仿生纳米医药与肿瘤诊疗一体

基因递送系统与肿瘤免疫治疗

硕士

博士

070305-高分子化学与物理
071010-生物化学与分子生物学
0703Z1-化学生物学

纳米医药
肿瘤诊疗
仿生递送

2011-09--2016-06   华中科技大学   博士
2007-09--2011-06   华中科技大学   本科

博士研究生

博士

   

2018-12~现在, 中国科学院深圳先进技术研究院, 副研究员
2018-09~2018-12,中国科学院深圳先进技术研究院, 助理研究员
2016-07~2018-08,中国科学院深圳先进技术研究院, 博士后

2023-02-01-今,深圳市生物医药促进会, 委员
2018-06-30-今,中国生物物理学会, 会员
2011-12-31-今,中国化学会, 会员

化学生物学

（1） 深圳市南山区领航人才, 特等奖, 市地级, 2019
（2） 深圳市高层次专业人才后备级人才, 特等奖, 市地级, 2018

（ 1 ） 一种基于低聚物交联剂制备脑靶向及酸响应裂解的纳米蛋白药物的方法和用途, 发明专利, 2022, 第 3 作者, 专利号: CN 202211519078.5

（ 2 ） 一种聚多肽基因载体及其制备方法和应用, 发明专利, 2022, 第 3 作者, 专利号: CN202211516694.5

（ 3 ） 一种靶向性仿生聚多肽纳米递送载体、纳米核酸递送系统及其制备方法和应用, 发明专利, 2022, 第 2 作者, 专利号: CN202211516651.7

（ 4 ） 一种克服肿瘤耐药的方法, 发明专利, 2021, 第 4 作者, 专利号: CN110755457B

（ 5 ） 阿霉素纳米颗粒及其制备方法和应用、声动力联合化学治疗肿瘤的药物, 发明专利, 2020, 第 2 作者, 专利号: CN111388447A

（ 6 ） 金属-ICG配合物及制备方法、金属-ICG配合物白蛋白纳米颗粒及制备方法和应用, 发明专利, 2020, 第 4 作者, 专利号: CN111358946A

（ 7 ） 负载金属卟啉的脂质体纳米颗粒及其制备方法和应用, 发明专利, 2020, 第 5 作者, 专利号: CN111358945A

（ 8 ） 一种改善肿瘤缺氧的新方法, 发明专利, 2020, 第 4 作者, 专利号: CN110893196A

（ 9 ） 一种脑肿瘤靶向的仿生载药纳米颗粒及其制备方法和用途, 发明专利, 2020, 第 3 作者, 专利号: CN110859826A

（ 10 ） 一种纳米颗粒载药系统及其制备方法和应用, 发明专利, 2020, 第 5 作者, 专利号: CN110859817A

（ 11 ） 一种包载免疫佐剂纳米颗粒及应用, 发明专利, 2020, 第 5 作者, 专利号: CN110755387A

（ 12 ） 复合声敏剂、其制备方法、应用、使用方法、用途及药物组合物, 发明专利, 2019, 第 2 作者, 专利号: CN109125723A

（ 13 ） 中空二氧化锰纳米颗粒及其制备方法和应用, 发明专利, 2018, 第 2 作者, 专利号: CN108529681A

（ 14 ） 一种白蛋白纳米颗粒的制备方法及制得的白蛋白纳米颗粒与应用, 发明专利, 2018, 第 6 作者, 专利号: CN108295046A

（ 15 ） 温敏金纳米笼及制备方法和应用、载药温敏金纳米笼及制备方法, 专利授权, 2018, 第 3 作者, 专利号: CN108030922A

（ 16 ） 一种白蛋白负载金属卟啉配合物纳米颗粒的制备方法及其应用, 发明专利, 2018, 第 7 作者, 专利号: CN108030921A

（ 17 ） 金纳米笼‑二氧化锰复合纳米颗粒及其制备方法和应用, 专利授权, 2018, 第 2 作者, 专利号: CN107670040A

（ 18 ） 一种生物可降解聚合物纳米粒子的无皂制备方法, 发明专利, 2012, 第 2 作者, 专利号: CN102516564A

（ 19 ） 一种生物可降解聚合物纳米粒子的制备方法, 发明专利, 2012, 第 2 作者, 专利号: CN102516566A

   

