基本信息

李敏  女  硕导  中国科学院高能物理研究所
电子邮件: limin@ihep.ac.cn
通信地址: 北京市石景山区玉泉路19号乙
邮政编码: 100049

研究领域

研究工作集中于可控构筑界面微纳米组装结构及多组分生物化学分析,利用纳米技术研究生命微观过程,开展肿瘤无创、早诊技术研究。


招生信息

硕士、博士生

1. 专业背景:纳米化学,材料学,生物化学,生物医学

2. 工作认真负责,积极主动;具有独立创新科研能力


招生专业
0703Z2-生物无机化学
招生方向
1.面微纳米功能结构的构筑及多组分生物化学分析
2.重大疾病的早期、精准诊断
3.功能性多孔纳米材料的制备及其在生物检测领域的应用

教育背景

2005-09--2008-07   中国科学院化学研究所   博士
学历
研究生

学位
博士

工作经历

   
工作简历
2011-09~现在, 中国科学院高能物理研究所, 副研究员、研究员
2008-09~2011-03,比利时鲁汶大学(KUL), 博士后

专利与奖励

   
专利成果
[1] 李敏, 孔德轩, 朱文凤. 一种SO2和/或亚硫酸盐快速灵敏检测试剂盒及其应用. 2 02110225444.5, 2022-04-29.

[2] 李敏, 闫学松, 王宜冰, 王德松. 一种纳米金咖啡环的制备方法及其在SERS检测中的应用. CN202010196478.1, 2021-08-13.

[3] 李敏, 朱文凤, 赵宇亮. 一种基于表面增强拉曼散射技术的检测芯片、制备方法以及试剂盒. CN: CN105823768B, 2020-03-27.

[4] 李敏, 马磊, 王娇娇, 赵宇亮. 一种银岛材料的制备方法. 中国: CN106148925A, 2016.11.23.

