中药色谱分离分析与纯化制备

   

070302-分析化学

基于本草物质组的新药发现
中药高效正交纯化制备方法发展

2004-09--2010-07   中国科学院大连化学物理研究所   博士
2000-09--2004-07   山西大学   学士

研究生

博士

   

2019-07~现在, 中国科学院大连化学物理研究所, 研究员
2013-07~2019-06,中国科学院大连化学物理研究所, 副研究员
2010-07~2013-07,中国科学院大连化学物理研究所, 助理研究员

   

（ 1 ） 苍术酮或苍术素作为FFA1激动剂的应用及药物组合物, 发明专利, 2022, 第 4 作者, 专利号: CN114129555A

（ 2 ） 香豆素类衍生物在制备治疗炎症性肠炎药物中应用及药物, 发明专利, 2022, 第 3 作者, 专利号: CN114129562A

（ 3 ） 一种从麻黄中提取麻黄碱的连续制备方法, 发明专利, 2022, 第 2 作者, 专利号: CN114133335A

（ 4 ） 一种木脂素类化合物及制备与应用和产品, 发明专利, 2022, 第 4 作者, 专利号: CN113880791A

（ 5 ） 双苄基异喹啉生物碱衍生物及制备和应用与药物组合物, 发明专利, 2021, 第 3 作者, 专利号: CN113730408A

（ 6 ） 一种有机酸化合物及其制备方法和用途, 发明专利, 2021, 第 4 作者, 专利号: CN111233662B

（ 7 ） 一种莪术中强极性成分的分离制备及分析方法和应用, 专利授权, 2021, 第 5 作者, 专利号: CN111610284B

（ 8 ） 一种穿山甲指纹图谱质量监测方法, 发明专利, 2021, 第 6 作者, 专利号: CN112924570A

（ 9 ） 一种胆南星定量指纹图谱质量监测方法, 发明专利, 2021, 第 5 作者, 专利号: CN112924569A

（ 10 ） 一种环状肉桂酰胺化合物及其制备方法和应用, 发明专利, 2021, 第 3 作者, 专利号: CN112898214A

（ 11 ） 一种不同厂家/或相同厂家不同批次银杏叶药物相似度的分析方法, 发明专利, 2021, 第 3 作者, 专利号: CN112858550A

（ 12 ） 无标记精氨酸加压素受体细胞模型构建和配体筛选方法, 发明专利, 2021, 第 4 作者, 专利号: CN112858673A

（ 13 ） 一种双黄连口服液定量指纹图谱质量监测方法, 发明专利, 2021, 第 4 作者, 专利号: CN112858549A

（ 14 ） 一种基于HPLC-DAD的六味地黄丸组方解析和质量分析方法, 发明专利, 2021, 第 4 作者, 专利号: CN112684091A

（ 15 ） 一种紫草液相分离时色谱峰的质量的定量分析方法, 发明专利, 2021, 第 4 作者, 专利号: CN112461939A

（ 16 ） 一种小金胶囊或小金丸或小金片质量的指纹图谱检测方法, 发明专利, 2021, 第 4 作者, 专利号: CN112444588A

（ 17 ） 磺酰胺衍生物、其药物组合物和应用, 发明专利, 2021, 第 4 作者, 专利号: CN112390734A

（ 18 ） 无标记血管紧张素Ⅱ受体细胞模型构建和筛选方法及应用, 发明专利, 2021, 第 4 作者, 专利号: CN112345745A

