Microfluidics, cell migration, organ on chip, biosensor

2011.07 - 2016.05, University of Manitoba, Ph.D.

2006.09 - 2009.06, Hefei Institutes of Physical Science, Chinese Academy of Sciences, M.S.

2001.09 - 2005.06, University of Science and Technology of China, B.S.

   

2020.04 - present, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Associate Professor

2016.06 - 2020.03, University of Manitoba, Postdoc

Council Member of the Division of  BioMEMS, Chinese Society of Micro-Nano Technology

Editorial Board Member of Scientific Reports

​Honoured with Springer Nature Editor of Distinction Awards 2025

Editorial Board Member of Bioengineering

   

1. S. Ding^#, W. Ding^#, X. Wang^#, Z. Li, Y. Fan, F. Lin^*, J. Wu^*, "Sorting and characterization of cancer cells with different migration phenotypes using a microfluidic platform", Sensors and Actuators B: Chemical, 2025, 440,  137875.
2. Y. Qi^#, H. Wang^#, J. Wu, R. Wang, Z. Xu, X. Cui^*, Z. Liu^*, "Microfluidic device reveals new insights into impairment of neutrophil transmigration in patients with sepsis", Biosensors and Bioelectronics, 2024, 260, 116460.
3. Y. Wang, Z. Liu, Y. Qi, J. Wu, B. Liu^*, X. Cui^*, "Activin A, a novel chemokine, induces mouse NK cell migration via AKT and calcium signaling", Cells, 2024, 13, 9: 728.
4. Y. Liu, J. Huang, C. Liu, Z. Song, J. Wu, Q. Zhao, Y. Li, F. Dong, L. Wang, and H. Xu^*, "Soft millirobot capable of switching motion modes on the fly for targeted drug delivery in the oviduct", ACS Nano, 2024, 18, 12: 8694–8705. 
5. J. Huang, Y. Liu, J. Wu, F. Dong, C. Liu, J. Luo, X. Liu, N. Wang, L. Wang, H. Xu^*, "An extracellular matrix-mimicking magnetic microrobot for targeted elimination of circulating cancer cells", Nanoscale, 2024,16: 624-634.
6. S. Huang^#, J. Wu^#, L. Zheng^#, Y. Long, J. Chen, J. Li, B. Dai^*, F. Lin^*, S. Zhuang, D. Zhang^*, “3D free-assembly modular microfluidics inspired by movable type printing”, Microsystems & Nanoengineering, 2023, 9, 111.
7. J. Ren^#, W. Chen^#, Z. Zhong^#, N. Wang, X. Chen, H. Yang, J. Li, P. Tang, Y. Fan, F. Lin, C. Bai^*, J. Wu^*, “Bronchoalveolar lavage fluid from chronic obstructive pulmonary disease patients increase neutrophil chemotaxis measured by a microfluidic platform”, Micromachines, 2023, 14(9), 1740.
8. G. Liu, Y. Qi, J. Wu, F. Lin, Z. Liu^*, X. Cui^*, “Follistatin is a crucial chemoattractant for mouse decidualized endometrial stromal cell migration by JNK signalling”, Journal of Cellular and Molecular Medicine, 2023, 27(1): 127-140.
9. Y. Fan^#, X. Wang^#, J. Ren, F. Lin, J. Wu^*, “Recent advances in acoustofluidic separation technology in biology”, Microsystems & Nanoengineering, 2022, 8, 94.
10. J. Ren, N. Wang, P. Guo, Y. Fan, F. Lin^*, J. Wu^*, “Recent advances in microfluidics-based cell migration research”, Lab on a Chip, 2022, 22, 3361-3376.
11. Y. Zhang, G. Xu, J. Wu, R. Lee, Z. Zhu, Y. Sun, K. Zhu, W. Losert, S. Liao, G. Zhang, T. Pan, Z. Xu^*, F. Lin^*, M. Zhao^*, “Propagation dynamics of electrotactic motility in large epithelial cell sheets”, iScience, 2022, 25(10).
12. Y. Wang, Y. Qi, J. Qi, J. Wu, F. Lin, X. Cui, J. Ge, Z. Liu, “Activin A is a novel chemoattractant for migration of microglial BV2 cells”, Journal of Neuroimmunology, 2022, 371: 577929.
13. Y. Liu, X. Ren, J. Wu, J. Wilkins^*, F. Lin^*, “T cells chemotaxis migration studies with a multi-channel microfluidic device”, Micromachines, 2022, 13(10): 1567.
