分子马达，细胞内物质转运，肌肉收缩，昆虫发育

2012年招生计划：博士研究生1名，硕士研究生1名

生物化学与分子生物学
细胞生物学

分子马达，细胞内物质转运
细胞骨架与细胞运动
昆虫发育

1993-09--1996-08 中国科学院上海生化所 博士
1990-09--1993-07 中国科学院上海昆虫研究所 硕士
1986-09--1990-07 华东化工学院 本科

-- 研究生

-- 博士

1996年11月起在美国 University of Massachusetts Medical School 从事研究工作，先后担任博士后 (Post-doctoral research fellow), 讲师 (Instructor), 和研究助理教授 (Research assistant professor)。2008年底入选中国科学院“****”，2009年起担任中国科学院动物研究所研究员，博士生导师。

   

[1] Yao, Lin Lin, Hou, WeiDong, Liang, Yi, Li, Xiangdong, Ji, HuanHong. Spire2 and Rab11a synergistically activate myosin-5b motor function. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2024, 第 4 作者703: http://dx.doi.org/10.1016/j.bbrc.2024.149653.
[2] Pan, Jiabin, Zhou, Rui, Yao, LinLin, Zhang, Jie, Zhang, Ning, Cao, QingJuan, Sun, Shaopeng, Li, Xiangdong. Identification of a third myosin-5a-melanophilin interaction that mediates the association of myosin-5a with melanosomes. ELIFE[J]. 2024, 第 8 作者  通讯作者  13: http://dx.doi.org/10.7554/eLife.93662.
[3] Wang, Min, Li, Xinxin, Wang, Chongnv, Zou, Ming, Yang, Jing, Li, Xiangdong, Guo, Baocheng. Asymmetric and parallel subgenome selection co-shape common carp domestication. BMC BIOLOGY[J]. 2024, 第 6 作者22(1): http://dx.doi.org/10.1186/s12915-023-01806-9.
[4] Jie Hao, Chang Liu, Ning Zhang, Jing Li, Tong Ni, Mingbo Qu, Xiangdong Li. Alternative relay regulates the adenosine triphosphatase activity of Locusta migratoria striated muscle myosin. INSECT SCIENCE[J]. 2024, 第 7 作者  通讯作者  31(2): 435-447, http://lib.cqvip.com/Qikan/Article/Detail?id=7111948854.
[5] Rui Zhou, Jiabing Pan, 张文博, 李向东. Myosin-5a facilitates stress granule formation by interacting with G3BP1. Cellular and Molecular Life Sciences[J]. 2024, 第 4 作者  通讯作者  81(null): 430, 
[6] Wei, Miao, Zhang, Ning, Li, Xiangdong. Characterisation of the myosin light chain kinase (MLCK) gene of Locusta migratoria and the encoded MLCK. INSECT MOLECULAR BIOLOGY[J]. 2024, 第 3 作者  通讯作者  33(4): 338-349, http://dx.doi.org/10.1111/imb.12902.
[7] QinRong Tan, Xiangdong Li. Fungal myosin-1 homologs as key molecular motors at the membrane–cytoskeleton interface. FUNGAL BIOLOGY REVIEWS[J]. 2023, 第 2 作者  通讯作者  45: http://dx.doi.org/10.1016/j.fbr.2023.100318.
[8] Ning Zhang, Shu-Jie Zhou, Huan-Hong Ji, 李向东. Effects of the IQ1 motif of Drosophila myosin-5 on the calcium interaction of calmodulin.. Cell Calcium[J]. 2022, 第 4 作者  通讯作者  103: 102549, 
[9] Liang, HuiFang, 李向东. Locusta migratoria flight muscle troponin partially activates thin filament in a calcium-dependent manner. INSECT MOLECULAR BIOLOGY[J]. 2022, 第 2 作者  通讯作者  31(3): 346-355, http://dx.doi.org/10.1111/imb.12763.
[10] Chang Liu, Jie Hao, LinLin Yao, Miao Wei, Wei Chen, Qing Yang, 李向东. Insect Sf9 cells are suitable for functional expression of insect, but not vertebrate, striated muscle myosin. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2022, 第 7 作者  通讯作者  http://dx.doi.org/10.1016/j.bbrc.2022.10.055.
[11] Tong Ni, Min Yuan, HuanHong Ji, Guangfei Tang, Yun Chen, Zhonghua Ma, Xiangdong Li. Effects of Mutations in the Phenamacril-Binding Site of Fusarium Myosin-1 on Its Motor Function and Phenamacril Sensitivity. ACS OMEGA[J]. 2020, 第 7 作者  通讯作者  5(34): 21815-21823, https://www.webofscience.com/wos/woscc/full-record/WOS:000568645300053.
[12] Liang, H F, Li, J, Li, X D. Identification and characterization of troponin genes in Locusta migratoria. INSECT MOLECULAR BIOLOGY[J]. 2020, 29(4): 391-403, http://dx.doi.org/10.1111/imb.12644.
