General
戴建武 男 汉族 博导 遗传与发育生物学研究所
Email: jwdai@genetics.ac.cn
Lab Homepage：http://dailab.genetics.ac.cn
Telephone: 82614426
Address: 北京市海淀区中关村南一条三号 中科院遗传发育所103室
Postcode: 100190
Email: jwdai@genetics.ac.cn
Lab Homepage：http://dailab.genetics.ac.cn
Telephone: 82614426
Address: 北京市海淀区中关村南一条三号 中科院遗传发育所103室
Postcode: 100190
Research Areas
Main research orientations:
1. Biomaterials and tissue regeneration
2. Stem cell self-renewal and directional differentiation
3. Stem cell microenvironment reconstruction and tissue engineering
1. Biomaterials and tissue regeneration
2. Stem cell self-renewal and directional differentiation
3. Stem cell microenvironment reconstruction and tissue engineering
Education
1998.9-2000.5 Postdoctorate, Harvard Medical School, MA, U.S.A.
1996.9-1998.9 Ph.D., Duke University, NC, U.S.A.
1988.9-1991.7 M.S., Beijing Medical University, Beijing, China.
1984.9-1988.7 B.S., Wuhan University, Wuhan, China
1996.9-1998.9 Ph.D., Duke University, NC, U.S.A.
1988.9-1991.7 M.S., Beijing Medical University, Beijing, China.
1984.9-1988.7 B.S., Wuhan University, Wuhan, China
Experience
Work Experience
2003.8-date Research Fellow, Institute of Genetics and Developmental Biology, Chinese Acdemy of Sciences.
Teaching Experience
1991.9-1993.7 Visiting Scholars, Duke University, NC, U.S.A.
1991.9-1993.7 Teacher, Beijing Medical University.
1991.9-1993.7 Teacher, Beijing Medical University.
Honors & Distinctions
(2014) CCTV annual scientific and Technological Innovation Award
(2012) Second Class Prize for STP of China
(2010) Excellent Teacher Award of Inst. of Genetics & Dev’t, CAS
(2012) Second Class Prize for STP of China
(2010) Excellent Teacher Award of Inst. of Genetics & Dev’t, CAS
Publications
Papers
1. Directed osteogenic differentiation of mesenchymal stem cell in three-dimensional biodegradable methylcellulose-based scaffolds. Colloids Surf B Biointerfaces. 2015; 135: 332- 338.
2. Urethral tissue regeneration using collagen scaffold modified with collagen binding VEGF in a beagle model. Biomaterials. 2015; 69: 45- 55.
3. Electrospun Collagen Fibers with Spatial Patterning of SDF1α for the Guidance of Neural Stem Cells. Adv Healthc Mater. 2015; 4(12): 1869- 1876.
4. Transplantation of hBMSCs Loaded on Collagen Scaffolds for the Regeneration of Canine Tissue-Engineered Urethras. J Genet Genome Res. 2015; 2: 1
5. Modified VEGF targets the ischemic myocardium and promotes functional recovery after myocardial infarction. J Control Release. 2015; 213: 27- 35
6. Functionalized Collagen Scaffold Neutralizing the Myelin-Inhibitory Molecules Promoted Neurites Outgrowth in Vitro and Facilitated Spinal Cord Regeneration in Vivo. ACS Appl Mater Interfaces. 2015; 7(25): 13960-13971.
7. A collagen-binding EGFR single-chain Fv antibody fragment for the targeted cancer therapy. J Control Release. 2015; 209: 101- 109.
8. Enhanced proliferation and osteogenic differentiation of mesenchymal stem cells on graphene oxide-incorporated electrospun poly (lactic-co-glycolic acid) nanofibrous mats. ACS Appl Mater Interfaces. 2015; 7(11): 6331- 6339.
9. The linear-ordered collagen scaffold-BDNF complex significantly promotes functional recovery after completely transected spinal cord injury in canine. Biomaterials. 2015; 41: 89- 96.
10. Collagen scaffolds combined with collagen-binding ciliary neurotrophic factor facilitate facial nerve repair in mini-pigs. J Biomed Mater Res A. 2015; 103(5): 1669- 1676
11. Repair of Extrahepatic Bile Duct Defect Using a Collagen Patch in a Swine Model. Artif Organs. 2015; 39(4): 352- 360
12. Paracrine factors from mesenchymal stem cells attenuate epithelial injury and lung fibrosis. Mol Med Rep. 2015; 11(4): 2831- 2837.
