Prof. Li YAO
Contact us:
Institute of Chemistry,Chinese Academy of Sciences (ICCAS)
Zhongguancun North First Street 2,100190 Beijing, PR China
Tel: +86-010-62588930
Email: yaoli@iccas.ac.cn
homepage: http://159.226.64.180/web/25982/home
Research Areas
- Nanobiotechnology
- Ultro-low-field detection
- High-performance magnetic nanoprober
- Molecular and cellular magnetic imaging
- Biomolecular recognition
- Biophysical chemistry on mocecular and cellular interactions
- Mechanism and regulation of cancer metastasis and mechanobiology
Education
09/2003 — 06/2008 Ph.D.
State Key Laboratory for Structural Chemistry of Unstable and Stable Species Institute of Chemistry, Chinese Academy of Sciences, Beijing, China
Advisor: Prof. Maofa G
09/1998 — 07/2002 B.S.
School of Materials Science and Engineering
Wuhan University of Technology, China
Experience
Work Experience
12/2013 — TODAY Professor
State Key Laboratory for Structural Chemistry of Unstable and Stable Species Institute of Chemistry, Chinese Academy of Sciences, Beijing, China
08/2008 — 11/2013 Postdoctoral
Department of Chemistry, University of Houston
Advisor: Prof. Shoujun Xu
Publications
Papers
1. Pan Lu, Di Zhang, Yahong Chai, Chanchan Yu, XiuyuWang, Yalin Tang, Maofa Ge, Li Yao.* Regulatory-sequence mechanical biosensor: A versatile platform for investigation of G-quadruplex/label-free protein interactions and tunable protein detection. Anal. Chim. Acta 2019, 1045, 1-9.
2. Di Zhang, Feng Feng, Ruping Liu, Wenjia Zhu, Li Yao.* Mechanochemistry in cancer cell metastasis. Chin. Chem. Lett. 2018, doi.org/10.1016/j.cclet.2018.06.011.
3. Di Zhang, Feng Feng, Qilong Li, Xiuyu Wang, Li Yao.* Nanopurpurin-based photodynamic therapy destructs extracellular matrix against intractable tumor metastasis. Biomaterials 2018, 173, 22-33.
4. Xueyan Feng, Xiuyu Wang,* Di Zhang, Feng Feng, Li Yao,* Guiping Ma.* One-step Preparation of Monodisperse Multifunctional Macroporous Particles through a Spontaneous Physical Process. Small 2017, 14(10), 1703570.
5. Shan Jiang,* Wei Wang, Yonghong Ding, Qiang Yu, Li Yao. Preparation and characterization of antibacterial microporous membranes fabricated by poly(AMS-co-DMAEMA) grafted polypropylene via melt-stretching method. Chin. Chem. Lett. 2018, 29, 390-394.
6. Xiuyu Wang, Xueyan Feng, Guiping Ma, Di Zhang, Yahong Chai, Maofa Ge, Li Yao.* Dual-phase separation in a semi-confined system: monodispersed heterogeneous block copolymer membranes for cell encoding and patterning. Adv. Mater. 2017, 29, 1605932.
7. Xiuyu Wang, Yi Hou, Li Yao,* Mingyuan Gao,* Maofa Ge. Generation, characterization, and application of hierarchically structured self-assembly induced by the combined effect of self-emulsification and phase separation. J. Am. Chem. Soc. 2016, 138, 2090-2093.
8. Xiuyu Wang, Xueyan Feng, Guiping Ma, Li Yao,* Maofa Ge. Amphiphilic Janus particles generated via a combination of diffusion-induced phase separation and magnetically driven dewetting and their synergistic self-assembly. Adv. Mater. 2016, 28, 3131-3137.
9. Pan Lu, Qibin Liu, Yuzhu Xiong, Qing Wang, Yuting Lei, Shengjun Lu,* Liwei Lu, Li Yao*. Nanosheets-assembled hierarchical microstructured Ni(OH)2 hollow spheres for highly sensitive enzyme-free glucose sensors. Electrochim. Acta 2015, 168, 148–156.
10. Liwei Lu, Xiuyu Wang, Chuanxi Xiong, Li Yao*. Recent advances in biological detection with magnetic nanoparticles as a useful tool. Sci. China Chem. 2015, 58(5), 793–809.
11. Li Yao*, Shoujun Xu. Detection of magnetic nanomaterials in molecular imaging and diagnosis applications. Nanotechnol. Rev. 2014, 3(3), 247-268.
12. Lashan De Silva, Li Yao, Shoujun Xu*. Mechanically resolving noncovalent bonds using acoustic radiation force. Chem. Commun. 2014, 50, 10786-10789.
