Kaikai Chen

Associate Professor

School of Nanoscience and Nanotechnology, University of Chinese Academy of Sciences

No.1 Yanqihu East Rd, Huairou District, Beijing, PR China, 101408

Email: chenkaikai (at)

Research Areas

Group website

Biophysics, Nanoscience and technology: Nanofluidics, Nanopore sensors, DNA nanotechnology.

Kaikai Chen joined UCAS as an Associate Professor in January 2023. Prior to this, he worked as a Research Associate at the Ulrich Keyser's group at the Cavendish Laboratory, University of Cambridge, starting from August 2017. He obtained his PhD in Engineering from Tsinghua University in June 2017, with a diverse background in engineering, biology, and physics. His research interests are mainly focused on biophysics and bionanotechnology, with a particular emphasis on nanofluidics, nanopore sensing, and DNA nanotechnology. Kaikai Chen has authored over 20 papers published in well-known journals such as Nature Physics, Nature Nanotechnology, Nature Communications, Advanced Materials, ACS Nano, Nano Letters, and Biophysical Journal, among others. His research findings have been featured by, Nanowerk, ScienMag,, and other media outlets.

We are looking for postdocs to joins us. See here for more information.

Please send your application to the email: chenkaikai (at)


09/2014 - 06/2017     PhD student (Supervisor: Prof. Yu Tian) in Mechanical Engineering
                                   State Key Laboratory of Tribology, Department of Mechanical Engineering Tsinghua University
09/2011 - 06/2014     Master of Mechanical Engineering, China University of Petroleum
09/2007 - 06/2011     Bacholar of Mechanical Design, Manufacturing and Automation, China University of Petroleum


01/2023 - present       Associate Professor
                                    School of Nanoscience and Nanotechnology, University of Chinese Academy of Sciences
08/2017 - 12/2022      Research Associate (Advisor: Prof. Ulrich F. Keyser)
                                    Cavendish Laboratory, Department of Physics, University of Cambridge



27.   S. M. Leitao, V. Navikas, H. Miljkovic, B. Drake, S. Marion, G. Pistoletti, K. Chen, S. Mayer, U. F. Keyser, A. Kuhn, G. E. Fantner, A. Radenovic. Spatially Multiplexed Single-molecule Translocations through a Nanopore at Controlled Speeds Nature Nanotechnology Accepted 2023.

26.    F. Boskovic, J. Zhu, R. Tivony, A. Ohmann, K. Chen, M. Alawami, M. Đorđević, N. Ermann, J. Pereira-Dias, M. Fairhead, M. Howarth, S. Baker, U. F. Keyser. Simultaneous identification of viruses and viral variants with programmable DNA nanobait. Nature Nanotechnology 2023, 18, 290-298. (IF: 40.52)

25.    K. Chen, A. Choudhary, S. E. Sandler, C. Maffeo, C. Ducati, A. Aksimentiev, U. F. Keyser. Super-resolution detection of DNA nanostructures using a nanopore. Advanced Materials 2023, 2207434. (IF: 32.09)

24.    A.F. Mohammed, F. Bošković, J. Zhu, K. Chen, S.E. Sandler, U. F. Keyser. Lifetime of glass nanopores in a PDMS chip for single-molecule sensing. iScience 2022, 25, 104191. (IF: 5.74)

23.    K. Chen, I. Jou, N. Ermann, M. Muthukumar, U. F. Keyser, N. A. W. Bell. Dynamics of driven polymer transport through a nanopore. Nature Physics 2021, 17, 1043-1049. (IF: 19.68)

22.    J. Zhu, J., N. Ermann, K. Chen, U. F. Keyser. Image encoding using multi-Level DNA barcodes with nanopore readout. Small 2021, 2100711. (IF: 15.15)

21.    F. Boskovic, A. Ohmann, U. F. Keyser,* K. Chen.* DNA structural barcode copying and random access. Small Structures 2021, 2000144. (Last corresponding author, IF: 11.34)

20.    K. Chen, F. Gularek, B. Liu, E. Weinhold, U. F. Keyser. Electrical DNA sequence mapping using oligodeoxynucleotide labels and nanopores. ACS Nano 2021, 15, 2679-2685. (IF: 18.03)

19.    K. Chen, J. Zhu, F. Bošković, U. F. Keyser. Nanopore-based DNA hard drives for rewritable and secure data storage. Nano Letters 2020, 20, 3754-3760. (IF: 12.26)

18.    N. E. Weckman, N. Ermann, R. Gutierrez, K. Chen, J. Graham, A. Heron, U. F. Keyser. Pushing the resolution of dCas9 barcodes for multiplexed DNA identification with nanopore sensors. 2019 IEEE Sensors (IF: 4.33)