14. H. Shen^#, M. Duan^#, J. Gao, Y. Wu, Q. Jiang^*, J. Wu, X. Li, S. Jiang, X. Ma, M. Wu, B. Tan, Y. Yin, “ECIS-based biosensors for real-time monitor and classification of the intestinal epithelial barrier damages”, Journal of Electroanalytical Chemistry, 2022, 915, 116334.
15. J. Wu^#*, B. Dai^#, Z. Li, T. Pan, D. Zhang^*, F. Lin^*, “Emerging optofluidic technologies for biodiagnostic applications”, View, 2021, 20200035.
16. B. Dai^#, Y. Long^#, J. Wu^#, S. Huang, Y. Zhao, L. Zheng, C. Tao, S. Guo, F. Lin^*, Y. Fu^*, D. Zhang^*, S. Zhuang, “Generation of flow and droplets with an ultra-long-range linear concentration gradient”, Lab on a Chip, 2021, 21(22): 4390-4400.
17. B. Dai^#, C. Yin^#, J. Wu^#, W. Li, L. Zheng, F. Lin, X. Han, Y. Fu^*, D. Zhang^*, S. Zhuang, “A flux-adaptable pump-free microfluidics-based self-contained platform for multiplex cancer biomarker detection”, Lab on a Chip, 2021, 21(1): 143-153.
18. F. Heide^*, M. McDougall, C. Harder-Viddal, R. Roshko, D. Davidson, J. Wu, C. Aprosoff, A. Moya-Torres, F. Lin, J. Stetefeld^*, “Boron rich nanotube drug carrier system is suited for boron neutron capture therapy”, Scientific Reports, 2021, 11(1): 15520.
19. J. Zhao, J. Wu, X. Wu, G. Deng, Y. Liu, F. Lin^*, L. Zhu^*, “A self-quenching fluorescence probe-mediated exponential isothermal amplification system for highly sensitive and specific detection of microRNAs”, Chemical Communications, 2021, 57 (94), 12599-12602.
20. Q. Jiang^#, J. Wu^#, K. Yao, Y. Yin, C. Yang^*, F. Lin^*, “Paper-based microfluidic device (DON-Chip) for rapid and low-cost deoxynivalenol quantification in foods, feeds and feed ingredients”, ACS Sensors, 2019 4 (11), 3072-3079, DOI: 10.1021/acssensors.9b01895.
21.  B. Dai, S. Chen, W. Li, L. Zheng, X. Han, Y. Fu^*, J. Wu, F. Lin, D. Zhang^*, S. Zhuang, “Fully-functional semi-automated microfluidic immunoassay platform for quantitation of multiple samples”, Sensors and Actuators B: Chemical, 2019, 300: 127017.
22. R. Yang, Q. Hui, Q. Jiang, S. Liu, H. Zhang, J. Wu, F. Lin, K. O, C. Yang^*, “Effect of Manitoba-grown red-osier dogwood extracts on recovering Caco-2 cells from H2O2-induced oxidative damage”, Antioxidants, 2019, 8, 250.
23. J. Li, R, Nickel, J. Wu, F. Lin, J. van Lierop^*, S. Liu^*, “A new tool to attack biofilms: Driving magnetic iron-oxide nanoparticles to disrupt the matrix”, Nanoscale, 2019, 11(14):6905-6915.
24. X. Ren, J. Wu, D. Levin, S. Santos, R. Lobato de Faria, M. Zhang, F. Lin^*, “Sputum from chronic obstructive pulmonary disease patients inhibits T cell migration in a microfluidic device”, Annals of the New York Academy of Sciences, 2019, doi: 10.1111/nyas.14029.
25. K. Yang, J. Wu, S. Santos, Y. Liu, L. Zhu^*, F. Lin^*, “Recent development of portable imaging platforms for cell-based assays”, Biosensors and Bioelectronics, 2019, 124-125, 150-160.
26. J. Wu, D. Tomsa, M. Zhang, P. Komenda, N. Tangri, C. Rigatto, F. Lin^*, "A passive mixing microfluidic urinary albumin chip for chronic kidney disease assessment", ACS Sensors, 2018, 3(10):2191-2197.
27. J. Wu, A. Kumar-Kanojia, S. Hombach-Klonisch, T. Klonisch^*, F. Lin^*, "A radial microfluidic platform for higher throughput chemotaxis studies with individual gradient control", Lab on a Chip, 2018, 18, 3855 - 3864.
