基本信息
焦建伟  男  博导  中国科学院动物研究所
电子邮件: jwjiao@ioz.ac.cn
通信地址: 北京市朝阳区北辰西路1号院5号
邮政编码: 100101

研究领域

实验室围绕干细胞与再生医学,重点研究神经干细胞分化机制,脑发育表观遗传调控机制,以及神经细胞的转分化。目前承担国家杰出青年基金、国家重点研发计划、中科院战略先导专项等。

招生信息

招生专业


发育生物学
神经生物学
细胞生物学

招收对干细胞和神经发育感兴趣的学生

招生专业
1001J6-再生医学
071008-发育生物学
071006-神经生物学
招生方向
神经干细胞与脑疾病
神经发育
神经影像

教育背景

1996-09--2002-07   北京大学   博士
学历
-- 研究生
学位
-- 博士

工作经历

   
工作简历
2011-08~现在, 中国科学院动物研究所, 博士生导师/研究员
2008-12~2011-07,中科院神经所, 博士生导师/研究员
2002-09~2008-11,哈佛医学院, 博士后, Instructor
社会兼职
2018-11-01-今,生理学会, 理事
2016-01-01-今,神经学会, 神经发育与再生分会委员
2016-01-01-今,神经学会, 神经干细胞与组织工程分会委员
2010-01-01-今,中国细胞生物学学报, 编委

教授课程

干细胞生物学
组织工程学
神经生物学

专利与奖励

   
专利成果
[1] 焦建伟, 史子啸. 一种诱导成纤维细胞转分化为神经元细胞的方法及其应用. 中国: CN105331634A, 2016-02-17.

