基本信息
李子龙 男 硕导 中国科学院微生物研究所
电子邮件： lizl@im.ac.cn
通信地址： 北京市朝阳区北辰西路1号院3号
邮政编码：
电子邮件： lizl@im.ac.cn
通信地址： 北京市朝阳区北辰西路1号院3号
邮政编码：
招生信息
招生专业
071010-生物化学与分子生物学
招生方向
微生物代谢工程与合成生物学
教育背景
2003-09--2011-06 中国科学院微生物研究所 理学博士
1996-09--2000-06 湘潭大学 食品科学与工程系 工学学士
1996-09--2000-06 湘潭大学 食品科学与工程系 工学学士
工作经历
工作简历
2020-10~现在, 中国科学院微生物研究所, 副研究员
2015-08~2020-09,中国科学院微生物研究所, 助理研究员
2013-07~2015-07,中国科学院过程工程研究所, 博士后
2011-07~2013-06,中国科学院微生物研究所, 项目聘用
2000-07~2003-08,唐人神集团湖南唐人神肉制品有限公司, 研发员
2015-08~2020-09,中国科学院微生物研究所, 助理研究员
2013-07~2015-07,中国科学院过程工程研究所, 博士后
2011-07~2013-06,中国科学院微生物研究所, 项目聘用
2000-07~2003-08,唐人神集团湖南唐人神肉制品有限公司, 研发员
专利与奖励
专利成果
[1] 李子龙, 杨志恒, 王为善, 张立新. 热葡萄糖苷酶地芽孢杆菌工程菌及其构建方法及应用. CN: CN111154705B, 2021-06-29.
[2] 李子龙, 张超波, 庞申, 范可强, 王为善, 王绘砖, 袁昉, 徐珍. 一种提高去甲四环素产量的方法. CN: CN110656122B, 2021-07-13.
[3] 张立新, 王为善, 李珊珊, 李子龙, 谭高翼, 范可强, 张敬宇. 提高链霉菌聚酮化合物产量的方法. CN: CN111944734A, 2020-11-17.
[4] 李子龙, 王俊阳, 范可强, 王为善, 王绘砖, 袁昉, 徐珍. 嗜热菌来源的热激蛋白基因的应用. CN: CN109929853A, 2019-06-25.
[5] 王雪峰, 王绘砖, 袁昉, 李子龙, 尹守亮, 王为善, 范可强, 赵宝华. 链霉菌底盘菌株及其构建方法、在异源表达研究中的应用. CN: CN110129244A, 2019-08-16.
[6] 李子龙, 齐凤仙, 范可强, 王为善, 王俊阳, 杨克迁. 高温产核黄素的工程菌及其构建方法与应用. CN: CN108641992A, 2018-10-12.
[7] 杨克迁, 王为善, 李珊珊, 范可强, 李子龙, 李子龙. 包含别构转录因子调控系统的生物传感器、试剂盒及其在小分子检测中的用途. CN: CN110283887A, 2019-09-27.
[8] 张立新, 王为善, 姚永鹏, 曹佳倩, 李子龙, 李子龙. 包含别构转录因子调控系统的生物传感器、试剂盒及其在小分子检测中的用途. CN: CN107976411A, 2018-05-01.
[9] 江宁, 李子龙, 贺鹏. 一种糖化酶及其编码基因与表达方法. CN: CN101532002A, 2009-09-16.
[2] 李子龙, 张超波, 庞申, 范可强, 王为善, 王绘砖, 袁昉, 徐珍. 一种提高去甲四环素产量的方法. CN: CN110656122B, 2021-07-13.
[3] 张立新, 王为善, 李珊珊, 李子龙, 谭高翼, 范可强, 张敬宇. 提高链霉菌聚酮化合物产量的方法. CN: CN111944734A, 2020-11-17.
[4] 李子龙, 王俊阳, 范可强, 王为善, 王绘砖, 袁昉, 徐珍. 嗜热菌来源的热激蛋白基因的应用. CN: CN109929853A, 2019-06-25.
[5] 王雪峰, 王绘砖, 袁昉, 李子龙, 尹守亮, 王为善, 范可强, 赵宝华. 链霉菌底盘菌株及其构建方法、在异源表达研究中的应用. CN: CN110129244A, 2019-08-16.