28. J. Wu, M.L. Dong, C. Rigatto, Y. Liu, F. Lin^*, “Lab-on-chip technology for chronic disease diagnosis”, npj Digital Medicine, 1.1 (2018): 7.
29. K. Yang^#, J. Wu^#, H. Peretz-Soroka, L. Zhu, Z. Li, Y. Sang, J. Hipolito, M. Zhang, S. Santos, C. Hillier, R. de Faria, Y. Liu^*, F. Lin^*, “Mkit: a cell migration assay based on microfluidic device and smartphone”, Biosensors and Bioelectronics, 2018, 99:259-267.
30. J. Wu^#, M. Dong^#, S. Santos, C. Rigatto, Y. Liu^*, F. Lin^*, “Lab-on-chip platforms for detection of cardiovascular disease and cancer biomarkers”, Sensors, 2017, 17(12), 2934.
31. Y. Ke^#, J. Wu^#, L. Zhu, Y. Liu, M. Zhang, F. Lin, “An all-on-chip method for rapid neutrophil chemotaxis analysis directly from a drop of blood”, Journal of Visualized Experiments, 2017, (124), e55615.
32. Y. Ke^#, J. Wu^#, G. Xu, D. Xie, H. Peretz-Soroka, S. Santos, M. Alexander, L. Zhu, M. Zhang, Y. Liu, F. Lin^*, "A dual-docking microfluidic cell migration assay (D²-Chip) for testing neutrophil chemotaxis and the memory effect", Integrative Biology, 2017, 9(4), 303-312.
33. M. Dong, J. Wu, Z.M. Ma, H. Peretz-Soroka, M. Zhang, P. Komenda, N. Tangri, Y. Liu^*, C. Rigatto^*, F. Lin^*, "Rapid and low-cost CRP measurement by integrating a paper-based microfluidic immunoassay with smartphone (CRP-Chip)", Sensors, 2017, 17(4), 684.
34. D. Xie^#, Z. Liu^#, J. Wu, W. Feng, K. Yang, J. Deng, G. Tian, S. Santos, X. Cui^*, F. Lin^*, "The effects of activin A on the migration of human breast cancer cells and neutrophils and their migratory interaction", Experimental Cell Research, 2017, 357, 107–115.
35. K. Yang, H. Peretz-Soroka, J. Wu, L. Zhu, X. Cui, M. Zhang, C. Rigatto, Y. Liu, F. Lin^*, "Fibroblast growth factor 23 weakens chemotaxis of human blood neutrophils in microfluidic devices", Scientific Reports, 2017, 7: 3100.
36. Y. Zhang, G. Xu, R. Lee, Z. Zhu, J. Wu, S. Liao, G. Zhang, Y. Sun, A. Mogilner, W. Losert, T. Pan, F. Lin^*, Z. Xu^*, M. Zhao^*, “Collective Cell Migration has Distinct Directionality and Speed Dynamics”, Cellular and Molecular Life Sciences, 2017, DOI 10.1007/s00018-017-2553-6.
37. J. Wu, C. Hillier, P. Komenda, R. Lobato de Faria, S. Santos, D. Levin, M. Zhang, F. Lin^*, “An all-on-chip method for testing neutrophil chemotaxis induced by fMLP and COPD patient’s sputum”, Technology, 2016, 4(02): 104-109.
38. J. Wu, C. Hillier, P. Komenda, R. Lobato de Faria, D. Levin, M. Zhang^*, F. Lin^*, “A microfluidic platform for evaluating neutrophil chemotaxis induced by sputum from COPD patients”, PLoS ONE, 2015, 10(5): e0126523.
39. I. Halilovic, J. Wu, M. Alexander, F. Lin^*, “Neutrophil migration under spatially-varying chemoattractant gradient profiles”, Biomedical Microdevices, 2015, Jun; 17(3):9963.
40. X. Wu, J. Wu, H. Li, D.F. Legler, A. J. Marshall, F. Lin^*, “Analysis of CCR7 mediated T cell transfectant migration using a microfluidic gradient generator”, Journal of Immunological Methods, 2015, 419: 9-17.
41. J. Wu, L. Ouyang, N. Wadhawana, J. Li, M. Zhang, S. Liao, D. Levin, F. Lin^*, "A compact microfluidic system for cell migration studies", Biomedical Microdevices, 2014, 16(4): 521-528.
42. J. Wu, F. Lin^*, “Recent developments in electrotaxis assays". Advances in Wound Care, 2014, 3(2):149-155.
43. J. Wu, X. Wu, F. Lin^*, “Recent developments in microfluidics-based chemotaxis studies". Lab on a Chip, 2013, 13(13):2484-99. Most read article for Jun. 2013.