出版信息

   
发表论文
(1) A facile and sensitive SERS-based platform for sulfite residues / SO2 detection in food, MICROCHEMICAL JOURNAL, 2021, 通讯作者
(2) Analysis of binding modes of biopanning heptapeptides with specific affinity to chitosan wrapped MSN, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021, 通讯作者
(3) Frequency Shift Surface-Enhanced Raman Spectroscopy Sensing: An Ultrasensitive Multiplex Assay for Biomarkers in Human Health, ACS SENSORS, 2021, 通讯作者
(4) SERS-Active MIL-100(Fe) Sensory Array for Ultrasensitive and Multiplex Detection of VOCs, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 通讯作者
(5) Monomer-targeting affinity peptide inhibitors of amyloid with no self-fibrillation and low cytotoxicity, CHEMICAL COMMUNICATIONS, 2020, 第 3 作者
(6) MIL-100(Fe)对有机染料的灵敏检测及其拉曼增强机制, SERS-active MIL-100(Fe)sensor for sensitive detection of organic dyes and its enhancement mechanism study, 科学通报, 2020, 通讯作者
(7) Construction of Cu-bridged Cu2O/MIL(Fe/Cu) catalyst with enhanced interfacial contact for the synergistic photo-Fenton degradation of thiacloprid, CHEMICAL ENGINEERING JOURNAL, 2020, 第 2 作者
(8) Ultrasensitive Detection of Circulating Tumor DNA of Lung Cancer via an Enzymatically Amplified SERS-Based Frequency Shift Assay, ACS APPLIED MATERIALS & INTERFACES, 2019, 通讯作者
(9) Exploring the Interaction of Fullerenol with Key Digestive Proteases Using Raman-Based Frequency-Shift Sensing and Molecular Simulation Analysis, ACS APPLIED BIO MATERIALS, 2019, 通讯作者
(10) Frequency Shift Raman-Based Sensing of Serum MicroRNAs for Early Diagnosis and Discrimination of Primary Liver Cancers, ANALYTICAL CHEMISTRY, 2018, 通讯作者
(11) In Situ Monitoring the Aggregation Dynamics of Amyloid-Protein A´2 in Physiological Media via a Raman-Based Frequency Shift Method, ACS APPLIED BIO MATERIALS, 2018, 
(12) Ultrasensitive Detection of Serum MicroRNA Using Branched DNA-Based SERS Platform Combining Simultaneous Detection of alpha-Fetoprotein for Early Diagnosis of Liver Cancer, ACS APPLIED MATERIALS & INTERFACES, 2018, 通讯作者
(13) In Situ Monitoring the Aggregation Dynamics of Amyloid-beta Protein A beta 42 in Physiological Media via a Raman-Based Frequency Shift Method, ACS APPLIED BIO MATERIALS, 2018, 通讯作者
(14) Study on orally delivered paclitaxel nanocrystals:modification,characterization and activity in the gastrointestinal tract, Royal Society open science, 2017, 通讯作者
(15) A highly sensitive SERS-based platform for Zn(II) detection in cellular media, Chemical Communications, 2017, 通讯作者
(16) Ultrasensitive, Multiplex Raman Frequency Shift Immunoassay of Liver Cancer Biomarkers in Physiological Media, ACS nano, 2016, 通讯作者
(17) Photochemical Reactions in Self-Assembled Organic Monolayers Characterized by using Scanning Tunneling Microscopy, CHEMPHYSCHEM, 2016, 通讯作者
(18) Formation of Ordered Coronene Clusters in Template Utilizing the Structural Transformation of Hexaphenylbenzene Derivative Networks on Graphite Surface, ACS NANO, 2016, 通讯作者
(19) SERS-based sensing technique for trace melamine detection - A new method exploring, Talanta, 2016, 通讯作者
(20) Viewing the Interaction between dsDNA and Graphene Oxide via Atomic Force Microscopy, J. Nanosci. Nanotechnol., 2016, 通讯作者
(21) Investigating the stability of gold nanorods modified with thiol molecules for biosensing, RSC Advances, 2016, 通讯作者
(22) Study of the Edge-on Self-Assembly of Axially Substituted Silicon(IV) Phthalocyanine Derivatives in a Template on the HOPG Surface, LANGMUIR, 2015, 第 5 作者
(23) Integration of a bio-chip technique with technetium-99m labeling provides zeptomolar sensitivity in liver cancer biomarker detection, Royal Society of Chemistry, 2015, 
(24) Orthogonal Supramolecular Polymer Formation on Highly Oriented Pyrolytic Graphite (HOPG) Surfaces Characterized by Scanning Probe Microscopy., LANGMUIR, 2015, 通讯作者
(25) Novel carbon nanohybrids as highly efficient magnetic resonance imaging contrast agents, NANO RESEARCH, 2015, 第 7 作者
(26) Highly efficient photodimerization of olefins in a nanotemplate on HOPG by scanning tunneling microscopy, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2014, 通讯作者
(27) A dynamic study of the structural change in the binary network in response to guest inclusion, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2014, 第 1 作者
(28) Assembling single gold nanorods into large-scale highly aligned nanoarrays via vacuum-enhanced capillarity, Nanoscale research letters, 2014, 第 2 作者
(29) Substituent Site Effect Induced Assemblies of Porphyrin Derivatives on Graphite Surface Characterized Using a Scanning Probe Microscope, CHEMISTRY LETTERS, 2014, 第 1 作者
(30) Tip-Induced Chemical Manipulation of Metal Porphyrins at a Liquid/Solid Interface, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2014, 第 1 作者
(31) Assemblies at the Liquid-Solid Interface: Chirality Expression from Molecular Conformers, CHEMPHYSCHEM, 2013, 通讯作者
(32) Detection of different oxidation states of individual manganese porphyrins during their reaction with oxygen at a solid/liquid interface, NATURE CHEMISTRY, 2013, 第 2 作者
(33) Self-assembling in fabrication of ordered porphyrins and phthalocyanines hybrid nano-arrays on HOPG, CRYSTENGCOMM, 2013, 第 3 作者
(34) In Situ Detection of Liver Cancer Biomarkers with Atomic Force Microscopy at a Single-molecule Level, Chemistry Letters, 2013, 第 2 作者
(35) Preprogrammed 2D Folding of Conformationally Flexible Oligoamides: Foldamers with Multiple Turn Elements, ACS NANO, 2012, 第 2 作者
(36) Photo-Induced Polymerization and Isomerization on the Surface Observed by Scanning Tunneling Microscopy, JOURNAL OF PHYSICAL CHEMISTRY C, 2012, 第 3 作者
(37) Hyperbranched microspheres formed by an EDTA-based coordination polymer with ternary architectures assembled by ultrathin nanoribbons and their tricolor luminescent properties, CRYSTENGCOMM, 2012, 第 4 作者
(38) Self-assembled supramolecular networks at interfaces: Molecular immobilization and recognition using nanoporous templates, Self-assembled supramolecular networks at interfaces: Molecular immobilization and recognition using nanoporous templates, 中国科学:物理学、力学、天文学英文版, 2011, 
(39) Molecular Patterning at a Liquid/Solid Interface: The Foldamer Approach, LANGMUIR, 2011, 第 1 作者
(40) Conformation-Dependent Stacking Behavior of Porphyrin Assemblies Observed by Using Scanning Tunneling Microscope, J. Phys. Chem. C, 2010, 第 1 作者
(41) Bipyridine-mediated assembling characteristics of aromatic acid derivatives, JOURNAL OF PHYSICAL CHEMISTRY C, 2008, 第 1 作者
(42) Site-selective fabrication of two-dimensional fullerene arrays by using a supramolecular template at the liquid-solid interface, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008, 第 1 作者
(43) Electronically engineered interface molecular superlattices: STM study of aromatic molecules on graphite, PHYSICAL REVIEW B, 2007, 通讯作者