（ 19 ） 一种双查尔酮类化合物及其制备方法和用途, 发明专利, 2020, 第 3 作者, 专利号: CN111233648A

（ 20 ） 一种动态质量重置法检测化合物临界聚合浓度的方法, 发明专利, 2020, 第 3 作者, 专利号: CN111239053A

（ 21 ） 一种新双黄酮类化合物及其制备方法和用途, 发明专利, 2020, 第 4 作者, 专利号: CN111233808A

（ 22 ） 一种甘草中生物碱类化合物的制备方法及用途, 发明专利, 2020, 第 4 作者, 专利号: CN111228326A

（ 23 ） 一种夜交藤中极性化合物的纯化制备方法, 发明专利, 2020, 第 4 作者, 专利号: CN111233757A

（ 24 ） 一种2-(2,2-二芳基乙基)-环胺衍生物或盐及合成和应用与组合物, 发明专利, 2019, 第 3 作者, 专利号: CN110372571A

（ 25 ） β 2 -肾上腺素受体拮抗剂及应用, 发明专利, 2019, 第 5 作者, 专利号: CN109893651A

（ 26 ） 一种枸杞子中二咖啡酰亚精胺类化合物选择性富集方法, 发明专利, 2019, 第 4 作者, 专利号: CN109810014A

（ 27 ） 一种莪术中β 2 -肾上腺素受体激动剂及其应用, 发明专利, 2019, 第 3 作者, 专利号: CN109806254A

（ 28 ） 柴胡活性成分在制备抗三阴性乳腺癌药物中的应用, 发明专利, 2019, 第 4 作者, 专利号: CN109549945A

（ 29 ） 一种高效分离纯化高纯度甘草酸的方法, 专利授权, 2018, 第 3 作者, 专利号: CN107759655A

（ 30 ） 一种化合物、毒蕈碱M受体拮抗剂、组合物及应用, 发明专利, 2017, 第 3 作者, 专利号: CN107129439A

（ 31 ） 化合物、毒蕈碱M受体拮抗剂、组合物及应用, 专利授权, 2017, 第 3 作者, 专利号: CN107129453A

（ 32 ） 一种黑果枸杞中花色苷类化合物异构体的分离纯化方法, 发明专利, 2016, 第 3 作者, 专利号: CN106188180A

（ 33 ） 一种黑果枸杞中花色苷类化合物的选择性富集方法, 专利授权, 2016, 第 3 作者, 专利号: CN106198172A

（ 34 ） 蟾蜍二烯内酯类化合物在制备抗胃癌药物中的应用, 发明专利, 2016, 第 4 作者, 专利号: CN106138067A

（ 35 ） 一种蟾蜍二烯内酯类化合物选择性分离纯化方法, 发明专利, 2015, 第 3 作者, 专利号: CN104774234A

（ 36 ） 一种基于亲水固相萃取技术的蟾蜍二烯内酯类化合物类分离纯化方法, 发明专利, 2015, 第 3 作者, 专利号: CN104774235A

（ 37 ） 一种嚏根草配基空间异构体化合物及其制备和应用, 发明专利, 2011, 第 2 作者, 专利号: CN102101878A

（ 38 ） 一种沙蟾毒精空间异构体化合物及其制备和应用, 发明专利, 2011, 第 2 作者, 专利号: CN102101879A

（ 39 ） 一类蟾蜍内酯类化合物在抑制肿瘤生长药物中的应用, 发明专利, 2010, 第 1 作者, 专利号: CN101829123A

（ 40 ） 一种蟾蜍内酯类化合物及其在制备抗肿瘤药物中的应用, 发明专利, 2010, 第 4 作者, 专利号: CN101830963A

   