13. Nerve regeneration and functional recovery by collagen-binding BDNF in an intracerebral hemorrhage model. Tissue Eng Part A. 2015; 21(1-2): 62- 74.
14. The collagen scaffold with collagen binding BDNF enhances functional recovery by facilitating peripheral nerve infiltrating and ingrowth in canine complete spinal cord transaction. Spinal Cord. 2014; 52(12): 867- 873
15. Acceleration of wound healing in acute full-thickness skin wounds using a collagen-binding peptide with an affinity for MSCs. Burns & Trauma. 2014; 2(4): 181- 186.
16. Use of natural neural scaffolds consisting of engineered vascular endothelial growth factor immobilized on ordered collagen fibers filled in a collagen tube for peripheral nerve regeneration in rats. Int J Mol Sci. 2014 15(10): 18593- 18609.
17. The inhibition effects of insulin on BMP2-induced muscle heterotopic ossification. Biomaterials. 2014; 35(34): 9322- 9331.
18. The importance of three-dimensional scaffold structure on stemness maintenance of mouse embryonic stem cells. Biomaterials. 2014; 35(27): 7724- 7733.
19. Collagen scaffolds modified with CNTF and bFGF promote facial nerve regeneration in minipigs. Biomaterials. 2014; 35(27): 7819- 7827.
20. Accelerated postero-lateral spinal fusion by collagen scaffolds modified with engineered collagen-binding human bone morphogenetic protein-2 in rats. PLoS One. 2014; 9(5): e98480.
21. Methods for detecting transcribed pseudogenes: PCR on regions of high sequence similarity followed by cloning and sequencing. Methods Mol Biol. 2014; 1167: 103- 115.
22. Methods for detecting transcribed pseudogenes: PCR on regions of high sequence similarity followed by cloning and sequencing. Methods Mol Biol. 2014; 1167: 103- 115.
23. Transplantation of bone marrow mesenchymal stem cells on collagen scaffolds for the functional regeneration of injured rat uterus. Biomaterials. 2014; 35(18): 4888- 4900.
24. Accelerating proliferation of neural stem/progenitor cells in collagen sponges immobilized with engineered basic fibroblast growth factor for nervous system tissue engineering. Biomacromolecules. 2014; 15(3): 1062- 1068.
25. Regulation of human mesenchymal stem cells differentiation into chondrocytes inextracellular matrix-based hydrogel scaffolds. Colloids Surf B Biointerfaces. 2014; 114: 316- 323.
26. Collagen scaffolds modified with collagen-binding bFGF promotes the neural regeneration in a rat hemisected spinal cord injury model. Sci China Life Sci. 2014; 57(2): 232- 240.
27. The miR-7 identified from collagen biomaterial based 3-D cultured cells regulates neural stem cell differentiation. Stem Cells Dev. 2014; 23(4): 393- 405.
28. Linear ordered collagen scaffolds loaded with collagen-binding basic fibroblast growth factor facilitate recovery of sciatic nerve injury in rats. Tissue Eng Part A. 20(7-8):1253-62. 2014
29. Three-dimensional culture may promote cell reprogramming. Organogenesis. 2013; 9: 118 – 120.
30. Effect of collagen scaffold with adipose-derived stromal vascular fraction cells on diabetic wound healing: A study in a diabetic porcine model. Tissue Engineering and Regenerative Medicine. 2013; 10(4): 192- 199.
31. Assembled 3D cell niches in chitosan hydrogel network to mimic extracellular matrix. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2013; 434: 78– 87.
32. Transplantation of human mesenchymal stem cells loaded on collagen scaffolds for the treatment of traumatic brain injury in rats. Biomaterials. 2013; 34（24）: 5937- 5946.
33. Direct conversion of fibroblasts into neural progenitor-like cells by forced growth into 3D spheres on low attachment surfaces. Biomaterials. 2013; 34(24): 5897- 5906.
34. Promotion of neuronal differentiation of neural progenitor cells by using EGFR antibody functionalized collagen scaffolds for spinal cord injury repair. Biomaterials. 2013; 34(21): 5107- 5116.