出版信息

   
发表论文
[1] Ma, Hongyan, Su, Libo, Xia, Wenlong, Wang, Wenwen, Tan, Guohe, Jiao, Jianwei. MacroH2A1.2 deficiency leads to neural stem cell differentiation defects and autism-like behaviors. EMBO REPORTS[J]. 2021, 22(7): http://dx.doi.org/10.15252/embr.202052150.
[2] Zhang, Mengtian, Zhao, Jinyue, Lv, Yuqing, Wang, Wenwen, Feng, Chao, Zou, Wenzheng, Su, Libo, Jiao, Jianwei. Histone Variants and Histone Modifications in Neurogenesis. TRENDS IN CELL BIOLOGYnull. 2020, 30(11): 869-880, https://www.webofscience.com/wos/woscc/full-record/WOS:000581926700004.
[3] Ji, Fen, Wang, Wenwen, Feng, Chao, Gao, Fei, Jiao, Jianwei. Brain-specific Wt1 deletion leads to depressive-like behaviors in mice via the recruitment of Tet2 to modulate Epo expression. MOLECULAR PSYCHIATRY. 2020, https://www.webofscience.com/wos/woscc/full-record/WOS:000531916400002.
[4] Feng, Chao, Zhao, Jinyue, Ji, Fen, Su, Libo, Chen, Yihui, Jiao, Jianwei. TCF20 dysfunction leads to cortical neurogenesis defects and autistic-like behaviors in mice. EMBO REPORTS[J]. 2020, 21(8): https://www.webofscience.com/wos/woscc/full-record/WOS:000538608900001.
[5] Zhang, Dongming, Liu, Chang, Li, Hong, Jiao, Jianwei. Deficiency of STING Signaling in Embryonic Cerebral Cortex Leads to Neurogenic Abnormalities and Autistic-Like Behaviors. ADVANCED SCIENCE[J]. 2020, 7(23): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000584526200001.
[6] Liang, Qingli, Su, Libo, Zhang, Dongming, Jiao, Jianwei. CD93 negatively regulates astrogenesis in response to MMRN2 through the transcriptional repressor ZFP503 in the developing brain. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2020, 117(17): 9413-9422, [7] Zou, Wenzheng, Lv, Yuqing, Liu, Zux Iang, Xia, Pengyan, Li, Hong, Jiao, Jianwei. Loss of Rsph9 causes neonatal hydrocephalus with abnormal development of motile cilia in mice. SCIENTIFIC REPORTS[J]. 2020, 10(1): http://dx.doi.org/10.1038/s41598-020-69447-4.
[8] Su, Libo, Lei, Xuepei, Ma, Hongyan, Feng, Chao, Jiang, Jing, Jiao, Jianwei. PRDM16 orchestrates angiogenesis via neural differentiation in the developing brain. CELL DEATH AND DIFFERENTIATION[J]. 2020, 27(8): 2313-2329, https://www.webofscience.com/wos/woscc/full-record/WOS:000510821900002.
[9] Li, Yanxin, Jiao, Jianwei. Deficiency of TRPM2 leads to embryonic neurogenesis defects in hyperthermia. SCIENCE ADVANCES[J]. 2020, 6(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000507552400026.
[10] Li, Zhongqiu, Li, Yanxin, Jiao, Jianwei. Neural progenitor cells mediated by H2AZ2 regulate microglial development via Cxcl14 in the embryonic brain. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2019, 116(48): 24122-24132, https://www.webofscience.com/wos/woscc/full-record/WOS:000499101100042.
[11] Shuangquan Chen, Juan Zhang, Dongming Zhang, Jianwei Jiao. Acquisition of functional neurons by direct conversion:Switching the developmental clock directly. 遗传学报:英文版null. 2019, 46(10): 459-465, http://lib.cqvip.com/Qikan/Article/Detail?id=7101033524.
[12] Chen, Shuangquan, Zhang, Juan, Zhang, Dongming, Jiao, Jianwei. Acquisition of functional neurons by direct conversion: Switching the developmental clock directly. JOURNAL OF GENETICS AND GENOMICSnull. 2019, 46(10): 459-465, http://lib.cqvip.com/Qikan/Article/Detail?id=7101033524.
