生物启发的有机合成方法学研究，有机小分子不对称催化研究，活性天然产物的结构改造，药物合成工艺研究。

   

100701-药物化学
070303-有机化学

药物化学，有机合成方法学，不对称催化

2008-09--中科院成都生物所   博士
2005-09--四川农业大学   学士
2005-09--中科院沈阳应用生态所   硕士

   

2013-09~现在, 中科院成都生物所, 副研究员
2011-08~现在, 中科院成都有机化学研究所, 博士后

   

[1] 李光勋, 唐卓, 韩敏. 一种手性溴代1，4-二氢吡啶类化合物的制备方法. 202210068642.X, 2022-01-20.

[2] 李光勋, 唐卓, 黄金. 一种手性氮取代四氢喹喔啉的制备方法. 202210068649.1, 2022-01-20.

[3] 唐卓, 付丁强, 袁奕, 李光勋. 靶向降解酪氨酸酶的PROTAC及其应用. 202111043833.2, 2021-09-07.

[4] 唐卓, 李光勋. (S,S)-八氢-6H-吡咯并3,4-b吡啶的制备方法. CN: CN103030638A, 2013-04-10.

[5] 唐卓, 李光勋. (S,S)-八氢-6H-吡咯并3,4-b吡啶的制备方法. CN: CN101830898A, 2010-09-15.

[6] 李光勋, 唐卓, 杨高峰, 张施琪. 一种手性氯代砜亚胺类化合物及其衍生物的制备方法. CN: CN114989058A, 2022-09-02.

[7] 李光勋, 唐卓, 黄金. 一种手性氮取代四氢喹喔啉的制备方法. CN: CN114478405A, 2022-05-13.

[8] 李光勋, 唐卓, 黄金. 一种手性氮取代四氢喹喔啉的制备方法. CN: CN114478405A, 2022-05-13.

[9] 李光勋, 唐卓, 韩敏. 一种手性溴代1,4-二氢吡啶类化合物的制备方法. CN: CN114516774A, 2022-05-20.

[10] 李光勋, 唐卓, 黄金. 一种手性氮取代四氢喹喔啉的制备方法. CN: CN114478405B, 2023-08-15.

[11] 李光勋, 唐卓, 杨高峰, 张施琪. 一种手性氯代砜亚胺类化合物及其衍生物的制备方法. CN: CN114989058B, 2024-04-16.

   

