2001/09-2005/07，University of Wuhan. Wuhan, China，B.S.

2007/09-2013/07，Beijing Institute of Genomics. Beijing, China ，Ph.D.

2018/11-                 Beijing Institute of Genomics. Beijing, China, Professor

2013/11-2018/11，Boston Children’s Hospital, Boston, MA, Postdoctoral training

2005/07-2007/07，The Beijing Genomics Institute (BGI)，Engineer

Molecular Genetics and Epigenetics

• • [1] Yun Li, Zheng Huang, Zhaojun Zhang, Qifei Wang, Fengxian Li, Shufang Wang, Xin Ji, Shaokun Shu, Xiangdong Fang, Lan Jiang. FIPRESCI: droplet microfluidics based combinatorial indexing for massive-scale 5′-end single-cell RNA sequencing. GENOME BIOLOGY[J]. 2023, 24(1): 1-32, http://dx.doi.org/10.1186/s13059-023-02893-1.
    [2] Shan Jiang, Zheng Huang, Yun Li, Chengwei Yu, Hao Yu, Yuwen Ke, Lan Jiang, Jiang Liu. Single-cell chromatin accessibility and transcriptome atlas of mouse embryos. CELL REPORTS[J]. 2023, 42(3): http://dx.doi.org/10.1016/j.celrep.2023.112210.
    [3] Gao, Xueliang, Wang, Yubao, Ribeiro, Caroline F, Manokaran, Cherubin, Chang, Hyeyoun, Von, Thanh, Rodrigues, Silvia, Cizmecioglu, Onur, Jia, Shidong, Korpal, Manav, Korn, Joshua M, Wang, Zhigang, Schmit, Fabienne, Jiang, Lan, Pagliarini, Raymond, Yang, Yi, Sethi, Isha, Signoretti, Sabina, Yuan, Guo-Cheng, Loda, Massimo, Zhao, Jean J, Roberts, Thomas M. Blocking PI3K p110β Attenuates Development of PTEN-Deficient Castration-Resistant Prostate Cancer. MOLECULAR CANCER RESEARCH[J]. 2022, 20(5): 673-685, https://aacrjournals.org/mcr/article-abstract/20/5/673/694646/Blocking-PI3K-p110-Attenuates-Development-of-PTEN?redirectedFrom=fulltext.
    [4] Hang, Xinxin, He, Shiqi, Dong, Zaizai, Li, Yun, Huang, Zheng, Zhang, Yanruo, Sun, Hong, Lin, Long, Li, Hu, Wang, Yang, Liu, Bing, Wu, Nan, Ren, Tianling, Fan, Yubo, Lou, Jizhong, Yang, Ruiguo, Jiang, Lan, Chang, Lingqian. High-throughput DNA tensioner platform for interrogating mechanical heterogeneity of single living cell. Small[J]. 2022, 18(12): https://onlinelibrary.wiley.com/doi/epdf/10.1002/smll.202106196.
    [5] Joyce, Cailin E, Saadatpour, Assieh, RuizGutierrez, Melisa, Bolukbasi, Ozge Vargel, Jiang, Lan, Thomas, Dolly D, Young, Sarah, Hofmann, Inga, Sieff, Colin A, Myers, Kasiani C, Whangbo, Jennifer, Libermann, Towia A, Nusbaum, Chad, Yuan, GuoCheng, Shimamura, Akiko, Novina, Carl D. TGF-beta signaling underlies hematopoietic dysfunction and bone marrow failure in Shwachman-Diamond syndrome. JOURNAL OF CLINICAL INVESTIGATION[J]. 2019, 129(9): 3821-3826, https://www.webofscience.com/wos/woscc/full-record/WOS:000484368600036.
    [6] Li, Juan, Jiang, Lan, Wu, ChungI, Lu, Xuemei, Fang, Shu, Ting, ChauTi. Small Segmental Duplications in DrosophilaHigh Rate of Emergence and Elimination. GENOME BIOLOGY AND EVOLUTION[J]. 2019, 11(2): 486-496, https://www.webofscience.com/wos/woscc/full-record/WOS:000467953500012.
    [7] Jiang, Lan, Tsoucas, Daphne, Yuan, GuoCheng. Assessing Inequality in Transcriptomic Data. CELL SYSTEMS[J]. 2018, 6(2): 149-150, http://dx.doi.org/10.1016/j.cels.2018.02.007.
    [8] Djekidel, Mohamed Nadhir, Inoue, Azusa, Matoba, Shogo, Suzuki, Tsukasa, Zhang, Chunxia, Lu, Falong, Jiang, Lan, Zhang, Yi. Reprogramming of Chromatin Accessibility in Somatic Cell Nuclear Transfer Is DNA Replication Independent. CELL REPORTS[J]. 2018, 23(7): 1939-1947, http://dx.doi.org/10.1016/j.celrep.2018.04.036.
    [9] Matoba, Shogo, Wang, Huihan, Jiang, Lan, Lu, Falong, Iwabuchi, Kumiko A, Wu, Xiaoji, Inoue, Kimiko, Yang, Lin, Press, William, Lee, Jeannie T, Ogura, Atsuo, Shen, Li, Zhang, Yi. Loss of H3K27me3 Imprinting in Somatic Cell Nuclear Transfer Embryos Disrupts Post-Implantation Development. CELL STEM CELL[J]. 2018, 23(3): 343-+, http://dx.doi.org/10.1016/j.stem.2018.06.008.
    [10] Inoue, Azusa, Jiang, Lan, Lu, Falong, Suzuki, Tsukasa, Zhang, Yi. Maternal H3K27me3 controls DNA methylation-independent imprinting. NATURE[J]. 2017, 547(7664): 419-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000406358300028.
    [11] Chen, Renchao, Wu, Xiaoji, Jiang, Lan, Zhang, Yi. Single-Cell RNA-Seq Reveals Hypothalamic Cell Diversity. CELL REPORTS[J]. 2017, 18(13): 3227-3241, http://dx.doi.org/10.1016/j.celrep.2017.03.004.
    [12] Inoue, Azusa, Jiang, Lan, Lu, Falong, Zhang, Yi. Genomic imprinting of Xist by maternal H3K27me3. GENES & DEVELOPMENT[J]. 2017, 31(19): 1927-1932, https://www.webofscience.com/wos/woscc/full-record/WOS:000414054000001.