[13] Liang, Qingli, Xia, Wenlong, Li, Wei, Jiao, Jianwei. RNF20 controls astrocytic differentiation through epigenetic regulation of STAT3 in the developing brain. CELL DEATH AND DIFFERENTIATION[J]. 2018, 25(2): 294-306, https://www.webofscience.com/wos/woscc/full-record/WOS:000424342100006.
[14] Shen, Tianjin, Ji, Fen, Wang, Yuanyuan, Lei, Xuepei, Zhang, Dongming, Jiao, Jianwei. Brain-specific deletion of histone variant H2A.z results in cortical neurogenesis defects and neurodevelopmental disorder. NUCLEIC ACIDS RESEARCH[J]. 2018, 46(5): 2290-2307, https://www.webofscience.com/wos/woscc/full-record/WOS:000427677100019.
[15] Yu, Yang, Wang, Xiaoxiao, Zhang, Xiaoxin, Zhai, Yanhua, Lu, Xukun, Ma, Haixia, Zhu, Kai, Zhao, Tongbiao, Jiao, Jianwei, Zhao, ZhenAo, Li, Lei. ERK inhibition promotes neuroectodermal precursor commitment by blocking self-renewal and primitive streak formation of the epiblast. STEM CELL RESEARCH & THERAPY[J]. 2018, 9(1): https://doaj.org/article/764aa9c206ec4311b97d8dcf2be4e4de.
[16] Lei, Xuepei, Jiao, Jianwei. UTX Affects Neural Stem Cell Proliferation and Differentiation through PTEN Signaling. STEM CELL REPORTS[J]. 2018, 10(4): 1193-1207, http://dx.doi.org/10.1016/j.stemcr.2018.02.008.
[17] Jianwei Jiao. Cold-induced protein RBM3 orchestrates neurogenesis via modulating Yap mRNA stability during cold stress. J Cell Biol. 2018, [18] Su, Libo, Xia, Wenlong, Shen, Tianjin, Liang, Qingli, Wang, Wenwen, Li, Hong, Jiao, Jianwei. H2AZ1 crosstalk with H3K56-acetylation controls gliogenesis through the transcription of folate receptor. NUCLEIC ACIDS RESEARCH[J]. 2018, 46(17): 8817-8831, https://www.webofscience.com/wos/woscc/full-record/WOS:000450952000019.
[19] Qiao, Huimin, Li, Yanxin, Feng, Chao, Duo, Shuguang, Ji, Fen, Jiao, Jianwei. Nap1l1 Controls Embryonic Neural Progenitor Cell Proliferation and Differentiation in the Developing Brain. CELL REPORTS[J]. 2018, 22(9): 2279-2293, http://dx.doi.org/10.1016/j.celrep.2018.02.019.
[20] Gao, Fengyi, Li, Guoping, Liu, Chao, Gao, Hui, Wang, Hao, Liu, Weixiao, Chen, Min, Shang, Yongliang, Wang, Lina, Shi, Jian, Xia, Wenlong, Jiao, Jianwei, Gao, Fei, Li, Jian, Chen, Liang, Li, Wei. Autophagy regulates testosterone synthesis by facilitating cholesterol uptake in Leydig cells. JOURNAL OF CELL BIOLOGY[J]. 2018, 217(6): 2103-2119, https://www.webofscience.com/wos/woscc/full-record/WOS:000438077800021.
[21] Xia, Wenlong, Su, Libo, Jiao, Jianwei. Cold-induced protein RBM3 orchestrates neurogenesis via modulating Yap mRNA stability in cold stress. JOURNAL OF CELL BIOLOGY[J]. 2018, 217(10): 3464-3479, [22] Ji, Fen, Shen, Tianjin, Zou, Wenzheng, Jiao, Jianwei. UCP2 Regulates Embryonic Neurogenesis via ROS-Mediated Yap Alternation in the Developing Neocortex. STEM CELLS[J]. 2017, 35(6): 1479-1492, [23] Li Yanxin, Jiao Jianwei. Histone Chaperone HIRA Regulates Neural Progenitor Cell Proliferation and Neurogenesis via β-Catenin. Journal of Cell Biology[J]. 2017, 216(7): 1975-1992, http://ir.ioz.ac.cn/handle/000000/12777.
[24] Liu, Chao, Song, Zhenhua, Wang, Lina, Yu, Haiyan, Liu, Weixiao, Shang, Yongliang, Xu, Zhiliang, Zhao, Haichao, Gao, Fengyi, Wen, Jiamin, Zhao, Linan, Gui, Yaoting, Jiao, Jianwei, Gao, Fei, Li, Wei. Sirt1 regulates acrosome biogenesis by modulating autophagic flux during spermiogenesis in mice. DEVELOPMENT[J]. 2017, 144(3): 441-451, http://dx.doi.org/10.1242/dev.147074.
