主要运用植物化学、分析化学、生物化学、细胞和分子生物学等手段，以及首创单细胞植物化学研究新技术方法LMD-cryoNMR-UPLC/MS/MS，揭示植物特殊结构（如腺毛、分泌囊、乳汁器、特定细胞等）中的次生代谢产物及其生物功能，在此基础上发现独特天然活性物质。同时开展云南特色资源或药用植物的化学成分与生物活性研究，进行创新天然药物研究开发。

100701-药物化学

天然药物化学
天然产物生物合成

100701-药物化学

1996-09--2001-08   中国科学院昆明植物研究所   博士学位
1992-09--1996-07   云南大学   学士学位

中科院昆明植物研究所 -- 研究生

中科院昆明植物研究所 -- 博士

天然药物化学
高级植物分子生物学
有机结构分析

已指导学生

骆世洪  博士研究生  100701-药物化学  

周艳英  硕士研究生  077901-药物化学  

石伟  硕士研究生  071010-生物化学与分子生物学  

李春环  博士研究生  100701-药物化学  

黄春帅  硕士研究生  105500-药学硕士  

杨敏杰  硕士研究生  078001-药物化学  

王英  博士研究生  100701-药物化学  

景树溪  博士研究生  100701-药物化学  

匡策  硕士研究生  078001-药物化学  

冯玲  博士研究生  100701-药物化学  

李德森  硕士研究生  085238-生物工程  

谭艳云  硕士研究生  078001-药物化学  

肖朝江  博士研究生  100701-药物化学  

华娟  博士研究生  100701-药物化学  

凌伊  硕士研究生  105500-药学  

罗菲  硕士研究生  078001-药物化学  

郭凯  博士研究生  100701-药物化学  

李文渊  博士研究生  100701-药物化学  

耿浩  博士研究生  100701-药物化学  

王莹  博士研究生  100701-药物化学  

罗柳琼  硕士研究生  078001-药物化学  

黄庆谱  硕士研究生  078001-药物化学  

符然  硕士研究生  078001-药物化学  

高建雄  硕士研究生  078001-药物化学  

滕林琳  博士研究生  100701-药物化学  

张嫚雯  硕士研究生  078001-药物化学  

现指导学生

陈月桂  博士研究生  100701-药物化学  

李德森  博士研究生  100701-药物化学  

李曼  博士研究生  100706-药理学  

严沁  硕士研究生  078001-药物化学  

张瀚  硕士研究生  078006-药理学  

周婷婷  博士研究生  100706-药理学  

母蓉芳  博士研究生  100706-药理学  

刘艳春  博士研究生  100706-药理学  

符然  博士研究生  100701-药物化学  

白秀英  硕士研究生  078001-药物化学  

   

2007-08~现在, 中国科学院昆明植物研究所, 研究员、引进国外杰出人才
2004-10~2008-01,德国马普化学生态研究所, 博士后（兼洪堡研究学者）
2004-03~2004-09,香港中文大学中医中药研究所, 博士后
2003-04~2004-02,中国科学院昆明植物研究所, 副研究员
2001-09~2003-03,中国科学院昆明植物研究所, 助理研究员

2022-01-01-今,Plant Medicinal Biology, 副主编
2021-12-01-2025-12-01,中国植物保护学会第十三届理事会, 常务理事
2019-12-01-2022-12-01,广西植物功能物质研究与利用重点实验室学术委员会, 副主任委员
2019-10-01-2024-10-01,国家药品监督管理局中药材质量监测评价重点实验室学术委员会, 委员
2019-07-01-2024-07-01,中国植物生理与植物分子生物学学会植物代谢专业委员会, 委员
2019-01-01-今,Plant Communications, 编委
2018-08-01-2023-08-01,国家天然药物工程技术研究中心技术委员会, 委员
2017-11-01-2025-12-01,中国植物保护学会植物化感作用专业委员会, 主任委员
2017-10-01-2022-10-01,中国生态学学会第四届化学生态专业委员会, 委员
2017-01-01-今,Chemistry & Biodiversity, 编委
2016-12-31-今,Frontiers in Plant Science, 副主编
2016-07-01-今,中国中药协会中药材检测认证技术专业委员会, 委员
2011-01-01-今,Natural Products and Bioprospecting, 编委

