尤磊 男 博导 中国科学院福建物质结构研究所
电子邮件： lyou@fjirsm.ac.cn
通信地址： 福建省福州市鼓楼区杨桥西路155号
邮政编码： 350002
电子邮件： lyou@fjirsm.ac.cn
通信地址： 福建省福州市鼓楼区杨桥西路155号
邮政编码： 350002
研究领域
有机化学，超分子化学，化学生物学
招生信息
招生专业
070303-有机化学
招生方向
有机超分子化学和组装，功能有机分子和材料
教育背景
2003-08--2008-07 美国圣路易斯华盛顿大学 博士
1999-09--2003-06 复旦大学 理学学士
1999-09--2003-06 复旦大学 理学学士
工作经历
工作简历
2013-01~现在, 中科院福建物质结构研究所, 研究员
2008-08~2013-01,美国德州大学奥斯汀分校, 博士后
2008-08~2013-01,美国德州大学奥斯汀分校, 博士后
教授课程
前沿领域系列专题讲座
专利与奖励
专利成果
（ 1 ） 环链异构二苯乙烯荧光分子以及制备方法、应用, 2023, 第 1 作者, 专利号: CN114907249B
（ 2 ） 一种荧光开关及其制备方法、应用, 专利授权, 2019, 第 1 作者, 专利号: CN109761930A
（ 3 ） 轴手性联苯环-链异构化合物及其制备方法与应用, 专利授权, 2021, 第 1 作者, 专利号: CN110734387B
（ 4 ） 一种用于水相中铜离子与氰根离子的可视化检测的聚合物, 发明专利, 2015, 第 2 作者, 专利号: CN104927049A
（ 2 ） 一种荧光开关及其制备方法、应用, 专利授权, 2019, 第 1 作者, 专利号: CN109761930A
（ 3 ） 轴手性联苯环-链异构化合物及其制备方法与应用, 专利授权, 2021, 第 1 作者, 专利号: CN110734387B
（ 4 ） 一种用于水相中铜离子与氰根离子的可视化检测的聚合物, 发明专利, 2015, 第 2 作者, 专利号: CN104927049A
出版信息
发表论文
[1] Shuaipeng Jia, Hebo Ye, Peng He, Xin Lin, Lei You. Selection of isomerization pathways of multistep photoswitches by chalcogen bonding. NATURE COMMUNICATIONS[J]. 2023, 第 5 作者 通讯作者 14: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628202/.
[2] Yin, Chaowei, Lu, Hanwei, Ye, Hebo, Feng, Zelin, Zou, Hanxun, Zhang, Meilan, You, Lei. Double n ->pi* Interactions with One Electron Donor: Structural and Mechanistic Insights. ORGANIC LETTERS[J]. 2023, 第 7 作者 通讯作者 http://dx.doi.org/10.1021/acs.orglett.3c00205.
[3] Jiang, Guoshan, Wang, Lifeng, Ye, Hebo, Zou, Hanxun, You, Lei. Dynamic Covalent Reactions and Chirality Sensing with Diphenylethene Derived Hemiaminals. CHEMPLUSCHEM[J]. 2023, 第 5 作者 通讯作者 88(5): http://dx.doi.org/10.1002/cplu.202300080.
[4] Hanwei Lu, Hebo Ye, Meilan Zhang, Zimu Liu, Hanxun Zou, Lei You. Photoswitchable dynamic conjugate addition-elimination reactions as a tool for light-mediated click and clip chemistry. NATURE COMMUNICATIONS[J]. 2023, 第 6 作者 通讯作者 14: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328932/.
[5] You, Lei. Dual reactivity based dynamic covalent chemistry: mechanisms and applications. CHEMICAL COMMUNICATIONS. 2023, 第 1 作者 通讯作者 59(87): 12943-12958, http://dx.doi.org/10.1039/d3cc04022d.
[6] Iumzhana A Bolotova, Alexander O Ustyuzhanin, Ekaterina S Sergeeva, Anna A Faizdrakhmanova, Yu Hai, Andrey V Stepanov, Igor A Ushakov, Konstantin A Lyssenko, Lei You, Andrey G Lvov. 2,3-Diarylmaleate salts as a versatile class of diarylethenes with a full spectrum of photoactivity in water † ‡. CHEMICAL SCIENCE[J]. 2023, 第 9 作者 通讯作者 14(35): 9553-9559, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10498723/.
[7] Zhang, Meilan, Lu, Hanwei, Ye, Hebo, Li, Ziyi, Hai, Yu, You, Lei. Photoinduced generation of carbocations enabled by the promotion of aromaticity. ORGANIC CHEMISTRY FRONTIERS[J]. 2023, 第 6 作者 通讯作者 10(15): 3889-3897, http://dx.doi.org/10.1039/d3qo00418j.
[8] She, Zijian, Zou, Hanxun, You, Lei. Tuning the selectivity of amino acid recognition with dynamic covalent bond constrained fluorophores in aqueous media. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2022, 第 3 作者 通讯作者 20(34): 6897-6904, http://dx.doi.org/10.1039/d2ob01361d.