[25] Li, Yanxin, Jiao, Jianwei. Histone chaperone HIRA regulates neural progenitor cell proliferation and neurogenesis via beta-catenin. JOURNAL OF CELL BIOLOGY[J]. 2017, 216(7): 1975-1992, https://www.webofscience.com/wos/woscc/full-record/WOS:000404563700017.
[26] 张娟, 陈双全, DongMing Zhang, 史子啸, 李红, 赵同标, 胡宝洋, 周琪, 焦建伟. TET3介导的DNA去甲基化诱导成纤维细胞转分化为功能神经元. 科学新闻. 2017, 164-164, http://lib.cqvip.com/Qikan/Article/Detail?id=672078148.
[27] 李忠秋, 焦建伟. 小胶质细胞的发育及在中枢神经系统的功能研究进展. 中国药理学与毒理学杂志[J]. 2017, 1050-1056, http://lib.cqvip.com/Qikan/Article/Detail?id=89766683504849554949484853.
[28] Xia, Wenlong, Jiao, Jianwei. Histone variant H3.3 orchestrates neural stem cell differentiation in the developing brain. CELL DEATH AND DIFFERENTIATION[J]. 2017, 24(9): 1548-1563, https://www.webofscience.com/wos/woscc/full-record/WOS:000407506500010.
[29] Yan, Long, Li, Yue, Shi, Zixiao, Lu, Xiaoyin, Ma, Jiao, Hu, Baoyang, Jiao, Jianwei, Wang, Hongmei. The zinc finger E-box-binding homeobox 1 (Zeb1) promotes the conversion of mouse fibroblasts into functional neurons. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2017, 292(31): 12959-12970, http://dx.doi.org/10.1074/jbc.M116.771493.
[30] Liu, Pinglei, Liu, Kun, Gu, Haifeng, Wang, Weixu, Gong, Jiaqi, Zhu, Yingjie, Zhao, Qian, Cao, Jiani, Han, Chunseng, Gao, Fei, Chen, Quan, Li, Wei, Jiao, Jianwei, Hu, Baoyang, Zhou, Qi, Zhao, Tongbiao. High autophagic flux guards ESC identity through coordinating autophagy machinery gene program by FOXO1. CELL DEATH AND DIFFERENTIATION[J]. 2017, 24(10): 1672-1680, https://www.webofscience.com/wos/woscc/full-record/WOS:000410166300002.
[31] Shi, Zixiao, Zhang, Juan, Chen, Shuangquan, Li, Yanxin, Lei, Xuepei, Qiao, Huimin, Zhu, Qianwen, Hu, Baoyang, Zhou, Qi, Jiao, Jianwei. Conversion of Fibroblasts to Parvalbumin Neurons by One Transcription Factor, Ascl1, and the Chemical Compound Forskolin. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2016, 291(26): 13560-13570, http://dx.doi.org/10.1074/jbc.M115.709808.
[32] Zhang, Chao, Cao, Jiani, Li, Xiaoyan, Xu, Haoyu, Wang, Weixu, Wang, Libin, Zhao, Xiaoyang, Li, Wei, Jiao, Jianwei, Hu, Baoyang, Zhou, Qi, Zhao, Tongbiao. Treatment of multiple sclerosis by transplantation of neural stem cells derived from induced pluripotent stem cells. SCIENCE CHINA-LIFE SCIENCES[J]. 2016, 59(9): 950-957, https://www.webofscience.com/wos/woscc/full-record/WOS:000382944400010.
[33] 张东明, 焦建伟. 神经细胞有效性安全性评估. 生命科学[J]. 2016, 28(8): 883-887, [34] Wang, Shukun, Liang, Qingli, Qiao, Huimin, Li, Hong, Shen, Tianjin, Ji, Fen, Jiao, Jianwei. DISC1 regulates astrogenesis in the embryonic brain via modulation of RAS/MEK/ERK signaling through RASSF7. DEVELOPMENT[J]. 2016, 143(15): 2732-2740, https://www.webofscience.com/wos/woscc/full-record/WOS:000393285000006.
[35] Zhang, Juan, Chen, Shuangquan, Zhang, Dongming, Shi, Zixiao, Li, Hong, Zhao, Tongbiao, Hu, Baoyang, Zhou, Qi, Jiao, Jianwei. Tet3-Mediated DNA Demethylation Contributes to the Direct Conversion of Fibroblast to Functional Neuron. CELL REPORTS[J]. 2016, 17(9): 2326-2339, http://dx.doi.org/10.1016/j.celrep.2016.10.081.
[36] Liu, Kun, Zhao, Qian, Liu, Pinglei, Cao, Jiani, Gong, Jiaqi, Wang, Chaoqun, Wang, Weixu, Li, Xiaoyan, Sun, Hongyan, Zhang, Chao, Li, Yufei, Jiang, Minggui, Zhu, Shaohua, Sun, Qingyuan, Jiao, Jianwei, Hu, Baoyang, Zhao, Xiaoyang, Li, Wei, Chen, Quan, Zhou, Qi, Zhao, Tongbiao. ATG3-dependent autophagy mediates mitochondrial homeostasis in pluripotency acquirement and maintenance. AUTOPHAGY[J]. 2016, 12(11): 2000-2008, https://www.webofscience.com/wos/woscc/full-record/WOS:000387665000004.