1. F. Lin, J. Wu, C. Rigatto, P. Komenda, N. Tangri, M. Zhang, A passive mixing microfluidic urinary albumin chip (UAL-Chip) for chronic kidney disease assessment, 2026-02-17, Canadian Patent (issued), CA3108813C.
2. F. Lin, J. Wu, C. Rigatto, P. Komenda, N. Tangri, M. Zhang, Passive mixing microfluidic urinary albumin chip (UAL-Chip) for chronic kidney disease, 2025-01-07, US Patent (issued), US12816753B2.
3. F. Lin, J. Wu, C. Rigatto, P. Komenda, N. Tangri, M. Zhang, A passive mixing microfluidic urinary albumin chip (UAL-Chip) for chronic kidney disease assessment, 2023-05-24, European Patent (issued), EP3857210B1.
4. Q. Jiang, J. Wu, F. Lin, C. Yang, Paper-based microfluidic DON-Chip for rapid and low-cost deoxynivalenol quantification in foods, feeds and feed ingredients, 2019-09-26, US Patent, US20220326209A1.
5. F. Lin, J. Wu, Method for development of microfluidic assay device prototype, 2019-08-08, US Patent, US20210299657A1.
6. F. Lin, J. Wu, Low-cost portable microfluidic system for cell migration studies, 2018-05-29, US patent (issued), US9983197B2.