[9] Jia, Shuaipeng, Ye, Hebo, You, Lei. Interplay between chalcogen bonds and dynamic covalent bonds. ORGANIC CHEMISTRY FRONTIERS[J]. 2022, 第 3 作者 通讯作者 9(15): 3966-3975, http://dx.doi.org/10.1039/d2qo00684g.
[10] Li, Ziyi, Zhang, Ling, Zhou, Yuntao, Zha, Daijun, Hai, Yu, You, Lei. Dynamic Covalent Reactions Controlled by Ring-Chain Tautomerism of 2-Formylbenzoic Acid. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY[J]. 2022, 第 6 作者 通讯作者 2022(5): https://www.doi.org/10.1002/ejoc.202101461.
[11] Jiang, Guoshan, Hai, Yu, Ye, Hebo, You, Lei. Dynamic covalent chemistry constrained diphenylethenes: control over reactivity and luminescence both in solution and in the solid state. ORGANIC CHEMISTRY FRONTIERS[J]. 2022, 第 4 作者 通讯作者 9(5): 1343-1353, http://dx.doi.org/10.1039/d2qo00057a.
[12] Qin, Shilong, Zou, Hanxun, Hai, Yu, You, Lei. Aggregation-induced emission luminogens and tunable multicolor polymer networks modulated by dynamic covalent chemistry. CHINESE CHEMICAL LETTERS[J]. 2022, 第 4 作者 通讯作者 33(6): 3267-3271, http://dx.doi.org/10.1016/j.cclet.2021.11.001.
[13] Lu, Hanwei, Ye, Hebo, Zhang, Meilan, Wang, Lifeng, You, Lei. Photoswitchable Keto-Enol Tautomerism Driven by Light-Induced Change in Antiaromaticity. ORGANIC LETTERS[J]. 2022, 第 5 作者 通讯作者 24(47): 8639-8644, http://dx.doi.org/10.1021/acs.orglett.2c03441.
[14] Hai, Yu, Ye, Hebo, Li, Ziyi, Zou, Hanxun, Lu, Hanwei, You, Lei. Light-Induced Formation/Scission of C-N, C-O, and C-S Bonds Enables Switchable Stability/Degradability in Covalent Systems. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2021, 第 6 作者 通讯作者 143(48): 20368-20376, http://dx.doi.org/10.1021/jacs.1c09958.
[15] Zhuo, Youzhen, Wang, Xiuxiu, Chen, Si, Chen, Hang, Ouyang, Jie, Yang, Liulin, Wang, Xinchang, You, Lei, Utz, Marcel, Tian, Zhongqun, Cao, Xiaoyu. Quantification and Prediction of Imine Formation Kinetics in Aqueous Solution by Microfluidic NMR Spectroscopy. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2021, 第 8 作者 通讯作者 27(37): 9508-9513, https://www.doi.org/10.1002/chem.202100874.
[16] Sattar, Fazli, Feng, Zelin, Zou, Hanxun, Ye, Hebo, Zhang, Yi, You, Lei. Dynamic covalent bond constrained ureas for multimode fluorescence switching, thermally induced emission, and chemical signaling cascades. ORGANIC CHEMISTRY FRONTIERS[J]. 2021, 第 6 作者 通讯作者 8(14): 3760-3769, http://dx.doi.org/10.1039/d1qo00500f.
[17] Chen, Hang, Tang, Xiao, Ye, Hebo, Wang, Xinchang, Zheng, Hao, Hai, Yu, Cao, Xiaoyu, You, Lei. Effects of n -> pi r* Orbital Interactions on Molecular Rotors: The Control and Switching of Rotational Pathway and Speed. ORGANIC LETTERS[J]. 2021, 第 8 作者 通讯作者 23(1): 231-235, http://dx.doi.org/10.1021/acs.orglett.0c03969.
[18] Feng, Zelin, Jia, Shuaipeng, Chen, Hang, You, Lei. Modulation of imine chemistry with intramolecular hydrogen bonding: Effects from ortho-OH to NH. TETRAHEDRON[J]. 2020, 第 4 作者 通讯作者 76(17): http://dx.doi.org/10.1016/j.tet.2020.131128.
[19] Mao, Jialin, Hai, Yu, Ye, Hebo, You, Lei. Adaptive Covalent Networks Enabled by Dual Reactivity: The Evolution of Reversible Covalent Bonds, Their Molecular Assemblies, and Guest Recognition. JOURNAL OF ORGANIC CHEMISTRY[J]. 2020, 第 4 作者 通讯作者 85(8): 5351-5361, https://www.webofscience.com/wos/woscc/full-record/WOS:000607535100019.
[20] Khan, Imran, Wang, Junling, Zou, Hanxun, Ye, Hebo, Zha, Daijun, Zhang, Yi, You, Lei. Noncovalent and Dynamic Covalent Chemistry Strategies for Driving Thermoresponsive Phase Transition with Multistimuli and Controlled Encapsulation/Release. ACS APPLIED MATERIALS & INTERFACES[J]. 2020, 第 7 作者 通讯作者 12(2): 2962-2973, https://www.webofscience.com/wos/woscc/full-record/WOS:000508464500109.