[37] Jiang, Huihui, Lv, Xiaohui, Lei, Xuepei, Yang, Ying, Yang, Xin, Jiao, Jianwei. Immune Regulator MCPIP1 Modulates TET Expression during Early Neocortical Development. STEM CELL REPORTS[J]. 2016, 7(3): 439-453, http://dx.doi.org/10.1016/j.stemcr.2016.07.011.
[38] Shi Zixiao, Zhang Juan, Chen Shuangquan, Li Yanxin, Lei Xuepei, Qiao Huimin, Zhu Qianwen, Hu Baoyang, Zhou Qi, Jiao Jianwei. Conversion of Fibroblasts to Parvalbumin Neurons by One Transcription Factor, Ascl1, and the Chemical Compound Forskolin.. The Journal of biological chemistry. 2016, 13560-13570, http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=1&recid=&FileName=SJPDD5E9A2904D3189DAE5B968FECA4B6265&DbName=SJPD_06&DbCode=SJPD&yx=&pr=&URLID=&bsm=.
[39] Zhang, Juan, Jiao, Jianwei. Molecular Biomarkers for Embryonic and Adult Neural Stem Cell and Neurogenesis. BIOMED RESEARCH INTERNATIONALnull. 2015, 2015: https://doaj.org/article/532ad8c4bece4a10b396256a434acc47.
[40] Shen, Tianjin, Ji, Fen, Yuan, Zengqiang, Jiao, Jianwei. CHD2 is Required for Embryonic Neurogenesis in the Developing Cerebral Cortex. STEM CELLS[J]. 2015, 33(6): 1794-1806, https://www.webofscience.com/wos/woscc/full-record/WOS:000354882500010.
[41] Xia, Wenlong, Liu, YanLi, Jiao, Jianwei. GRM7 Regulates Embryonic Neurogenesis via CREB and YAP. STEM CELL REPORTS[J]. 2015, 4(5): 795-810, http://dx.doi.org/10.1016/j.stemcr.2015.03.004.
[42] Shen, Tianjin, Ji, Fen, Jiao, Jianwei. Epigenetics: major regulators of embryonic neurogenesis. SCIENCE BULLETINnull. 2015, 60(20): 1734-1743, http://dx.doi.org/10.1007/s11434-015-0871-3.
[43] Zhang, Juan, Ji, Fen, Liu, Yanli, Lei, Xuepei, Li, Hong, Ji, Guangju, Yuan, Zengqiang, Jiao, Jianwei. Ezh2 Regulates Adult Hippocampal Neurogenesis and Memory. JOURNAL OF NEUROSCIENCE[J]. 2014, 34(15): 5184-5199, https://www.webofscience.com/wos/woscc/full-record/WOS:000334347700013.
[44] Yao, Minghui, Wang, Yadong, Zhang, Peng, Chen, Hong, Xu, Zhiheng, Jiao, Jianwei, Yuan, Zengqiang. BMP2-SMAD Signaling Represses the Proliferation of Embryonic Neural Stem Cells through YAP. JOURNAL OF NEUROSCIENCE[J]. 2014, 34(36): 12039-12048, https://www.webofscience.com/wos/woscc/full-record/WOS:000341765400016.
[45] Lv, Xiaohui, Jiang, Huihui, Liu, Yanli, Lei, Xuepei, Jiao, Jianwei. MicroRNA-15b promotes neurogenesis and inhibits neural progenitor proliferation by directly repressing TET3 during early neocortical development. EMBO REPORTS[J]. 2014, 15(12): 1305-1314, https://www.webofscience.com/wos/woscc/full-record/WOS:000345765800013.
[46] Jiang, Mei Hua, Cai, Bing, Tuo, Ying, Wang, Jiancheng, Zang, Zhi Jun, Tu, Xiangan, Gao, Yong, Su, Zhijian, Li, Weiqiang, Li, Guilan, Zhang, Min, Jiao, Jianwei, Wan, Zi, Deng, Chunhua, Lahn, Bruce T, Xiang, Andy Peng. Characterization of Nestin-positive stem Leydig cells as a potential source for the treatment of testicular Leydig cell dysfunction. CELL RESEARCH[J]. 2014, 24(12): 1466-1485, https://www.webofscience.com/wos/woscc/full-record/WOS:000345894800010.
[47] 蒲慕明. SIRT1 suppresses self-renewal of adult hippocampal neural stem cells. Development[J]. 2014, 141(24): 4697-4709, http://ir.sibs.ac.cn/handle/331001/2679.