科研活动

   
科研项目
( 1 ) 利用微纳技术和光谱手段实现生物分子低浓度检测, 主持, 国家级, 2013-05--2015-08
( 2 ) 基于STM/AFM技术的表面分子组装及石墨烯的生物功能化研究, 主持, 市地级, 2011-11--2013-11
( 3 ) 氢键调控实现超分子组装结构整体光响, 主持, 国家级, 2014-01--2016-12
( 4 ) 拉曼散射光谱联用扫描探针显微技术(TERS)研究具, 主持, 研究所(学校), 2013-12--2015-12
( 5 ) 利用微纳技术和光谱手段实现生物分子低浓度检测, 主持, 国家级, 2013-06--2015-08
( 6 ) 基于纳应力传感和微接触印刷技术的肝癌标志物组合高灵敏SERS检测研究, 主持, 国家级, 2017-01--2020-12
( 7 ) 室内空气有机污染物在细胞水平的生物效应研究, 主持, 研究所(学校), 2020-06--2021-12
( 8 ) 微纳机器人表面功能化修饰, 主持, 国家级, 2020-08--2022-12
( 9 ) 基于MILs-MOF材料”拉曼活性“和”阵列传感“双重特性构建人工嗅觉系统及对肺癌呼出标志物的传感研究, 主持, 国家级, 2021-01--2024-12
参与会议
(1)基于拉曼检测技术对肺癌血清/呼出标志物的传感研究   中国化学会第32届年会   2021-04-19
(2)基于MOF 材料构建人工嗅觉系统对VOCs的传感研究   中国微米纳米技术学会第四届微米纳米技术应用创新大会   2020-10-23
(3)Ultra-sensitive Detection of Circulating Tumor DNA of Lung Cancer via Enzymatically Amplified SERS Based Frequency Shift Assay   2019-08-17
(4)SERS Frequency-Shift Sensing Method: A Way of Detecting Event from Biomolecules to Ions   2019-08-04
(5)拉曼检测新技术对肿瘤标志物及小分子的灵敏检测   全国纳米生物与医学学术会议    2018-10-25
(6)基于拉曼频移检测技术实现原发性肝癌的早期和精准诊断   中国生物医学工程学会    2018-08-03
(7)基于拉曼频移检测技术的肿瘤早期诊断研究   中国化学会第31届年会   2018-05-05
(8)Raman-based methods for liver cancer diagnosis and Zn(II) sensing   2017-08-07

指导学生

已指导学生

汤博崇  博士研究生  070322-生物无机化学  

解鹏  硕士研究生  085216-化学工程  

庄洪军  硕士研究生  085216-化学工程