[21] Chen, Hang, Ye, Hebo, Hai, Yu, Zhang, Ling, You, Lei. n -> pi* interactions as a versatile tool for controlling dynamic imine chemistry in both organic and aqueous media. CHEMICAL SCIENCE[J]. 2020, 第 5 作者 通讯作者 11(10): 2707-2715, https://www.webofscience.com/wos/woscc/full-record/WOS:000519742300009.
[22] Zheng, Hao, Ni, Cailing, Chen, Hang, Zha, Daijun, Hai, Yu, Ye, Hebo, You, Lei. Regulation of Axial Chirality through Dynamic Covalent Bond Constrained Biaryls. ACS OMEGA[J]. 2019, 第 7 作者 通讯作者 4(6): 10273-10278, https://doaj.org/article/49cc2887605a4ebf97bed06f5d72d11a.
[23] Zou, Hanxun, Hai, Yu, Ye, Hebo, You, Lei. Dynamic Covalent Switches and Communicating Networks for Tunable Multicolor Luminescent Systems and Vapor-Responsive Materials. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2019, 第 4 作者 通讯作者 141(41): 16344-16353, https://www.webofscience.com/wos/woscc/full-record/WOS:000491220300024.
[24] Zheng, Hao, Ye, Hebo, Yu, Xiaoxia, You, Lei. Interplay between n ->pi* Interactions and Dynamic Covalent Bonds: Quantification and Modulation by Solvent Effects. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2019, 第 4 作者 通讯作者 141(22): 8825-8833, https://www.webofscience.com/wos/woscc/full-record/WOS:000470939200030.
[25] Hai, Yu, Zou, Hanxun, Ye, Hebo, You, Lei. Three Switchable Orthogonal Dynamic Covalent Reactions and Complex Networks Based on the Control of Dual Reactivity. JOURNAL OF ORGANIC CHEMISTRY[J]. 2018, 第 4 作者 通讯作者 83(17): 9858-9869, https://www.webofscience.com/wos/woscc/full-record/WOS:000444364600023.
[26] Ni, Cailing, Wang, Meng, You, Lei. Dynamic Covalent Chemistry within Biphenyl Scaffolds: Effects from Endocyclic to Exocyclic Sulfonamides. SYNLETT[J]. 2018, 第 3 作者 通讯作者 29(16): 2131-2136, https://www.webofscience.com/wos/woscc/full-record/WOS:000445494200008.
[27] Ni, Cailing, Zha, Daijun, Ye, Hebo, Hai, Yu, Zhou, Yuntao, Anslyn, Eric V, You, Lei. Dynamic Covalent Chemistry within Biphenyl Scaffolds: Reversible Covalent Bonding, Control of Selectivity, and Chirality Sensing with a Single System. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2018, 第 7 作者 通讯作者 57(5): 1300-1305, https://www.webofscience.com/wos/woscc/full-record/WOS:000422940600028.
[28] Gao, Siheng, Li, Lijie, Vohra, Ismail, Zha, Daijun, You, Lei. Differential metal-binding properties of dynamic acylhydrazone polymers and their sensing applications. ROYAL SOCIETY OPEN SCIENCE[J]. 2017, 第 5 作者 通讯作者 4(8): https://doaj.org/article/59d0feb5f9444ec391c5640588c42eec.
[29] Ye, Hebo, Hai, Yu, Ren, Yulong, You, Lei. Versatile Dynamic Covalent Assemblies for Probing -Stacking and Chirality Induction from Homotopic Faces. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2017, 第 4 作者 通讯作者 23(16): 3804-3809, https://www.webofscience.com/wos/woscc/full-record/WOS:000397505400002.
[30] Wang, Meng, Ye, Hebo, You, Lei, Chen, Xueyuan. A Supramolecular Sensor Array Using Lanthanide-Doped Nanoparticles for Sensitive Detection of Glyphosate and Proteins. ACS APPLIED MATERIALS & INTERFACES[J]. 2016, 第 3 作者 通讯作者 8(1): 574-581, https://www.webofscience.com/wos/woscc/full-record/WOS:000368563000069.
[31] Zha, Daijun, You, Lei. Multiresponsive Dynamic Covalent Assemblies for the Selective Sensing of Both Cu2+ and CN- in Water. ACS APPLIED MATERIALS & INTERFACES[J]. 2016, 第 2 作者 通讯作者 8(3): 2399-2405, https://www.webofscience.com/wos/woscc/full-record/WOS:000369044100100.
[32] Zhou, Yuntao, Li, Lijie, Ye, Hebo, Zhang, Ling, You, Lei. Quantitative Reactivity Scales for Dynamic Covalent and Systems Chemistry. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2016, 第 5 作者 通讯作者 138(1): 381-389, https://www.webofscience.com/wos/woscc/full-record/WOS:000368323100056.
[33] Ren, Yulong, You, Lei. Dynamic Signaling Cascades: Reversible Covalent Reaction-Coupled Molecular Switches. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2015, 第 2 作者 通讯作者 137(44): 14220-14228, https://www.webofscience.com/wos/woscc/full-record/WOS:000364727600034.