13. Li Yao, Yue Li, Te-Wie Tsai, Shoujun Xu*, Yuhong Wang*. Noninvasive measurement of the mechanical force generated by motor protein EF-G during ribosome translocation. Angew. Chem. Int. Ed. 2013, 52(52), 14041-14044.
14. Li Yao, Yuhong Wang,* Shoujun Xu*. Label-free microRNA detection based on exchange-induced remnant magnetization. Chem. Commun. 2013, 49(45), 5183-5185.
15. Songtham Ruangchaithaweesuk, Vasudeva Chintamsetti, Li Yao, Te-Wei Tsai, Shoujun Xu*. High-resolution optically-detected magnetic resonance imaging in an ambient magnetic field. J. Magn. Reson. 2013, 233, 1-6.
16. Lashan De Silva, Li Yao, Yuhong Wang, Shoujun Xu*. Well-Defined and Sequence-Specific Noncovalent Binding Forces of DNA. J. Phys. Chem. B. 2013, 117(25), 7554-7558.
17. Nahir Y. Dugarte, Mauricio F. Erben, Evamarie Hey-Hawkins, Peter Loennecke, Sven Stadlbauer, MaoFa Ge, Li Yao, Oscar E. Piro, Gustavo A. Echeverria, Carlos O. Della Vedova*. Conformational Transferability of the Sulfenyl Carbonyl Group -SC(O)- in Cyclic Thioesters. J. Phys. Chem. A 2013, 117, 5706-5714.
18. Li Yao, Shoujun Xu*. Force-induced selective dissociation of noncovalent antibody- antigen bonds. J. Phys. Chem. B. 2012, 116(33), 9944-9948.
19. Dindi Yu, Songtham Ruangchaithaweesuk, Li Yao, Shoujun Xu*. Detecting molecules and cells labeled with magnetic particles using an atomic magnetometer. J. Nanoparticle Res. 2012, 14, 1135.
20. Songtham Ruangchaithaweesuk, Dindi Yu, Nissa C Garcia, Li Yao, Shoujun Xu*. Applications of optically detected MRI for enhanced contrast and penetration in metal. J. Magn. Reson. 2012, 223, 20-24.
21. Li Yao, Shoujun Xu*. Force-induced remnant magnetization spectroscopy for specific magnetic imaging of molecules. Angew. Chem. Int. Ed. 2011, 50(19), 4407-4409.
22. Li Yao, Andrew C. Jamison, Shoujun Xu*. Scanning Imaging of Magnetic Nanoparticles for Quantitative Molecular Imaging. Angew. Chem. Int. Ed. 2010, 49, 7493-7496.
23. Nissa C Garcia, Dindi Yu, Li Yao, Shoujun Xu*. Optical atomic magnetometer at body temperature for magnetic particle imaging and nuclear magnetic resonance. Opt. Lett. 2010, 35, 1539-4794.
24. Nahir Y. Dugarte, Mauricio F. Erben, Roland Boese, MaoFa Ge, Li Yao, Carlos O. Della Védova*. Molecular and electronic structure of δ-valerothiolactone. J. Phys. Chem. A 2010, 114, 12540-12547.
25. Nahir Y Dugarte, Mauricio F. Erben, Rosana M. Romano, Maofa Ge, Li Yao, Carlos O. Della Védova*. Matrix photochemistry at low temperatures and spectroscopic properties of γ-butyrothiolactone. J. Phys. Chem. A 2010, 114, 9462-9470
26. Li Yao, Shoujun Xu*. Long-Range, High-Resolution Magnetic Imaging of Nanoparticles. Angew. Chem. Int. Ed. 2009, 48, 5679-5682.
27. Dugarte Nahir, Erben Mauricio, Romano Rosana, Boese Roland, Maofa Ge, Li Yao, Carlos O. Della Védova*. Matrix photochemistry, photoelectron spectroscopy, solid phase structure and ring strain energy of β-propiothiolactone. J. Phys. Chem. A 2009, 113, 3662-3672.
28. Chifeng Tu, Jingjie Du, Li Yao, Chunhui Yang, Maofa Ge, Chuanlai Xu, Mingyuan Gao*. Magnetic Ni/SiO2 composite microcapsules prepared by one-pot synthesis. J. Mater. Chem. 2009, 19, 1245-1251.
29. Li Yao, Lin Du, Shi Yin, Maofa Ge*. Study on the atmospheric photochemical reaction of CF3 radicals using ultraviolet photoelectron and photoionization mass spectrometer. Sci. China Ser B-Chem. 2008, 51, 316-321.