[13] Ji, HuanHong, Yao, LinLin, Liu, Chang, Li, Xiangdong. Regulation of Myosin-5b by Rab11a and the Rab11 family interacting protein 2. BIOSCIENCE REPORTS[J]. 2019, 第 4 作者  通讯作者  39(1): 
[14] Cao, QingJuan, Zhang, Ning, Zhou, Rui, Yao, LinLin, Li, Xiangdong. The cargo adaptor proteins RILPL2 and melanophilin co-regulate myosin-5a motor activity. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2019, 第 5 作者  通讯作者  294(29): 11333-11341, http://dx.doi.org/10.1074/jbc.RA119.007384.
[15] Zhanghao, Karl, Chen, Xingye, Liu, Wenhui, Li, Meiqi, Liu, Yiqiong, Wang, Yiming, Luo, Sha, Wang, Xiao, Shan, Chunyan, Xie, Hao, Gao, Juntao, Chen, Xiaowei, Jin, Dayong, Li, Xiangdong, Zhang, Yan, Dai, Qionghai, Xi, Peng. Super-resolution imaging of fluorescent dipoles via polarized structured illumination microscopy. NATURE COMMUNICATIONS[J]. 2019, 第 14 作者10(1): https://doaj.org/article/080c2362f4c04472a1ce4e4338f97ada.
[16] 李静怡, 徐小艾, 晁雨竹, 李向东, 沈红, 张永红. 地鳖肽对H2O2刺激鸡骨骼肌卫星细胞增殖的影响. 北京农学院学报[J]. 2019, 第 4 作者34(1): 70-75, http://lib.cqvip.com/Qikan/Article/Detail?id=7001104369.
[17] Zhang, Ning, Yao, LinLin, Li, Xiangdong. Regulation of class V myosin. CELLULAR AND MOLECULAR LIFE SCIENCES. 2018, 第 3 作者  通讯作者  75(2): 261-273, https://www.webofscience.com/wos/woscc/full-record/WOS:000419471500007.
[18] Zhang, HaiMan, Ji, HuanHong, Ni, Tong, Ma, RongNa, Wang, Aibing, Li, Xiangdong. Characterization of Blebbistatin Inhibition of Smooth Muscle Myosin and Nonmuscle Myosin-2. BIOCHEMISTRY[J]. 2017, 第 6 作者  通讯作者  56(32): 4235-4243, https://www.webofscience.com/wos/woscc/full-record/WOS:000407987600013.
[19] LinLin Yao, Mei Shen, Zekuan Lu, Mitsuo Ikebe, Xiangdong Li. Identification of the Isoform-specific Interactions between the Tail and the Head of Class V Myosin *. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 2016, 第 5 作者291(15): 8241-8250, http://dx.doi.org/10.1074/jbc.M115.693762.
[20] Yao, LinLin, Shen, Mei, Lu, Zekuan, Ikebe, Mitsuo, Li, Xiangdong. Identification of the Isoform-specific Interactions between the Tail and the Head of Class V Myosin. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2016, 第 5 作者  通讯作者  291(15): 8241-8250, http://dx.doi.org/10.1074/jbc.M115.693762.
[21] WenBo Zhang, LinLin Yao, Xiangdong Li. The Globular Tail Domain of Myosin-5a Functions as a Dimer in Regulating the Motor Activity *. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 2016, 第 3 作者291(26): 13571-13579, http://dx.doi.org/10.1074/jbc.M116.724328.
[22] Li, J, Lu, Z, He, J, Chen, Q, Wang, X, Kang, L, Li, X D. Alternative exon-encoding regions of Locusta migratoria muscle myosin modulate the pH dependence of ATPase activity. INSECT MOLECULAR BIOLOGY[J]. 2016, 25(6): 689-700, https://www.webofscience.com/wos/woscc/full-record/WOS:000387659900002.
[23] Su Qian, Zheng Sanduo, Zhang Wenbo, Zhang Haiman, Lu Zekuan, Sun Yujie, Li Xiangdong, Ye Keqiong, Shen Mei, Zhang Ning. Calmodulin in Complex with the First IQ Motif of Myosin-5a Functions as an Intact Calcium Sensor. PNAS[J]. 2016, 第 7 作者113(40): E5812-E5820, http://ir.ioz.ac.cn/handle/000000/12119.
[24] Chen, Nan, Fan, YongLiang, Bai, Yu, Li, Xiangdong, Zhang, ZhanFeng, Liu, TongXian. Cytochrome P450 gene, CYP4G51, modulates hydrocarbon production in the pea aphid, Acyrthosiphon pisum. INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY[J]. 2016, 第 4 作者76: 84-94, http://dx.doi.org/10.1016/j.ibmb.2016.07.006.