[6] 李子龙, 齐凤仙, 范可强, 王为善, 王俊阳, 杨克迁. 高温产核黄素的工程菌及其构建方法与应用. CN: CN108641992A, 2018-10-12.
[7] 杨克迁, 王为善, 李珊珊, 范可强, 李子龙, 李子龙. 包含别构转录因子调控系统的生物传感器、试剂盒及其在小分子检测中的用途. CN: CN110283887A, 2019-09-27.
[8] 张立新, 王为善, 姚永鹏, 曹佳倩, 李子龙, 李子龙. 包含别构转录因子调控系统的生物传感器、试剂盒及其在小分子检测中的用途. CN: CN107976411A, 2018-05-01.
[9] 江宁, 李子龙, 贺鹏. 一种糖化酶及其编码基因与表达方法. CN: CN101532002A, 2009-09-16.
出版信息
发表论文
[1] Shiwen Qiu, Bowen Yang, Zilong Li, Shanshan Li, Hao Yan, Zhenguo Xin, Jingfang Liu, Xuejin Zhao, Lixin Zhang, Wensheng Xiang, Weishan Wang. Building a highly efficient Streptomyces super-chassis for secondary metabolite production by reprogramming naturally-evolved multifaceted shifts. METABOLIC ENGINEERING[J]. 2024, 第 3 作者81: 210-226, http://dx.doi.org/10.1016/j.ymben.2023.12.007.
[2] Zhiheng Yang, Zilong Li, Bixiao Li, Ruihong Bu, GaoYi Tan, Zhengduo Wang, Hao Yan, Zhenguo Xin, Guojian Zhang, Ming Li, Hua Xiang, Lixin Zhang, Weishan Wang. A thermostable type I-B CRISPR-Cas system for orthogonal and multiplexed genetic engineering. NATURE COMMUNICATIONS[J]. 2023, 第 2 作者14(1): 1-14, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10551041/.
[3] Zhang, Chaobo, Zhao, Youbao, Li, Zilong, Wang, Weishan, Huang, Ying, Pan, Guohui, Fan, Keqiang. Molecular mechanism of GylR-mediated regulation of glycerol metabolism in Streptomyces clavuligerus NRRL 3585. FRONTIERS IN MICROBIOLOGY[J]. 2022, 第 3 作者13: http://dx.doi.org/10.3389/fmicb.2022.1078293.
[4] 刘文溪, 李子龙, 闫浩, 张立新, 王为善. 异源重构白色链霉菌土霉素生产菌株. 微生物学报[J]. 2022, 第 2 作者62(10): 3858-3870, https://actamicro.ijournals.cn/actamicrocn/article/abstract/20221014?st=article_issue.
[5] Wang, Junyang, Li, Zilong, Wang, Weishan, Pang, Shen, Yao, Yongpeng, Yuan, Fang, Wang, Huizhuan, Xu, Zhen, Pan, Guohui, Liu, Zihe, Chen, Yihua, Fan, Keqiang. Dynamic Control Strategy to Produce Riboflavin with Lignocellulose Hydrolysate in the Thermophile Geobacillus thermoglucosidasius. ACS SYNTHETIC BIOLOGY[J]. 2022, 第 2 作者11(6): 2163-2174, http://dx.doi.org/10.1021/acssynbio.2c00087.
[6] Yang, Yiying, Sun, Qingqing, Liu, Yang, Yin, Hanzhi, Yang, Wenping, Wang, Yang, Liu, Ying, Li, Yuxian, Pang, Shen, Liu, Wenxi, Zhang, Qian, Yuan, Fang, Qiu, Shiwen, Li, Jiong, Wang, Xuefeng, Fan, Keqiang, Wang, Weishan, Li, Zilong, Yin, Shouliang. Development of a pyrF-based counterselectable system for targeted gene deletion in Streptomyces rimosus. JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B[J]. 2021, 第 18 作者 通讯作者 22(5): 383-396, http://dx.doi.org/10.1631/jzus.B2000606.
