聚焦界面微纳米组装结构的精准可控构筑与多组分生物化学分析，融合纳米材料技术与同步辐射表征手段，解析生命体系微观反应机制与动态过程，围绕肿瘤无创检测与早期诊断的关键技术难题，开展高灵敏、高特异性无创早筛方法与技术研究。

硕士、博士生

1. 专业背景：化学，材料学，生物化学，生物医学

2. 工作认真负责，积极主动；具有科研创新精神

同时欢迎感兴趣的联培生共同投入人类生命大健康的无创早筛研究事业！

0703Z2-生物无机化学

1.微纳米功能结构的构筑及多组分生物化学分析
2.重大疾病的早期、精准诊断
3.功能性多孔纳米材料的制备及其在生物检测领域的应用

2005-09--2008-07   中国科学院化学研究所   博士

研究生

博士

   

2011-09~现在, 中国科学院高能物理研究所, 副研究员、研究员
2008-09~2011-03,比利时鲁汶大学（KUL), 博士后

部分发表论文

（1）A sensitive 2D Cu-TCPP-based respiratory ammonia sensor for non-invasive and more accessible detection of Helicobacter pylori infection, Chemical Communications, 2025, 第 9 作者  通讯作者

（2） Review of Techniques for the Detection, Removal, and Transformation of Environmental Microplastics and Nanoplastics, ACS APPLIED MATERIALS & INTERFACES, 2025, 第 4 作者  通讯作者

（3） A Rapid and Sensitive SERS-Based Au/MIL-125(Ti) Biosensor for Hyperuricemia Diagnosis via Saliva Analysis, ANALYTICAL CHEMISTRY, 2025, 第 5 作者  通讯作者

（4） MOF-based hypocrellin composite nanomaterials as advanced plant-derived photosensitizers for multimodal therapy, Chem. Eng. J., 2025, 第 9 作者  通讯作者

（5） Metal–organic framework thin films: review of their room-temperature synthesis and applications, J. Mater. Chem. C, 2024, 第 3 作者  通讯作者

（6） Mini-review of DNA Methylation Detection Techniques and Their Potential Applications in Disease Diagnosis, Prognosis, and Treatment, ACS Sensors, 2024, 第 3 作者  通讯作者

（7） Coffee Ring” Fabrication and Its Application in Aflatoxin Detection Based on SERS, Chemosensors, 2023, 第 6 作者  通讯作者

（8） Preparation of two‐dimensional porphyrin‐based MOFs/ derivatives and their potential in sensing and biomedical applications, Interdiscip. Med., 2023, 第 5 作者  通讯作者

（9） Preparation of two‐dimensional porphyrin‐based MOFs/derivatives and their potential in sensing and biomedical applications, Interdiscip. Med., 2023, 第 5 作者 通讯作者

（10） A novel SERS substrate of MIL-100(Fe)-AgNFs for sensitive detection of ascorbic acid in cellular media, RSC Adv., 2022, 第 7 作者  通讯作者

（11） A facile and sensitive SERS-based platform for sulfite residues / SO2 detection in food, MICROCHEMICAL JOURNAL, 2021, 第 3 作者  通讯作者

（12） Analysis of binding modes of biopanning heptapeptides with specific affinity to chitosan wrapped MSN, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021, 第 4 作者  通讯作者

（13） Frequency Shift Surface-Enhanced Raman Spectroscopy Sensing: An Ultrasensitive Multiplex Assay for Biomarkers in Human Health, ACS SENSORS, 2021, 第 4 作者  通讯作者

（14） SERS-Active MIL-100(Fe) Sensory Array for Ultrasensitive and Multiplex Detection of VOCs, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 第 8 作者  通讯作者

（15） Construction of Cu-bridged Cu2O/MIL(Fe/Cu) catalyst with enhanced interfacial contact for the synergistic photo-Fenton degradation of thiacloprid, CHEMICAL ENGINEERING JOURNAL, 2020, 共同第一作者

（16） Exploring the Interaction of Fullerenol with Key Digestive Proteases Using Raman-Based Frequency-Shift Sensing and Molecular Simulation Analysis, ACS APPLIED BIO MATERIALS, 2019, 第 5 作者  通讯作者

（17） Ultrasensitive Detection of Circulating Tumor DNA of Lung Cancer via an Enzymatically Amplified SERS-Based Frequency Shift Assay, ACSAPPLIEDMATERIALSINTERFACES, 2019, 第 7 作者  通讯作者

（18） Frequency Shift Raman-Based Sensing of Serum MicroRNAs for Early Diagnosis and Discrimination of Primary Liver Cancers, ANALYTICAL CHEMISTRY, 2018, 第 3 作者  通讯作者

（19） Ultrasensitive Detection of Serum MicroRNA Using Branched DNA-Based SERS Platform Combining Simultaneous Detection of alpha-Fetoprotein for Early Diagnosis of Liver Cancer, ACS APPLIED MATERIALS & INTERFACES, 2018, 第 8 作者  通讯作者

（20） In Situ Monitoring the Aggregation Dynamics of Amyloid-beta Protein A beta 42 in Physiological Media via a Raman-Based Frequency Shift Method, ACS APPLIED BIO MATERIALS, 2018, 第 7 作者  通讯作者

（21） A highly sensitive SERS-based platform for Zn(II) detection in cellular media, CHEMICAL COMMUNICATIONS, 2017, 第 8 作者  通讯作者

（22） Ultrasensitive, Multiplex Raman Frequency Shift Immunoassay of Liver Cancer Biomarkers in Physiological Media, ACS NANO, 2016, 第 8 作者  通讯作者

（23） Formation of Ordered Coronene Clusters in Template Utilizing the Structural Transformation of Hexaphenylbenzene Derivative Networks on Graphite Surface, ACS NANO, 2016, 第 4 作者  通讯作者

（24） SERS-based sensing technique for trace melamine detection - A new method exploring, TALANTA, 2016, 第 4 作者  通讯作者

（25） Orthogonal Supramolecular Polymer Formation on Highly Oriented Pyrolytic Graphite (HOPG) Surfaces Characterized by Scanning Probe Microscopy., LANGMUIR, 2015, 第 7 作者  通讯作者

（26） A dynamic study of the structural change in the binary network in response to guest inclusion, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2014, 第 1 作者

（27） Substituent Site Effect Induced Assemblies of Porphyrin Derivatives on Graphite Surface Characterized Using a Scanning Probe Microscope, CHEMISTRY LETTERS, 2014, 第 1 作者

（28） Tip-Induced Chemical Manipulation of Metal Porphyrins at a Liquid/Solid Interface, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2014, 第 1 作者

（29） Assemblies at the Liquid-Solid Interface: Chirality Expression from Molecular Conformers, CHEMPHYSCHEM, 2013, 第 6 作者  通讯作者

（30） Detection of different oxidation states of individual manganese porphyrins during their reaction with oxygen at a solid/liquid interface, NATURE CHEMISTRY, 2013, 共同第一 作者

已指导学生

汤博崇  博士研究生  070322-生物无机化学  

解鹏  硕士研究生  085216-化学工程  

庄洪军  硕士研究生  085216-化学工程