General

LIU Yunhui

PhD, Associate Investigator

Investigating the neural mechanism underlying stress-induced metabolic disorders
Email: 
yh.liu@siat.ac.cn

Research Areas

Moderate stress can help us improve concentration and work efficiency, but persistent stress can lead to emotional disorders such as anxiety and depression. On the other hand, stress is also closely related to metabolic disorders, including abnormal glucose metabolism, lipid metabolism disorders, and imbalance of bone remodeling. In most cases, stress-induced mood disorders and metabolic disturbances often co-occur, but the underlying mechanisms are unclear. Using cutting-edge interdisciplinary technology, we explored the central nervous and peripheral physiological mechanisms of stress-induced anxiety, bone loss, and energy metabolism disorders in our previous research. Currently, our research interests include: 1) The central circuit mechanism of stress-induced metabolic disorders. 2) The role and mechanism of astrocytes in regulating stress-induced metabolic disorders. 3) The central neural mechanism of endocrine hormones in regulating stress-induced metabolic diseases. In general, our research interest lies in using the concepts of "central nervous system to regulate peripheral organs" and "functional interaction between organs" to study the physiological mechanism of stress-induced metabolic diseases.

Education

2016-2021          Ph.D. in Neuroscience, University of Chinese Academy of Sciences

2008-2011          M.S. in Biochemistry and Molecular Biology, Shantou University

2004-2008          B.S. in Biotechnology, Hunan University of Science and Technology

Experience

   
Work Experience

2022-present       Associate Investigator at Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences

2015-2021          Assistant Investigator at Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences

2011-2015          Research Assistant at Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences

Publications

   
Papers (# Co-first author, * Corresponding author)

  1. Shao J#, Gao DS#, Liu YH#, Chen SP, Liu N, Zhang L, Zhou XY, Xiao Q, Wang LP, Hu HL, Yang F*. Cav3.1-driven bursting firing in ventromedial hypothalamic neurons exerts dual control of anxiety-like behavior and energy expenditure. Mol Psychiatry. 2022 Mar 22. doi: 10.1038/s41380-022-01513-x.

  2. Liu YH#, Zhang L#, Hu N#, Shao J, Yang DZ, Ruan CS, Huang SS, Wang LP, Lu WW, Zhang XZ*, Yang F*. An Optogenetic Approach for Regulating Human Parathyroid Hormone Secretion. Nat Commun. 2022 Feb 9;13(1):771. doi: 10.1038/s41467-022-28472-9.

  3. Shao J#, Liu YH#, Gao DS, Tu J, Yang F*. Neural Burst Firing and its Roles in Mental and Neurological Disorders. Front. Cell. Neurosci. 2021. 15:741292. doi: 10.3389/ fncel.2021. 741292

  4. Liu YH#, Shao J#, Gao DS, Zhang L, Yang F*. Astrocytes in the Ventromedial Hypothalamus Involve Chronic Stress-Induced Anxiety and Bone Loss in Mice. Neural Plast. 2021 Jul 8;2021:7806370. doi: 10.1155/2021/7806370.

  5. Xu XR, Xiao Q, Hong YC, Liu YH, Liu Y, Tu J*. Activation of dopaminergic VTA inputs to the mPFC ameliorates chronic stress‐induced breast tumor progression. CNS Neurosci Ther. 2021 Feb;27(2):206-219

  6. Yang F#*, Liu YH#, Chen SP, Dai ZQ, Yang DZ, Gao DS, Shao J, Wang YY, Wang T, Zhang ZJ, Zhang L, Lu WW, Li YH*, Wang LP*. A GABAergic neural circuit in the ventromedial hypothalamus mediates chronic stress-induced bone loss. J Clin Invest. 2020 Dec 1;130(12):6539-6554.

  7. Li D#, Guo BC#, Liang QF, Liu YH, Zhang L, Hu N*, Zhang XZ, Yang F*, Ruan CS*. Tissue-engineered Parathyroid Gland and Its Regulatory Secretion of Parathyroid Hormone. J Tissue Eng Regen Med. 2020 Oct;14(10):1363-1377.

  8. Huang SS#*, Li ZX#, Liu YH, Gao DS, Zhang XZ, Hao J*, Yang F*. Neural regulation of bone remodeling: Identifying novel neural molecules and pathways between brain and bone. J Cell Physiol. 2019 May;234(5):5466-5477.

  9. Yang F#, Liu YH#, Tu J#, Wan J, Zhang J, Wu BF, Chen SP, Zhou JW, Mu YL, Wang LP*, Activated astrocytes enhance the dopaminergic differentiation of stem cells and promote brain repair through bFGF, Nat Commun, 2014.12.17, 5(5627) 

  10. Tu J, Yang F, Wan J, Liu YH, Zhang J, Wu BF, Liu YF, Zeng SQ, Wang LP*, Light-controlled astrocytes promote human mesenchymal stem cells toward neuronal differentiation and improve the neurological deficit in stroke rats, Glia, 2014.01.10, 62(1): 106~121

  11. Yang F#, Tu J#, Pan JQ#, Luo HL, Liu YH, Wan J, Zhang J, Wei PF, Jiang T, Chen YH, Wang LP*, Light-controlled inhibition of malignant glioma by opsin gene transfer, Cell death & disease,2013.10.31, 4: e893

  12. Zhang Q, Liu YH, Chen KC, Zhang GG, Shi XH, Chen HJ* Surface biocompatible modification of polyurethane by entrapment of a  modifier, Colloids Surf B Biointerfaces, 2013.02.01, 102: 354~360

  13. Li GY, Liu YH, Li DD, Zhang LL, Xu KT*, A comparative study on structure-property elucidation of P3/4HB and PEG-based block polyurethanes, J Biomed Mater Res A, 2012.09.12, 100(9): 2319~2329

Students

现指导学生

袁倩  硕士研究生  086000-生物与医药