071009-细胞生物学
071010-生物化学与分子生物学

肿瘤表观遗传学和药物精准应用
肿瘤转录异常的分子机制和创新药物发现

2009-09--2014-07   中国科学院上海药物研究所   博士学位
2005-09--2009-07   山东大学药学院   学士学位

   

2020-08~现在, 中国科学院广州生物医药与健康研究院, 研究员
2015-02~2020-07,Johns Hopkins University, 博士后

2023-10-01-今,Pharmaceutical Science Advances编委, 青年编委

生物技术制药
现代医药生物技术概论
生物技术前沿

   

（1） Structure-guided design of 7-azaindole DNMT1 inhibitors active against hypomethylating agent–resistant acute myeloid leukemia, Proc Natl Acad Sci U S A , 2026, 第 17 作者  通讯作者
（2） High-throughput ligand discovery in living cells using the cellular protein stability enhancement assay, Acta Pharmaceutica Sinica B, 2026, 第 12 作者  通讯作者
（3） Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia, Advanced Science, 2026, 第 19 作者  通讯作者
（4） Reduced Maintenance DNA Methylation Thresholds Enable Sensitive Reporter Assays for UHRF1 and DNMT1 Inhibition, Advanced Science, 2026, 第 16 作者  通讯作者
（5） Defining ortholog-specific UHRF1 inhibition by STELLA for cancer therapy, Nature Communications, 2025, 第 22 作者  通讯作者
（6） DNMT1 inhibition reprograms T cells to NK-like cells with potent antitumor activity, Science Immunology, 2025, 第 17 作者  通讯作者
（7） Development of a first-in-class DNMT1/HDAC inhibitor with improved therapeutic potential and potentiated antitumor immunity, Journal of Medicinal Chemistry, 2024, 第 10 作者  通讯作者
（8） Clerodane diterpenoids with in-vitro anti-neuroinflammatory activity from the tuberous root of Tinospora sagittata (Menispermaceae), PHYTOCHEMISTRY, 2024, 第 5 作者
（9） Synthesis of STM2457, a selective small-molecule inhibitor of METTL3, Tetrahedron Letters, 2024, 
（10） Discovery of KW0113 as a First and Effective PROTAC Degrader of DNMT1 Protein, ChemMedChem, 2024, 第 8 作者  通讯作者
（11） Select EZH2 inhibitors enhance viral mimicry effects of DNMT inhibition through a mechanism involving NFAT: AP-1 signaling, Science Advances, 2024, 第 4 作者
（12） Enhancing nicotinamide N-methyltransferase bisubstrate inhibitor activity through 7-deazaadenosine and linker modifications, Bioorganic Chemistry, 2024, 第 3 作者  通讯作者
（13） Discovery of a Covalent Inhibitor Selectively Targeting the Autophosphorylation Site of c-Src Kinase, ACS Chemical Biology, 2024, 第 13 作者  通讯作者
（14） Design, synthesis, and biological evaluation of novel carbazole derivatives as potent DNMT1 inhibitors with reasonable PK properties, JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2022, 第 11 作者  通讯作者
（15） Epigenetic Therapy Inhibits Metastases by Disrupting Premetastatic Niches, NATURE, 2021, 第 9 作者
（16） A Cost-Effective and Non-Invasive pfeRNA-Based Test Differentiates Benign and Suspicious Pulmonary Nodules from Malignant Ones, NON-CODING RNA, 2021, 第 10 作者
（17） Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction, JOURNAL OF MEDICINAL CHEMISTRY, 2021, 第 16 作者
（18） High-resolution Epigenome Mapping Reveals Distinct and Divergent Roles for UHRF1 in the Maintenance of DNA Methylation, FASEB JOURNAL, 2020, 第 4 作者
（19） Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties, CANCER CELL, 2019, 第 1 作者
（20） Aging-like Spontaneous Epigenetic Silencing Facilitates WntActivation, Stemness, and Braf V600E -InducedTumorigenesis, CANCER CELL, 2019, 第 7 作者
（21） Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1, ACS CHEMICAL BIOLOGY, 2018, 第 2 作者
（22） DNA Methylation Patterns Separate Senescence from Transformation Potential and Indicate Cancer Risk, CANCER CELL, 2018, 第 7 作者
（23） developmentofahighthroughputfluorescencepolarizationassayforthediscoveryofezh2eedinteractioninhibitors, ACTA PHARMACOLOGICA SINICA, 2018, 第 7 作者
（24） Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells, GENOME RESEARCH, 2017, 第 5 作者
（25） Functional interplay between the RK motif and linker segment dictates Oct4–DNA recognition, NUCLEIC ACIDS RESEARCH, 2015, 第 1 作者
