基本信息
李光勋  男  硕导  中国科学院成都生物研究所
电子邮件: ligx@cib.ac.cn
通信地址: 成都市高新区科园南路93号成都生物所
邮政编码:

研究领域

生物启发的有机合成方法学研究,有机小分子不对称催化研究,活性天然产物的结构改造,药物合成工艺研究。


招生信息

   
招生专业
100701-药物化学
070303-有机化学
招生方向
药物化学,有机合成方法学,不对称催化

教育背景

2008-09--中科院成都生物所   博士
2005-09--四川农业大学   学士
2005-09--中科院沈阳应用生态所   硕士

工作经历

   
工作简历
2013-09~现在, 中科院成都生物所, 副研究员
2011-08~现在, 中科院成都有机化学研究所, 博士后

专利与奖励

   
专利成果
[1] 李光勋, 唐卓, 韩敏. 一种手性溴代1,4-二氢吡啶类化合物的制备方法. 202210068642.X, 2022-01-20.

[2] 李光勋, 唐卓, 黄金. 一种手性氮取代四氢喹喔啉的制备方法. 202210068649.1, 2022-01-20.

[3] 唐卓, 付丁强, 袁奕, 李光勋. 靶向降解酪氨酸酶的PROTAC及其应用. 202111043833.2, 2021-09-07.

[4] 唐卓, 李光勋. (S,S)-八氢-6H-吡咯并3,4-b吡啶的制备方法. CN: CN101830898A, 2010-09-15.