[34] Zhou, Yuntao, Ye, Hebo, You, Lei. Reactivity-Based Dynamic Covalent Chemistry: Reversible Binding and Chirality Discrimination of Monoalcohols. JOURNAL OF ORGANIC CHEMISTRY[J]. 2015, 第 3 作者 通讯作者 80(5): 2627-2633, https://www.webofscience.com/wos/woscc/full-record/WOS:000350841600017.
[35] You, Lei, Zha, Daijun, Anslyn, Eric V. Recent Advances in Supramolecular Analytical Chemistry Using Optical Sensing. CHEMICAL REVIEWS. 2015, 第 1 作者 通讯作者 115(15): 7840-7892, http://dx.doi.org/10.1021/cr5005524.
[36] Zhou, Yuntao, Ren, Yulong, Zhang, Ling, You, Lei, Yuan, Yaofeng, Anslyn, Eric V. Dynamic covalent binding and chirality sensing of mono secondary amines with a metal-templated assembly. TETRAHEDRON[J]. 2015, 第 4 作者 通讯作者 71(21): 3515-3521, http://dx.doi.org/10.1016/j.tet.2015.03.121.
[37] Jo, Hyun Hwa, Edupuganti, Ramakrishna, You, Lei, Dalby, Kevin N, Anslyn, Eric V. Mechanistic studies on covalent assemblies of metal-mediated hemi-aminal ethers. CHEMICAL SCIENCE[J]. 2015, 第 3 作者6(1): 158-164, https://www.webofscience.com/wos/woscc/full-record/WOS:000345901600012.
[38] Zhou, Yuntao, Yuan, Yaofeng, You, Lei, Anslyn, Eric V. Dynamic Aminal-Based TPA Ligands. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2015, 第 3 作者 通讯作者 21(22): 8207-8213, https://www.webofscience.com/wos/woscc/full-record/WOS:000354651300032.
[39] Barman, Sanmitra, You, Lei, Chen, Ran, Codrea, Vlad, Kago, Grace, Edupuganti, Ramakrishna, Robertus, Jon, Krug, Robert M, Anslyn, Eric V. Exploring naphthyl-carbohydrazides as inhibitors of influenza A viruses. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2014, 第 2 作者71: 81-90, http://dx.doi.org/10.1016/j.ejmech.2013.10.063.
[40] Daschbach, Megan M, Negin, Saeedeh, You, Lei, Walsh, Matthew, Gokel, George W. Aggregation and Supramolecular Membrane Interactions that Influence Anion Transport in Tryptophan-Containing Synthetic Peptides. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2012, 第 3 作者18(24): 7608-7623, https://www.webofscience.com/wos/woscc/full-record/WOS:000304755700036.
[41] Lei You. Correlating sterics parameters and diastereomeric ratio values for a multicomponent assembly to predict exciton-coupled circular dichroism intensity and thereby enantiometic excess of chiral secondary alcohols. J. Am. Chem. Soc.. 2012, 第 1 作者
[42] Zhang, Xiaojun, You, Lei, Anslyn, Eric V, Qian, Xuhong. Discrimination and Classification of Ginsenosides and Ginsengs Using Bis-Boronic Acid Receptors in Dynamic Multicomponent Indicator Displacement Sensor Arrays. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2012, 第 2 作者18(4): 1102-1110, https://www.webofscience.com/wos/woscc/full-record/WOS:000299075600014.
[43] You, Lei, Pescitelli, Gennaro, Anslyn, Eric V, Di Bari, Lorenzo. An Exciton-Coupled Circular Dichroism Protocol for the Determination of Identity, Chirality, and Enantiomeric Excess of Chiral Secondary Alcohols. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2012, 第 1 作者134(16): 7117-7125, https://www.webofscience.com/wos/woscc/full-record/WOS:000303139800041.
[44] You, Lei, Long, S Reid, Lynch, Vincent M, Anslyn, Eric V. Dynamic Multicomponent Hemiaminal Assembly. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2011, 第 1 作者17(39): 11017-11023, https://www.webofscience.com/wos/woscc/full-record/WOS:000296262400030.
[45] You, Lei, Berman, Jeffrey S, Anslyn, Eric V. Dynamic multi-component covalent assembly for the reversible binding of secondary alcohols and chirality sensing. NATURE CHEMISTRY[J]. 2011, 第 1 作者 通讯作者 3(12): 943-948, https://www.webofscience.com/wos/woscc/full-record/WOS:000297685800012.
[46] You, Lei, Cho, Eun Jeong, Leavitt, John, Ma, LiChung, Montelione, Gaetano T, Anslyn, Eric V, Krug, Robert M, Ellington, Andrew, Robertus, Jon D. Synthesis and evaluation of quinoxaline derivatives as potential influenza NS1A protein inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2011, 第 1 作者21(10): 3007-3011, http://dx.doi.org/10.1016/j.bmcl.2011.03.042.
[2] Yin, Chaowei, Lu, Hanwei, Ye, Hebo, Feng, Zelin, Zou, Hanxun, Zhang, Meilan, You, Lei. Double n ->pi* Interactions with One Electron Donor: Structural and Mechanistic Insights. ORGANIC LETTERS[J]. 2023, 第 7 作者 通讯作者 http://dx.doi.org/10.1021/acs.orglett.3c00205.