    [13] Wang, Kaile, Ma, Qin, Jiang, Lan, Lai, Shujuan, Lu, Xuemei, Hou, Yali, Wu, ChungI, Ruan, Jue. Ultra-precise detection of mutations by droplet-based amplification of circularized DNA (vol 17, 214, 2016). BMC GENOMICS[J]. 2016, 17: https://www.webofscience.com/wos/woscc/full-record/WOS:000377562700001.
    [14] Jiang, Lan, Chen, Huidong, Pinello, Luca, Yuan, GuoCheng. GiniClust: detecting rare cell types from single-cell gene expression data with Gini index. GENOME BIOLOGY[J]. 2016, 17: https://www.webofscience.com/wos/woscc/full-record/WOS:000378902100001.
    [15] Cailin Joyce PhD, Assieh Saadatpour PhD, Lan Jiang PhD, Melisa RuizGutierrez MDPhD, Ozge Vargel Bolukbasi PhD, Inga Hofmann MD, Colin A Sieff MBBCh, Chad Nusbaum PhD, Akiko Shimamura MD PhD, GuoCheng Yuan PhD, Carl D Novina MDPhD. Single Cell Transcriptional Profiling Reveals Activation of TNF-Alpha Signaling in Hematopoietic Stem and Progenitor Cells from Shwachman-Diamond Syndrome Patients. BLOOD. 2016, 128(22): 335-335, [16] Kim, TaeHee, Saadatpour, Assieh, Guo, Guoji, Saxena, Madhurima, Cavazza, Alessia, Desai, Niyati, Jadhav, Unmesh, Jiang, Lan, Rivera, Miguel N, Orkin, Stuart H, Yuan, GuoCheng, Shivdasani, Ramesh A. Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5(+) Intestinal Stem Cells. CELL REPORTS[J]. 2016, 16(8): 2053-2060, http://dx.doi.org/10.1016/j.celrep.2016.07.056.
    [17] Lu, Falong, Liu, Yuting, Jiang, Lan, Yamaguchi, Shinpei, Zhang, Yi. Role of Tet proteins in enhancer activity and telomere elongation. GENES & DEVELOPMENT[J]. 2014, 28(19): 2103-2119, https://www.webofscience.com/wos/woscc/full-record/WOS:000342888200004.
    [18] Chong, Zechen, Zhai, Weiwei, Li, Chunyan, Gao, Min, Gong, Qiang, Ruan, Jue, Li, Juan, Jiang, Lan, Lv, Xuemei, Hungate, Eric, Wu, ChungI. The Evolution of Small Insertions and Deletions in the Coding Genes of Drosophila melanogaster. MOLECULAR BIOLOGY AND EVOLUTION[J]. 2013, 30(12): 2699-2708, https://www.webofscience.com/wos/woscc/full-record/WOS:000327793000015.
    [19] Ruan, Jue, Jiang, Lan, Chong, Zechen, Gong, Qiang, Li, Heng, Li, Chunyan, Tao, Yong, Zheng, Caihong, Zhai, Weiwei, Turissini, David, Cannon, Charles H, Lu, Xuemei, Wu, ChungI. Pseudo-Sanger sequencing: massively parallel production of long and near error-free reads using NGS technology. BMC GENOMICS[J]. 2013, 14(711): http://ir.xtbg.org.cn/handle/353005/4786.
    [20] Jiang, Lan, Zhang, Jing, Wang, JingJing, Wang, Lu, Zhang, Li, Li, Guoqiang, Yang, Xiaodan, Ma, Xin, Sun, Xin, Cai, Jun, Zhang, Jun, Huang, Xingxu, Yu, Miao, Wang, Xuegeng, Liu, Feng, Wu, ChungI, He, Chuan, Zhang, Bo, Ci, Weimin, Liu, Jiang. Sperm, but Not Oocyte, DNA Methylome Is Inherited by Zebrafish Early Embryos. CELL[J]. 2013, 153(4): 773-784, http://dx.doi.org/10.1016/j.cell.2013.04.041.
    [21] Tao, Yong, Ruan, Jue, Yeh, ShiouHwei, Lu, Xuemei, Wang, Yu, Zhai, Weiwei, Cai, Jun, Ling, Shaoping, Gong, Qiang, Chong, Zecheng, Qu, Zhengzhong, Li, Qianqian, Liu, Jiang, Yang, Jin, Zheng, Caihong, Zeng, Changqing, Wang, HurngYi, Zhang, Jing, Wang, ShengHan, Hao, Lingtong, Dong, Lili, Li, Wenjie, Sun, Min, Zou, Wei, Yu, Caixia, Li, Chaohua, Liu, Guojing, Jiang, Lan, Xu, Jin, Huang, Huanwei, Li, Chunyan, Mi, Shuangli, Zhang, Bing, Chen, Baoxian, Zhao, Wenming, Hu, Songnian, Zhuang, ShiMei, Shen, Yang, Shi, Suhua, Brown, Christopher, White, Kevin P, Chen, DingShinn, Chen, PeiJer, Wu, ChungI. Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2011, 108(29): 12042-12047, http://dx.doi.org/10.1073/pnas.1108715108.
    [22] Lei Wang, Lan Jiang, Songnian Hu, Yejun Wang. Characterization of Evolutionarily Conserved MicroRNAs in Amphioxus. 基因组蛋白质组与生物信息学报：英文版[J]. 2010, 10-21, http://lib.cqvip.com/Qikan/Article/Detail?id=33671406.
    [23] Xia, Qingyou, Guo, Yiran, Zhang, Ze, Li, Dong, Xuan, Zhaoling, Li, Zhuo, Dai, Fangyin, Li, Yingrui, Cheng, Daojun, Li, Ruiqiang, Cheng, Tingcai, Jiang, Tao, Becquet, Celine, Xu, Xun, Liu, Chun, Zha, Xingfu, Fan, Wei, Lin, Ying, Shen, Yihong, Jiang, Lan, Jensen, Jeffrey, Hellmann, Ines, Tang, Si, Zhao, Ping, Xu, Hanfu, Yu, Chang, Zhang, Guojie, Li, Jun, Cao, Jianjun, Liu, Shiping, He, Ningjia, Zhou, Yan, Liu, Hui, Zhao, Jing, Ye, Chen, Du, Zhouhe, Pan, Guoqing, Zhao, Aichun, Shao, Haojing, Zeng, Wei, Wu, Ping, Li, Chunfeng, Pan, Minhui, Li, Jingjing, Yin, Xuyang, Li, Dawei, Wang, Juan, Zheng, Huisong, Wang, Wen, Zhang, Xiuqing, Li, Songgang, Yang, Huanming, Lu, Cheng, Nielsen, Rasmus, Zhou, Zeyang, Wang, Jian, Xiang, Zhonghuai, Wang, Jun. Complete Resequencing of 40 Genomes Reveals Domestication Events and Genes in Silkworm (Bombyx). SCIENCE[J]. 2009, 326(5951): 433-436, http://dx.doi.org/10.1126/science.1176620.
    
