仿生纳米医药与肿瘤诊疗一体

基因递送系统与肿瘤免疫治疗

硕士

博士

070305-高分子化学与物理
071010-生物化学与分子生物学
0703Z1-化学生物学

2011-09--2016-06   华中科技大学   博士
2007-09--2011-06   华中科技大学   本科

博士研究生

博士

   

2018-12~现在, 中国科学院深圳先进技术研究院, 副研究员
2018-09~2018-12,中国科学院深圳先进技术研究院, 助理研究员
2016-07~2018-08,中国科学院深圳先进技术研究院, 博士后

2023-12-01-今,广东省专业标准化技术委员会, 委员
2023-03-01-今,深圳市‘20+8’产业集群生物医药专家库, 专家
2023-01-31-今,深圳市生物医药促进会, 委员
2018-06-29-今,中国生物物理学会, 会员
2011-12-30-今,中国化学会, 会员

化学生物学进展
化学生物学

   

（1） Chemically engineered antibodies for autophagy-based receptor degradation, NATURE CHEMICAL BIOLOGY, 2025, 第 6 作者
（2） Programmable ultrasound-mediated swarms manipulation of bacteria-red blood cell microrobots for tumor-specific thrombosis and robust photothermal therapy, TRENDS IN BIOTECHNOLOGY, 2025, 第 4 作者
（3） Cyanobacteria-intelligent biohybrid system enables light-guided tumor-associated macrophage-specific siRNA delivery, CELL REPORTS PHYSICAL SCIENCE, 2024, 第 9 作者  通讯作者
（4） Astroglial membrane camouflaged Ptbp1 siRNA delivery hinders glutamate homeostasis via SDH/Nrf2 pathway, Biomaterials, 2024, 第 8 作者  通讯作者
（5） Nanotherapeutic Approaches of Interleukin-3 to Clear the α-Synuclein Pathology in Mouse Models of Parkinson's Disease, Advanced Science, 2024, 第 8 作者  通讯作者
（6） 抗体工程化微型机器人清除水中新型冠状病毒的研究, Research on Antibody-Functionalized Microrobots for Removal of SARS-CoV-2 from Water, 集成技术, 2024, 第 5 作者
（7） Reconstructing Tumor Microenvironment Using Photoresponsive Cyanobacteria to Reversal Chemoresistance for Robust Chemotherapy, Small Structures, 2023, 第 9 作者  通讯作者
（8） A Dual-Biomineralized Yeast Micro-/Nanorobot with Self-Driving Penetration for Gastritis Therapy and Motility Recovery, Acs Nano, 2023, 第 3 作者
（9） A Mitochondria-Targeting Self-assembly Carrier-free Lonidamine Nanodrug for Redox-activated Drug Release to Enhance Cancer Chemotherapy, Journal of Materials Chemistry B, 2023, 第 1 作者  通讯作者
（10） Biomimetic Nanosonosensitizers Combined with Noninvasive Ultrasound Actuation to Reverse Drug Resistance and Sonodynamic-Enhanced Chemotherapy against Orthotopic Glioblastoma, Acs Nano, 2023, 第 11 作者  通讯作者
（11） 细菌驱动的免疫调控与肿瘤精准治疗, Bacteria-driven immune regulation and tumor precision therapy, 生命科学, 2023, 第 2 作者
（12） Photosensitizer-loaded gold nanocages for immunogenic phototherapy of aggressive melanoma, Acta Biomaterialia, 2022, 第 2 作者
（13） Click CAR-T cell engineering for robustly boosting cell immunotherapy in blood and subcutaneous xenograft tumor, Click CAR-T cell engineering for robustly boosting cell immunotherapy in blood and subcutaneous xenograft tumor, BIOACTIVE MATERIALS, 2021, 第 13 作者
（14） Sequential Magneto-Actuated and Optics-Triggered Biomicrorobots for Targeted Cancer Therapy, ADVANCED FUNCTIONAL MATERIALS, 2021, 第 11 作者
（15） Noninvasively immunogenic sonodynamic therapy with manganese protoporphyrin liposomes against triple-negative breast cancer, BIOMATERIALS, 2021, 第 6 作者
（16） In situ poly I:C released from living cell drug nanocarriers for macrophage-mediated antitumor immunotherapy, Biomaterials, 2021, 第 3 作者
（17） In Situ Photocatalysis of TiO-Porphyrin-Encapsulated Nanosystem for Highly Efficient Oxidative Damage against Hypoxic Tumors, ACS APPLIED MATERIALS & INTERFACES, 2020, 第 5 作者
（18） In Situ Photocatalyzed Oxygen Generation with Photosynthetic Bacteria to Enable Robust Immunogenic Photodynamic Therapy in Triple-Negative Breast Cancer, ADVANCED FUNCTIONAL MATERIALS, 2020, 第 5 作者
（19） Tumor-targeted nanoplatform for in situ oxygenation-boosted immunogenic phototherapy of colorectal cancer, Acta Biomaterialia, 2020, 第 3 作者  通讯作者
（20） Intrinsic Adjuvanticity of Branched Polyethylenimine In Vitro and Subcutaneously, ACS APPLIED POLYMER MATERIALS, 2020, 第 5 作者
（21） Smart gold nanocages for mild heat-triggered drug release and breaking chemoresistance, Journal of Controlled Release, 2020, 第 9 作者  通讯作者
（22） T Cell Membrane Mimicking Nanoparticles with Bioorthogonal Targeting and Immune Recognition for Enhanced Photothermal Therapy, ADVANCED SCIENCE, 2019, 第 7 作者
（23） Metalloporphyrin Complex-Based Nanosonosensitizers for Deep-Tissue Tumor Theranostics by Noninvasive Sonodynamic Therapy, SMALL, 2019, 第 5 作者
（24） Surface-Functionalized Nanoparticles as Efficient Tools in Targeted Therapy of Pregnancy Complications, International Journal of Molecular Sciences, 2019, 第 2 作者