[25] Shen, Mei, Zhang, Ning, Zheng, Sanduo, Zhang, WenBo, Zhang, HaiMan, Lu, Zekuan, Su, Qian Peter, Sun, Yujie, Ye, Keqiong, Li, Xiangdong. Calmodulin in complex with the first IQ motif of myosin-5a functions as an intact calcium sensor. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2016, 第 10 作者  通讯作者  113(40): E5812-E5820, https://www.webofscience.com/wos/woscc/full-record/WOS:000384528900007.
[26] Zhang, WenBo, Yao, LinLin, Li, Xiangdong. The Globular Tail Domain of Myosin-5a Functions as a Dimer in Regulating the Motor Activity. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2016, 第 3 作者  通讯作者  291(26): 13571-13579, http://dx.doi.org/10.1074/jbc.M116.724328.
[27] Ji, HuanHong, Zhang, HaiMan, Shen, Mei, Yao, LinLin, Li, Xiangdong. The motor function of Drosophila melanogaster myosin-5 is activated by calcium and cargo-binding protein dRab11. BIOCHEMICAL JOURNAL[J]. 2015, 第 5 作者  通讯作者  469: 135-144, https://www.webofscience.com/wos/woscc/full-record/WOS:000361050900013.
[28] Ji, HuanHong, Zhang, HaiMan, Shen, Mei, Li, Xiangdong. Activation of Drosophila Melanogaster Myosin-5 Motor Function by Calcium and Cargo-Binding Protein. BIOPHYSICAL JOURNAL. 2015, 第 4 作者108(2): 302A-303A, https://www.webofscience.com/wos/woscc/full-record/WOS:000362849100724.
[29] Zhang, Chengqi, Chen, Yun, Yin, Yanni, Ji, HuanHong, Shim, WonBo, Hou, Yiping, Zhou, Mingguo, Li, Xiangdong, Ma, Zhonghua. A small molecule species specifically inhibits Fusarium myosin I. ENVIRONMENTAL MICROBIOLOGY[J]. 2015, 第 8 作者17(8): 2735-2746, https://www.webofscience.com/wos/woscc/full-record/WOS:000360048800014.
[30] Yao, LinLin, Cao, QingJuan, Zhang, HaiMan, Zhang, Jie, Cao, Yang, Li, Xiangdong. Melanophilin Stimulates Myosin-5a Motor Function by Allosterically Inhibiting the Interaction between the Head and Tail of Myosin-5a. SCIENTIFIC REPORTS[J]. 2015, 第 6 作者  通讯作者  5: http://dx.doi.org/10.1038/srep10874.
[31] Shen, Mei, Zheng, Sanduo, Zhang, WenBo, Lu, Zekuan, Li, Xiangdong. Structural Basis for Calcium Regulation of the Motor Function of Myosin-5a. BIOPHYSICAL JOURNAL. 2015, 第 5 作者108(2): 25A-25A, https://www.webofscience.com/wos/woscc/full-record/WOS:000359471700121.
[32] Cao, Yang, White, Howard D, Li, Xiangdong. Drosophila Myosin-XX Functions as an Actin-Binding Protein To Facilitate the Interaction between Zyx102 and Actin. BIOCHEMISTRY[J]. 2014, 第 3 作者  通讯作者  53(2): 350-360, https://www.webofscience.com/wos/woscc/full-record/WOS:000330204800009.
[33] Lu Zekuan, Ma XiaoNan, Zhang HaiMan, Ji HuanHong, Ding Hao, Zhang Jie, Luo Dan, Sun Yujie, Li XiangDong. Mouse myosin-19 is a plus-end-directed, high-duty ratio molecular motor.. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 2014, 第 9 作者18535-18548, http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=1&recid=&FileName=SJPDA50FA82F9DA9931E88929DB9092FD0B5&DbName=SJPD_06&DbCode=SJPD&yx=&pr=&URLID=&bsm=.
[34] Lu, Zekuan, Ma, XiaoNan, Zhang, HaiMan, Ji, HuanHong, Ding, Hao, Zhang, Jie, Luo, Dan, Sun, Yujie, Li, Xiangdong. Mouse Myosin-19 Is a Plus-end-directed, High-duty Ratio Molecular Motor. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2014, 第 9 作者  通讯作者  289(26): 18535-18548, http://dx.doi.org/10.1074/jbc.M114.569087.
[35] Ma, RongNa, Mabuchi, Katsuhide, Li, Jing, Lu, Zekuan, Li, Xiangdong. Stable Double-Headed Structure is Essential not only for the Inhibited State, but also for the Fully Activated State of Smooth Muscle Myosin. BIOPHYSICAL JOURNAL. 2013, 第 5 作者104(2): 451A-452A, https://www.webofscience.com/wos/woscc/full-record/WOS:000316074304293.