[1] 何潇, 伍慧敏, 熊乐乐, 金红利, 刘艳芳, 沈爱金, 梁鑫淼. 基于UPLC-Q-TOF-MS技术的赤芍单萜类成分研究. 中国中药杂志[J]. 2023, 48(4): 1005-1013, http://lib.cqvip.com/Qikan/Article/Detail?id=7109265889.
[2] 徐鑫, 魏彤, 薛倩倩, 艾嘉浩, 李桂馨, 刘忠国, 李丹, 侯金才, 金红利, 刘艳芳, 梁鑫淼. 基于定量指纹图谱技术的经典名方清骨散基准样品量值传递分析. 色谱[J]. 2023, 41(2): 142-151, http://lib.cqvip.com/Qikan/Article/Detail?id=7108745443.
[3] Zhao, Yaopeng, Wang, Jixia, Hou, Tao, Yu, Yancheng, Zhou, Han, Han, Yang, Cheng, Junxiang, Liu, Yanfang, Wang, Chaoran, Chen, Long, Liang, Xinmiao. Design and synthesis of 2-(2,2-diarylethyl)-cyclamine derivatives as M3 receptor antagonists and functional evaluation on COPD. BIOORGANIC CHEMISTRY[J]. 2023, 131: http://dx.doi.org/10.1016/j.bioorg.2022.106308.
[4] Xu, Yang, Liu, Yanfang, Zhou, Han, Wang, Rong, Yu, Dongping, Guo, Zhimou, Liang, Xinmiao. A guide of column selection for two-dimensional liquid chromatography method development of natural alkaloids. TALANTA[J]. 2023, 251: http://dx.doi.org/10.1016/j.talanta.2022.123738.
[5] Jiang, Hui, Hou, Tao, Han, Yan, Lu, ShuBin, Liu, Lei, Li, Ding Xiang, Zhu, YunHui, Huang, Hang, Li, WenJie, Xue, XiangYa, Liu, YanFang, Liang, XinMiao. Preparation and identification of isoquinoline alkaloids with ATP citrate lyase inhibitory activity from Dactylicapnos scandens. FITOTERAPIA[J]. 2023, 165: http://dx.doi.org/10.1016/j.fitote.2022.105397.
[6] Xinwei Zhao, Tao Hou, Han Zhou, Ziling Liu, Yanfang Liu, Chaoran Wang, Zhimou Guo, Dongping Yu, Qing Xu, Jixia Wang, Xinmiao Liang. Multi-effective components and their target mechanism of Ziziphi Spinosae Semen in the treatment of insomnia. FITOTERAPIA. 2023, 171: http://dx.doi.org/10.1016/j.fitote.2023.105712.
[7] Xu, Yang, Wang, Rong, Hou, Tao, Li, Hao, Han, Yang, Li, Yan, Xu, Linli, Lu, Shubin, Liu, Lei, Cheng, JunXiang, Wang, JiXia, Xu, Qing, Liu, Yanfang, Liang, Xinmiao. Uncariphyllin A-J, indole alkaloids from Uncaria rhynchophylla as antagonists of dopamine D2 and Mu opioid receptors. BIOORGANIC CHEMISTRY[J]. 2023, 130: http://dx.doi.org/10.1016/j.bioorg.2022.106257.
[8] Zhao, Xinwei, Yu, Dongping, Zhou, Weijia, Yu, Long, Zhou, Han, Liu, Yanfang, Guo, Zhimou, Shen, Aijing, Han, Ziwei, Wang, Chaoran, Wang, Jixia, Liang, Xinmiao. Chemical profiling of Ziziphi spinosae semen using on-line comprehensive two-dimensional liquid chromatography-mass spectrometry based on a novel phthalic anhydride bonded stationary phase. JOURNAL OF SEPARATION SCIENCE[J]. 2023, 46(10): http://dx.doi.org/10.1002/jssc.202200704.
[9] 陆绍铭, 徐鑫, 薛倩倩, 肖柳君, 余文怡, 魏彤, 金红利, 刘艳芳, 梁鑫淼. 基于超高效液相色谱-紫外检测定量指纹图谱结合化学模式识别的复方金钱草颗粒质量评价. 色谱[J]. 2022, 40(12): 1102-1110, http://lib.cqvip.com/Qikan/Article/Detail?id=7108398156.
