基本信息
刘真  男  博导  中国科学院脑科学与智能技术卓越创新中心
电子邮件: zliu2010@ion.ac.cn
通信地址: Shanghai
邮政编码: 200030

招生信息

   
招生专业
071006-神经生物学
071009-细胞生物学
招生方向
胚胎发育,生殖生理,细胞重编程,神经生殖内分泌

教育背景

2014-09--2017-06   中国科学院大学   博士
2010-09--2013-06   中国科学院大学   硕士
2006-09--2010-06   山东师范大学   学士

工作经历

   
工作简历
2018-09~现在, 中国科学院脑科学与智能技术卓越创新中心, 研究员
2017-07~2018-08,中国科学院神经科学研究所, 博士后
2013-07~2014-08,中国科学院神经科学研究所, 研究实习员

专利与奖励

   
奖励信息
(1) 上海市科学技术奖, 一等奖, 省级, 2023
(2) 干细胞卓越青年研究员, 其他, 2023
(3) 中国青年五四奖章, , 部委级, 2021
(4) 上海市青年五四奖章标兵, 省级, 2021
(5) 中科院先进工作者, 研究所(学校), 2019
(6) 何梁何利科技创新奖, 专项, 2019
(7) 中科院创新交叉团队, 院级, 2018
(8) 中科院院长特别奖, 院级, 2016
专利成果
( 1 ) 一种非人哺乳动物性早熟动物模型的建立方法及其用途, 发明专利, 2022, 第 2 作者, 专利号: CN114592008A