[48] Lv, Xiaohui, Jiang, Huihui, Li, Baoguo, Liang, Qingli, Wang, Shukun, Zhao, Qianwei, Jiao, Jianwei. The Crucial Role of Atg5 in Cortical Neurogenesis During Early Brain Development. SCIENTIFIC REPORTS[J]. 2014, 4: https://www.webofscience.com/wos/woscc/full-record/WOS:000340604400002.
[49] Wang, Shukun, Li, Baoguo, Qiao, Huimin, Lv, Xiaohui, Liang, Qingli, Shi, Zixiao, Xia, Wenlong, Ji, Fen, Jiao, Jianwei. Autophagy-related gene Atg5 is essential for astrocyte differentiation in the developing mouse cortex. EMBO REPORTS[J]. 2014, 15(10): 1053-1061, https://www.webofscience.com/wos/woscc/full-record/WOS:000342890700008.
[50] Shi, Zixiao, Shen, Tianjin, Liu, Yanli, Huang, Yuanyuan, Jiao, Jianwei. Retinoic Acid Receptor gamma (Rarg) and Nuclear Receptor Subfamily 5, Group A, Member 2 (Nr5a2) Promote Conversion of Fibroblasts to Functional Neurons. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2014, 289(10): 6415-6428, https://www.webofscience.com/wos/woscc/full-record/WOS:000332389400010.
[51] Yuanyuan Huang, Yanli Liu, Zixiao Shi, Tianjin Shen, Jianwei Jiao. Retinoic acid receptor gamma (rarg) and nuclear receptor subfamily 5, group a, member 2 (nr5a2) promote conversion of fibroblasts to functional neurons.. The journal of biological chemistry[J]. 2014, http://www.corc.org.cn/handle/1471x/2159027.
[52] Ji, Fen, Lv, Xiaohui, Jiao, Jianwei. The Role of microRNAs in Neural Stem Cells and Neurogenesis. JOURNAL OF GENETICS AND GENOMICSnull. 2013, 40(2): 61-66, http://dx.doi.org/10.1016/j.jgg.2012.12.008.
[53] Meng, Fengxi, Chen, Siye, Miao, Qinglong, Zhou, Kechun, Lao, Qicheng, Zhang, Xiaohui, Guo, Wenyi, Jiao, Jianwei. Induction of fibroblasts to neurons through adenoviral gene delivery. CELL RESEARCHnull. 2012, 22(2): 436-440, http://lib.cqvip.com/Qikan/Article/Detail?id=42510485.
[54] Zhao, Junli, He, Hua, Zhou, Kechun, Ren, Yonggang, Shi, Zixiao, Wu, Zhiyuan, Wang, Yizheng, Lu, Yicheng, Jiao, Jianwei. Neuronal Transcription Factors Induce Conversion of Human Glioma Cells to Neurons and Inhibit Tumorigenesis. PLOS ONE[J]. 2012, 7(7): http://www.irgrid.ac.cn/handle/1471x/647534.
[55] Shi, Zixiao, Jiao, Jianwei. Direct lineage conversion: induced neuronal cells and induced neural stem cells. PROTEIN & CELLnull. 2012, 3(11): 826-833, https://www.webofscience.com/wos/woscc/full-record/WOS:000310970600005.
[56] Jiao, JianWei, Feldheim, David A, Chen, Dong Feng. Ephrins as negative regulators of adult neurogenesis in diverse regions of the central nervous system. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2008, 105(25): 8778-8783, https://www.webofscience.com/wos/woscc/full-record/WOS:000257185700053.
[57] Jianwei Jiao. Induction of neurogenesis in non-conventional neurogenic regions of the adult CNS by niche astrocyte-produced signals. Stem Cells. 2008, [58] Jiao, JW, Huang, XZ, FeitLeithman, RA, Neve, RL, Snider, W, Dartt, DA, Chen, DF. Bcl-2 enhances Ca2+ signaling to support the intrinsic regenerative capacity of CNS axons. EMBO JOURNAL[J]. 2005, 24(5): 1068-1078, https://www.webofscience.com/wos/woscc/full-record/WOS:000227495100018.

科研活动

   
科研项目
( 1 ) 神经细胞的转分化研究, 主持, 部委级, 2011-01--2015-12
( 2 ) 小分子药物调控细胞命运及其机理研究, 参与, 国家级, 2015-01--2019-12
( 3 ) 调节表观遗传修饰提高胚胎干细胞多能性水平和细胞转分化与重编程效率的方法研究, 主持, 国家级, 2014-01--2018-08
( 4 ) 组蛋白变体对脑发育的调控机制研究, 主持, 国家级, 2018-01--2022-12
( 5 ) 类脑的表观遗传调控, 主持, 部委级, 2017-12--2021-11
( 6 ) 国家杰出青年基金, 主持, 国家级, 2019-01--2023-12
( 7 ) 引进人才资助计划, 主持, 部委级, 2011-01--2014-12
( 8 ) 干细胞命运决定的免疫因素及调控, 主持, 国家级, 2019-09--2022-12