[7] Li, Shanshan, Li, Zilong, Pang, Shen, Xiang, Wensheng, Wang, Weishan. Coordinating precursor supply for pharmaceutical polyketide production in Streptomyces. CURRENT OPINION IN BIOTECHNOLOGY. 2021, 第 2 作者69: 26-34, http://dx.doi.org/10.1016/j.copbio.2020.11.006.
[8] Yuan, Fang, Yin, Shouliang, Xu, Yang, Xiang, Lijun, Wang, Haiyan, Li, Zilong, Fan, Keqiang, Pan, Guohui. The Richness and Diversity of Catalases in Bacteria. FRONTIERS IN MICROBIOLOGY[J]. 2021, 第 6 作者12: https://www.webofscience.com/wos/woscc/full-record/WOS:000635791400001.
[9] Zhao, Xiangxiang, Li, Shanshan, Liu, Guang, Wang, Zhong, Yang, Zhiheng, Zhang, Quanwei, Liang, Mindong, Liu, Jiakun, Li, Zilong, Tong, Yaojun, Zhu, Guoliang, Wang, Xinye, Jiang, Lan, Wang, Weishan, Tan, GaoYi, Zhang, Lixin. A versatile biosensing platform coupling CRISPR-Cas12a and aptamers for detection of diverse analytes. SCIENCE BULLETIN[J]. 2021, 第 9 作者66(1): 69-77, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6916571&detailType=1.
[10] Yang, Zhiheng, Sun, Qingqing, Tan, Gaoyi, Zhang, Quanwei, Wang, Zhengduo, Li, Chuan, Qi, Fengxian, Wang, Weishan, Zhang, Lixin, Li, Zilong. Engineering thermophilic Geobacillus thermoglucosidasius for riboflavin production. MICROBIAL BIOTECHNOLOGY[J]. 2021, 第 10 作者 通讯作者 14(2): 363-373, https://doaj.org/article/bd019966daf949cc98e749fa637d7ea6.
[11] 冯宝琪, 冯娇, 张苗, 刘洋, 曹睿, 尹涵之, 齐凤仙, 李子龙, 尹守亮. 利用Tn5型转座突变系统筛选高产阿维菌素菌株*. 中国生物工程杂志[J]. 2021, 第 8 作者41(7): 32-41, https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.2102033.
[12] Wang, Weishan, Li, Shanshan, Li, Zilong, Zhang, Jingyu, Fan, Keqiang, Tan, Gaoyi, Ai, Guomin, Lam, Sin Man, Shui, Guanghou, Yang, Zhiheng, Lu, Hongzhong, Jin, Pinjiao, Li, Yihong, Chen, Xiangyin, Xia, Xuekui, Liu, Xueting, Dannelly, H Kathleen, Yang, Chen, Yang, Yi, Zhang, Siliang, Alterovitz, Gil, Xiang, Wensheng, Zhang, Lixin. Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces. NATURE BIOTECHNOLOGY[J]. 2020, 第 3 作者38(1): 76-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000510337700016.
[13] Liang, Mindong, Li, Zilong, Wang, Weishan, Liu, Jiakun, Liu, Leshi, Zhu, Guoliang, Karthik, Loganathan, Wang, Man, Wang, KeFeng, Wang, Zhong, Yu, Jing, Shuai, Yuting, Yu, Jiaming, Zhang, Lu, Yang, Zhiheng, Li, Chuan, Zhang, Qian, Shi, Tong, Zhou, Liming, Xie, Feng, Dai, Huanqin, Liu, Xueting, Zhang, Jingyu, Liu, Guang, Zhuo, Ying, Zhang, Buchang, Liu, Chenli, Li, Shanshan, Xia, Xuekui, Tong, Yaojun, Liu, Yanwen, Alterovitz, Gil, Tan, GaoYi, Zhang, LiXin. A CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules. NATURE COMMUNICATIONS[J]. 2019, 第 2 作者10(1):
[14] Wang, Junyang, Wang, Weishan, Wang, Huizhuan, Yuan, Fang, Xu, Zhen, Yang, Keqian, Li, Zilong, Chen, Yihua, Fan, Keqiang. Improvement of stress tolerance and riboflavin production of Bacillus subtilis by introduction of heat shock proteins from thermophilic bacillus strains. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2019, 第 7 作者 通讯作者 103(11): 4455-4465, https://www.webofscience.com/wos/woscc/full-record/WOS:000467209500016.