( 2 ) 一种性早熟动物模型的构建方法及其应用, 发明专利, 2021, 第 2 作者, 专利号: CN113615638A

( 3 ) STXBP1突变动物模型的构建及其应用, 2023, 第 3 作者, 专利号: CN113528584B

出版信息

   
发表论文
[1] Lu, Zongyang, He, Siting, Jiang, Jian, Zhuang, Ling, Wang, Yan, Yang, Guang, Jiang, Xiaoyu, Nie, Yanhong, Fu, Jiqiang, Zhang, Xiaotong, Lu, Yong, Bian, Xinyan, Chang, HungChun, Xiong, Zhiqi, Huang, Xingxu, Liu, Zhen, Sun, Qiang. Base-edited cynomolgus monkeys mimic core symptoms of STXBP1 encephalopathy. MOLECULAR THERAPY[J]. 2022, 第 16 作者  通讯作者  30(6): 2163-2175, http://dx.doi.org/10.1016/j.ymthe.2022.03.001.
[2] Wang, Zhanyang, Li, Yuzhuo, Yang, Xianfa, Wang, Yan, Nie, Yanhong, Xu, Yuting, Zhang, Xiaotong, Lu, Yong, Zhang, Tikui, Liu, Qiming, Jing, Naihe, Liu, Zhen, Sun, Qiang. Mitochondrial replacement in macaque monkey offspring by first polar body transfer. CELL RESEARCH. 2021, 第 12 作者  通讯作者  31(2): 233-236, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6907319&detailType=1.
[3] He, Xiaozhen, Chen, Wenfeng, Liu, Zhen, Yu, Guirong, Chen, Youbang, Cai, YiJun, Sun, Ling, Xu, Wanli, Zhong, Lili, Gao, Caixi, Chen, Jishen, Zhang, Minjie, Yang, Shengxi, Yao, Yizhou, Zhang, Zhiping, Ma, Fujun, Zhang, ChenChen, Lu, HuiPing, Yu, Bin, Cheng, TianLin, Qiu, Juhui, Sheng, Qing, Zhou, HaiMeng, Lv, ZhiRong, Yan, Junjun, Zhou, Yongjian, Qiu, Zilong, Cui, Zongbin, Zhang, Xi, Meng, Anming, Sun, Qiang, Yang, Yufeng. Efficient and risk-reduced genome editing using double nicks enhanced by bacterial recombination factors in multiple species. NUCLEIC ACIDS RESEARCH[J]. 2020, 第 3 作者48(10): e57-e57, https://www.webofscience.com/wos/woscc/full-record/WOS:000569071800003.
[4] Yang, Qiyuan, Li, Ronghong, Lyu, Qifeng, Hou, Li, Liu, Zhen, Sun, Qiang, Liu, Miao, Shi, Huijuan, Xu, Beiying, Yin, Mingru, Yan, Zhiguang, Huang, Ying, Liu, Mofang, Li, Yiping, Wu, Ligang. Single-cell CAS-seq reveals a class of short PIWI-interacting RNAs in human oocytes. NATURE COMMUNICATIONS[J]. 2019, 第 5 作者10(1): http://dx.doi.org/10.1038/s41467-019-11312-8.
[5] Long, Hui, Nie, Yanhong, Wang, Li, Lu, Yong, Wang, Yan, Cai, Yijun, Liu, Zhen, Jia, Miaomiao, Lyu, Qifeng, Kuang, Yanping, Sun, Qiang. Serum anti-Mullerian hormone predicts ovarian response in (Macaca fascicularis) monkeys. ENDOCRINE CONNECTIONS[J]. 2018, 第 7 作者7(9): 983-989, https://doi.org/10.1530/EC-18-0189.
[6] Liu, Zhen, Cai, Yijun, Wang, Yan, Nie, Yanhong, Zhang, Chenchen, Xu, Yuting, Zhang, Xiaotong, Lu, Yong, Wang, Zhanyang, Poo, Muming, Sun, Qiang. Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer. CELL[J]. 2018, 第 1 作者172(4): 881-+, http://dx.doi.org/10.1016/j.cell.2018.01.020.
[7] Zhen Liu, Zongyang Lu, Guang Yang, Shisheng Huang, Guanglei Li, Songjie Feng, Yajing Liu, Jianan Li, Wenxia Yu, Yu Zhang, Jia Chen, Qiang Sun, Xingxu Huang. Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing. NATURE COMMUNICATIONS[J]. 2018, 第 1 作者9(1): https://doaj.org/article/00d2609bd86e4a84801435f8046ddda4.
[8] Yao, Xuan, Liu, Zhen, Wang, Xing, Wang, Yan, Nie, YanHong, Lai, Liang, Sun, Ruilin, Shi, Linyu, Sun, Qiang, Yang, Hui. Generation of knock-in cynomolgus monkey via CRISPR/Cas9 editing. CELL RESEARCH[J]. 2018, 第 2 作者28(3): 379-382, https://www.webofscience.com/wos/woscc/full-record/WOS:000426547800010.
[9] Yao, Xuan, Wang, Xing, Hu, Xinde, Liu, Zhen, Liu, Junlai, Zhou, Haibo, Shen, Xiaowen, Wei, Yu, Huang, Zijian, Ying, Wenqin, Wang, Yan, Nie, YanHong, Zhang, ChenChen, Li, Sanlan, Cheng, Leping, Wang, Qifang, Wu, Yan, Huang, Pengyu, Sun, Qiang, Shi, Linyu, Yang, Hui. Homology-mediated end joining-based targeted integration using CRISPR/Cas9. CELL RESEARCH[J]. 2017, 第 4 作者27(6): 801-814, http://www.corc.org.cn/handle/1471x/2188444.
[10] Zuo, Erwei, Cai, YiJun, Li, Kui, Wei, Yu, Wang, BangAn, Sun, Yidi, Liu, Zhen, Liu, Jiwei, Hu, Xinde, Wei, Wei, Huo, Xiaona, Shi, Linyu, Tang, Cheng, Liang, Dan, Wang, Yan, Nie, YanHong, Zhang, ChenChen, Yao, Xuan, Wang, Xing, Zhou, Changyang, Ying, Wenqin, Wang, Qifang, Chen, RenChao, Shen, Qi, Xu, GuoLiang, Li, Jinsong, Sun, Qiang, Xiong, ZhiQi, Yang, Hui. One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs. CELL RESEARCH[J]. 2017, 第 7 作者27(7): 933-945, http://www.corc.org.cn/handle/1471x/2188612.
[11] Liu, Zhen, Nie, YanHong, Zhang, ChenChen, Cai, YiJun, Wang, Yan, Lu, HuiPing, Li, YuZhuo, Cheng, Cheng, Qiu, ZiLong, Sun, Qiang. Generation of macaques with sperm derived from juvenile monkey testicular xenografts. CELL RESEARCH[J]. 2016, 第 1 作者26(1): 139-142, http://ir.sibs.ac.cn/handle/331001/4051.
[12] Liu, Zhen, Li, Xiao, Zhang, JunTao, Cai, YiJun, Cheng, TianLin, Cheng, Cheng, Wang, Yan, Zhang, ChenChen, Nie, YanHong, Chen, ZhiFang, Bian, WenJie, Zhang, Ling, Xiao, Jianqiu, Lu, Bin, Zhang, YueFang, Zhang, XiaoDi, Sang, Xiao, Wu, JiaJia, Xu, Xiu, Xiong, ZhiQi, Zhang, Feng, Yu, Xiang, Gong, Neng, Zhou, WenHao, Sun, Qiang, Qiu, Zilong. Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2. NATURE[J]. 2016, 第 1 作者530(7588): 98-+, http://dx.doi.org/10.1038/nature16533.
[13] Yang, Hui, Liu, Zhen, Ma, Yu, Zhong, Cuiqing, Yin, Qi, Zhou, Chikai, Shi, Linyu, Cai, Yijun, Zhao, Hanzhi, Wang, Hui, Tang, Fan, Wang, Yan, Zhang, Chenchen, Liu, Xinyuan, Lai, Dongmei, Jin, Ying, Sun, Qiang, Li, Jinsong. Generation of haploid embryonic stem cells from Macaca fascicularis monkey parthenotes. CELL RESEARCH[J]. 2013, 第 2 作者23(10): 1187-1200, http://dx.doi.org/10.1038/cr.2013.93.