   

（1） 云南省自然科学奖, 一等奖, 省级, 2022
（2） 兴滇人才奖, , 省级, 2020
（3） 国家“万人计划”领军人才, 国家级, 2017
（4） 云南省高层次人才, , 省级, 2017
（5） 科技部中青年科技创新领军人才, 国家级, 2017
（6） 中科院特聘研究员核心骨干, 院级, 2017
（7） 云南省创新团队带头人, 省级, 2017
（8） 科技部中青年科技创新领军人才, 部委级, 2016
（9） 云南省科研标兵, 省级, 2016
（10） 国务院政府特殊津贴, 国家级, 2016
（11） 云南省自然科学奖, 一等奖, 省级, 2014
（12） 中国科学院优秀研究生指导教师奖, , 院级, 2013
（13） 中国科学院优秀导师奖, , 院级, 2011
（14） 中国科学院****, , 院级, 2010
（15） 云南省中青年学术和技术带头人, , 省级, 2008
（16） 德国洪堡（AvH）奖学金, , 其他, 2005
（17） 云南省自然科学奖, 一等奖, 省级, 2003

（ 1 ） 米团花中二倍半萜化合物及其制备方法和在制药中的应用, 发明专利, 2023, 第 1 作者, 专利号: CN115745924A

（ 2 ） 用于重楼皂苷生物合成的糖基转移酶及其编码基因和应用, 发明专利, 2022, 第 1 作者, 专利号: CN114561369A

（ 3 ） 重楼皂苷在制备抗白色念珠菌氟康唑耐药株制品以及抗皮肤癣菌制品中的应用, 发明专利, 2022, 第 1 作者, 专利号: CN114432326A

（ 4 ） 双功能二倍半萜/二萜合酶LcTPS2、编码基因及其产物和应用, 发明专利, 2021, 第 1 作者, 专利号: CN113186183A

（ 5 ） 火把花烷二倍半萜化合物及其制备方法、药物组合物及应用和火把花总提物的应用, 发明专利, 2021, 第 1 作者, 专利号: CN113024498A

（ 6 ） 二倍半萜化合物及其制备方法和在制备抗炎药物和免疫抑制药物中的应用, 专利授权, 2021, 第 1 作者, 专利号: CN111302924B

（ 7 ） 雪松醇合酶Lc-CedS编码基因及其应用, 发明专利, 2019, 第 1 作者, 专利号: CN109735523A

（ 8 ） 克罗烷二萜化合物及其提取物和其作为昆虫拒食剂, 发明专利, 2014, 第 1 作者, 专利号: CN103923076A

（ 9 ） 苯并吡喃三萜,其药物组合物及其制备方法与应用, 发明专利, 2013, 第 1 作者, 专利号: CN102898499A

（ 10 ） 二倍半萜类化合物及其制备方法与应用, 发明专利, 2012, 第 1 作者, 专利号: CN102659803A

（ 11 ） 昆虫拒食剂及其制备方法与应用, 发明专利, 2012, 第 1 作者, 专利号: CN102657241A

（ 12 ） 米团花醌,其制备方法与应用, 发明专利, 2012, 第 1 作者, 专利号: CN102617435A

（ 13 ） 二倍半萜化合物及其应用, 发明专利, 2010, 第 1 作者, 专利号: CN101787007A

（ 14 ） 一种抗血小板药物及其用途, 发明专利, 2005, 第 1 作者, 专利号: CN1561998A

   

（ 1 ） 植物次生代谢产物化学生态学研究, 负责人, 中国科学院计划, 2010-01--2015-04
（ 2 ） 云南特征唇形科植物的萜类次生代谢产物化学及防御功能研究, 负责人, 国家任务, 2013-01--2016-12
（ 3 ） 植物源杀线虫活性化合物的发掘及作用机制研究, 负责人, 国家任务, 2013-01--2017-12
（ 4 ） 植物特殊结构中的次生代谢产物与生物功能, 负责人, 国家任务, 2016-01--2020-12
（ 5 ） 活性天然产物发现与生物合成, 负责人, 地方任务, 2017-08--2020-08
（ 6 ） 重要药用唇形科植物腺毛中的活性天然产物研究, 负责人, 国家任务, 2018-01--2021-12
（ 7 ） 新颖结构植物二倍半萜的发现与免疫抑制活性研究, 负责人, 国家任务, 2020-01--2024-12
（ 8 ） 重要植物药单体化合生成应用研究 —重楼皂苷等重要植物药单体化合生成途经关键技术研究, 负责人, 地方任务, 2019-01--2022-12

