生物启发的有机合成方法学研究，有机小分子不对称催化研究，活性天然产物的结构改造，药物合成工艺研究。

   

100701-药物化学
070303-有机化学

药物化学，有机合成方法学，不对称催化

2008-09--中科院成都生物所   博士
2005-09--四川农业大学   学士
2005-09--中科院沈阳应用生态所   硕士

   

2013-09~现在, 中科院成都生物所, 副研究员
2011-08~现在, 中科院成都有机化学研究所, 博士后

   

[1] 李光勋, 唐卓, 韩敏. 一种手性溴代1，4-二氢吡啶类化合物的制备方法. 202210068642.X, 2022-01-20.

[2] 李光勋, 唐卓, 黄金. 一种手性氮取代四氢喹喔啉的制备方法. 202210068649.1, 2022-01-20.

[3] 唐卓, 付丁强, 袁奕, 李光勋. 靶向降解酪氨酸酶的PROTAC及其应用. 202111043833.2, 2021-09-07.

[4] 唐卓, 李光勋. (S,S)-八氢-6H-吡咯并3,4-b吡啶的制备方法. CN: CN103030638A, 2013-04-10.

[5] 唐卓, 李光勋. (S,S)-八氢-6H-吡咯并3,4-b吡啶的制备方法. CN: CN101830898A, 2010-09-15.

[6] 李光勋, 唐卓, 杨高峰, 张施琪. 一种手性氯代砜亚胺类化合物及其衍生物的制备方法. CN: CN114989058A, 2022-09-02.

[7] 李光勋, 唐卓, 黄金. 一种手性氮取代四氢喹喔啉的制备方法. CN: CN114478405A, 2022-05-13.

[8] 李光勋, 唐卓, 黄金. 一种手性氮取代四氢喹喔啉的制备方法. CN: CN114478405A, 2022-05-13.

[9] 李光勋, 唐卓, 韩敏. 一种手性溴代1,4-二氢吡啶类化合物的制备方法. CN: CN114516774A, 2022-05-20.

[10] 李光勋, 唐卓, 黄金. 一种手性氮取代四氢喹喔啉的制备方法. CN: CN114478405B, 2023-08-15.

   

