液体核磁共振实验技术的研发及应用

蛋白与配体相互作用

代谢组学

   

070208-无线电物理

无线电物理，分析化学

2001-09--2007-06   中国科学院武汉物理与数学研究所   博士
1997-09--2001-06   华中师范大学   学士

2011-10~现在, 中国科学院武汉物理与数学研究所, 高级工程师
2007-07~2011-09,中国科学院武汉物理与数学研究所, 助理研究员

2011-10~现在, 中国科学院武汉物理与数学研究所, 高级工程师
2007-07~2011-09,中国科学院武汉物理与数学研究所, 助理研究员

磁共振实验技术
磁共振技术
核磁共振实验技术
液体核磁共振实验技术

   

[1] 陈雷, 刘红兵, 刘惠丽. 一种结合双极性梯度和形状脉冲的饱和照射水峰抑制方法. CN: CN115078439A, 2022-09-20.
[2] 王杰, 郑丹昊, 蔡奥灵, 刘惠丽, 李爽, 徐富强. 一种适用于磁共振成像仪的小动物生物安全微循环装置. CN: CN112426145A, 2021-03-02.

   

[1] Food Research International. 2024, 第 10 作者
[2] NATURE COMMUNICATIONS. 2022,   通讯作者  
[3] Molecules. 2022, 第 3 作者
[4] Food Control. 2021, 第 3 作者
[5] ACS Omega. 2021,   通讯作者  
[6] Liu, Taotao, Li, Zhengqian, He, Jindan, Yang, Ning, Han, Dengyang, Li, Yue, Tian, Xuebi, Liu, Huili, Manyande, Anne, Xiang, Hongbing, Xu, Fuqiang, Wang, Jie, Guo, Xiangyang. Regional Metabolic Patterns of Abnormal Postoperative Behavioral Performance in Aged Mice Assessed by H-1-NMR Dynamic Mapping Method. NEUROSCIENCE BULLETIN[J]. 2020, 第 8 作者36(1): 25-38, http://dx.doi.org/10.1007/s12264-019-00414-4.
[7] Wu, Liang, Niu, Zhanfeng, Hu, Xulei, Liu, Huili, Li, Shuang, Chen, Lei, Zheng, Danhao, Liu, Zhuang, Liu, Taotao, Xu, Fuqiang, Manyande, Anne, Wang, Jie, Xia, Hechun. Regional cerebral metabolic levels and turnover in awake rats after acute or chronic spinal cord injury. FASEB JOURNAL[J]. 2020, 第 4 作者34(8): 10547-10559, https://www.doi.org/10.1096/fj.202000447R.
[8] Liu Huili. (1)H-NMR based metabolomics reveals the nutrient differences of two kinds of freshwater fish soups before and after simulated gastrointestinal digestion.. Food Funct. 2020, 第 1 作者
[9] Wang, Sanxi, Wen, Shi, Guo, Pengfei, Liu, Huili, Feng, Jianghua, Huang, Heguang. Understanding metabolomic characteristics of pancreatic ductal adenocarcinoma by HR-MAS NMR detection of pancreatic tissues. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS[J]. 2020, 第 4 作者190: http://dx.doi.org/10.1016/j.jpba.2020.113546.
[10] He, Chenxi, Liu, Yun, Liu, Huili, Zheng, Xin, Shen, Guiping, Feng, Jianghua. Compositional identification and authentication of Chinese honeys by H-1 NMR combined with multivariate analysis. FOOD RESEARCH INTERNATIONAL[J]. 2020, 第 3 作者130: https://www.webofscience.com/wos/woscc/full-record/WOS:000521512900055.
[11] Pi, Ni, Gao, Meng, Cheng, Xiyao, Liu, Huili, Kuang, Zhengkun, Yang, Zixin, Yang, Jing, Zhang, Bailing, Chen, Yao, Liu, Sen, Huang, Yongqi, Su, Zhengding. Recombinant Butelase-Mediated Cyclization of the p53-Binding Domain of the Oncoprotein MdmX-Stabilized Protein Conformation as a Promising Model for Structural Investigation. BIOCHEMISTRY[J]. 2019, 第 4 作者58(27): 3005-3015, https://www.webofscience.com/wos/woscc/full-record/WOS:000475408700006.
[12] Jiang, Zhiming, Lin, Chenghong, Liu, Huili, Feng, Jianghua, Zheng, Zhenyao, Cai, Shuhui. Specific biological responses following dextran-coated ultra-small superparamagnetic particles of iron oxides administration. NANOMEDICINE[J]. 2019, 第 3 作者14(11): 1371-1386, 
[13] Liu Huili. irst-in-Class Inhibitors of the Biogenesis of the Type 3 Secretion System Needle of Pseudomonas aeruginosa for Antibiotic Therapy.. Acs Central Science. 2019, 第 1 作者
[14] Du, Hongying, Li, Shuang, Zhang, Yingfeng, Guo, Huiling, Wu, Liang, Liu, Huili, Manyande, Anne, Xu, Fuqiang, Wang, Jie. NMR Based Metabolomics Comparison of Different Blood Sampling Techniques in Awake and Anesthetized Rats. MOLECULES[J]. 2019, 第 6 作者24(14): https://www.webofscience.com/wos/woscc/full-record/WOS:000482303000025.