（1）植物二倍半萜的研究   中国植物保护学会2018年学术年会暨植保科技奖颁奖大会   2018-10-24
（2）植物二倍半萜多样性与生物合成   中国植物学会第十六次全国会员代表大会暨85周年学术年会   2018-10-10
（3）Natural products of two Lamiaceae plants and sesterterpenoid biosynthesis   2018-08-31
（4）Terpenoid diversity and biosynthesis in Leucosceptrum canum   第十九届全国植物基因组学大会   2018-08-19
（5）现代植物化学研究   第十二届全国天然有机化学会议   2018-07-28
（6）二倍半萜类植物天然产物结构多样性与生物合成   中国化学会第31届学术年会   2018-05-04
（7）几种云南特色植物腺毛中的天然产物及二倍半萜生物合成研究   植物与微生物促大健康产业发展学术研讨会   2017-12-03
（8）植物二倍半萜多样性与生物合成   基因组学与植物生物技术暨第二届植物青年科学家论坛   2017-11-24
（9）Bioactive natural proudcts in plant glandular trichomes   2017-10-13
（10）Unusual specialized metabolites of two Himalayan Lamiaceae plants and their biological functions   2017-09-18
（11）植物特殊结构中的次生代谢产物及其生物功能   第八届植物化感作用学术研讨会   2017-09-12
（12）几种云南特色植物的次生代谢产物与生物功能   第9届西部地区植物科学与资源利用研讨会   2017-08-25
（13）Terpenoids in the glandular trichomes of several Himalayan Lamiaceae species and sesterterpenoid biosynthesis   2017-07-16
（14）The Unusual Secondary Metabolism of Two Himalayan Mint Species   2016-11-14
（15）植物二倍半萜：化学多样性、生物功能与生物合成   中国化学会第十一届全国天然有机化学学术会议   2016-09-25
（16）Chemistry and Biological Functions of Plant Secondary Metabolites   黎胜红   2014-05-22
（17）植物次生代谢产物化学与生物功能   中国植物学会第十五届会员代表大会暨80周年学术年会   黎胜红   2013-10-13
（18）Secondary Metabolites and Biological Functions of Two Lamiaceae Plants   第九届中美华人化学教授会议   黎胜红   2013-08-05
（19）Chemistry and Ecological Functions of Plant Secondary Metabolites   黎胜红   2011-10-04
（20）植物次生代谢产物化学及生态学功能   第八届全国化学生态学学术研讨会   黎胜红   2010-10-09
（21）Secondary metabolites of the invasive Eupatorium adebophorum and their possible ecological functions    黎胜红   2010-10-04
（22）Investigation on the Allelochemicals of the Invasive Eupatorium adenophotum   黎胜红   2009-09-25

   