• • 发表论著

Epigenetics, Single-cell genomics

Lan Jiang, Detecting rare cell types from single-cell gene expression data, Statistical Methods for Single Cell RNA Sequencing Analysis, South San Francisco, USA, 20-22 February, 2017

​

已指导学生

赵婷  硕士研究生  071010-生物化学与分子生物学  

孙少省  硕士研究生  0710J3-生物信息学  

李子仪  硕士研究生  0710J3-生物信息学  

高晓玥  硕士研究生  0710J3-生物信息学  

现指导学生

李芸  博士研究生  0710Z1-基因组学  

虞程伟  博士研究生  0710Z1-基因组学  

黄正  博士研究生  0710J3-生物信息学  

刘蒙蒙  博士研究生  071007-遗传学  

徐矗  博士研究生  0710Z1-基因组学  

元杨  硕士研究生  0710Z1-基因组学  

陈甚之  硕士研究生  0710J3-生物信息学  

艾娜  博士研究生  0710J3-生物信息学  

徐扬清  硕士研究生  0710J3-生物信息学  

孟熹霓  硕士研究生  0710Z1-基因组学  

陈彦洁  硕士研究生  0710Z1-基因组学  

王弃非  博士研究生  0710Z1-基因组学  

Excellent Doctoral Dissertation, Chinese Academy of Sciences (2014)

Ray Wu Prize for Excellence in Life Sciences, The Ray Wu Memorial Fund, USA (2013)

Special Prize of the Presidential Scholarship, Chinese Academy of Sciences (2013)

Outstanding Graduate Award, Graduate School of Chinese Academy of Sciences (2013)

Honored Graduate, Beijing Municipal Commission of Education (2013)

Merit student, Graduate School of Chinese Academy of Sciences (2013)

First-class Prize of PhD Graduates Scholarship, Chinese Academy of Sciences (2010)

The Second Prize Scholarship, Wuhan University  (2003)

The Third Prize Scholarship, Wuhan University (2001)

​