（1） Catalytic Enantioselective Nucleophilic Desymmetrization at Phosphorus(V): A Three-Phase Strategy for Modular Preparation of Phosphoramidates, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2025, 第 9 作者  通讯作者
（2） Enantioselective Desymmetrization of Phosphinic Acids via Cu-Catalyzed O-Arylation, ACS CATALYSIS, 2025, 第 7 作者  通讯作者
（3） Synthesis of sul���namides via photocatalytic alkylation or arylation of sul���nylamine, Org. Biomol. Chem., 2024, 
（4） Photocatalytic Carbamoyl Radical Transfer to Alkenyl Azaarenes, SYNLETT, 2024, 第 3 作者  通讯作者
（5） Enantioselective Synthesis of Chiral Sulfonimidoyl Fluorides Facilitates Stereospecific SuFEx Click Chemistry, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2024, 第 9 作者  通讯作者
（6） Catalytic Asymmetric Hydrogen Atom Transfer Based on a Chiral Hydrogen Atom Donor Generated from TBADT and Chiral BINOL, Organic Letters, 2024, 第 6 作者  通讯作者
（7） Synthesis of Chiral Sulfonimidoyl Chloride via Desymmetrizing Enantioselective Hydrolysis, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2023, 第 7 作者  通讯作者
（8） Enantioselective Sulfonation of Enones with Sulfinates by Thiourea/Tertiary-Amine Catalysis,, Synlett, 2023, 
（9） One-Pot Tandem Oxidative Bromination and Amination of Sulfenamide for the Synthesis of Sulfinamidines, The Journal of Organic Chemistry, 2023, 
（10） Biomimetic Dynamic Kinetic Asymmetric N Oxidation with H2O2 and O2, ACS Catalysis, 2023, 
（11） Synthesis of Sulfilimines via Selective S���C Bond Formation in Water, Organic Letters, 2023, 
（12） Quinoxaline-specific enantioselective sulfa-michael reaction catalyzed by chiral phosphoric acid, Chinese Chemical Letters, 2023, 
（13） Synthesis of sul���namides via photocatalytic alkylation or arylation of sul���nylamine, Org. Biomol. Chem., 2023, 第 6 作者  通讯作者
（14） Chiral Phosphoric Acid Catalyzed Enantioselective Desymmetrization of 1,4-Dihydropyridines by C(sp3 ), Angew. Chem. Int. Ed., 2022, 第 5 作者  通讯作者
（15） Chiral Primary Amine Catalyzed Enantioselective Tandem Reactions Based on Heyns Rearrangement: Synthesis of �����Tertiary Amino Ketones, Organic Letters, 2022, 第 6 作者  通讯作者
（16） A heterobifunctional molecule recruits cereblon to an RNA scaffold and activates its PROTAC function, CELL REPORTS PHYSICAL SCIENCE, 2022, 第 8 作者
（17） Photoredox Alkylation of Sulfinylamine Enables the Synthesis of Highly Functionalized Sulfinamides and S(VI) Derivatives, ACS CATALYSIS, 2022, 第 7 作者  通讯作者
（18） Preparation of Dihydronaphthofurans from �����Hydroxyl Ketones via a One-Pot Multicomponent Reaction Based on Heyns Rearrangement, JOURNAL OF ORGANIC CHEMISTRY, 2022, 第 6 作者  通讯作者
（19） Electrochemical oxidation chemoselective sulfimidation of thioether with sulfonamide via catalytic iodobenzene, Tetrahedron Lett., 2022, 
（20） Synthesis of axially chiral N-aryl benzimidazoles via chiral phosphoric acid catalyzed enantioselective oxidative aromatization, New J. Chem., 2022, 
（21） Regioselective, Diastereoselective, and Enantioselective One-Pot Tandem Reaction Based on an in Situ Formed Reductant: Preparation of 2,3-Disubstituted 1,5-Benzodiazepine, JOURNAL OF ORGANIC CHEMISTRY, 2021, 第 2 作者  通讯作者
（22） Catalytic asymmetric synthesis of N-substituted tetrahydroquinoxalines via regioselective Heyns rearrangement and stereoselective transfer hydrogenation in one pot, CHEMICAL SCIENCE, 2021, 第 2 作者  通讯作者
（23） An organocatalytic asymmetric Friedel���Crafts reaction of 2-substituted indoles with aldehydes: enantioselective synthesis of a-hydroxyl ketones by low loading of chiral phosphoric acid, ChemComm, 2020, 
（24） Alloxan-Catalyzed Biomimetic Oxidations with Hydrogen Peroxide or Molecular Oxygen, ACS CATALYSIS, 2020, 第 2 作者
（25） Pictet-Spengler reaction based onin situgenerated alpha-amino iminium ions through the Heyns rearrangement, ORGANIC CHEMISTRY FRONTIERS, 2020, 第 6 作者  通讯作者
（26） Chiral Bronsted-Acid-Catalyzed Asymmetric Oxidation of Sulfenamide by Using H2O2: A Versatile Access to Sulfinamide and Sulfoxide with High Enantioselectivity, ACS CATALYSIS, 2019, 第 3 作者  通讯作者
（27） Preparation of Bicyclic Ketal Skeletons with Aldehyde and alpha-Ketone Acid through Cascade Friedel-Crafts Reaction and Stereoselective Acetalization in One Pot, SYNLETT, 2019, 第 5 作者  通讯作者
（28） Chiral Br��nsted-Acid-Catalyzed Asymmetric Oxidation of Sulfenamide by Using H2O2: A Versatile Access to Sulfinamide and Sulfoxide with High Enantioselectivity, ACS Catalysis, 2019, 第 1 作者  通讯作者
（29） Solvent-free synthesis of -amino ketones from -hydroxyl ketones via a novel tandem reaction sequence based on heyns rearrangement, SYNLETT, 2019, 第 3 作者  通讯作者
（30） Bioinspired Catalysis: Self-Assembly of a Protein and DNA as a Catalyst for the Aldol Reaction in Aqueous Media, SYNLETT, 2018, 第 2 作者  通讯作者
（31） Synthesis of asymmetrical thioethers with sulfinamides as the sulfenylation agent under metal-free conditions, TETRAHEDRON LETTERS, 2018, 第 2 作者  通讯作者
（32） Using sulfinamides as high oxidation state sulfur reagent for preparation of sulfenamides, TETRAHEDRON LETTERS, 2018, 第 2 作者  通讯作者
（33） Br��nsted-Acid-Catalyzed Substrate-Controlled and Site-Selective Friedel���Crafts Alkylation: A New Strategy for Post-Modification of 1,2-Dihydroquinolines, Asian Journal of Organic Chemistry, 2017, 
（34） BrOnsted-Acid-Catalyzed Substrate-Controlled and Site-Selective Friedel-Crafts Alkylation: A New Strategy for Post-Modification of 1,2-Dihydroquinolines, ASIANJOURNALOFORGANICCHEMISTRY, 2017, 第 2 作者  通讯作者
（35） Step-Controlled Povarov-Type Reaction with 1,2-Dihydroquinolines as Precursors of Dienophiles: Direct Synthesis of Spirocyclic Bi-tetrahydroquinolines and Functionalized 1,2-Dihydroquinolines., ORGANIC LETTERS, 2017, 第 2 作者  通讯作者
（36） Bio-inspired enantioselective full transamination using readily available cyclodextrin, RSC ADVANCES, 2017, 第 2 作者
（37） A one pot three-component reaction for the preparation of dihydroquinolines with two different ketones and aromatic amines, ORGANIC & BIOMOLECULAR CHEMISTRY, 2017, 第 2 作者  通讯作者
（38） The catalytic enantioselective synthesis of tetrahydroquinolines containing all-carbon quaternary stereocenters via the formation of aza-ortho-xylylene with 1,2-dihydroquinoline as a precursor, CHEMICAL COMMUNICATIONS, 2016, 第 1 作者  通讯作者
（39） Investigation and Application of Amphoteric alpha-Amino Aldehyde: An in Situ Generated Species Based on Heyns Rearrangement, ORGANIC LETTERS, 2016, 第 1 作者  通讯作者
（40） The catalytic enantioselective synthesis of tetrahydroquinolines containing all-carbon quaternary stereocenters via the formation of aza-ortho-xylylene with 1,2-dihydroquinoline as a precursor., CHEMICAL COMMUNICATIONS (CAMBRIDGE, ENGLAND), 2016, 第 1 作者
（41） Simple Br��nsted acid catalyzed C���H functionalization: efficient access to poly-substituted pyridines, TETRAHEDRON LETTERS, 2016, 第 5 作者
（42） 一种制备盐酸西那卡塞的新方法, A New Synthetic Method of Cinacalcet Hydrochloride, 合成化学, 2016, 第 1 作者
（43） 一种氨基酸衍生物消旋的新方法, A New Method for Racemization of Amino Acid Derivatives, 合成化学, 2016, 第 1 作者
（44） Simple Bronsted acid catalyzed C-H functionalization: efficient access to poly-substituted pyridines, TETRAHEDRON LETTERS, 2016, 第 5 作者  通讯作者
（45） First example of an organocatalytic asymmetric Mannich reaction between aldimines of glycinates and sulphonyl imines, CANADIAN JOURNAL OF CHEMISTRY, 2016, 第 2 作者
（46） Enantioselective Organocatalytic Transfer Hydrogenation of 1,2-Dihydroquinoline through Formation of Aza-o-xylylene, ORGANIC LETTERS, 2015, 第 1 作者  通讯作者
（47） Alkyl transfer from C-C cleavage: replacing the nitro group of nitro-olefins, CHEMICALCOMMUNICATIONS, 2014, 第 1 作者
（48） Alkyl Transfer from C-C Cleavage, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, 第 1 作者
（49） First way of enantioselective synthesis of moxifloxacin intermediate, SCIENCE CHINA Chemistry, 2013, 第 1 作者
（50） Organocatalytic asymmetric Michael reaction with acylsilane donors., ORGANIC & BIOMOLECULAR CHEMISTRY, 2013, 第 2 作者
（51） First way of enantioselective synthesis of moxifloxacin intermediate, SCIENCE CHINA CHEMISTRY,, 2013, 第 1 作者
（52） First asymmetric intermolecular bromoesterification catalyzed by chiral Bronsted acid, TETRAHEDRON-ASYMMETRY, 2012, 第 1 作者
（53） Enantiodifferentiating photoisomerization of cyclooctene included and sensitized by benzoate modified beta-cyclodextrin derivatives: switching of product chirality by solvent, TETRAHEDRON LETTERS, 2011, 第 1 作者
（54） 两种草本层台湾桤木林地细根分解及养分动态研究, Study on Fine Root Decomposition and Nutrient Dynamics in Alnus formosana Woodland Covered with Two Herbages, 水土保持学报, 2008, 
（55） Quinoxaline-specific enantioselective sulfa-michael reaction catalyzed by chiral phosphoric acid, CHINESE CHEMICAL LETTERS, 第 6 作者  通讯作者