30. Shengrui Tong, Lin Du, Li Yao, Maofa Ge*, Carlos O. Della Védova. Gas-Phase Generation, Structure, Spectroscopy, and Quantum Chemical Calculations of Fluorocarbonylsulfur Thiocyanate, FC(O)SSCN. Eur. J. Inorg. Chem. 2008, 25, 3987-3995.
31. Mariana Geronés, Anthony J. Downs, Mauricio F. Erben, Maofa Ge, Rosana M. Romano, Li Yao, Carlos O. Della Védova*. HeI photoelectron and valence synchrotron photoionization studies of the thioester molecule CH3C(O)SCH3: Evidence of vibronic structure. J. Phys. Chem. A 2008, 112, 5947-5953.
32. Mariana Geronés, Mauricio F. Erben, Rosana M. Romano, Carlos O. Della Védova,* Li Yao, Maofa Ge. HeI photoelectron spectra and valence synchrotron photoionization for XC(O)SCl (X = F, Cl) compounds. J. Phys. Chem. A 2008, 112, 2228-2234.
33. Lin Du, Li Yao, Maofa Ge*. Photoelectron spectroscopy, photoionization mass spectroscopy, and theoretical study on CCl(3)SSCN. Chinese J. Chem. Phys. 2008, 21, 93-98.
34. Maofa Ge,* Li Yao. Substituent effect on electronic structures of halonitrobenzenes. Spectrochim. Acta A 2008, 71, 1499-1502.
35. Lin Du, Li Yao, Maofa Ge*. A novel thioperoxide, chlorocarbonylsulfenyl acetate, ClC(O)SOC(O)CH3: Characterized by HeI photoelectron spectroscopy (PES), and theoretical investigation. J. Mol. Struct. 2008, 882, 146-152.
36. Chunping Ma, Li Yao, Maofa Ge*. Substituent effects of halopyridines. J. Mol. Struct. 2008, 881, 123-131.
37. Lin Du, Li Yao, Xiaoqing Zeng, Maofa Ge*. Experimental and theoretical study of two novel thioperoxides: Methoxycarbonylsulfenyl acetate CH3OC(O)SOC(O)CH3 and methoxycarbonylsulfenyl trifluoroacetate CH3OC(O)SOC(O)CF3. J. Mol. Struct. 2008, 876, 140-146.
38. Lin Du, Li Yao, Maofa Ge,* Dianxun Wang. HeI photoelectron spectroscopy and quantum chemical investigation on trichloromethanesulfenyl benzoate, C6H5C(O)OSCCl3. J. Mol. Struct. 2008, 875, 400-405.
39. Shi Yin, Li Yao, Xiaoqing Zeng, Manyu Li, Maofa Ge*. A HeI photoelectron spectroscopy and theoretical study of 2,6-dichloropyrazine, 2,3-dichloropyrazine, 4,6-dichloropyrimidine and 3,6-dichloropyridazine. J. Mol. Struct. 2008, 872, 24-29.
40. Li Yao, Lin Du, Maofa Ge,* Chunping Ma, Dianxun Wang. Experimental and Theoretical Study for Substituent Effects of Iodonitrobenzenes. J. Phys. Chem. A 2007, 111, 10105-10110.
41. Li Yao, Lin Du, Maofa Ge,* Dianxun Wang. Experimental and Theoretical Studies of the Electronic Structure and the Ionization and Dissociation Processes of Trifluoromethyl Peroxynitrate. J. Chem. Phys. 2007, 126, 184301-184307.
42. Li Yao, Xiaoqing Zeng, Maofa Ge,* Dianxun Wang. Experimental and theoretical studies on the electronic structure of trisubstituted boroxine. J. Mol. Struct. 2007, 841, 104-109.
43. Maofa Ge,* Li Yao, Dianxun Wang. Electronic Structure, Photoionization and Dissociation Processes of Bis(trifluoromethoxy)disulfurylperoxide, CF3OS(O)2OOS(O)2OCF3. J. Phys. Chem. A 2007, 111, 13425-13431.
44. Lin Du, Li Yao, Maofa Ge*. He I Photoelectron Spectroscopy and Theoretical Investigation on Diaceto Disulfide CH3C(O)OSSOC(O)CH3. J. Phys. Chem. A 2007, 111, 11787-11792.
45. Lin Du, Li Yao, Xiaoqing Zeng, Maofa Ge,* Dianxun Wang. HeI Photoelectron Spectroscopy and Theoretical Study of Trichloromethanesulfenyl Acetate CCl3SOC(O)CH3 and Trichloromethanesulfenyl Trifluoroacetate CCl3SOC(O)CF3. J. Phys. Chem. A 2007, 111, 4944-4949.