[1] Yang, MinJie, Luo, ShiHong, Guo, Kai, Liu, Yan, Li, ShengHong. Chemical investigation of Buddleja officinalis leaves and localization of defensive triterpenoids to its glandular trichomes. FITOTERAPIA[J]. 2023, 164: http://dx.doi.org/10.1016/j.fitote.2022.105379.
[2] Yonghong Chen, Xiaoyu Yang, Longlong Zhang, Qunfu Wu, Shuhong Li, Jianghui Gou, Jiangbo He, Keqin Zhang, Shenghong Li, Xuemei Niu. Tryptophan-centered metabolic alterations coincides with lipid-mediated fungal response to cold stress. HELIYON[J]. 2023, 9(2): e13066-, http://dx.doi.org/10.1016/j.heliyon.2023.e13066.
[3] Chen, Yuegui, Yan, Qin, Ji, Yunheng, Bai, Xue, Li, Desen, Mu, Rongfang, Guo, Kai, Yang, Minjie, Tao, Yang, Jonathan Gershenzon, Liu, Yan, Li, Shenghong. Unraveling the serial glycosylation in the biosynthesis of steroidal saponins in the medicinal plant Paris polyphylla and their antifungal action. Acta Pharmaceutica Sinica B[J]. 2023, [4] Liu, Yan, Zhou, YanYing, Luo, ShiHong, Guo, Kai, Zhang, ManWen, Jing, ShuXi, Li, ChunHuan, Hua, Juan, Li, ShengHong. Labdane diterpenoids from the heartwood of Leucosceptrum canum that impact on root growth and seed germination of Arabidopsis thaliana. PHYTOCHEMISTRY[J]. 2023, 206: http://dx.doi.org/10.1016/j.phytochem.2022.113531.
[5] Yang, Xiaoyu, Chen, Yonghong, Zhang, Longlong, He, Jiangbo, Wu, Qunfu, Li, Shuhong, Wang, Donglou, Gou, Jianghui, Wu, Zhuang, Zhang, Keqin, Li, Shenghong, Niu, Xuemei. Melanin precursors mediated adaption to temperature changes in fungus and animal via inhibition of lipid-mediated ferroptosis. Science China Life Sciences[J]. 2023, [6] Li, Desen, Yang, Minjie, Mu, Rongfang, Luo, Shihong, Chen, Yuegui, Li, Wenyuan, Wang, An, Guo, Kai, Liu, Yan, Li, Shenghong. Characterization of two chimeric sesterterpene synthases from a fungal symbiont isolated from a sesterterpenoid-producing Lamiaceae plant Leucosceptrum canum. CHINESE CHEMICAL LETTERS[J]. 2023, 34(1): 279-283, http://dx.doi.org/10.1016/j.cclet.2022.04.067.
[7] DeSen Li, LinLin Shi, Kai Guo, ShiHong Luo, YanChun Liu, YueGui Chen, Yan Liu, ShengHong Li. A new sesquiterpene synthase catalyzing the formation of (R)-β-bisabolene from medicinal plant Colquhounia coccinea var. mollis and its anti-adipogenic and antibacterial activities. PHYTOCHEMISTRY[J]. 2023, 211: http://dx.doi.org/10.1016/j.phytochem.2023.113681.
[8] Jie Liu, Qin Yan, LiXia Wang, XiaoPing He, Hong Hu, YanChun Liu, Dan Li, Yan Liu, Kai Guo, ShengHong Li. Secoiridoids from the traditional Chinese medicine Swertia pseudochinensis. PHYTOCHEMISTRY[J]. 2023, 210: http://dx.doi.org/10.1016/j.phytochem.2023.113642.
[9] Guo, Kai, Ren, Xue, Zhou, TingTing, Li, Tao, Liu, YanChun, Tao, Yang, Hu, Hong, Li, Dan, Liu, Yan, Li, ShengHong. Secondary metabolites from the Mongolian medicine Lomatogonium carinthiacum. FITOTERAPIA[J]. 2023, 165: http://dx.doi.org/10.1016/j.fitote.2022.105402.
[10] Luo, Shihong, Huang, Chunshuai, Hua, Juan, Jing, Shuxi, Teng, Linlin, Tang, Ting, Liu, Yan, Li, Shenghong. Defensive Specialized Metabolites from the Latex of Euphorbia jolkinii. JOURNAL OF CHEMICAL ECOLOGY. 2023, http://dx.doi.org/10.1007/s10886-023-01413-6.
[11] Guo, Kai, Luo, ShiHong, Guo, DaLe, Li, DeSen, Hua, Juan, Liu, Yan Chun, Liu, Yan, Li, ShengHong. A monocarbocyclic sesterterpenoid biosynthetic precursor of leucosceptroids from Leucosceptrum canum and its metabolic isomerization by a specialist insect. ORGANIC CHEMISTRY FRONTIERS[J]. 2022, 9(8): 2209-2214, http://dx.doi.org/10.1039/d2qo00138a.