   

（ 1 ） 具有免疫调控作用的药用植物资源高效挖掘与作用机制研究, 参与, 其他, 2024-11--2027-10
（ 2 ） 基于黄素依赖型卤化酶模拟的绿色仿生氧化卤代体系的开发与应用, 参与, 地方任务, 2024-01--2025-12
（ 3 ） 中国科学院青年创新促进会, 参与, 中国科学院计划, 2023-01--2026-12
（ 4 ） 基于黄素酶仿生催化的药物活性分子的绿色制备, 参与, 中国科学院计划, 2022-01--2023-12
（ 5 ） 基于Heyns重排的若干不对称串联反应研究, 负责人, 地方任务, 2021-07--2022-07
（ 6 ） 中国科学院“西部青年学者”(A类), 负责人, 中国科学院计划, 2019-08--2023-07
（ 7 ） 中国科学院青年创新促进会, 负责人, 中国科学院计划, 2018-01--2021-12
（ 8 ） 药物创新研究员西南分部经费, 参与, 中国科学院计划, 2017-09--2018-12
（ 9 ） 若干具有潜在药物活性分子的设计与合成(重点), 负责人, 地方任务, 2017-01--2019-12
（ 10 ） 生物启发的有机烷基化试剂的开发与应用, 负责人, 国家任务, 2015-01--2017-12

已指导学生

聂小康  硕士研究生  085238-生物工程  

陈月  硕士研究生  086002-制药工程  

黄鹤森  硕士研究生  078001-药物化学  

现指导学生

杨婉婷  硕士研究生  078001-药物化学  

张霞  硕士研究生  078001-药物化学  

陈尚菁  硕士研究生  086002-制药工程