[1] Org. Biomol. Chem.. 2024, 
[2] Synlett. 2024, 
[3] Yang, Gaofeng, Yuan, Yi, Tian, Yin, Zhang, Shiqi, Cui, Xin, Xia, Bing, Li, Guangxun, Tang, Zhuo. Synthesis of Chiral Sulfonimidoyl Chloride via Desymmetrizing Enantioselective Hydrolysis. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2023, 第 7 作者  通讯作者  http://dx.doi.org/10.1021/jacs.2c13758.
[4] Synlett. 2023, 
[5] Synlett. 2023, 
[6] The Journal of Organic Chemistry. 2023, 
[7] ACS Catalysis. 2023, 
[8] Organic Letters. 2023, 
[9] Chinese Chemical Letters. 2023, 
[10] Min Han, Shi-qi Zhang, Xin Cui, Qi-wei Wang, Guang-xun Li, zhuo tang. Chiral Phosphoric Acid Catalyzed Enantioselective Desymmetrization of 1,4-Dihydropyridines by C(sp3 ). Angew. Chem. Int. Ed.[J]. 2022, 第 5 作者  通讯作者  61(22): e202201418, 
[11] Xiao-kang Nie, Yue Chen, Shi-qi Zhang, Xin Cui, Zhuo Tang, Guang-xun Li. Chiral Primary Amine Catalyzed Enantioselective Tandem Reactions Based on Heyns Rearrangement: Synthesis of α‑Tertiary Amino Ketones. Organic Letters[J]. 2022, 第 6 作者  通讯作者  24(10): 2069-2074, 
[12] Xu, Yan, Fu, Dingqiang, Yuan, Yi, Peng, Yan, Dong, Juan, Du, Feng, Huang, Xin, Li, Guangxun, Chen, Xiaohua, Wang, Qiwei, Tang, Zhuo. A heterobifunctional molecule recruits cereblon to an RNA scaffold and activates its PROTAC function. CELL REPORTS PHYSICAL SCIENCE[J]. 2022, 第 8 作者3(10): http://dx.doi.org/10.1016/j.xcrp.2022.101064.
[13] Li, Ling, Zhang, Shiqi, Chen, Yue, Cui, Xin, Zhao, Gang, Tang, Zhuo, Li, Guangxun. Photoredox Alkylation of Sulfinylamine Enables the Synthesis of Highly Functionalized Sulfinamides and S(VI) Derivatives. ACS CATALYSIS[J]. 2022, 第 7 作者  通讯作者  12(24): 15334-15340, http://dx.doi.org/10.1021/acscatal.2c05169.
[14] Jin Huang, Jin-fang Chen, Xin Cui, Jin-zhong Zhao, Zhuo Tang, Guang-xun Li. Preparation of Dihydronaphthofurans from α‑Hydroxyl Ketones via a One-Pot Multicomponent Reaction Based on Heyns Rearrangement. JOURNAL OF ORGANIC CHEMISTRY[J]. 2022, 第 6 作者  通讯作者  87(5): 3311-3318, 
[15] Tetrahedron Lett.. 2022, 
[16] New J. Chem.. 2022, 
[17] Yang, Gaofeng, Li, Guangxun, Huang, Jin, Fu, Dingqiang, Nie, Xiaokang, Cui, Xin, Zhao, Jinzhong, Tang, Zhuo. Regioselective, Diastereoselective, and Enantioselective One-Pot Tandem Reaction Based on an in Situ Formed Reductant: Preparation of 2,3-Disubstituted 1,5-Benzodiazepine. JOURNAL OF ORGANIC CHEMISTRY[J]. 2021, 第 2 作者  通讯作者  86(7): 5110-5119, http://dx.doi.org/10.1021/acs.joc.0c03064.
[18] Huang, Jin, Li, Guangxun, Yang, Gaofeng, Fu, Dingqiang, Nie, Xiaokang, Cui, Xin, Zhao, Jinzhong, Tang, Zhuo. Catalytic asymmetric synthesis of N-substituted tetrahydroquinoxalines via regioselective Heyns rearrangement and stereoselective transfer hydrogenation in one pot. CHEMICAL SCIENCE[J]. 2021, 第 2 作者  通讯作者  12(13): 4789-4793, http://dx.doi.org/10.1039/d0sc06264b.
[19] Deng, Xiongfei, Tang, Zhuo. An organocatalytic asymmetric Friedel–Crafts reaction of 2-substituted indoles with aldehydes: enantioselective synthesis of a-hydroxyl ketones by low loading of chiral phosphoric acid. ChemComm[J]. 2020, 56(16): 2499-2502, 