[15] Wang, Xuefeng, Yin, Shouliang, Bai, Jing, Liu, Yang, Fan, Keqiang, Wang, Huizhuan, Yuan, Fang, Zhao, Baohua, Li, Zilong, Wang, Weishan. Heterologous production of chlortetracycline in an industrial grade Streptomyces rimosus host. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2019, 第 9 作者 通讯作者 103(16): 6645-6655, https://www.webofscience.com/wos/woscc/full-record/WOS:000477927800021.
[16] Yin, Hanzhi, Wang, Weishan, Fan, Keqiang, Li, Zilong. Regulatory perspective of antibiotic biosynthesis in Streptomyces. SCIENCE CHINA-LIFE SCIENCES[J]. 2019, 第 4 作者 通讯作者 62(5): 698-700, http://lib.cqvip.com/Qikan/Article/Detail?id=74678871504849574853484948.
[17] Li, Shanshan, Wang, Junyang, Xiang, Wensheng, Yang, Keqian, Li, Zilong, Wang, Weishan. An Autoregulated Fine-Tuning Strategy for Titer Improvement of Secondary Metabolites Using Native Promoters in Streptomyces. ACS SYNTHETIC BIOLOGY[J]. 2018, 第 5 作者 通讯作者 7(2): 522-530, http://dx.doi.org/10.1021/acssynbio.7b00318.
[18] Li, Shanshan, Zhou, Li, Yao, Yongpeng, Fan, Keqiang, Li, Zilong, Zhang, Lixin, Wang, Weishan, Yang, Keqian. A platform for the development of novel biosensors by configuring allosteric transcription factor recognition with amplified luminescent proximity homogeneous assays. CHEMICAL COMMUNICATIONS[J]. 2017, 第 5 作者53(1): 99-102, http://dx.doi.org/10.1039/c6cc07244e.
[19] Yin, Shouliang, Wang, Xuefeng, Shi, Mingxin, Yuan, Fang, Wang, Huizhuan, Jia, Xiaole, Yuan, Fang, Sun, Jinliang, Liu, Tiejun, Yang, Keqian, Zhang, Yuxiu, Fan, Keqiang, Li, Zilong. Improvement of oxytetracycline production mediated via cooperation of resistance genes in Streptomyces rimosus. SCIENCE CHINA-LIFE SCIENCES[J]. 2017, 第 13 作者 通讯作者 60(9): 992-999, http://dx.doi.org/10.1007/s11427-017-9121-4.
[20] Li, Zilong, Jiang, Ning, Yang, Keqian, Zheng, Jianting. Cloning, expression, and characterization of a thermostable glucose-6-phosphate dehydrogenase from Thermoanaerobacter tengcongensis. EXTREMOPHILES[J]. 2016, 第 1 作者20(2): 149-156, http://dx.doi.org/10.1007/s00792-016-0808-z.
[21] Yin, Shouliang, Li, Zilong, Wang, Xuefeng, Wang, Huizhuan, Jia, Xiaole, Ai, Guomin, Bai, Zishang, Shi, Mingxin, Yuan, Fang, Liu, Tiejun, Wang, Weishan, Yang, Keqian. Heterologous expression of oxytetracycline biosynthetic gene cluster in Streptomyces venezuelae WVR2006 to improve production level and to alter fermentation process. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2016, 第 2 作者100(24): 10563-10572, http://dx.doi.org/10.1007/s00253-016-7873-1.
[22] Cheng, Hairong, Lv, Jiyang, Wang, Hengwei, Wang, Ben, Li, Zilong, Deng, Zixin. Genetically engineered Pichia pastoris yeast for conversion of glucose to xylitol by a single-fermentation process. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2014, 第 5 作者98(8): 3539-3552, https://www.webofscience.com/wos/woscc/full-record/WOS:000334171100014.