17.    F. Boskovic, J. Zhu, K. Chen, U. F. Keyser. Monitoring G-quadruplex formation with DNA carriers and solid-state nanopores. Nano Letters 2019, 19, 7996-8001. (IF: 12.26)

16.    N. E. Weckman, N. Ermann, R. Gutierrez, K. Chen, J. Graham, R. Tivony, A. Heron, U. F. Keyser. Multiplexed DNA identification using site specific dCas9 barcodes and nanopore sensing. ACS Sensors 2019, 4, 2065-2072. (IF: 8.57)

15.    K. Chen, J. Kong, J. Zhu, N. Ermann, P. Predki, U. F. Keyser. Digital data storage using DNA nanostructures and solid-state nanopores. Nano Letters 2019, 19, 1210-1215. (IF: 12.26)

14.    J. Kong, J. Zhu, K. Chen, U. F. Keyser. Specific biosensing using DNA aptamers and nanopores. Advanced Functional Materials 2018, 1807555. (IF: 19.92)

13.    N. Ermann, N. Hanikel, V. Wang, K. Chen, N. E. Weckman, U. F. Keyser. Promoting single-file DNA translocations through nanopores using electro-osmotic flow. The Journal of Chemical Physics 2018, 149, 163311. (IF: 4.3)

12.    M. Zhou,* K. Chen,* X. Li, L. Liu, Q. Zeng, Y. Mo, L. Jin, L. Li, G. Su, J. Che, Y. Tian.* Clumping stability of vertical nanofibers on surfaces. Langmuir 2018, 34, 11629-11636. (*Corresponding author, IF: 4.33)

11.    N. A. W. Bell,# K. Chen,# S. Ghosal, M. Ricci, U. F. Keyser. Asymmetric dynamics of DNA entering and exiting a strongly confining nanopore. Nature Communications 2017, 8, 380. (#Equal contribution, IF: 17.69)

10.    K. Chen, M. Juhasz, F. Gularek, E. Weinhold, Y. Tian, U. F. Keyser, N. A. W. Bell. Ionic current-based mapping of short sequence motifs in single DNA molecules using solid-state nanopores. Nano Letters 2017, 17, 5199-5205. (IF: 12.26)

9.      K. Chen, N. A. W. Bell, J. Kong, Y. Tian, U. F. Keyser. Direction- and salt-dependent ionic current signatures for DNA sensing with asymmetric nanopores. Biophysical Journal 2017, 112, 674-682. (IF: 4.03)

8.      C. Xue, X. Zheng, K. Chen, Y. Tian, G. Hu. Probing non-gaussianity in confined diffusion of nanoparticles. The Journal of Physical Chemistry Letters 2016, 7, 514-9. (IF: 6.88)

7.      L. Shan, K. Chen, M. Zhou, X. Zhang, Y. Meng, Y. Tian. Shear history effect of magnetorheological fluids. Smart Materials and Structures 2015, 24, 105030. (IF: 3.59)

6.      K. Chen, L. Shan, S. He, G. Hu, Y. Meng, Y. Tian. Biphasic resistive pulses and ion concentration modulation during particle translocation through cylindrical nanopores. The Journal of Physical Chemistry C 2015, 119, 8329-8335. (IF: 4.18)

5.      K. Chen, W. L. Zhang, L. Shan, X. Zhang, Y. Meng, H. J. Choi, Y. Tian. Magnetorheology of suspensions based on graphene oxide coated or added carbonyl iron microspheres and sunflower oil. Journal of Applied Physics 2014, 116, 153508. (IF: 2.88)

4.      K. Chen, Y. Tian, L. Shan, X. Zhang, Y. Meng. Squeeze behaviors of magnetic powders between two parallel plates. Smart Materials and Structures 2014, 23, 117004. (IF: 3.59)

3.      Y. Tian, K. Chen, L. Shan, X. Zhang, Y. Meng. Unexpected shear strength change in magnetorheological fluids. APL Materials 2014, 2, 096102. (IF: 6.64)

2.      K. Chen, Y. Tian, L. Shan, X. Zhang, Y. Meng. The rheological properties of magnetic field excited magnetic powders sheared between two parallel plates. Smart Materials and Structures 2013, 22, 115036. (IF: 3.59)

1.      K. Chen, Y. Tian, L. Shan, J. Jiang. Transient response of sheared magnetic powder excited by a stepwise magnetic field and its comparison with ER and MR fluids. Smart Materials and Structures 2013, 22, 097001. (IF: 3.59)