[20] Zhang, Shiqi, Li, Guangxun, Li, Ling, Deng, Xiongfei, Zhao, Gang, Cui, Xin, Tang, Zhuo. Alloxan-Catalyzed Biomimetic Oxidations with Hydrogen Peroxide or Molecular Oxygen. ACS CATALYSIS[J]. 2020, 第 2 作者10(1): 245-252, https://www.webofscience.com/wos/woscc/full-record/WOS:000506725100029.
[21] Liang, Junxiu, Yang, Guobin, Zhang, Yongpo, Guo, Dongdong, Zhao, Jinzhong, Li, Guangxun, Tang, Zhuo. Pictet-Spengler reaction based onin situgenerated alpha-amino iminium ions through the Heyns rearrangement. ORGANIC CHEMISTRY FRONTIERS[J]. 2020, 第 6 作者  通讯作者  7(20): 3242-3246, https://www.webofscience.com/wos/woscc/full-record/WOS:000579143200014.
[22] Ma, Longjun, Chen, Shusen, Li, Guangxun, Zhu, Jin, Wang, Qiwei, Tang, Zhuo. Chiral Bronsted-Acid-Catalyzed Asymmetric Oxidation of Sulfenamide by Using H2O2: A Versatile Access to Sulfinamide and Sulfoxide with High Enantioselectivity. ACS CATALYSIS[J]. 2019, 第 3 作者  通讯作者  9(2): 1525-1530, http://dx.doi.org/10.1021/acscatal.8b04850.
[23] Li, Ling, Wang, Yingwei, Zhang, Shiqi, Dong, Xiongfei, Li, Guangxun, Zhao, Gang, Tang, Zhuo. Preparation of Bicyclic Ketal Skeletons with Aldehyde and alpha-Ketone Acid through Cascade Friedel-Crafts Reaction and Stereoselective Acetalization in One Pot. SYNLETT[J]. 2019, 第 5 作者  通讯作者  30(18): 2091-2095, 
[24] Guangxun Li. Chiral Brønsted-Acid-Catalyzed Asymmetric Oxidation of Sulfenamide by Using H2O2: A Versatile Access to Sulfinamide and Sulfoxide with High Enantioselectivity. ACS Catalysis. 2019, 第 1 作者  通讯作者  
[25] Li, Lingyu, Zeng, Qingle, Li, Guangxun, Tang, Zhuo. Solvent-Free Synthesis of -Amino Ketones from -Hydroxyl Ketones via A Novel Tandem Reaction Sequence Based on Heyns Rearrangement. SYNLETT[J]. 2019, 第 3 作者  通讯作者  30(6): 694-698, http://210.75.237.14/handle/351003/29660.
[26] Liu, Hongxin, Li, Guangxun, Wang, Yingwei, Zhang, Shiqi, Tang, Zhuo. Bioinspired Catalysis: Self-Assembly of a Protein and DNA as a Catalyst for the Aldol Reaction in Aqueous Media. SYNLETT[J]. 2018, 第 2 作者  通讯作者  29(5): 560-565, https://www.webofscience.com/wos/woscc/full-record/WOS:000426600100005.
[27] Ma, Longjun, Li, Guangxun, Huang, Jin, Zhu, Jin, Tang, Zhuo. Synthesis of asymmetrical thioethers with sulfinamides as the sulfenylation agent under metal-free conditions. TETRAHEDRON LETTERS[J]. 2018, 第 2 作者  通讯作者  59(48): 4255-4258, http://dx.doi.org/10.1016/j.tetlet.2018.10.038.
[28] Ma, Longjun, Li, Guangxun, Huang, Jin, Zhu, Jin, Tang, Zhuo. Using sulfinamides as high oxidation state sulfur reagent for preparation of sulfenamides. TETRAHEDRON LETTERS[J]. 2018, 第 2 作者  通讯作者  59(16): 1600-1603, http://dx.doi.org/10.1016/j.tetlet.2018.03.033.
[29] Zhuo Tang. Brønsted-Acid-Catalyzed Substrate-Controlled and Site-Selective Friedel–Crafts Alkylation: A New Strategy for Post-Modification of 1,2-Dihydroquinolines. Asian Journal of Organic Chemistry. 2017, 
[30] Huang, Jin, Li, Guangxun, Yang, Guobin, Zhao, Jinzhong, Tang, Zhuo. BrOnsted-Acid-Catalyzed Substrate-Controlled and Site-Selective Friedel-Crafts Alkylation: A New Strategy for Post-Modification of 1,2-Dihydroquinolines. ASIANJOURNALOFORGANICCHEMISTRY[J]. 2017, 第 2 作者  通讯作者  6(12): 1741-1744, http://www.chinair.org.cn/handle/1471x/1749224.