[3] Jiang, Guoshan, Wang, Lifeng, Ye, Hebo, Zou, Hanxun, You, Lei. Dynamic Covalent Reactions and Chirality Sensing with Diphenylethene Derived Hemiaminals. CHEMPLUSCHEM[J]. 2023, 第 5 作者 通讯作者 88(5): http://dx.doi.org/10.1002/cplu.202300080.
[4] Hanwei Lu, Hebo Ye, Meilan Zhang, Zimu Liu, Hanxun Zou, Lei You. Photoswitchable dynamic conjugate addition-elimination reactions as a tool for light-mediated click and clip chemistry. NATURE COMMUNICATIONS[J]. 2023, 第 6 作者 通讯作者 14: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328932/.
[5] You, Lei. Dual reactivity based dynamic covalent chemistry: mechanisms and applications. CHEMICAL COMMUNICATIONS. 2023, 第 1 作者 通讯作者 59(87): 12943-12958, http://dx.doi.org/10.1039/d3cc04022d.
[6] Iumzhana A Bolotova, Alexander O Ustyuzhanin, Ekaterina S Sergeeva, Anna A Faizdrakhmanova, Yu Hai, Andrey V Stepanov, Igor A Ushakov, Konstantin A Lyssenko, Lei You, Andrey G Lvov. 2,3-Diarylmaleate salts as a versatile class of diarylethenes with a full spectrum of photoactivity in water † ‡. CHEMICAL SCIENCE[J]. 2023, 第 9 作者 通讯作者 14(35): 9553-9559, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10498723/.
[7] Zhang, Meilan, Lu, Hanwei, Ye, Hebo, Li, Ziyi, Hai, Yu, You, Lei. Photoinduced generation of carbocations enabled by the promotion of aromaticity. ORGANIC CHEMISTRY FRONTIERS[J]. 2023, 第 6 作者 通讯作者 10(15): 3889-3897, http://dx.doi.org/10.1039/d3qo00418j.
[8] She, Zijian, Zou, Hanxun, You, Lei. Tuning the selectivity of amino acid recognition with dynamic covalent bond constrained fluorophores in aqueous media. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2022, 第 3 作者 通讯作者 20(34): 6897-6904, http://dx.doi.org/10.1039/d2ob01361d.
[9] Jia, Shuaipeng, Ye, Hebo, You, Lei. Interplay between chalcogen bonds and dynamic covalent bonds. ORGANIC CHEMISTRY FRONTIERS[J]. 2022, 第 3 作者 通讯作者 9(15): 3966-3975, http://dx.doi.org/10.1039/d2qo00684g.
[10] Li, Ziyi, Zhang, Ling, Zhou, Yuntao, Zha, Daijun, Hai, Yu, You, Lei. Dynamic Covalent Reactions Controlled by Ring-Chain Tautomerism of 2-Formylbenzoic Acid. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY[J]. 2022, 第 6 作者 通讯作者 2022(5): https://www.doi.org/10.1002/ejoc.202101461.
[11] Jiang, Guoshan, Hai, Yu, Ye, Hebo, You, Lei. Dynamic covalent chemistry constrained diphenylethenes: control over reactivity and luminescence both in solution and in the solid state. ORGANIC CHEMISTRY FRONTIERS[J]. 2022, 第 4 作者 通讯作者 9(5): 1343-1353, http://dx.doi.org/10.1039/d2qo00057a.
[12] Qin, Shilong, Zou, Hanxun, Hai, Yu, You, Lei. Aggregation-induced emission luminogens and tunable multicolor polymer networks modulated by dynamic covalent chemistry. CHINESE CHEMICAL LETTERS[J]. 2022, 第 4 作者 通讯作者 33(6): 3267-3271, http://dx.doi.org/10.1016/j.cclet.2021.11.001.
[13] Lu, Hanwei, Ye, Hebo, Zhang, Meilan, Wang, Lifeng, You, Lei. Photoswitchable Keto-Enol Tautomerism Driven by Light-Induced Change in Antiaromaticity. ORGANIC LETTERS[J]. 2022, 第 5 作者 通讯作者 24(47): 8639-8644, http://dx.doi.org/10.1021/acs.orglett.2c03441.
[14] Hai, Yu, Ye, Hebo, Li, Ziyi, Zou, Hanxun, Lu, Hanwei, You, Lei. Light-Induced Formation/Scission of C-N, C-O, and C-S Bonds Enables Switchable Stability/Degradability in Covalent Systems. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2021, 第 6 作者 通讯作者 143(48): 20368-20376, http://dx.doi.org/10.1021/jacs.1c09958.
[15] Zhuo, Youzhen, Wang, Xiuxiu, Chen, Si, Chen, Hang, Ouyang, Jie, Yang, Liulin, Wang, Xinchang, You, Lei, Utz, Marcel, Tian, Zhongqun, Cao, Xiaoyu. Quantification and Prediction of Imine Formation Kinetics in Aqueous Solution by Microfluidic NMR Spectroscopy. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2021, 第 8 作者 通讯作者 27(37): 9508-9513, https://www.doi.org/10.1002/chem.202100874.