[23] Li, Zilong, Wei, Pingying, Cheng, Hairong, He, Peng, Wang, Qinhong, Jiang, Ning. Functional role of beta domain in the Thermoanaerobacter tengcongensis glucoamylase. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2014, 第 1 作者98(5): 2091-2099, http://dx.doi.org/10.1007/s00253-013-5051-2.
[24] Lin, Yuping, He, Peng, Wang, Qinhong, Lu, Dajun, Li, Zilong, Wu, Changsheng, Jiang, Ning. The Alcohol Dehydrogenase System in the Xylose-Fermenting Yeast Candida maltosa. PLOS ONE[J]. 2010, 第 5 作者5(7): http://124.16.144.217/handle/311023/2373.
[25] Cheng, Hairong, Li, Zilong, Jiang, Ning, Deng, Zixin. Cloning, Purification and Characterization of an NAD-Dependent d-Arabitol Dehydrogenase from Acetic Acid Bacterium, Acetobacter suboxydans. PROTEIN JOURNAL[J]. 2009, 第 2 作者28(6): 263-272, https://www.webofscience.com/wos/woscc/full-record/WOS:000270192600002.
[26] Alexander, N., Glazer, 李子龙. 微生物生物技术：应用微生物学基础. 国外科技新书评介[J]. 2008, 第 4 作者15-16, http://lib.cqvip.com/Qikan/Article/Detail?id=28393579.
[27] Wei, Pingying, Li, Zilong, He, Peng, Lin, Yuping, Jiang, Ning. Genome shuffling in the ethanologenic yeast Candida krusei to improve acetic acid tolerance. BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY[J]. 2008, 第 2 作者49: 113-120, http://www.corc.org.cn/handle/1471x/2388364.
[28] Wei, Pingying, Li, Zilong, Lin, Yuping, He, Peng, Jiang, Ning. Improvement of the multiple-stress tolerance of an ethanologenic Saccharomyces cerevisiae strain by freeze-thaw treatment. BIOTECHNOLOGY LETTERS[J]. 2007, 第 2 作者29(10): 1501-1508, http://124.16.144.217/handle/311023/2587.
[29] Shanshan Li, Zilong Li, GaoYi Tan, Zhenguo Xin, Weishan Wang. In vitro allosteric transcription factor-based biosensing. TRENDS IN BIOTECHNOLOGY. 第 2 作者http://dx.doi.org/10.1016/j.tibtech.2023.03.001.
[2] Zhiheng Yang, Zilong Li, Bixiao Li, Ruihong Bu, GaoYi Tan, Zhengduo Wang, Hao Yan, Zhenguo Xin, Guojian Zhang, Ming Li, Hua Xiang, Lixin Zhang, Weishan Wang. A thermostable type I-B CRISPR-Cas system for orthogonal and multiplexed genetic engineering. NATURE COMMUNICATIONS[J]. 2023, 第 2 作者14(1): 1-14, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10551041/.
[3] Zhang, Chaobo, Zhao, Youbao, Li, Zilong, Wang, Weishan, Huang, Ying, Pan, Guohui, Fan, Keqiang. Molecular mechanism of GylR-mediated regulation of glycerol metabolism in Streptomyces clavuligerus NRRL 3585. FRONTIERS IN MICROBIOLOGY[J]. 2022, 第 3 作者13: http://dx.doi.org/10.3389/fmicb.2022.1078293.
[4] 刘文溪, 李子龙, 闫浩, 张立新, 王为善. 异源重构白色链霉菌土霉素生产菌株. 微生物学报[J]. 2022, 第 2 作者62(10): 3858-3870, https://actamicro.ijournals.cn/actamicrocn/article/abstract/20221014?st=article_issue.
[5] Wang, Junyang, Li, Zilong, Wang, Weishan, Pang, Shen, Yao, Yongpeng, Yuan, Fang, Wang, Huizhuan, Xu, Zhen, Pan, Guohui, Liu, Zihe, Chen, Yihua, Fan, Keqiang. Dynamic Control Strategy to Produce Riboflavin with Lignocellulose Hydrolysate in the Thermophile Geobacillus thermoglucosidasius. ACS SYNTHETIC BIOLOGY[J]. 2022, 第 2 作者11(6): 2163-2174, http://dx.doi.org/10.1021/acssynbio.2c00087.