（25） Nanophotosensitizer-engineered Salmonella bacteria with hypoxia targeting and photothermal-assisted mutual bioaccumulation for solid tumor therapy, BIOMATERIALS, 2019, 第 8 作者
（26） Bioinspired Hybrid Protein Oxygen Nanocarrier Amplified Photodynamic Therapy for Eliciting Anti-tumor Immunity and Abscopal Effect, ACSNANO, 2018, 第 3 作者
（27） Oxygen-boosted immunogenic photodynamic therapy with gold nanocages@manganese dioxide to inhibit tumor growth and metastases, BIOMATERIALS, 2018, 第 1 作者
（28） Ros-inducing micelles sensitize tumor-associated macrophages to tlr3 stimulation for potent immunotherapy, BIOMACROMOLECULES, 2018, 第 3 作者
（29） Tumor-targeted hybrid protein oxygen carrier to simultaneously enhance hypoxia-dampened chemotherapy and photodynamic therapy at a single dose, THERANOSTICS, 2018, 第 5 作者
（30） Hollow mesoporous silica nanoparticles with encapsulated immunogenic peptides for melanoma therapy, NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY, AND MEDICINE, 2018, 第 4 作者
（31） Cancer Cell Membrane-Biomimetic Oxygen Nanocarrier for Breaking Hypoxia-Induced Chemoresistance, ADVANCED FUNCTIONAL MATERIALS, 2017, 第 7 作者
（32） Liposomes-coated gold nanocages with antigens and adjuvants targeted delivery to dendritic cells for enhancing antitumor immune response, BIOMATERIALS, 2017, 第 1 作者
（33） Encapsulation of Hydrophilic and Hydrophobic Peptides into Hollow Mesoporous Silica Nanoparticles for Enhancement of Antitumor Immune Response, SMALL, 2017, 第 5 作者
（34） Block Copolymer Capsules with Structure-Dependent Release Behavior, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2016, 第 7 作者
（35） Electric-Field-Assisted Assembly of Polymer-Tethered Gold Nanorods in Cylindrical Nanopores, ACS NANO, 2016, 第 4 作者
（36） Precise Localization of Inorganic Nanoparticles in Block Copolymer Micellar Aggregates: From Center to Interface, MACROMOLECULES, 2015, 第 1 作者
（37） Structural Transformation of Diblock Copolymer/Homopolymer Assemblies by Tuning Cylindrical Confinement and Interfacial Interactions, LANGMUIR, 2015, 第 3 作者
（38） Non-Spherical Hollow Microgels with Uniform Sizes and Tunable Shapes from Microfluidic-Assisted Approach, SCIENCE OF ADVANCED MATERIALS, 2015, 第 5 作者
（39） Recent advances in targeted nanoparticles drug delivery to melanoma, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2015, 第 3 作者
（40） Uniform Core-Shell Photonic Crystal Microbeads as Microcarriers for Optical Encoding, LANGMUIR, 2014, 第 4 作者
（41） Assembly of Polymer-Tethered Gold Nanoparticles under Cylindrical Confinement, ACS MACRO LETTERS, 2014, 第 1 作者
（42） Fabrication of porous polymer microparticles with tunable pore size and density through the combination of phase separation and emulsion-solvent evaporation approach, KOREA-AUSTRALIA RHEOLOGY JOURNAL, 2014, 第 5 作者
（43） Surfactant-free biodegradable polymeric nanoparticles generated from self-organized precipitation route: Cellular uptake and cytotoxicity, EUROPEAN POLYMER JOURNAL, 2014, 第 1 作者
（44） Encapsulation of pristine fullerene C60 within block copolymer micelles through interfacial instabilities of emulsion droplets, JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2014, 第 4 作者
（45） Multifunctional biodegradable polymer nanoparticles with uniform sizes: generation and in vitro anti-melanoma activity, NANOTECHNOLOGY, 2013, 第 1 作者
（46） pH-Sensitive cisplatin-loaded gold nanoparticles for potential melanoma therapy, JOURNAL OF CONTROLLED RELEASE, 2013, 第 2 作者
（47） Ordering of Gold Nanorods in Confined Spaces by Directed Assembly, MACROMOLECULES, 2013, 第 8 作者
（48） A simple route to prepare multifunctional PLA nanoparticles against melanoma, JOURNALOFCONTROLLEDRELEASE, 2013, 第 2 作者
（49） Generation of polymer nanocapsules via a membrane-extrusion emulsification approach, MATERIALS LETTERS, 2012, 第 3 作者
（50） Monodisperse PLA/PLGA nanoparticle fabrication through a surfactant-free route, JOURNAL OF CONTROLLED RELEASE, 2011, 第 1 作者
（51） Biodegradable Polymer Microcapsules Fabrication through a Template-Free Approach, LANGMUIR, 2011, 第 6 作者

已指导学生

杨婷  硕士研究生  070300-化学  

方全  硕士研究生  071000-生物学  

任健  博士研究生  0703Z1-化学生物学  

现指导学生

何婧  硕士研究生  086000-生物与医药  

钟金凤  硕士研究生  086000-生物与医药