[16] Sattar, Fazli, Feng, Zelin, Zou, Hanxun, Ye, Hebo, Zhang, Yi, You, Lei. Dynamic covalent bond constrained ureas for multimode fluorescence switching, thermally induced emission, and chemical signaling cascades. ORGANIC CHEMISTRY FRONTIERS[J]. 2021, 第 6 作者 通讯作者 8(14): 3760-3769, http://dx.doi.org/10.1039/d1qo00500f.
[17] Chen, Hang, Tang, Xiao, Ye, Hebo, Wang, Xinchang, Zheng, Hao, Hai, Yu, Cao, Xiaoyu, You, Lei. Effects of n -> pi r* Orbital Interactions on Molecular Rotors: The Control and Switching of Rotational Pathway and Speed. ORGANIC LETTERS[J]. 2021, 第 8 作者 通讯作者 23(1): 231-235, http://dx.doi.org/10.1021/acs.orglett.0c03969.
[18] Feng, Zelin, Jia, Shuaipeng, Chen, Hang, You, Lei. Modulation of imine chemistry with intramolecular hydrogen bonding: Effects from ortho-OH to NH. TETRAHEDRON[J]. 2020, 第 4 作者 通讯作者 76(17): http://dx.doi.org/10.1016/j.tet.2020.131128.
[19] Mao, Jialin, Hai, Yu, Ye, Hebo, You, Lei. Adaptive Covalent Networks Enabled by Dual Reactivity: The Evolution of Reversible Covalent Bonds, Their Molecular Assemblies, and Guest Recognition. JOURNAL OF ORGANIC CHEMISTRY[J]. 2020, 第 4 作者 通讯作者 85(8): 5351-5361, https://www.webofscience.com/wos/woscc/full-record/WOS:000607535100019.
[20] Khan, Imran, Wang, Junling, Zou, Hanxun, Ye, Hebo, Zha, Daijun, Zhang, Yi, You, Lei. Noncovalent and Dynamic Covalent Chemistry Strategies for Driving Thermoresponsive Phase Transition with Multistimuli and Controlled Encapsulation/Release. ACS APPLIED MATERIALS & INTERFACES[J]. 2020, 第 7 作者 通讯作者 12(2): 2962-2973, https://www.webofscience.com/wos/woscc/full-record/WOS:000508464500109.
[21] Chen, Hang, Ye, Hebo, Hai, Yu, Zhang, Ling, You, Lei. n -> pi* interactions as a versatile tool for controlling dynamic imine chemistry in both organic and aqueous media. CHEMICAL SCIENCE[J]. 2020, 第 5 作者 通讯作者 11(10): 2707-2715, https://www.webofscience.com/wos/woscc/full-record/WOS:000519742300009.
[22] Zheng, Hao, Ni, Cailing, Chen, Hang, Zha, Daijun, Hai, Yu, Ye, Hebo, You, Lei. Regulation of Axial Chirality through Dynamic Covalent Bond Constrained Biaryls. ACS OMEGA[J]. 2019, 第 7 作者 通讯作者 4(6): 10273-10278, https://doaj.org/article/49cc2887605a4ebf97bed06f5d72d11a.
[23] Zou, Hanxun, Hai, Yu, Ye, Hebo, You, Lei. Dynamic Covalent Switches and Communicating Networks for Tunable Multicolor Luminescent Systems and Vapor-Responsive Materials. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2019, 第 4 作者 通讯作者 141(41): 16344-16353, https://www.webofscience.com/wos/woscc/full-record/WOS:000491220300024.
[24] Zheng, Hao, Ye, Hebo, Yu, Xiaoxia, You, Lei. Interplay between n ->pi* Interactions and Dynamic Covalent Bonds: Quantification and Modulation by Solvent Effects. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2019, 第 4 作者 通讯作者 141(22): 8825-8833, https://www.webofscience.com/wos/woscc/full-record/WOS:000470939200030.
[25] Hai, Yu, Zou, Hanxun, Ye, Hebo, You, Lei. Three Switchable Orthogonal Dynamic Covalent Reactions and Complex Networks Based on the Control of Dual Reactivity. JOURNAL OF ORGANIC CHEMISTRY[J]. 2018, 第 4 作者 通讯作者 83(17): 9858-9869, https://www.webofscience.com/wos/woscc/full-record/WOS:000444364600023.
[26] Ni, Cailing, Wang, Meng, You, Lei. Dynamic Covalent Chemistry within Biphenyl Scaffolds: Effects from Endocyclic to Exocyclic Sulfonamides. SYNLETT[J]. 2018, 第 3 作者 通讯作者 29(16): 2131-2136, https://www.webofscience.com/wos/woscc/full-record/WOS:000445494200008.
[27] Ni, Cailing, Zha, Daijun, Ye, Hebo, Hai, Yu, Zhou, Yuntao, Anslyn, Eric V, You, Lei. Dynamic Covalent Chemistry within Biphenyl Scaffolds: Reversible Covalent Bonding, Control of Selectivity, and Chirality Sensing with a Single System. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2018, 第 7 作者 通讯作者 57(5): 1300-1305, https://www.webofscience.com/wos/woscc/full-record/WOS:000422940600028.