[6] Yang, Yiying, Sun, Qingqing, Liu, Yang, Yin, Hanzhi, Yang, Wenping, Wang, Yang, Liu, Ying, Li, Yuxian, Pang, Shen, Liu, Wenxi, Zhang, Qian, Yuan, Fang, Qiu, Shiwen, Li, Jiong, Wang, Xuefeng, Fan, Keqiang, Wang, Weishan, Li, Zilong, Yin, Shouliang. Development of a pyrF-based counterselectable system for targeted gene deletion in Streptomyces rimosus. JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B[J]. 2021, 第 18 作者 通讯作者 22(5): 383-396, http://dx.doi.org/10.1631/jzus.B2000606.
[7] Li, Shanshan, Li, Zilong, Pang, Shen, Xiang, Wensheng, Wang, Weishan. Coordinating precursor supply for pharmaceutical polyketide production in Streptomyces. CURRENT OPINION IN BIOTECHNOLOGY. 2021, 第 2 作者69: 26-34, http://dx.doi.org/10.1016/j.copbio.2020.11.006.
[8] Yuan, Fang, Yin, Shouliang, Xu, Yang, Xiang, Lijun, Wang, Haiyan, Li, Zilong, Fan, Keqiang, Pan, Guohui. The Richness and Diversity of Catalases in Bacteria. FRONTIERS IN MICROBIOLOGY[J]. 2021, 第 6 作者12: https://www.webofscience.com/wos/woscc/full-record/WOS:000635791400001.
[9] Zhao, Xiangxiang, Li, Shanshan, Liu, Guang, Wang, Zhong, Yang, Zhiheng, Zhang, Quanwei, Liang, Mindong, Liu, Jiakun, Li, Zilong, Tong, Yaojun, Zhu, Guoliang, Wang, Xinye, Jiang, Lan, Wang, Weishan, Tan, GaoYi, Zhang, Lixin. A versatile biosensing platform coupling CRISPR-Cas12a and aptamers for detection of diverse analytes. SCIENCE BULLETIN[J]. 2021, 第 9 作者66(1): 69-77, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6916571&detailType=1.
[10] Yang, Zhiheng, Sun, Qingqing, Tan, Gaoyi, Zhang, Quanwei, Wang, Zhengduo, Li, Chuan, Qi, Fengxian, Wang, Weishan, Zhang, Lixin, Li, Zilong. Engineering thermophilic Geobacillus thermoglucosidasius for riboflavin production. MICROBIAL BIOTECHNOLOGY[J]. 2021, 第 10 作者 通讯作者 14(2): 363-373, https://doaj.org/article/bd019966daf949cc98e749fa637d7ea6.
[11] 冯宝琪, 冯娇, 张苗, 刘洋, 曹睿, 尹涵之, 齐凤仙, 李子龙, 尹守亮. 利用Tn5型转座突变系统筛选高产阿维菌素菌株*. 中国生物工程杂志[J]. 2021, 第 8 作者41(7): 32-41, https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.2102033.
[12] Wang, Weishan, Li, Shanshan, Li, Zilong, Zhang, Jingyu, Fan, Keqiang, Tan, Gaoyi, Ai, Guomin, Lam, Sin Man, Shui, Guanghou, Yang, Zhiheng, Lu, Hongzhong, Jin, Pinjiao, Li, Yihong, Chen, Xiangyin, Xia, Xuekui, Liu, Xueting, Dannelly, H Kathleen, Yang, Chen, Yang, Yi, Zhang, Siliang, Alterovitz, Gil, Xiang, Wensheng, Zhang, Lixin. Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces. NATURE BIOTECHNOLOGY[J]. 2020, 第 3 作者38(1): 76-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000510337700016.