[31] Ren, Xuwen, Li, Guangxun, Huang, Jin, Wang, Weidong, Zhang, Yongpo, Xing, Guomin, Gao, Chunyan, Zhao, Gang, Zhao, Jinzhong, Tang, Zhuo. Step-Controlled Povarov-Type Reaction with 1,2-Dihydroquinolines as Precursors of Dienophiles: Direct Synthesis of Spirocyclic Bi-tetrahydroquinolines and Functionalized 1,2-Dihydroquinolines. ORGANIC LETTERS[J]. 2017, 第 2 作者  通讯作者  19(1): 58-61, https://www.webofscience.com/wos/woscc/full-record/WOS:000391781600016.
[32] Zhang, Shiqi, Li, Guangxun, Liu, Hongxin, Wang, Yingwei, Cao, Yuan, Zhao, Gang, Tang, Zhuo. Bio-inspired enantioselective full transamination using readily available cyclodextrin. RSC ADVANCES[J]. 2017, 第 2 作者7(7): 4203-4208, https://www.webofscience.com/wos/woscc/full-record/WOS:000393750100074.
[33] Yang, Guobin, Li, Guangxun, Huang, Jin, Tang, Zhuo, Zhao, Jinzhong. A one pot three-component reaction for the preparation of dihydroquinolines with two different ketones and aromatic amines. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2017, 第 2 作者  通讯作者  15(48): 10167-10171, https://www.webofscience.com/wos/woscc/full-record/WOS:000418070800007.
[34] Li, Guangxun, Liu, Hongxin, Wang, Yingwei, Zhang, Shiqi, Lai, Shujun, Tang, Ling, Zhao, Jinzhong, Tang, Zhuo. The catalytic enantioselective synthesis of tetrahydroquinolines containing all-carbon quaternary stereocenters via the formation of aza-ortho-xylylene with 1,2-dihydroquinoline as a precursor. CHEMICAL COMMUNICATIONS[J]. 2016, 第 1 作者  通讯作者  52(11): 2304-2306, https://www.webofscience.com/wos/woscc/full-record/WOS:000369587800020.
[35] Li, Guangxun, Tang, Ling, Liu, Hongxin, Wang, Yingwei, Zhao, Gang, Tang, Zhuo. Investigation and Application of Amphoteric alpha-Amino Aldehyde: An in Situ Generated Species Based on Heyns Rearrangement. ORGANIC LETTERS[J]. 2016, 第 1 作者  通讯作者  18(18): 4526-4529, https://www.webofscience.com/wos/woscc/full-record/WOS:000383640600021.
[36] Li Guangxun, Liu Hongxin, Wang Yingwei, Zhang Shiqi, Lai Shujun, Tang Ling, Zhao Jinzhong, Tang Zhuo. The catalytic enantioselective synthesis of tetrahydroquinolines containing all-carbon quaternary stereocenters via the formation of aza-ortho-xylylene with 1,2-dihydroquinoline as a precursor.. CHEMICAL COMMUNICATIONS (CAMBRIDGE, ENGLAND). 2016, 第 1 作者http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=1&recid=&FileName=SJPDF8D2991D7C2990DED7DB229D872F1DDF&DbName=SJPDLAST&DbCode=SJPD&yx=&pr=&URLID=&bsm=.
[37] Lai Shujun, Ren Xuwen, Zhao Jinzhong, Tang Zhuo, Li Guangxun. Simple Brønsted acid catalyzed C–H functionalization: efficient access to poly-substituted pyridines. TETRAHEDRON LETTERS[J]. 2016, 第 5 作者57(27-28): 2957-2961, http://dx.doi.org/10.1016/j.tetlet.2016.05.061.
[38] 李光勋, 吕刚, 唐卓. 一种制备盐酸西那卡塞的新方法. 合成化学[J]. 2016, 第 1 作者24(6): 537-539, http://lib.cqvip.com/Qikan/Article/Detail?id=669185917.
[39] 李光勋, 唐玲, 刘洪鑫, 唐卓. 一种氨基酸衍生物消旋的新方法. 合成化学[J]. 2016, 第 1 作者24(12): 1083-1085, http://lib.cqvip.com/Qikan/Article/Detail?id=670845193.
[40] Lai, Shujun, Ren, Xuwen, Zhao, Jinzhong, Tang, Zhuo, Li, Guangxun. Simple Bronsted acid catalyzed C-H functionalization: efficient access to poly-substituted pyridines. TETRAHEDRON LETTERS[J]. 2016, 第 5 作者  通讯作者  57(27-28): 2957-2961, https://www.webofscience.com/wos/woscc/full-record/WOS:000378667600004.