出版信息

   
发表论文
[1] Min Han, Shi-qi Zhang, Xin Cui, Qi-wei Wang, Guang-xun Li, zhuo tang. Chiral Phosphoric Acid Catalyzed Enantioselective Desymmetrization of 1,4-Dihydropyridines by C(sp3 ). Angew. Chem. Int. Ed.[J]. 2022, 61(22): e202201418-, [2] Xiao-kang Nie, Yue Chen, Shi-qi Zhang, Xin Cui, Zhuo Tang, Guang-xun Li. Chiral Primary Amine Catalyzed Enantioselective Tandem Reactions Based on Heyns Rearrangement: Synthesis of α‑Tertiary Amino Ketones. Organic Letters[J]. 2022, 24(10): 2069-2074, [3] Jin Huang, Jin-fang Chen, Xin Cui, Jin-zhong Zhao, Zhuo Tang, Guang-xun Li. Preparation of Dihydronaphthofurans from α‑Hydroxyl Ketones via a One-Pot Multicomponent Reaction Based on Heyns Rearrangement. JOURNAL OF ORGANIC CHEMISTRY[J]. 2022, 87(5): 3311-3318, [4] Yang, Gaofeng, Li, Guangxun, Huang, Jin, Fu, Dingqiang, Nie, Xiaokang, Cui, Xin, Zhao, Jinzhong, Tang, Zhuo. Regioselective, Diastereoselective, and Enantioselective One-Pot Tandem Reaction Based on an in Situ Formed Reductant: Preparation of 2,3-Disubstituted 1,5-Benzodiazepine. JOURNAL OF ORGANIC CHEMISTRY[J]. 2021, 86(7): 5110-5119, http://dx.doi.org/10.1021/acs.joc.0c03064.
[5] Huang, Jin, Li, Guangxun, Yang, Gaofeng, Fu, Dingqiang, Nie, Xiaokang, Cui, Xin, Zhao, Jinzhong, Tang, Zhuo. Catalytic asymmetric synthesis of N-substituted tetrahydroquinoxalines via regioselective Heyns rearrangement and stereoselective transfer hydrogenation in one pot. CHEMICAL SCIENCE[J]. 2021, 12(13): 4789-4793, http://dx.doi.org/10.1039/d0sc06264b.
[6] Deng, Xiongfei, Tang, Zhuo. An organocatalytic asymmetric Friedel–Crafts reaction of 2-substituted indoles with aldehydes: enantioselective synthesis of a-hydroxyl ketones by low loading of chiral phosphoric acid. ChemComm[J]. 2020, 56(16): 2499-2502, [7] Zhang, Shiqi, Li, Guangxun, Li, Ling, Deng, Xiongfei, Zhao, Gang, Cui, Xin, Tang, Zhuo. Alloxan-Catalyzed Biomimetic Oxidations with Hydrogen Peroxide or Molecular Oxygen. ACS CATALYSIS[J]. 2020, 10(1): 245-252, https://www.webofscience.com/wos/woscc/full-record/WOS:000506725100029.
[8] Li, Ling, Wang, Yingwei, Zhang, Shiqi, Dong, Xiongfei, Li, Guangxun, Zhao, Gang, Tang, Zhuo. Preparation of Bicyclic Ketal Skeletons with Aldehyde and alpha-Ketone Acid through Cascade Friedel-Crafts Reaction and Stereoselective Acetalization in One Pot. SYNLETT[J]. 2019, 30(18): 2091-2095, [9] Guangxun Li. Chiral Brønsted-Acid-Catalyzed Asymmetric Oxidation of Sulfenamide by Using H2O2: A Versatile Access to Sulfinamide and Sulfoxide with High Enantioselectivity. ACS Catalysis. 2019, [10] Li, Lingyu, Zeng, Qingle, Li, Guangxun, Tang, Zhuo. Solvent-Free Synthesis of -Amino Ketones from -Hydroxyl Ketones via A Novel Tandem Reaction Sequence Based on Heyns Rearrangement. SYNLETT[J]. 2019, 30(6): 694-698, http://210.75.237.14/handle/351003/29660.
[11] Liu, Hongxin, Li, Guangxun, Wang, Yingwei, Zhang, Shiqi, Tang, Zhuo. Bioinspired Catalysis: Self-Assembly of a Protein and DNA as a Catalyst for the Aldol Reaction in Aqueous Media. SYNLETT[J]. 2018, 29(5): 560-565, https://www.webofscience.com/wos/woscc/full-record/WOS:000426600100005.
[12] Ma, Longjun, Li, Guangxun, Huang, Jin, Zhu, Jin, Tang, Zhuo. Synthesis of asymmetrical thioethers with sulfinamides as the sulfenylation agent under metal-free conditions. TETRAHEDRON LETTERS[J]. 2018, 59(48): 4255-4258, http://dx.doi.org/10.1016/j.tetlet.2018.10.038.
[13] Ma, Longjun, Li, Guangxun, Huang, Jin, Zhu, Jin, Tang, Zhuo. Using sulfinamides as high oxidation state sulfur reagent for preparation of sulfenamides. TETRAHEDRON LETTERS[J]. 2018, 59(16): 1600-1603, http://dx.doi.org/10.1016/j.tetlet.2018.03.033.