[13] Liang, Mindong, Li, Zilong, Wang, Weishan, Liu, Jiakun, Liu, Leshi, Zhu, Guoliang, Karthik, Loganathan, Wang, Man, Wang, KeFeng, Wang, Zhong, Yu, Jing, Shuai, Yuting, Yu, Jiaming, Zhang, Lu, Yang, Zhiheng, Li, Chuan, Zhang, Qian, Shi, Tong, Zhou, Liming, Xie, Feng, Dai, Huanqin, Liu, Xueting, Zhang, Jingyu, Liu, Guang, Zhuo, Ying, Zhang, Buchang, Liu, Chenli, Li, Shanshan, Xia, Xuekui, Tong, Yaojun, Liu, Yanwen, Alterovitz, Gil, Tan, GaoYi, Zhang, LiXin. A CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules. NATURE COMMUNICATIONS[J]. 2019, 第 2 作者10(1):
[14] Wang, Junyang, Wang, Weishan, Wang, Huizhuan, Yuan, Fang, Xu, Zhen, Yang, Keqian, Li, Zilong, Chen, Yihua, Fan, Keqiang. Improvement of stress tolerance and riboflavin production of Bacillus subtilis by introduction of heat shock proteins from thermophilic bacillus strains. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2019, 第 7 作者 通讯作者 103(11): 4455-4465, https://www.webofscience.com/wos/woscc/full-record/WOS:000467209500016.
[15] Wang, Xuefeng, Yin, Shouliang, Bai, Jing, Liu, Yang, Fan, Keqiang, Wang, Huizhuan, Yuan, Fang, Zhao, Baohua, Li, Zilong, Wang, Weishan. Heterologous production of chlortetracycline in an industrial grade Streptomyces rimosus host. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2019, 第 9 作者 通讯作者 103(16): 6645-6655, https://www.webofscience.com/wos/woscc/full-record/WOS:000477927800021.
[16] Yin, Hanzhi, Wang, Weishan, Fan, Keqiang, Li, Zilong. Regulatory perspective of antibiotic biosynthesis in Streptomyces. SCIENCE CHINA-LIFE SCIENCES[J]. 2019, 第 4 作者 通讯作者 62(5): 698-700, http://lib.cqvip.com/Qikan/Article/Detail?id=74678871504849574853484948.
[17] Li, Shanshan, Wang, Junyang, Xiang, Wensheng, Yang, Keqian, Li, Zilong, Wang, Weishan. An Autoregulated Fine-Tuning Strategy for Titer Improvement of Secondary Metabolites Using Native Promoters in Streptomyces. ACS SYNTHETIC BIOLOGY[J]. 2018, 第 5 作者 通讯作者 7(2): 522-530, http://dx.doi.org/10.1021/acssynbio.7b00318.
[18] Li, Shanshan, Zhou, Li, Yao, Yongpeng, Fan, Keqiang, Li, Zilong, Zhang, Lixin, Wang, Weishan, Yang, Keqian. A platform for the development of novel biosensors by configuring allosteric transcription factor recognition with amplified luminescent proximity homogeneous assays. CHEMICAL COMMUNICATIONS[J]. 2017, 第 5 作者53(1): 99-102, http://dx.doi.org/10.1039/c6cc07244e.
[19] Yin, Shouliang, Wang, Xuefeng, Shi, Mingxin, Yuan, Fang, Wang, Huizhuan, Jia, Xiaole, Yuan, Fang, Sun, Jinliang, Liu, Tiejun, Yang, Keqian, Zhang, Yuxiu, Fan, Keqiang, Li, Zilong. Improvement of oxytetracycline production mediated via cooperation of resistance genes in Streptomyces rimosus. SCIENCE CHINA-LIFE SCIENCES[J]. 2017, 第 13 作者 通讯作者 60(9): 992-999, http://dx.doi.org/10.1007/s11427-017-9121-4.
[20] Li, Zilong, Jiang, Ning, Yang, Keqian, Zheng, Jianting. Cloning, expression, and characterization of a thermostable glucose-6-phosphate dehydrogenase from Thermoanaerobacter tengcongensis. EXTREMOPHILES[J]. 2016, 第 1 作者20(2): 149-156, http://dx.doi.org/10.1007/s00792-016-0808-z.
[21] Yin, Shouliang, Li, Zilong, Wang, Xuefeng, Wang, Huizhuan, Jia, Xiaole, Ai, Guomin, Bai, Zishang, Shi, Mingxin, Yuan, Fang, Liu, Tiejun, Wang, Weishan, Yang, Keqian. Heterologous expression of oxytetracycline biosynthetic gene cluster in Streptomyces venezuelae WVR2006 to improve production level and to alter fermentation process. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2016, 第 2 作者100(24): 10563-10572, http://dx.doi.org/10.1007/s00253-016-7873-1.