1. J. Wu, F. Lin, Micro-engineered tools for studying cell migration in electric fields, Cambridge University Press, 2015

1. J. Wu, L. Ouyang, N. Wadhawan, J. Li, M. Zhang, S. Liao, D. Levin, F. Lin, “A passive mixing microfluidic urinary albumin chip for chronic kidney disease assessment”, The Manitoba Materials conference, Winnipeg, MB, May 2019. Best Poster Award.
2. J. Wu, X. Ren, J. Hipolito, N. Jimeno, F. Lin, “Integration of 3D extracellular matrix and flow-based chemical field generation in a microfluidic device for cell migration study”, Biomedical Engineering Society Annual Meeting, October 17-20, 2018, Atlanta, Georgia
3. J. Wu, A. Kumar-Kanojia, S. Hombach-Klonisch, T. Klonisch, F. Lin, “A radial microfluidic platform for higher throughput chemotaxis studies with individual gradient control”, Biomedical Engineering Society Annual Meeting, October 17-20, 2018, Atlanta, Georgia.
4. J. Wu, D. Tomsa, M. Zhang, P. Komenda, N. Tangri, C. Rigatto, F. Lin, “A passive mixing microfluidic urinary albumin chip (UAL-Chip) for chronic kidney disease assessment”, Biomedical Engineering Society Annual Meeting, October 17-20, 2018, Atlanta, Georgia.
5. X. Ren, J. Wu, F. Lin. “Investigating T cell migration in chronic obstructive pulmonary disease using a microfluidic device”, Biomedical Engineering Society Annual Meeting, October 17-20, 2018, Atlanta, Georgia.
6. M. Dong, J. Wu, Z. Ma, H. Peretz-Soroka, M. Zhang, P. Komenda, N. Tangri, Y. Liu, C. Rigatto, F. Lin, “Rapid on-chip protein biomarker detection and data mining analysis for chronic kidney disease assessment”, Biomedical Engineering Society Annual Meeting, October 11-14, 2017, Phoenix, Arizona.
7. K. Yang, J. Wu, G. Xu, D. Xie, H. Peretz-Soroka, S. Santos, M. Alexander, L. Zhu, M. Zhang, X. Ren, Y. Liu, F. Lin, “A dual-docking microfluidic device for studying immune cell migration and chemotaxis”, Biomedical Engineering Society Annual Meeting, October 11-14, 2017, Phoenix, Arizona.
8. K. Yang, H. Peretz-Soroka, J. Wu, L. Zhu, X. Cui, M. Zhang, C. Rigatto, Y. Liu, F. Lin, “Studying the effect of fibroblast growth factor 23 on neutrophil chemotaxis using microfluidic devices”, Biomedical Engineering Society Annual Meeting, October 11-14, 2017, Phoenix, Arizona.
9. K. Yang, J. Wu, H. Peretz-Soroka, L. Zhu, Z. Li, Y. Sang, J. Hipolito, M. Zhang, S. Santos, Y. Liu, F. Lin, “A Smartphone-based Microfluidic Cell Migration Assay”, Biomedical Engineering Society Annual Meeting, October 11-14, 2017, Phoenix, Arizona.
10. M. Dong, J. Wu, Z. Ma, H. Peretz-Soroka, M. Zhang, P. Komenda, N. Tangri, Y. Liu, C. Rigatto, F. Lin, “Rapid CRP detection using a paper microfluidic chip”, SelectBio Conference: POC Diagnostics, Global Health-Viral Diseases 2017, October 02-04, 2017, Coronado Island, California.
11. J. Wu, F. Lin, “An all-on-chip method for testing neutrophil chemotaxis from one drop of blood”, SelectBio Conference: Lab-on-a-Chip and Microfluidics: Emerging Themes, Technologies and Applications, October 02-04, 2017, Coronado Island, California.
12. M. Dong, J. Wu, Z. Ma, H. Peretz-Soroka, M. Zhang, P. Komenda, N. Tangri, Y. Liu, C. Rigatto, F. Lin, “Rapid CRP detection using a paper microfluidic chip”, Canadian Biomaterials Society Annual Meeting, Winnipeg, MB, May 2017.
13. X. Wu, S. Lafarge, A. Ali, J. Wu, F. Lin, S. Gibson, A. Marshall, “Role of pi3k enzymes in chronic lymphocytic leukemia and interaction with lymphoid tissue microenvironment”, Canadian Society of Immunology Conference, Winnipeg, MB, June 2015.
14. J. Wu, C. Hillier, P. Komenda, R. L. de Faria, D. Levin, M. Zhang, F. Lin, “Quantitative characterizations of neutrophil chemotaxis in COPD using a microfluidics-based approach”, The Manitoba Materials Conference, Winnipeg, MB, May 2015.
15. J. Wu, C. Hillier, P. Komenda, R. de Faria, D. Levin, M. Zhang, F. Lin, “Quantitative characterizations of neutrophil chemotaxis in COPD using a microfluidics-based approach”, The ASME 2015 4th Global Congress on NanoEngineering for Medicine and Biology, April 2015, Minneapolis, MN, USA. Honorable mention.
16. J. Wu, L. Ouyang, M. Zhang, S. Liao, C. Hillier, P. Komenda, R. de Faria, F. Lin, “Assessing neutrophil chemotaxis in COPD using a compact microfluidic system”, The 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC’14), Chicago, U.S.A., August 26-30, 2014.
17. J. Wu, L. Ouyang, M. Zhang, S. Liao, C. Hillier, P. Komenda, R. de Faria, F. Lin, “Assessing neutrophil chemotaxis in COPD using a compact microfluidic system”, Prairie Infectious Immunology Network (PIIN) Meeting, Hekla, MB, May 2014.
18. X. Wu, H. Li, J. Wu, D. Legler, A. Marshall, F. Lin, “Quantitative cell migration analysis of jurkat transfectants using a microfluidic device”, Prairie Infectious Immunology Network (PIIN) Meeting, Hekla, MB, May 2014. Honorable mention.
19. J. Wu, L. Ouyang, M. Zhang, S. Liao, C. Hillier, P. Komenda, R. de Faria, F. Lin, “Assessing neutrophil chemotaxis in COPD using a compact microfluidic system”, The Manitoba Materials Conference, Winnipeg, MB, May 2014.
20. I. Halilovic, J. Wu, F. Lin, "Neutrophil migration in a step-like chemoattractant gradient", University of Manitoba Undergraduate Student Research Poster Competition, Winnipeg, MB, Canada, October 2013.
21. J. Wu, F. Lin, "A simple and rapid method for neutrophil enrichment and chemotaxis Analysis", Biomedical Engineering Society Annual Meeting, Seattle, WA, USA, September 2013.
22. J. Wu, L. Ouyang, N. Wadhawan, J. Li, M. Zhang, S. Liao, D. Levin, F. Lin, “A low-cost portable microfluidic system for cell migration studies”, The Manitoba Materials conference, Winnipeg, MB, May 2013.
23. X. Wu, J. Wu, H.Z. Li, S. Pauls, A. Marshall, F. Lin, “Studying jurkat cell migration using a PDMS microfluidic device”, The Manitoba Materials Conference, Winnipeg, MB, May 2013.
24.  D. Ogundu, J. Wu, F. Lin, "A new microfluidic device for parallel gradient generation", 2012 Undergraduate Student Research Poster Competition, University of Manitoba, Winnipeg, MB, November 2012.
25. J. Wu, L. Ouyang, N. Wadhawan, J. Li, M. Zhang, S. Lao, F. Lin, “A low-cost portable microfluidic system for cell migration studies”, Prairie Infectious Immunology Network (PIIN) Meeting, Moose Jaw, SK, September 2012.
26. J. Wu, F. Lin, "A simple craft cutting based microfluidic device for chemical gradient generation and cell migration studies", The Manitoba Materials Conference, Winnipeg, MB, May 2012. Best Poster Award.