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[17] Shen, Chen, Gao, Yujie, Li, Jun, Du, Hongyao, Liang, Ruijing, Sun, Yanhong, Xie, Jun, Dong, Liyun, Zhang, Yamin, Zhu, Jinjin, Zhang, Bo, Shen, Guanxin, Chen, Xiang, Zhu, Jintao, Tao, Juan. Intrinsic Adjuvanticity of Branched Polyethylenimine In Vitro and Subcutaneously. ACS APPLIED POLYMER MATERIALS[J]. 2020, 第 5 作者2(4): 1438-1447, https://www.webofscience.com/wos/woscc/full-record/WOS:000526391500004.
[18] He, Huamei, Liu, Lanlan, Zhang, Shengping, Zheng, Mingbin, Ma, Aiqing, Chen, Ze, Pan, Hong, Zhou, Haimei, Liang, Ruijing, Cai, Lintao. Smart gold nanocages for mild heat -triggered drug release and breaking chemoresistance. Journal of Controlled Release[J]. 2020, 第 9 作者  通讯作者  323: 387-397, http://dx.doi.org/10.1016/j.jconrel.2020.04.029.
[19] Li, Wenjun, Han, Yutong, Pan, Hong, Chen, Ze, Ma, Aiqing, Yin, Ting, Liang, Ruijing, Chen, Fuming, Ma, Nan, Jin, Yan, Zheng, Mingbin, Li, Baohong, Cai, Lintao. T Cell Membrane Mimicking Nanoparticles with Bioorthogonal Targeting and Immune Recognition for Enhanced Photothermal Therapy. ADVANCED SCIENCE[J]. 2019, 第 7 作者6(15): https://doaj.org/article/7cb0059b4e0e44bdb9a278463a7861cc.
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[21] Baozhen Zhang, Ruijing Liang, Mingbin Zheng, Lintao Cai, Xiujun Fan. Surface-Functionalized Nanoparticles as Efficient Tools in Targeted Therapy of Pregnancy Complications. International Journal of Molecular Sciences[J]. 2019, 第 2 作者20(15): https://doaj.org/article/aef5f06cd8e2407996eaab6907b3a215.
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（ 1 ） 靶向增氧纳米金笼的构建及肿瘤诊疗一体化研究, 负责人, 国家任务, 2018-01--2020-12
（ 2 ） 基于靶向增氧纳米光敏剂的氧干预肿瘤诊疗研究, 负责人, 地方任务, 2018-03--2020-03
（ 3 ） 靶向增氧纳米光敏剂的构建及肿瘤精准诊疗研究, 负责人, 研究所自选, 2017-08--2019-08
（ 4 ） 肿瘤光学精准诊疗关键技术研发, 参与, 地方任务, 2021-01--2023-12
（ 5 ） 基于巨噬细胞的纳米基因递送系统的构建及肿瘤精准治疗研究, 负责人, 地方任务, 2022-01--2024-12
（ 6 ） 病原示踪复合标记体系的设计与合成, 参与, 国家任务, 2021-12--2026-11
（ 7 ） 新型智能仿生聚集态纳米诊疗系统, 参与, 国家任务, 2020-12--2022-11
（ 8 ） 靶向增氧纳米光敏剂的构建及其肿瘤诊疗应用, 负责人, 国家任务, 2017-05--2018-09
（ 9 ） 级联靶向聚氨基酸纳米载体用于体内基因递送和巨噬细胞重编程, 负责人, 地方任务, 2023-01--2024-12
（ 10 ） 多级靶向纳米基因递送系统用于肿瘤相关巨噬细胞重编程研究, 负责人, 地方任务, 2023-01--2025-12

（1）超声激活的靶向仿生纳米药物协同治疗逆转脑胶质瘤耐药   中国化学会第 32 届学术年会   2021-04-19
（2）Oxygen-Boosted Immunogenic Photodynamic Therapy Based on Gold Nanocages@MnO2 to Inhibit Tumor Growth and Metastases   第三届国际纳米药物大会   2018-10-15

现指导学生

杨婷  硕士研究生  070300-化学  

方全  硕士研究生  071000-生物学  

任健  博士研究生  0703Z1-化学生物学