[22] Cheng, Hairong, Lv, Jiyang, Wang, Hengwei, Wang, Ben, Li, Zilong, Deng, Zixin. Genetically engineered Pichia pastoris yeast for conversion of glucose to xylitol by a single-fermentation process. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2014, 第 5 作者98(8): 3539-3552, https://www.webofscience.com/wos/woscc/full-record/WOS:000334171100014.
[23] Li, Zilong, Wei, Pingying, Cheng, Hairong, He, Peng, Wang, Qinhong, Jiang, Ning. Functional role of beta domain in the Thermoanaerobacter tengcongensis glucoamylase. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2014, 第 1 作者98(5): 2091-2099, http://dx.doi.org/10.1007/s00253-013-5051-2.
[24] Lin, Yuping, He, Peng, Wang, Qinhong, Lu, Dajun, Li, Zilong, Wu, Changsheng, Jiang, Ning. The Alcohol Dehydrogenase System in the Xylose-Fermenting Yeast Candida maltosa. PLOS ONE[J]. 2010, 第 5 作者5(7): http://124.16.144.217/handle/311023/2373.
[25] Cheng, Hairong, Li, Zilong, Jiang, Ning, Deng, Zixin. Cloning, Purification and Characterization of an NAD-Dependent d-Arabitol Dehydrogenase from Acetic Acid Bacterium, Acetobacter suboxydans. PROTEIN JOURNAL[J]. 2009, 第 2 作者28(6): 263-272, https://www.webofscience.com/wos/woscc/full-record/WOS:000270192600002.
[26] Alexander, N., Glazer, 李子龙. 微生物生物技术：应用微生物学基础. 国外科技新书评介[J]. 2008, 第 4 作者15-16, http://lib.cqvip.com/Qikan/Article/Detail?id=28393579.
[27] Wei, Pingying, Li, Zilong, He, Peng, Lin, Yuping, Jiang, Ning. Genome shuffling in the ethanologenic yeast Candida krusei to improve acetic acid tolerance. BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY[J]. 2008, 第 2 作者49: 113-120, http://www.corc.org.cn/handle/1471x/2388364.
[28] Wei, Pingying, Li, Zilong, Lin, Yuping, He, Peng, Jiang, Ning. Improvement of the multiple-stress tolerance of an ethanologenic Saccharomyces cerevisiae strain by freeze-thaw treatment. BIOTECHNOLOGY LETTERS[J]. 2007, 第 2 作者29(10): 1501-1508, http://124.16.144.217/handle/311023/2587.
[29] Shanshan Li, Zilong Li, GaoYi Tan, Zhenguo Xin, Weishan Wang. In vitro allosteric transcription factor-based biosensing. TRENDS IN BIOTECHNOLOGY. 第 2 作者http://dx.doi.org/10.1016/j.tibtech.2023.03.001.
科研活动
科研项目
（ 1 ） 在地芽孢杆菌中进行合成生物学研究，开发高温核黄素生产技术, 参与, 国家任务, 2020-07--2025-06
（ 2 ） 关于红霉素高产菌株及高温菌平台生产PHA产品的技术开发合同, 负责人, 境内委托项目, 2022-12--2025-12
（ 3 ） 关于一种高附加值氨基酸衍生物的关键技术开发合同, 负责人, 境内委托项目, 2023-04--2024-04
（ 4 ） 高产龟裂霉素的龟裂链霉菌底盘细胞的设计、构建与改造, 负责人, 国家任务, 2023-11--2028-10
（ 2 ） 关于红霉素高产菌株及高温菌平台生产PHA产品的技术开发合同, 负责人, 境内委托项目, 2022-12--2025-12
（ 3 ） 关于一种高附加值氨基酸衍生物的关键技术开发合同, 负责人, 境内委托项目, 2023-04--2024-04
（ 4 ） 高产龟裂霉素的龟裂链霉菌底盘细胞的设计、构建与改造, 负责人, 国家任务, 2023-11--2028-10