

史雪晶  硕士研究生  086000-生物与医药  

江欣泽  硕士研究生  086000-生物与医药  

伍锦鹏  博士研究生  100103-病原生物学