071009-细胞生物学
071010-生物化学与分子生物学

肿瘤表观遗传学和药物精准应用
肿瘤转录异常的分子机制和创新药物发现

2009-09--2014-07   中国科学院上海药物研究所   博士学位
2005-09--2009-07   山东大学药学院   学士学位

   

2020-08~现在, 中国科学院广州生物医药与健康研究院, 研究员
2015-02~2020-07,Johns Hopkins University, 博士后

2023-10-01-今,Pharmaceutical Science Advances编委, 青年编委

生物技术制药
现代医药生物技术概论
生物技术前沿

   

（1） Defining ortholog-specific UHRF1 inhibition by STELLA for cancer therapy, Nature Communications, 2025, 第 22 作者  通讯作者
（2） DNMT1 inhibition reprograms T cells to NK-like cells with potent antitumor activity, Science Immunology, 2025, 第 17 作者  通讯作者
（3） Development of a first-in-class DNMT1/HDAC inhibitor with improved therapeutic potential and potentiated antitumor immunity, Journal of Medicinal Chemistry, 2024, 第 10 作者  通讯作者
（4） Synthesis of STM2457, a selective small-molecule inhibitor of METTL3, Tetrahedron Letters, 2024, 
（5） Discovery of KW0113 as a First and Effective PROTAC Degrader of DNMT1 Protein, ChemMedChem, 2024, 第 8 作者  通讯作者
（6） Select EZH2 inhibitors enhance viral mimicry effects of DNMT inhibition through a mechanism involving NFAT: AP-1 signaling, Science Advances, 2024, 第 4 作者
（7） Enhancing nicotinamide N-methyltransferase bisubstrate inhibitor activity through 7-deazaadenosine and linker modifications, Bioorganic Chemistry, 2024, 
（8） Discovery of a Covalent Inhibitor Selectively Targeting the Autophosphorylation Site of c-Src Kinase, ACS Chemical Biology, 2024, 
（9） Design, synthesis, and biological evaluation of novel carbazole derivatives as potent DNMT1 inhibitors with reasonable PK properties, JOURNALOFENZYMEINHIBITIONANDMEDICINALCHEMISTRY, 2022, 第 11 作者
（10） A Cost-Effective and Non-Invasive pfeRNA-Based Test Differentiates Benign and Suspicious Pulmonary Nodules from Malignant Ones, NON-CODING RNA, 2021, 第 10 作者
（11） Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction, JOURNAL OF MEDICINAL CHEMISTRY, 2021, 第 16 作者
（12） Epigenetic Therapy Inhibits Metastases by Disrupting Premetastatic Niches, NATURE, 2021, 第 9 作者
（13） High-resolution Epigenome Mapping Reveals Distinct and Divergent Roles for UHRF1 in the Maintenance of DNA Methylation, FASEB JOURNAL, 2020, 第 4 作者
（14） Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties, CANCER CELL, 2019, 第 1 作者
（15） Aging-like Spontaneous Epigenetic Silencing Facilitates WntActivation, Stemness, and Braf V600E -InducedTumorigenesis, CANCER CELL, 2019, 第 7 作者
（16） Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1, ACS CHEMICAL BIOLOGY, 2018, 第 2 作者
（17） DNA Methylation Patterns Separate Senescence from Transformation Potential and Indicate Cancer Risk, CANCER CELL, 2018, 第 7 作者
（18） developmentofahighthroughputfluorescencepolarizationassayforthediscoveryofezh2eedinteractioninhibitors, ACTA PHARMACOLOGICA SINICA, 2018, 第 7 作者
（19） Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells, GENOME RESEARCH, 2017, 第 5 作者
（20） Functional interplay between the RK motif and linker segment dictates Oct4���DNA recognition, NUCLEIC ACIDS RESEARCH, 2015, 第 1 作者
（21） An Arginine-rich Motif of Ring Finger Protein 4 (RNF4) Oversees the Recruitment and Degradation of the Phosphorylated and SUMOylated Kruppel-associated Box Domain-associated Protein 1 (KAP1)/TRIM28 Protein during Genotoxic Stress, JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 第 3 作者
（22） Catalytic Mechanism of Histone Acetyltransferase p300: From the Proton Transfer to Acetylation Reaction, JOURNAL OF PHYSICAL CHEMISTRY B, 2014, 第 3 作者
（23） An Arginine-rich Motif of Ring Finger Protein 4 (RNF4) Oversees the Recruitment and Degradation of the Phosphorylated and SUMOylated Kr��ppel-associated Box Domain-associated Protein 1 (KAP1)/TRIM28 Protein during Genotoxic Stress, JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 第 3 作者
（24） K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5, NATURE IMMUNOLOGY, 2014, 第 10 作者
（25） Flumatinib, a selective inhibitor of BCR-ABL/PDGFR/KIT, effectively overcomes drug resistance of certain KIT mutants, CANCER SCIENCE, 2014, 第 4 作者
（26） Astemizole arrests the proliferation of cancer cells by disrupting the EZH2-EED interaction of polycomb repressive complex 2., JOURNAL OF MEDICINAL CHEMISTRY, 2014, 第 1 作者
（27） Discovery of two aminoglycoside antibiotics as inhibitors targeting the menin���mixed lineage leukaemia interface, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 第 8 作者
（28） c-MET kinase inhibitors: a patent review (2011-2013), EXPERT OPINION ON THERAPEUTIC PATENTS, 2014, 第 2 作者
（29） dna和组蛋白表观遗传修饰与糖尿病和肥胖的关系以及小分子抑制剂的研究进展, 中国药物化学杂志, 2013, 第 4 作者
（30） Identification and synthesis of N-(thiophen-2-yl) benzamide derivatives as BRAFV600E inhibitors, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 第 4 作者
（31） Targeting Epigenetics in Nervous System Disease, CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2013, 第 3 作者
（32） Salvianolic Acid A, a Novel Matrix Metalloproteinase-9 Inhibitor, Prevents Cardiac Remodeling in Spontaneously Hypertensive Rats, PLOS ONE, 2013, 第 7 作者
（33） Application of epigenome-modifying small molecules in induced pluripotent stem cells., MEDICINAL RESEARCH REVIEWS, 2013, 第 2 作者
（34） Structure-based computational study of the hydrolysis of New Delhi metallo-beta-lactmase-1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2013, 第 5 作者
（35） Theoretical Insights into Catalytic Mechanism of Protein Arginine Methyltransferase 1, PLOS ONE, 2013, 第 6 作者
（36） A quantum mechanics/molecular mechanics study on the hydrolysis mechanism of New Delhi metallo-beta-lactamase-1, JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2013, 第 4 作者
（37） Helix Unfolding/Refolding Characterizes the Functional Dynamics of Staphylococcus aureus Clp Protease, JOURNALOFBIOLOGICALCHEMISTRY, 2013, 第 6 作者
（38） 组蛋白乙酰转移酶hMOF小分子抑制剂的发现及应用研究, 2013, 第 1 作者
（39） Computational drug discovery, ACTA PHARMACOLOGICA SINICA, 2012, 第 3 作者
（40） Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 第 3 作者
（41） Development of a novel class of B-Raf V600E -selective inhibitors through virtual screening and hierarchical hit optimization, ORGANIC & BIOMOLECULAR CHEMISTRY, 2012, 第 1 作者
（42） Discovering potent inhibitors against c-Met kinase: molecular design, organic synthesis and bioassay, ORGANIC & BIOMOLECULAR CHEMISTRY, 2012, 第 4 作者
（43） Theoretical Study of the Mechanism of Proton Transfer in the Esterase Estb from Burkholderia Gladioli, JOURNAL OF PHYSICAL CHEMISTRY B, 2011, 第 2 作者
（44） Catalytic Mechanism Investigation of Lysine-Specific Demethylase 1 (LSD1): A Computational Study, PLOS ONE, 2011, 第 11 作者
（45） Molecular Basis of NDM-1, a New Antibiotic Resistance Determinant, PLOS ONE, 2011, 第 5 作者
（46） Identification and synthesis of N���-(2-oxoindolin-3-ylidene)hydrazide derivatives against c-Met kinase, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 第 6 作者
（47） 鞘氨醇磷酸酯调控机制的研究进展, ADVANCE IN THE STUDY OF THE MECHANISMS REGULATED BY SPHINGOSINE-1-PHOSPHATE, 中国科学基金, 2010, 第 2 作者