[15] Hongying Du, Yinqiang Huo, Huili Liu, Ghulam Mustafa Kamal, Jiaren Yang, Yongchao Zeng, Siming Zhao, Youming Liu. Fast nutritional characterization of different pigmented rice grains using a combination of NMR and decision tree analysis. CYTA - JOURNAL OF FOOD[J]. 2019, 第 3 作者17(1): 128-136, https://doaj.org/article/d607729364c8411e98a40d71e3f2d3a8.
[16] Jinquan Li, Zhongxue Yuan, Huili Liu, Jianghua Feng, Zhong Chen. Size-dependent tissue-specific biological effects of core–shell structured Fe3O4@SiO2–NH2 nanoparticles. JOURNAL OF NANOBIOTECHNOLOGY[J]. 2019, 第 3 作者17(1): 1-14, http://dx.doi.org/10.1186/s12951-019-0561-4.
[17] Du, Hongying, Fu, Jialing, Wang, Siqi, Liu, Huili, Zeng, Yongchao, Yang, Jiaren, Xiong, Shanbai. H-1-NMR metabolomics analysis of nutritional components from two kinds of freshwater fish brain extracts. RSC ADVANCES[J]. 2018, 第 4 作者8(35): 19470-19478, https://www.webofscience.com/wos/woscc/full-record/WOS:000434261100017.
[18] Wang, Jie, Zeng, HaoLong, Du, Hongying, Liu, Zeyuan, Cheng, Ji, Liu, Taotao, Hu, Ting, Kamal, Ghulam Mustafa, Li, Xihai, Liu, Huili, Xu, Fuqiang. Evaluation of metabolites extraction strategies for identifying different brain regions and their relationship with alcohol preference and gender difference using NMR metabolomics. TALANTA[J]. 2018, 第 10 作者179: 369-376, http://dx.doi.org/10.1016/j.talanta.2017.11.045.
[19] Qin, Lingyun, Liu, Huili, Chen, Rong, Zhou, Jingjing, Cheng, Xiyao, Chen, Yao, Huang, Yongqi, Su, Zhengding. Effect of the Flexible Regions of the Oncoprotein Mouse Double Minute X on Inhibitor Binding Affinity. BIOCHEMISTRY[J]. 2017, 第 2 作者56(44): 5943-5954, https://www.webofscience.com/wos/woscc/full-record/WOS:000414886900011.
[20] Liu, Taotao, He, Zhigang, Tian, Xuebi, Kamal, Ghulam Mustafa, Li, Zhixiao, Liu, Zeyuan, Liu, Huili, Xu, Fuqiang, Wang, Jie, Xiang, Hongbing. Specific patterns of spinal metabolites underlying alpha-Me-5-HT-evoked pruritus compared with histamine and capsaicin assessed by proton nuclear magnetic resonance spectroscopy. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE[J]. 2017, 第 7 作者1863(6): 1222-1230, http://dx.doi.org/10.1016/j.bbadis.2017.03.011.
[21] Liu, Yue, Cheng, Ji, Liu, Huili, Deng, Yinghua, Wang, Jie, Xu, Fuqiang. NMRSpec: An integrated software package for processing and analyzing one dimensional nuclear magnetic resonance spectra. CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS[J]. 2017, 第 3 作者162: 142-148, http://dx.doi.org/10.1016/j.chemolab.2017.01.005.
[22] Chen, Rong, Zhou, Jingjing, Qin, Lingyun, Chen, Yao, Huang, Yongqi, Liu, Huili, Su, Zhengding. A Fusion Protein of the p53 Transaction Domain and the p53-Binding Domain of the Oncoprotein MdmX as an Efficient System for High-Throughput Screening of MdmX Inhibitors. BIOCHEMISTRY[J]. 2017, 第 6 作者  通讯作者  56(25): 3273-3282, https://www.webofscience.com/wos/woscc/full-record/WOS:000404493000012.
[23] Lan, Wenxian, Hu, Zhongpei, Shen, Jie, Wang, Chunxi, Jiang, Feng, Liu, Huili, Long, Dewu, Liu, Maili, Cao, Chunyang. Structural investigation into physiological DNA phosphorothioate modification. SCIENTIFIC REPORTS[J]. 2016, 第 6 作者6(-): http://ir.wipm.ac.cn/handle/112942/9353.
[24] Fang, Yan, Duan, Bo, Lu, Ang, Liu, Maili, Liu, Huili, Xu, Xiaojuan, Zhang, Lina. Intermolecular Interaction and the Extended Wormlike Chain Conformation of Chitin in NaOH/Urea Aqueous Solution. BIOMACROMOLECULES[J]. 2015, 第 5 作者16(4): 1410-1417, http://ir.wipm.ac.cn/handle/112942/1071.

   

（ 1 ） 用于磁共振成像的小动物呼吸安全系统, 主持, 部委级, 2018-01--2019-12
（ 2 ） 香血藤生物活性成分及作用研究机制, 参与, 研究所（学校）, 2016-01--2018-12
（ 3 ） 癌蛋白Mdm2抑制剂对MdmX的构效关系及新型双靶向抗肿瘤药物筛选和设计, 参与, 研究所（学校）, 2017-01--2019-12
（ 4 ） 非均相生物样品中分子间相互作用的NMR分析方法和应用的研究, 参与, 国家级, 2007-01--2015-12
（ 5 ） 谢组重叠强背景信号剔除的小波分析方法研究, 主持, 国家级, 2010-01--2012-12

（1）小波变换在代谢组学数据分析中的应用   第十七届全国波谱学学术会议   2012-10-24