[14] Zhuo Tang. Brønsted-Acid-Catalyzed Substrate-Controlled and Site-Selective Friedel–Crafts Alkylation: A New Strategy for Post-Modification of 1,2-Dihydroquinolines. Asian Journal of Organic Chemistry. 2017, [15] Ren, Xuwen, Li, Guangxun, Huang, Jin, Wang, Weidong, Zhang, Yongpo, Xing, Guomin, Gao, Chunyan, Zhao, Gang, Zhao, Jinzhong, Tang, Zhuo. Step-Controlled Povarov-Type Reaction with 1,2-Dihydroquinolines as Precursors of Dienophiles: Direct Synthesis of Spirocyclic Bi-tetrahydroquinolines and Functionalized 1,2-Dihydroquinolines. ORGANIC LETTERS[J]. 2017, 19(1): 58-61, https://www.webofscience.com/wos/woscc/full-record/WOS:000391781600016.
[16] Yang, Guobin, Li, Guangxun, Huang, Jin, Tang, Zhuo, Zhao, Jinzhong. A one pot three-component reaction for the preparation of dihydroquinolines with two different ketones and aromatic amines. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2017, 15(48): 10167-10171, https://www.webofscience.com/wos/woscc/full-record/WOS:000418070800007.
[17] Li, Guangxun, Tang, Ling, Liu, Hongxin, Wang, Yingwei, Zhao, Gang, Tang, Zhuo. Investigation and Application of Amphoteric alpha-Amino Aldehyde: An in Situ Generated Species Based on Heyns Rearrangement. ORGANIC LETTERS[J]. 2016, 18(18): 4526-4529, https://www.webofscience.com/wos/woscc/full-record/WOS:000383640600021.
[18] Lai Shujun, Ren Xuwen, Zhao Jinzhong, Tang Zhuo, Li Guangxun. Simple Brønsted acid catalyzed C–H functionalization: efficient access to poly-substituted pyridines. Tetrahedron Letters[J]. 2016, 57(27-28): 2957-2961, http://dx.doi.org/10.1016/j.tetlet.2016.05.061.
[19] Li Guangxun, Liu Hongxin, Wang Yingwei, Zhang Shiqi, Lai Shujun, Tang Ling, Zhao Jinzhong, Tang Zhuo. The catalytic enantioselective synthesis of tetrahydroquinolines containing all-carbon quaternary stereocenters via the formation of aza-ortho-xylylene with 1,2-dihydroquinoline as a precursor.. Chemical communications (Cambridge, England). 2016, http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=1&recid=&FileName=SJPDF8D2991D7C2990DED7DB229D872F1DDF&DbName=SJPDLAST&DbCode=SJPD&yx=&pr=&URLID=&bsm=.
[20] 李光勋, 吕刚, 唐卓. 一种制备盐酸西那卡塞的新方法. 合成化学. 2016, 24(6): 537-539, http://lib.cqvip.com/Qikan/Article/Detail?id=669185917.
[21] 李光勋, 唐玲, 刘洪鑫, 唐卓. 一种氨基酸衍生物消旋的新方法. 合成化学. 2016, 24(12): 1083-1085, http://lib.cqvip.com/Qikan/Article/Detail?id=670845193.
[22] Li, Guangxun, Liu, Hongxin, Lv, Gang, Wang, Yingwei, Fu, Qingquan, Tang, Zhuo. Enantioselective Organocatalytic Transfer Hydrogenation of 1,2-Dihydroquinoline through Formation of Aza-o-xylylene. ORGANIC LETTERS[J]. 2015, 17(17): 4125-4127, http://210.75.237.14/handle/351003/27569.
[23] Li, Guangxun, Wu, Lei, Lv, Gang, Liu, Hongxin, Fu, Qingquan, Zhang, Xiaomei, Tang, Zhuo. Alkyl transfer from C-C cleavage: replacing the nitro group of nitro-olefins. CHEMICAL COMMUNICATIONS[J]. 2014, 50(47): 6246-6248, http://210.75.237.14/handle/351003/26706.
[24] Li, Guangxun, Chen, Rong, Wu, Lei, Fu, Qingquan, Zhang, Xiaomei, Tang, Zhuo. Alkyl Transfer from C-C Cleavage. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2013, 52(32): 8432-8436, http://www.irgrid.ac.cn/handle/1471x/900540.
[25] GuangXun Li, Lei Wu, QingQuan Fu, Zhuo Tang, XiaoMei Zhang. First way of enantioselective synthesis of moxifloxacin intermediate. Science China Chemistry,[J]. 2013, 56(3): 307-311, http://www.irgrid.ac.cn/handle/1471x/900497.
[26] 李光勋. 修饰环糊精增感环辛烯不对称光异构化以及烯烃的不对称卤代酯化反应研究. 2011, [27] 王敬, 范川, 李贤伟, 张健, 李光勋, 荣丽. 两种草本层台湾桤木林地细根分解及养分动态研究. 水土保持学报. 2008, 22(6): 89-93, http://lib.cqvip.com/Qikan/Article/Detail?id=29093355.

科研活动

   
科研项目
( 1 ) 生物启发的有机烷基化试剂的开发与应用, 负责人, 国家任务, 2015-01--2017-12
( 2 ) 若干具有潜在药物活性分子的设计与合成(重点), 负责人, 地方任务, 2017-01--2019-12
( 3 ) 中国科学院青年创新促进会, 负责人, 中国科学院计划, 2018-01--2021-12
( 4 ) 药物创新研究员西南分部经费, 参与, 中国科学院计划, 2017-09--2018-12
( 5 ) 中国科学院“西部青年学者”(A类), 负责人, 中国科学院计划, 2019-08--2023-07
( 6 ) 基于Heyns重排的若干不对称串联反应研究, 负责人, 地方任务, 2021-07--2022-07