   

（ 1 ） 基于化学干预的神经内分泌阴性小细胞肺癌靶标确证及药物发现研究, 负责人, 地方任务, 2024-01--2026-12
（ 2 ） 吸烟诱导的慢阻肺早期演进表观机制研究, 负责人, 国家任务, 2023-12--2028-10
（ 3 ） BR计划, 负责人, 中国科学院计划, 2023-01--2025-12
（ 4 ） DNA甲基化维持蛋白UHRF1特异性抑制剂的发现和抗肿瘤活性研究, 负责人, 国家任务, 2022-01--2024-12
（ 5 ） 基于全新作用机制的DNA甲基化抑制剂发现和抗实体瘤研究, 负责人, 国家任务, 2022-01--2024-12
（ 6 ） 粤桂特色药用植物中靶向UHRF1的活性天然产物发现、优化和抗肿瘤活性研究, 负责人, 地方任务, 2020-12--2024-11
（ 7 ） 中科院广州生物医药与健康研究院启动费, 负责人, 研究所自主部署, 2020-07--2025-07

（1）基于新机制的DNA甲基化抑制剂发现与抗实体瘤研究   2024基础医学与临床转化研究前沿论坛   2024-12-03
（2）基于新机制的DNA甲基化抑制剂发现与应用研究   2024年中国药学会药物化学研讨会   2024-10-24
（3）Defining ortholog-specific UHRF1 inhibition by STELLA for cancer therapy   冷泉港亚洲会议   2024-05-15
（4）基于新机制的DNA甲基化抑制剂发现和应用研究   第八届《药学学报》药学前沿论坛   2024-03-30
（5）基于新靶标、新机制的DNA甲基化抑制剂发现和抗肿瘤活性研究   第六届表观遗传与生物医药研发国际学术会议   2021-11-25
（6）Defining UHRF1 domains that support maintenance of human colon cancer DNA methylation and tumorigenicity   2019-03-29