[28] Gao, Siheng, Li, Lijie, Vohra, Ismail, Zha, Daijun, You, Lei. Differential metal-binding properties of dynamic acylhydrazone polymers and their sensing applications. ROYAL SOCIETY OPEN SCIENCE[J]. 2017, 第 5 作者 通讯作者 4(8): https://doaj.org/article/59d0feb5f9444ec391c5640588c42eec.
[29] Ye, Hebo, Hai, Yu, Ren, Yulong, You, Lei. Versatile Dynamic Covalent Assemblies for Probing -Stacking and Chirality Induction from Homotopic Faces. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2017, 第 4 作者 通讯作者 23(16): 3804-3809, https://www.webofscience.com/wos/woscc/full-record/WOS:000397505400002.
[30] Wang, Meng, Ye, Hebo, You, Lei, Chen, Xueyuan. A Supramolecular Sensor Array Using Lanthanide-Doped Nanoparticles for Sensitive Detection of Glyphosate and Proteins. ACS APPLIED MATERIALS & INTERFACES[J]. 2016, 第 3 作者 通讯作者 8(1): 574-581, https://www.webofscience.com/wos/woscc/full-record/WOS:000368563000069.
[31] Zha, Daijun, You, Lei. Multiresponsive Dynamic Covalent Assemblies for the Selective Sensing of Both Cu2+ and CN- in Water. ACS APPLIED MATERIALS & INTERFACES[J]. 2016, 第 2 作者 通讯作者 8(3): 2399-2405, https://www.webofscience.com/wos/woscc/full-record/WOS:000369044100100.
[32] Zhou, Yuntao, Li, Lijie, Ye, Hebo, Zhang, Ling, You, Lei. Quantitative Reactivity Scales for Dynamic Covalent and Systems Chemistry. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2016, 第 5 作者 通讯作者 138(1): 381-389, https://www.webofscience.com/wos/woscc/full-record/WOS:000368323100056.
[33] Ren, Yulong, You, Lei. Dynamic Signaling Cascades: Reversible Covalent Reaction-Coupled Molecular Switches. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2015, 第 2 作者 通讯作者 137(44): 14220-14228, https://www.webofscience.com/wos/woscc/full-record/WOS:000364727600034.
[34] Zhou, Yuntao, Ye, Hebo, You, Lei. Reactivity-Based Dynamic Covalent Chemistry: Reversible Binding and Chirality Discrimination of Monoalcohols. JOURNAL OF ORGANIC CHEMISTRY[J]. 2015, 第 3 作者 通讯作者 80(5): 2627-2633, https://www.webofscience.com/wos/woscc/full-record/WOS:000350841600017.
[35] You, Lei, Zha, Daijun, Anslyn, Eric V. Recent Advances in Supramolecular Analytical Chemistry Using Optical Sensing. CHEMICAL REVIEWS. 2015, 第 1 作者 通讯作者 115(15): 7840-7892, http://dx.doi.org/10.1021/cr5005524.
[36] Zhou, Yuntao, Ren, Yulong, Zhang, Ling, You, Lei, Yuan, Yaofeng, Anslyn, Eric V. Dynamic covalent binding and chirality sensing of mono secondary amines with a metal-templated assembly. TETRAHEDRON[J]. 2015, 第 4 作者 通讯作者 71(21): 3515-3521, http://dx.doi.org/10.1016/j.tet.2015.03.121.
[37] Jo, Hyun Hwa, Edupuganti, Ramakrishna, You, Lei, Dalby, Kevin N, Anslyn, Eric V. Mechanistic studies on covalent assemblies of metal-mediated hemi-aminal ethers. CHEMICAL SCIENCE[J]. 2015, 第 3 作者6(1): 158-164, https://www.webofscience.com/wos/woscc/full-record/WOS:000345901600012.
[38] Zhou, Yuntao, Yuan, Yaofeng, You, Lei, Anslyn, Eric V. Dynamic Aminal-Based TPA Ligands. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2015, 第 3 作者 通讯作者 21(22): 8207-8213, https://www.webofscience.com/wos/woscc/full-record/WOS:000354651300032.
[39] Barman, Sanmitra, You, Lei, Chen, Ran, Codrea, Vlad, Kago, Grace, Edupuganti, Ramakrishna, Robertus, Jon, Krug, Robert M, Anslyn, Eric V. Exploring naphthyl-carbohydrazides as inhibitors of influenza A viruses. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2014, 第 2 作者71: 81-90, http://dx.doi.org/10.1016/j.ejmech.2013.10.063.
[40] Daschbach, Megan M, Negin, Saeedeh, You, Lei, Walsh, Matthew, Gokel, George W. Aggregation and Supramolecular Membrane Interactions that Influence Anion Transport in Tryptophan-Containing Synthetic Peptides. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2012, 第 3 作者18(24): 7608-7623, https://www.webofscience.com/wos/woscc/full-record/WOS:000304755700036.