[36] Ma, RongNa, Mabuchi, Katsuhide, Li, Jing, Lu, Zekuan, Wang, ChihLueh Albert, Li, Xiangdong. Cooperation between the Two Heads of Smooth Muscle Myosin Is Essential for Full Activation of the Motor Function by Phosphorylation. BIOCHEMISTRY[J]. 2013, 第 6 作者  通讯作者  52(36): 6240-6248, https://www.webofscience.com/wos/woscc/full-record/WOS:000330099900012.
[37] Lu, Zekuan, Shen, Mei, Cao, Yang, Zhang, HaiMan, Yao, LinLin, Li, Xiangdong. Calmodulin Bound to the First IQ Motif Is Responsible for Calcium-dependent Regulation of Myosin 5a. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2012, 第 6 作者  通讯作者  287(20): 16530-16540, http://dx.doi.org/10.1074/jbc.M112.343079.
[38] 曹洋, 沈梅, 张洁, 李向东. 果蝇非常规肌球蛋白的结构与功能. 应用昆虫学报[J]. 2011, 第 4 作者48(2): 239-246, http://lib.cqvip.com/Qikan/Article/Detail?id=37676442.
[39] Umeki, Nobuhisa, Jung, Hyun Suk, Watanabe, Shinya, Sakai, Tsuyoshi, Li, Xiangdong, Ikebe, Reiko, Craig, Roger, Ikebe, Mitsuo. The tail binds to the head-neck domain, inhibiting ATPase activity of myosin VIIA. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2009, 第 5 作者106(21): 8483-8488, https://www.webofscience.com/wos/woscc/full-record/WOS:000266432700016.
[40] Li Xiangdong. The globular tail domain puts on the brake to stop the ATPase cycle of the myosin Va.. Proceedings of the National Academy of Sciences USA. 2008, 第 1 作者  通讯作者  
[41] Sato, Osamu, Li, Xiangdong, Ikebe, Mitsuo. Myosin Va becomes a low duty ratio motor in the inhibited form. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2007, 第 2 作者282(18): 13228-13239, http://dx.doi.org/10.1074/jbc.M610766200.
[42] Li, Xiangdong, Jung, Hyun Suk, Mabuchi, Katsuhide, Craig, Roger, Ikebe, Mitsuo. The globular tail domain of myosin Va functions as an inhibitor of the myosin Va motor. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2006, 第 1 作者  通讯作者  281(31): 21789-21798, http://dx.doi.org/10.1074/jbc.M602957200.
[43] Li, XD, Ikebe, R, Ikebe, M. Activation of myosin Va function by melanophilin, a specific docking partner of myosin Va. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2005, 280(18): 17815-17822, http://dx.doi.org/10.1074/jbc.M413295200.
[44] Li, XD, Mabuchi, K, Ikebe, R, Ikebe, M. Ca2+-induced activation of ATPase activity of myosin Va is accompanied with a large conformational change. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2004, 315(3): 538-545, https://www.webofscience.com/wos/woscc/full-record/WOS:000189291900003.
[45] Li, XD, Ikebe, M. Two functional heads are required for full activation of smooth muscle myosin. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2003, 278(32): 29435-29441, http://dx.doi.org/10.1074/jbc.M301784200.
[46] Li, XD, Saito, J, Ikebe, R, Mabuchi, K, Ikebe, M. The interaction between the regulatory light chain domains on two heads is critical for regulation of smooth muscle myosin. BIOCHEMISTRY[J]. 2000, 39(9): 2254-2260, https://www.webofscience.com/wos/woscc/full-record/WOS:000085769700014.
[47] Lu Zekuan, Shen Mei, Cao Yang, Zhang Hai-Man, Yao Lin-Lin, Li Xiang-dong. Calmodulin Bound to the First IQ Motif Is Responsible for Calcium-dependent Regulation of Myosin 5a *. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 第 6 作者287(20): 16530-16540, http://dx.doi.org/10.1074/jbc.M112.343079.

现指导学生

张文博  硕士研究生  071012-生态学  

李晶  硕士研究生  071010-生物化学与分子生物学  

张洁  硕士研究生  071010-生物化学与分子生物学  

冀焕红  博士研究生  071010-生物化学与分子生物学  

曹洋  博士研究生  071010-生物化学与分子生物学  

张海满  硕士研究生  071010-生物化学与分子生物学  

马晓楠  硕士研究生  071010-生物化学与分子生物学