[10] Han, Yang, Hou, Tao, Zhang, ZiHui, Zhu, YunHui, Cheng, JunXiang, Zhou, Han, Wang, JiXia, Feng, JiaTao, Liu, YanFang, Guo, ZhiMou, Liang, XinMiao. Corybungines A-K: Isoquinoline alkaloids from Corydalis bungeana with dopamine D2 receptor activity. PHYTOCHEMISTRY[J]. 2022, 199: http://dx.doi.org/10.1016/j.phytochem.2022.113209.
[11] Han, Yang, Hou, Tao, Zhang, ZiHui, Wang, YaoDong, Cheng, JunXiang, Zhou, Han, Wang, JiXia, Feng, JiaTao, Liu, YanFang, Guo, ZhiMou, Liang, XinMiao. Structurally diverse isoquinoline and amide alkaloids with dopamine D2 receptor antagonism from Corydalis bungeana. FITOTERAPIA[J]. 2022, 159: http://dx.doi.org/10.1016/j.fitote.2022.105175.
[12] Han, Yang, Hou, Tao, Zhang, ZiHui, Wang, YaoDong, Cheng, JunXiang, Zhou, Han, Wang, JiXia, Feng, JiaTao, Liu, YanFang, Guo, ZhiMou, Liang, XinMiao. Structurally diverse isoquinoline and amide alkaloids with dopamine D2 receptor antagonism from Corydalis bungeana. FITOTERAPIA[J]. 2022, 159: http://dx.doi.org/10.1016/j.fitote.2022.105175.
[13] Hui Jiang, Yuansheng Xiao, Xingya Xue, Hongli Jin, Yang Xiang, Yanfang Liu, Gaowa Jin. Computer-Aided Rapid Establishment of Fingerprint of Xiaojin Capsule by HPLC. INTERNATIONAL JOURNAL OF ANALYTICAL CHEMISTRY[J]. 2021, 2021: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826213/.
[14] Wei, Hongli, Han, Yang, Wang, Jixia, Hou, Tao, Yao, Yumin, Jin, Jingmei, Zhao, Tianyuan, Zhang, Xiuli, Liu, Yanfang, Liang, Xinmiao. Analgesic bisbenzylisoquinoline alkaloids from the rhizoma of Menispermum dauricum DC. BIOORGANIC CHEMISTRY[J]. 2021, 107: http://dx.doi.org/10.1016/j.bioorg.2020.104517.
[15] 戚华文, 徐鑫, 温柔, 高德嵩, 王超然, 刘艳芳, 金红利, 梁鑫淼. 基于化学模式识别技术的枳实HPLC定量指纹图谱研究. 分析测试学报[J]. 2021, 40(1): 72-78, http://lib.cqvip.com/Qikan/Article/Detail?id=7104183319.
[16] Hou, Tao, Xu, Fangfang, Peng, Xingrong, Zhou, Han, Zhang, Xiuli, Qiu, Minghua, Wang, Jixia, Liu, Yanfang, Liang, Xinmiao. Label-free cell phenotypic study of opioid receptors and discovery of novel mu opioid ligands from natural products. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2021, 270: http://dx.doi.org/10.1016/j.jep.2021.113872.
[17] Xu, Fangfang, Wang, Pan, Zhang, Xiuli, Hou, Tao, Qu, Lala, Wang, Chaoran, Wang, Jixia, Liu, Yanfang, Liang, Xinmiao. Identification and target-pathway deconvolution of FFA4 agonists with anti-diabetic activity from Arnebia euchroma (Royle) Johnst. PHARMACOLOGICAL RESEARCH[J]. 2021, 163: http://dx.doi.org/10.1016/j.phrs.2020.105173.
[18] 徐芳芳, 张秀莉, 侯滔, 曲腊腊, 王纪霞, 刘艳芳, 梁鑫淼. 天然产物中FFA1受体新激动剂的发现与研究. 上海中医药大学学报[J]. 2021, 35(1): 12-19, http://lib.cqvip.com/Qikan/Article/Detail?id=7104082893.
[19] 戚华文, 徐鑫, 高德嵩, 王引, 金红利, 王超然, 刘艳芳, 梁鑫淼. 吴茱萸HPLC指纹图谱的建立及基原鉴别研究. 中草药[J]. 2021, 52(14): 4341-4347, http://lib.cqvip.com/Qikan/Article/Detail?id=7105348269.