[12] 李德森, 陈月桂, 郭凯, 凌伊, 刘燕, 黎胜红. 二倍半萜类天然产物的生物合成研究进展. 药学学报[J]. 2022, 57(4): 931-942, http://lib.cqvip.com/Qikan/Article/Detail?id=7107185016.
[13] Zheng, Yu, Liu, ZhiWei, Li, Tao, Li, Xian, Li, ShengHong. KIO3-Mediated gamma-C(sp3)-H Sulfenylation of Enaminones. ORGANIC LETTERS[J]. 2022, 24(41): 7533-7537, http://dx.doi.org/10.1021/acs.orglett.2c02824.
[14] Guo, Kai, Ren, Xue, Mu, RongFang, Zhou, TingTing, Li, Dan, Hu, Hong, Liu, Yan, Li, ShengHong. Ecdysteroids and spirosterane steroids from the traditional Chinese medicine Paris polyphylla var. yunnanensis. PHYTOCHEMISTRY LETTERS[J]. 2021, 45: 117-120, http://dx.doi.org/10.1016/j.phytol.2021.08.008.
[15] Teng, Linlin, Mu, Rongfang, Liu, Yanchun, Xiao, Chaojiang, Li, Desen, Gao, Jiangxiong, Guo, Kai, Li, Xiaonian, Liu, Yan, Li, Shenghong. Immunosuppressive and Adipogenesis Inhibitory Seterterpenoids with a Macrocyclic Ether System from Eurysolen gracilis. ORGANIC LETTERS[J]. 2021, 23(6): 2232-2237, https://pubs.acs.org/doi/10.1021/acs.orglett.1c00369.
[16] Zhang, ManWen, Guo, Kai, Zhang, Yu, Teng, LinLin, Huang, QingPu, Liu, Yan, Li, ShengHong. Leucoabietenes A and B, rearranged abietane and ent-abietane diterpene hydrocarbons against resistant infectious fungus and bacterium from the leaves of Leucosceptrum canum. TETRAHEDRON LETTERS[J]. 2021, 81: http://dx.doi.org/10.1016/j.tetlet.2021.153356.
[17] Wang, Ying, Liu, YanChun, Li, WenYuan, Guo, Kai, Liu, Yan, Li, ShengHong. Antifeedant, cytotoxic, and anti-inflammatory neo-clerodane diterpenoids in the peltate glandular trichomes and fresh leaves of Ajuga forrestii. PHYTOCHEMISTRY[J]. 2021, 186: http://dx.doi.org/10.1016/j.phytochem.2021.112731.
[18] Hua, Juan, Liu, YanChun, Luo, ShiHong, Liu, Yan, Xiao, ChaoJiang, Li, XiaoNian, Li, ShengHong. Immunostimulatory 6/6/6/6 Tetracyclic Triterpenoid Saponins with the Methyl-30 Incorporated Cyclization from the Root of Colquhounia elegans. ORGANIC LETTERS[J]. 2021, 23(19): 7462-7466, http://dx.doi.org/10.1021/acs.orglett.1c02673.
[19] Gao, JianXiong, Chen, YueGui, Li, DeSen, Lin, Liang, Liu, Yan, Li, ShengHong. Cloning and Functional Characterization of a Squalene Synthase from Paris polyphylla var. yunnanensis. CHEMISTRY & BIODIVERSITY[J]. 2021, 18(7): http://dx.doi.org/10.1002/cbdv.202100342.
[20] Jing, ShuXi, Fu, Ran, Li, ChunHuan, Zhou, TingTing, Liu, YanChun, Liu, Yan, Luo, ShiHong, Li, XiaoNian, Zeng, Fang, Li, ShengHong. Immunosuppresive Sesterterpenoids and Norsesterterpenoids from Colquhounia coccinea var. mollis. JOURNAL OF ORGANIC CHEMISTRY[J]. 2021, 86(16): 11169-11176, http://dx.doi.org/10.1021/acs.joc.1c00374.
[21] Guo, Kai, Liu, Yan, Li, ShengHong. The untapped potential of plant sesterterpenoids: chemistry, biological activities and biosynthesis. NATURAL PRODUCT REPORTS[J]. 2021, 38(12): [22] Teng, LinLin, Mu, RongFang, Liu, YanChun, Xiao, ChaoJiang, Li, DeSen, Gao, JianXiong, Guo, Kai, Li, XiaoNian, Liu, Yan, Zeng, Fang, Li, ShengHong. Immunosuppressive and Adipogenesis Inhibitory Sesterterpenoids with a Macrocyclic Ether System from Eurysolen gracilis. ORGANIC LETTERS[J]. 2021, 23(6): 2232-2237, https://www.webofscience.com/wos/woscc/full-record/WOS:000631439700052.
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