[41] Wu, Lei, Li, Guangxun, He, Migu, Wang, Yingwei, Zhao, Gang, Tang, Zhuo. First example of an organocatalytic asymmetric Mannich reaction between aldimines of glycinates and sulphonyl imines. CANADIAN JOURNAL OF CHEMISTRY[J]. 2016, 第 2 作者94(9): 769-772, https://www.webofscience.com/wos/woscc/full-record/WOS:000382752000006.
[42] Li, Guangxun, Liu, Hongxin, Lv, Gang, Wang, Yingwei, Fu, Qingquan, Tang, Zhuo. Enantioselective Organocatalytic Transfer Hydrogenation of 1,2-Dihydroquinoline through Formation of Aza-o-xylylene. ORGANIC LETTERS[J]. 2015, 第 1 作者  通讯作者  17(17): 4125-4127, http://210.75.237.14/handle/351003/27569.
[43] Li, Guangxun, Wu, Lei, Lv, Gang, Liu, Hongxin, Fu, Qingquan, Zhang, Xiaomei, Tang, Zhuo. Alkyl transfer from C-C cleavage: replacing the nitro group of nitro-olefins. CHEMICALCOMMUNICATIONS[J]. 2014, 第 1 作者50(47): 6246-6248, http://210.75.237.14/handle/351003/26706.
[44] Li, Guangxun, Chen, Rong, Wu, Lei, Fu, Qingquan, Zhang, Xiaomei, Tang, Zhuo. Alkyl Transfer from C-C Cleavage. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2013, 第 1 作者52(32): 8432-8436, http://www.irgrid.ac.cn/handle/1471x/900540.
[45] Li GuangXun, Wu Lei, Fu QingQuan, Tang Zhuo, Zhang XiaoMei. First way of enantioselective synthesis of moxifloxacin intermediate. SCIENCE CHINA-CHEMISTRY[J]. 2013, 第 1 作者56(3): 307-311, http://www.irgrid.ac.cn/handle/1471x/900497.
[46] Wu, Lei, Li, Guangxun, Fu, Qingquan, Yu, Luoting, Tang, Zhuo. Organocatalytic asymmetric Michael reaction with acylsilane donors. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2013, 第 2 作者11(3): 443-447, http://www.irgrid.ac.cn/handle/1471x/900513.
[47] GuangXun Li, Lei Wu, QingQuan Fu, Zhuo Tang, XiaoMei Zhang. First way of enantioselective synthesis of moxifloxacin intermediate. SCIENCE CHINA CHEMISTRY,[J]. 2013, 第 1 作者56(3): 307-311, http://www.irgrid.ac.cn/handle/1471x/900497.
[48] Li, Guangxun, Fu, Qingquan, Zhang, Xiaomei, Jiang, Jun, Tang, Zhuo. First asymmetric intermolecular bromoesterification catalyzed by chiral Bronsted acid. TETRAHEDRON-ASYMMETRY[J]. 2012, 第 1 作者23(3-4): 245-251, http://www.irgrid.ac.cn/handle/1471x/656405.
[49] Li, Guangxun, Wang, Zhizhong, Lu, Runhua, Tang, Zhuo. Enantiodifferentiating photoisomerization of cyclooctene included and sensitized by benzoate modified beta-cyclodextrin derivatives: switching of product chirality by solvent. TETRAHEDRON LETTERS[J]. 2011, 第 1 作者52(24): 3097-3101, http://www.irgrid.ac.cn/handle/1471x/517882.
[50] 王敬, 范川, 李贤伟, 张健, 李光勋, 荣丽. 两种草本层台湾桤木林地细根分解及养分动态研究. 水土保持学报[J]. 2008, 第 5 作者22(6): 89-93, http://lib.cqvip.com/Qikan/Article/Detail?id=29093355.
[51] Xiongfei Deng, Shiqi Zhang, Hesen Huang, Xin Cui, Zhuo Tang, Guangxun Li. Quinoxaline-specific enantioselective sulfa-michael reaction catalyzed by chiral phosphoric acid. CHINESE CHEMICAL LETTERS. 第 6 作者  通讯作者  http://dx.doi.org/10.1016/j.cclet.2023.108145.

   

（ 1 ） 生物启发的有机烷基化试剂的开发与应用, 负责人, 国家任务, 2015-01--2017-12
（ 2 ） 若干具有潜在药物活性分子的设计与合成(重点), 负责人, 地方任务, 2017-01--2019-12
（ 3 ） 中国科学院青年创新促进会, 负责人, 中国科学院计划, 2018-01--2021-12
（ 4 ） 药物创新研究员西南分部经费, 参与, 中国科学院计划, 2017-09--2018-12
（ 5 ） 中国科学院“西部青年学者”(A类), 负责人, 中国科学院计划, 2019-08--2023-07
（ 6 ） 基于Heyns重排的若干不对称串联反应研究, 负责人, 地方任务, 2021-07--2022-07