（26） An Arginine-rich Motif of Ring Finger Protein 4 (RNF4) Oversees the Recruitment and Degradation of the Phosphorylated and SUMOylated Kruppel-associated Box Domain-associated Protein 1 (KAP1)/TRIM28 Protein during Genotoxic Stress, JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 第 3 作者
（27） Catalytic Mechanism of Histone Acetyltransferase p300: From the Proton Transfer to Acetylation Reaction, JOURNAL OF PHYSICAL CHEMISTRY B, 2014, 第 3 作者
（28） An Arginine-rich Motif of Ring Finger Protein 4 (RNF4) Oversees the Recruitment and Degradation of the Phosphorylated and SUMOylated Krüppel-associated Box Domain-associated Protein 1 (KAP1)/TRIM28 Protein during Genotoxic Stress, JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 第 3 作者
（29） Flumatinib, a selective inhibitor of BCR-ABL/PDGFR/KIT, effectively overcomes drug resistance of certain KIT mutants, CANCER SCIENCE, 2014, 第 4 作者
（30） K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5, NATURE IMMUNOLOGY, 2014, 第 10 作者
（31） Astemizole arrests the proliferation of cancer cells by disrupting the EZH2-EED interaction of polycomb repressive complex 2., JOURNAL OF MEDICINAL CHEMISTRY, 2014, 第 1 作者
（32） Discovery of two aminoglycoside antibiotics as inhibitors targeting the menin–mixed lineage leukaemia interface, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 第 8 作者
（33） c-MET kinase inhibitors: a patent review (2011-2013), EXPERT OPINION ON THERAPEUTIC PATENTS, 2014, 第 2 作者
（34） dna和组蛋白表观遗传修饰与糖尿病和肥胖的关系以及小分子抑制剂的研究进展, 中国药物化学杂志, 2013, 第 4 作者
（35） Identification and synthesis of N-(thiophen-2-yl) benzamide derivatives as BRAFV600E inhibitors, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 第 4 作者
（36） Targeting Epigenetics in Nervous System Disease, CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2013, 第 3 作者
（37） Salvianolic Acid A, a Novel Matrix Metalloproteinase-9 Inhibitor, Prevents Cardiac Remodeling in Spontaneously Hypertensive Rats, PLOS ONE, 2013, 第 7 作者
（38） Application of epigenome-modifying small molecules in induced pluripotent stem cells., MEDICINAL RESEARCH REVIEWS, 2013, 第 2 作者
（39） Structure-based computational study of the hydrolysis of New Delhi metallo-beta-lactmase-1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2013, 第 5 作者
（40） Theoretical Insights into Catalytic Mechanism of Protein Arginine Methyltransferase 1, PLOS ONE, 2013, 第 6 作者
（41） A quantum mechanics/molecular mechanics study on the hydrolysis mechanism of New Delhi metallo-beta-lactamase-1, JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2013, 第 4 作者
（42） Helix Unfolding/Refolding Characterizes the Functional Dynamics of Staphylococcus aureus Clp Protease, JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 第 6 作者
（43） 组蛋白乙酰转移酶hMOF小分子抑制剂的发现及应用研究, 2013, 第 1 作者
（44） Computational drug discovery, ACTA PHARMACOLOGICA SINICA, 2012, 第 3 作者
（45） Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 第 3 作者
（46） Development of a novel class of B-Raf V600E -selective inhibitors through virtual screening and hierarchical hit optimization, ORGANIC & BIOMOLECULAR CHEMISTRY, 2012, 第 1 作者
（47） Discovering potent inhibitors against c-Met kinase: molecular design, organic synthesis and bioassay, ORGANIC & BIOMOLECULAR CHEMISTRY, 2012, 第 4 作者
（48） Theoretical Study of the Mechanism of Proton Transfer in the Esterase Estb from Burkholderia Gladioli, JOURNAL OF PHYSICAL CHEMISTRY B, 2011, 第 2 作者
（49） Catalytic Mechanism Investigation of Lysine-Specific Demethylase 1 (LSD1): A Computational Study, PLOS ONE, 2011, 第 1 作者  通讯作者
（50） Molecular Basis of NDM-1, a New Antibiotic Resistance Determinant, PLOS ONE, 2011, 第 5 作者
（51） Identification and synthesis of N′-(2-oxoindolin-3-ylidene)hydrazide derivatives against c-Met kinase, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 第 6 作者
（52） 鞘氨醇磷酸酯调控机制的研究进展, ADVANCE IN THE STUDY OF THE MECHANISMS REGULATED BY SPHINGOSINE-1-PHOSPHATE, 中国科学基金, 2010, 第 2 作者