1.¹⁹F MRI 造影剂研发

  （1）利用对称性组装氟原子和调控弛豫时间等策略构建高灵敏 ¹⁹F MRI 造影剂，发展了新型高灵敏造影剂、生物活性分子和离子探针等，解决了长期困扰 ¹⁹F MRI 造影剂的信号裂分、灵敏度低和易产生伪影等难题。

  

（2）针对造影剂研发中多分散聚乙二醇导致的产物成分复杂、纯化困难和批次差异性大等突出问题，从单分散聚乙二醇和含多个对称氟原子的化工原料出发，设计和合成了一系列高灵敏、高稳定性、高生物相容性、环境响应型和无需制剂的高性能造影剂，克服了现有造影剂的诸多缺陷。

3.氟-19磁共振成像在药物可视化和癌症诊疗一体化的应用研究

  ¹⁹F MRI造影剂与纳米科学、药物传递、癌症治疗等研究热点结合，发展了多个具有多模态成像、环境响应性和癌症治疗等功能的自组装分子模块，通过模块化自组装策略方便灵活地构建了一系列多功能、可视化和靶向性的抗肿瘤纳米药物，首次实现了治疗剂量下抗肿瘤药物的体内¹⁹F MRI可视化，荧光/光声/磁共振等多模态影像指导下的癌症联合治疗，为癌症个性化治疗打下了基础。

070300 化学、086000生物与医药等方向的硕士和博士研究生

070302-分析化学
0703J1-纳米科学与技术
070303-有机化学

氟-19磁共振成像
磁共振诊疗一体化
磁共振功能分子

070300 化学 086000生物与医药

1999-08--2004-07   中科院上海有机化学研究所   化学博士学位
1995-09--1999-07   西南大学化学化工学院   理学学士学位

   

（1） 湖北省“****”, 一等奖, 省级, 2015
（2） 湖北省“楚天学者”特聘教授, 一等奖, 省级, 2013

（ 1 ） 单分散聚乙二醇单甲醚修饰的丙泊酚前药的制备与应用, 专利授权, 2021, 第 1 作者, 专利号: CN108164419B

（ 2 ） 一种高灵敏度水溶性树枝状大分子F19显影剂的制备及其应用, 专利授权, 2020, 第 1 作者, 专利号: CN108129673B

（ 3 ） 一种制备烷基硫甲基酯类化合物的方法, 发明专利, 2018, 第 2 作者, 专利号: CN106957251B

（ 4 ） 一种结构新颖的盐霉素衍生物的制备与应用, 发明专利, 2018, 第 1 作者, 专利号: CN105732655B

（ 5 ） 一种烯烃的卤化三氟甲基化反应的方法, 发明专利, 2018, 第 2 作者, 专利号: CN105503688B

（ 6 ） 单分散九聚乙二醇十二烷基醇单醚及其硫酸盐的制备方法和应用, 发明专利, 2017, 第 1 作者, 专利号: CN106316802A

（ 7 ） 一种树枝状大分子氟-19磁共振显影剂及其制备方法和应用, 发明专利, 2015, 第 1 作者, 专利号: CN104548146A

（ 8 ） 一种单一分子量聚乙二醇及其衍生物的合成方法, 发明专利, 2014, 第 1 作者, 专利号: CN103642023A

（ 9 ） 一种新型大环环硫酸酯及其制备方法与应用, 发明专利, 2014, 第 1 作者, 专利号: CN103613576A

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（ 1 ） 基于单分散聚乙二醇精准组装白蛋白的纳米抗肿瘤药物传递系统研究, 负责人, 国家任务, 2021-01--2024-12
（ 2 ） 肿瘤靶向光/热/声一体化探测技术, 负责人, 国家任务, 2019-09--2024-08