[41] Lei You. Correlating sterics parameters and diastereomeric ratio values for a multicomponent assembly to predict exciton-coupled circular dichroism intensity and thereby enantiometic excess of chiral secondary alcohols. J. Am. Chem. Soc.. 2012, 第 1 作者
[42] Zhang, Xiaojun, You, Lei, Anslyn, Eric V, Qian, Xuhong. Discrimination and Classification of Ginsenosides and Ginsengs Using Bis-Boronic Acid Receptors in Dynamic Multicomponent Indicator Displacement Sensor Arrays. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2012, 第 2 作者18(4): 1102-1110, https://www.webofscience.com/wos/woscc/full-record/WOS:000299075600014.
[43] You, Lei, Pescitelli, Gennaro, Anslyn, Eric V, Di Bari, Lorenzo. An Exciton-Coupled Circular Dichroism Protocol for the Determination of Identity, Chirality, and Enantiomeric Excess of Chiral Secondary Alcohols. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2012, 第 1 作者134(16): 7117-7125, https://www.webofscience.com/wos/woscc/full-record/WOS:000303139800041.
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[46] You, Lei, Cho, Eun Jeong, Leavitt, John, Ma, LiChung, Montelione, Gaetano T, Anslyn, Eric V, Krug, Robert M, Ellington, Andrew, Robertus, Jon D. Synthesis and evaluation of quinoxaline derivatives as potential influenza NS1A protein inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2011, 第 1 作者21(10): 3007-3011, http://dx.doi.org/10.1016/j.bmcl.2011.03.042.
科研活动
科研项目
（ 1 ） 青年****, 负责人, 国家任务, 2013-01--2017-12
（ 2 ） 酰腙类动态共价双亲分子的组装及其和生物膜的相互作用, 负责人, 国家任务, 2015-01--2017-12
（ 3 ） 新型动态作用及其对生物分子的修饰、分析和调控, 负责人, 研究所自主部署, 2015-01--2017-12
（ 4 ） 基于氮杂环鎓盐的新型动态共价键和复杂动态信号级联体系, 负责人, 国家任务, 2017-01--2020-12
（ 5 ） 动态共价键、组装及其导向的传感和标记功能研究, 负责人, 中国科学院计划, 2016-07--2021-06
（ 6 ） 基于双重反应性的动态共价化学及其光调控, 负责人, 国家任务, 2021-01--2024-12
（ 7 ） 动态共价键化学：设计、组装和应用, 负责人, 地方任务, 2020-11--2023-11
（ 8 ） 基于动态共价聚合物的柔性自修复发光材料, 负责人, 地方任务, 2021-03--2023-02
（ 9 ） 基于4-环戊烯-1,3-二酮衍生物的新型分子转子和单向分子马达, 负责人, 国家任务, 2022-01--2024-12
（ 10 ） 中国科学院上海分院青年博士后合作导师支持计划, 负责人, 中国科学院计划, 2024-04--2025-12
（ 2 ） 酰腙类动态共价双亲分子的组装及其和生物膜的相互作用, 负责人, 国家任务, 2015-01--2017-12
（ 3 ） 新型动态作用及其对生物分子的修饰、分析和调控, 负责人, 研究所自主部署, 2015-01--2017-12
（ 4 ） 基于氮杂环鎓盐的新型动态共价键和复杂动态信号级联体系, 负责人, 国家任务, 2017-01--2020-12
（ 5 ） 动态共价键、组装及其导向的传感和标记功能研究, 负责人, 中国科学院计划, 2016-07--2021-06
（ 6 ） 基于双重反应性的动态共价化学及其光调控, 负责人, 国家任务, 2021-01--2024-12
（ 7 ） 动态共价键化学：设计、组装和应用, 负责人, 地方任务, 2020-11--2023-11
（ 8 ） 基于动态共价聚合物的柔性自修复发光材料, 负责人, 地方任务, 2021-03--2023-02
（ 9 ） 基于4-环戊烯-1,3-二酮衍生物的新型分子转子和单向分子马达, 负责人, 国家任务, 2022-01--2024-12
（ 10 ） 中国科学院上海分院青年博士后合作导师支持计划, 负责人, 中国科学院计划, 2024-04--2025-12
指导学生
已指导学生
李利杰 硕士研究生 085204-材料工程
高司恒 硕士研究生 085204-材料工程
倪彩玲 博士研究生 070304-物理化学
叶何波 博士研究生 070303-有机化学
邹汉勋 博士研究生 070303-有机化学
陈航 博士研究生 070303-有机化学
毛佳琳 硕士研究生 070304-物理化学
姜国山 博士研究生 070303-有机化学
海宇 博士研究生 070303-有机化学
陆涵葳 博士研究生 070303-有机化学
尹超伟 硕士研究生 085600-材料与化工
现指导学生
郏帅鹏 博士研究生 070303-有机化学
林鑫 硕士研究生 070303-有机化学
吕友明 博士研究生 070303-有机化学
吴国祯 硕士研究生 085600-材料与化工
饶钦华 硕士研究生 070301-无机化学
尹超伟 博士研究生 070303-有机化学
黄洁云 硕士研究生 070301-无机化学