46. Lin Du, Li Yao, Maofa Ge*. Two Novel Species, (Methoxycarbonyl)sulfenyl Thiocyanate and (Methoxycarbonyl)sulfenyl Selenocyanate: Spectroscopic Characterization by Photoelectron Spectroscopy and Quantum Chemical Investigation. Eur. J. Inorg. Chem. 2007, 4514-4519.
47. Weigang Wang, Maofa Ge,* Yuxi Tian, Li Yao. A Flow Tube study of Methyl Iodine Uptake on Soot Surface. Chem. Phys. Lett. 2007, 440, 348-351.
48. Lin Du, Yongfu Xu,* Maofa Ge,* Long Jia, Li Yao, Weigang Wang. Rate constant of the gas phase reaction of dimethyl sulfide (CH3SCH3) with ozone. Chem. Phys. Lett. 2007, 436, 36-40.
49. Weigang Wang, Maofa Ge,* Li Yao, Xiaoqing Zeng, Zifa Wang. A novel heterogeneous reaction for generating gaseous nitrous acid. Chinese Sci. Bull. 2007, 52, 3056-3060.
50. Lin Du, Yongfu Xu,* Maofa Ge,* Long Jia, Li Yao. Experimental investigation of incremental reactivity of di-tert-butyl peroxide. Chinese Sci. Bull. 2007, 52, 1629-1634.
51. Li Yao, Maofa Ge,* Weigang Wang, Xiaoqing Zeng, Zheng Sun, Dianxun Wang. Gas Phase Generation and Electronic Structure Investigation of Chlorosulfanyl Thiocyanate ClSSCN. Inorg. Chem. 2006, 45, 5971-5975.
52. Li Yao, Xiaoqing Zeng, Maofa Ge,* Weigang Wang, Zheng Sun, Lin Du, Dianxun Wang. First Experimental Observation of Gas-phase Nitrosyl Thiocyanate. Eur. J. Inorg. Chem. 2006, 2469-2475.
53. Li Yao, Xiaoqing Zeng, Maofa Ge,* Yunfeng Ding, Weigang Wang, Lin Du, Zheng Sun, Qiao Sun, Dianxun Wang. First Experimental Observation On Different Ionic States of Isopropylthio ((CH3)2CHS) Radical. Chem. Phys. Lett. 2006, 422, 466-469.
54. Li Yao, Maofa Ge,* Dianxun Wang, Chengyin Wu, Nan Xu, Qihuang Gong. Ionization and dissociation of nitrosyl chloride molecule in the intense femtosecond laser field. Chinese J. Chem. 2006, 24, 867-871.
55. Weigang Wang, Maofa Ge,* Li Yao, Xiaoqing Zeng, Zheng Sun, Dianxun Wang. Gas-Phase Spectroscopy of the Unstable Sulfur Diisocyanate Molecule S(NCO)2. ChemPhysChem 2006, 7, 1382-1387.
56. Weigang Wang, Li Yao, Xiaoqing Zeng, Maofa Ge,* Zheng Sun, Dianxun Wang, Yunfeng Ding. Evidence of the Formation and Conversion of Unstable Thionyl Isocyanate: Gas-Phase Spectroscopic Studies. J. Chem. Phys. 2006, 125, 2343031-2343036.
57. Xiaoqing Zeng, Li Yao, Maofa Ge,* Dianxun Wang. Experimental and theoretical studies on the electronic properties of acetyl pseudohalides CH3C(O)X (X=NCO NCS and N3). J. Mol. Struct. 2006, 789, 92-99.
58. Xiaoqing Zeng, Li Yao, Weigang Wang, Fengyi Liu, Qiao Sun, Maofa Ge,* Zheng Sun, Jianping Zhang, Dianxun Wang. Electronic structures of acyl nitrites and nitrates. Spectrochim. Acta A 2006, 64, 949-955.
59. Long Jia, Maofa Ge,* Guoshun Zhuang, Li Yao, Dianxun Wang. Advances in tropospheric night-time chemistry. Prog. Chem. 2006, 18, 1034-1040.
Research Interests
We are developing state-of-the-art ultra-low field techniques and high-performance magnetic nanoprober for the application on molecular and cellular magnetic imaging, environmental biochemistry, and biophysical chemistry, especially the investigation of mechanism and regulation of cancer metastasis and mechanobiology.
Students
已指导学生
张娣 博士研究生 070304-物理化学
现指导学生
鲁攀 博士研究生 070304-物理化学
于婵婵 博士研究生 070304-物理化学
许敏 硕士研究生 070304-物理化学
柴亚红 博士研究生 070304-物理化学
冯雪艳 博士研究生 070304-物理化学
冯峰 博士研究生 070304-物理化学
展金秀 硕士研究生 070304-物理化学
刘亚静 博士研究生 070304-物理化学
李起龙 博士研究生 070304-物理化学