[20] Liu, Dian, Han, Yang, Zhou, Han, Jin, Hongli, Kang, Hongjian, Huang, FeiFei, Liu, Yanfang, Liang, Xinmiao. Offline preparative three-dimensional HPLC for systematic and efficient purification of alkaloids from Gelsemium elegans Benth. JOURNAL OF CHROMATOGRAPHY A[J]. 2021, 1640: http://dx.doi.org/10.1016/j.chroma.2021.461935.
[21] 黄飞飞, 王荣, 陈玥, 沈爱金, 刘艳芳, 梁鑫淼, 金红利, 阎松. 基于HPLC-Q-TOF-MS/MS的分子网络技术快速分析夏天无生物碱. 质谱学报[J]. 2021, 42(3): 228-240, http://lib.cqvip.com/Qikan/Article/Detail?id=7104618254.
[22] Zhang, Feng, Huang, Jian, Liu, Wei, Wang, ChaoRan, Liu, YanFang, Tu, DongZhu, Liang, XinMiao, Yang, Ling, Zhang, WeiDong, Chen, HongZhuan, Ge, GuangBo. Inhibition of drug-metabolizing enzymes by Qingfei Paidu decoction: Implication of herb-drug interactions in COVID-19 pharmacotherapy. FOOD AND CHEMICAL TOXICOLOGY[J]. 2021, 149: 111998-111998, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816587/.
[23] 金高娃, 宋春颖, 闫竞宇, 刘艳芳, 沈爱金, 郭志谋, 梁鑫淼. 超高效液相色谱-质谱法同时测定舒血宁注射剂中20种黄酮醇苷与萜类内酯成分. 分析测试学报[J]. 2020, 39(1): 115-121, http://lib.cqvip.com/Qikan/Article/Detail?id=7101155755.
[24] Wang, JiXia, Zhao, YaoPeng, Du, NaNa, Han, Yang, Li, Hao, Wang, Rong, Xu, Yang, Liu, YanFang, Liang, XinMiao. Scocycamides, a Pair of Macrocyclic Dicaffeoylspermidines with Butyrylcholinesterase Inhibition and Antioxidation Activity from the Roots of Scopolia tangutica. ORGANIC LETTERS[J]. 2020, 22(21): 8240-8244, http://dx.doi.org/10.1021/acs.orglett.0c02838.
[25] 乔亚丽, 刘喆, 沈爱金, 郭志谋, 刘艳芳, 陈相银, 徐青, 梁鑫淼. 穿山甲色谱指纹谱的建立及其在基源鉴别和质量等级区分方面的应用. 色谱[J]. 2020, 38(12): 1440-1448, https://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFQ&dbname=CJFDLAST2020&filename=SPZZ202012011&v=MTU4NDVMRzRITkhOclk5RVpZUjhlWDFMdXhZUzdEaDFUM3FUcldNMUZyQ1VSN3VmWnVabkZpamdVN3ZLTmozUmQ=.
[26] Wei Si, Yanfang Liu, Yuansheng Xiao, Zhimou Guo, Gaowa Jin, Jingyu Yan, Aijin Shen, Han Zhou, Fan Yang, Xinmiao Liang. An offline two-dimensional supercritical fluid chromatography × reversed phase liquid chromatography tandem quadrupole time-of-flight mass spectrometry system for comprehensive gangliosides profiling in swine brain extract. TALANTA. 2020, 208: http://dx.doi.org/10.1016/j.talanta.2019.120366.
[27] Si, Wei, Qiao, Yali, Liu, Zhe, Jin, Gaowa, Liu, Yanfang, Xue, Xingya, Zhou, Han, Liu, Yanming, Shen, Aijin, Liang, Xinmiao. Combination of multi-model statistical analysis and quantitative fingerprinting in quality evaluation of Shuang-huang-lian oral liquid (vol 412, pg 7073, 2020). ANALYTICAL AND BIOANALYTICAL CHEMISTRYnull. 2020, 412(29): 8223-8223, http://dx.doi.org/10.1007/s00216-020-02937-6.
[28] Wang, Rong, Liu, Yanfang, Zhou, Han, Chen, Yue, Wang, Jixia, Zhang, Xiuli, Yu, Ruitao, Liang, Xinmiao. Integration of micro-fractionation, high-performance liquid chromatography-ultraviolet detector-charged aerosol detector-mass spectrometry analysis and cellular dynamic mass redistribution assay to accelerate alkaloid drug discovery. JOURNAL OF CHROMATOGRAPHY A[J]. 2020, 1616: http://dx.doi.org/10.1016/j.chroma.2019.460779.
[29] Si, Wei, Liu, Yanfang, Xiao, Yuansheng, Guo, Zhimou, Jin, Gaowa, Yan, Jingyu, Shen, Aijin, Zhou, Han, Yang, Fan, Liang, Xinmiao. An offline two-dimensional supercritical fluid chromatography x reversed phase liquid chromatography tandem quadrupole time-of-flight mass spectrometry system for comprehensive gangliosides profiling in swine brain extract. TALANTA[J]. 2020, 208: http://dx.doi.org/10.1016/j.talanta.2019.120366.
[30] Ahad, Hasanjan, Jin, Hongli, Liu, Yanfang, Wang, Jixia, Sun, Guangying, Liang, Xinmiao, Aisa, Haji Akber. Chemical profiling of spermidines in goji berry by strong cation exchange solid-phase extraction (SCX-SPE) combined with ultrahigh-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS/MS). JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES[J]. 2020, 1137(1): http://dx.doi.org/10.1016/j.jchromb.2019.121923.
[31] Wu, Nan, Liu, Yanfang, Liang, Xinmiao, Mei, Lijuan, Tao, Yanduo, Yu, Ruitao. Phytochemical and chemotaxonomic study on Saussurea medusa Maxim. (Compositae). BIOCHEMICAL SYSTEMATICS AND ECOLOGY[J]. 2020, 93: http://dx.doi.org/10.1016/j.bse.2020.104171.
[32] Si, Wei, Qiao, Yali, Liu, Zhe, Jin, Gaowa, Liu, Yanfang, Xue, Xingya, Zhou, Han, Liu, Yanming, Shen, Aijin, Liang, Xinmiao. Combination of multi-model statistical analysis and quantitative fingerprinting in quality evaluation of Shuang-huang-lian oral liquid. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2020, 412(26): 7073-7083, http://dx.doi.org/10.1007/s00216-020-02841-z.
[33] 徐鑫, 戚华文, 高德嵩, 蔡新娜, 金磊, 金红利, 王超然, 刘艳芳, 梁鑫淼. 基于化学模式识别的栀子UPLC定量指纹图谱研究. 中国中药杂志[J]. 2020, 45(18): 4416-4422, http://lib.cqvip.com/Qikan/Article/Detail?id=7103202362.
[34] Xu, Fangfang, Zhao, Yaopeng, Zhou, Han, Li, Chunzhi, Zhang, Xiuli, Hou, Tao, Qu, Lala, Wei, Lai, Wang, Jixia, Liu, Yanfang, Liang, Xinmiao. Synthesis and evaluation of 3-(4-(phenoxymethyl)phenyl)propanoic acid and N-phenylbenzenesulfonamide derivatives as FFA4 agonists. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2020, 30(24): http://dx.doi.org/10.1016/j.bmcl.2020.127650.
[35] Guo, Meng, Li, Fangbing, Ji, Junsong, Liu, Yanfang, Liu, Fang, Zhao, Yuanyu, Li, Junhui, Han, Shu, Wang, Quanxing, Ding, Guoshan. Inhibition of miR-93 promotes interferon effector signaling to suppress influenza A infection by upregulating JAK1. INTERNATIONAL IMMUNOPHARMACOLOGY[J]. 2020, 86: http://dx.doi.org/10.1016/j.intimp.2020.106754.
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（ 1 ） 唐古特山莨菪生物碱的高效制备与毒蕈碱型受体活性的构效研究, 负责人, 国家任务, 2017-01--2020-12

已指导学生

张羽  硕士研究生  070302-分析化学  

现指导学生

徐林莉  硕士研究生  070302-分析化学