45. Promotion of diabetic wound healing by collagen scaffold with collagen-binding vascular endothelial growth factor in diabetic rat model. J Tissue Eng Regen Med. 2013; 8(3): 195- 201.
36. Three-dimensional graphene foam as a biocompatible and conductive scaffold for neural stem cells. Sci. Rep. 2013; 3: 1604.
37. The effect of forced growth of cells into 3D spheres using low attachment surfaces on the acquisition of stemness properties. Biomaterials. 2013; 34(13): 3215- 3222.
38. Maintenance of the self-renewal properties of neural progenitor cells cultured in three-dimensional collagen scaffolds by the REDD1-mTOR signal pathway. Biomaterials. 2013; 34(8): 1921- 1928.
39. Induction of rat facial nerve regeneration by functional collagen scaffolds. Biomatierials. 2013; 34(4): 1302- 1310.
40. The three-dimensional collagen scaffold improves the stemness of rat bone marrow mesenchymal stem cells. J Genet Genomics. 2012; 39(12): 633- 641.
41. Extrahepatic bile duct regeneration in pigs using collagen scaffolds loaded with human collagen-binding bFGF. Biomaterials. 2012; 33(17): 4298- 4308.
42. MiR-125b orchestrates cell proliferation, differentiation and migration in neural stem/progenitor cells by targeting Nestin. BMC Neurosci. 2012; 13(1): 116.
43. The novel function of OCT4B isoform-265 in genotoxic stress. Stem Cells. 2012; 30(4): 665- 672.
44. Collagen-based Functional Biomaterials for Tissue Regeneration. Regenerative Medicine in China, S. Sanders Ed. A Sponsored supplement to Science (Science/AAAS, Washington, DC, 2012):43-5. Science. 2012; 336(6080): 497.
45. The effect of collagen-binding vascular endothelial growth factor on the remodeling of scarred rat uterus following full-thickness injury. Biomaterials. 2012; 33(6): 1801- 1807.
46. Controllable synthesis of monodispersed silver nanoparticles as standards for quantitative assessment of their cytotoxicity. Biomaterials. 2012; 33(6): 1714- 1721.
47. Neuronal regeneration and protection by collagen-binding BDNF in the rat middle cerebral artery occlusion model. Biomaterials. 2012; 33(5): 1386- 1395.
48. The enhancement of cancer stem cell properties of MCF-7 cells in 3D collagen scaffolds for modeling of cancer and anti-cancer drugs. Biomaterials. 2012; 33(5): 1437- 1444.
49. A Myocardial Patch Made of Collagen Membranes Loaded with Collagen-Binding Human Vascular Endothelial Growth Factor Accelerates Healing of the Injured Rabbit Heart. Tissue Engineering Part A. 2011; 17(21-22): 2739- 2747.
50. Regeneration of uterine horns in rats by collagen scaffolds loaded with collagen-binding human basic fibroblast growth factor. Biomaterials. 2011; 32(32): 8172- 8181.
51. The promotion of cerebral ischemia recovery in rats by laminin-binding BDNF. Biomaterials. 2011; 32(22): 5077- 5085.
52. The use of laminin modified linear ordered collagen scaffolds loaded with laminin-binding ciliary neurotrophic factor for sciatic nerve regeneration in rats. Biomaterials. 2011; 32(16): 3939- 3948.
53. Neural regrowth induced by PLGA nerve conduits and neurotrophin-3 in rats with complete spinal cord transaction. JBMRB. 2011; 97(2): 271- 277.
54. The promotion of neurological recovery in an intracerebral hemorrhage model using fibrin-binding brain derived neurotrophic factor. Biomaterials. 2011; 32(12): 3244- 3252.
55. Stem-cell-capturing collagen scaffold promotes cardiac tissue regeneration. Biomaterials. 2011; 32(10): 2508- 2515.
56. Regeneration of full-thickness abdominal wall defects in rats using collagen scaffolds loaded with collagen-binding basic fibroblast growth factor. Biomaterials. 2011; 32(3): 753- 759.
57. Improved cellularization and angiogenesis using collagen scaffolds chemically conjugated with vascular endothelial growth factor. Acta Biomaterialia. 2011; 7(3): 1084- 1093.
58. The human pluripotency gene NANOG/NANOGP8 is expressed in gastric cancer and associated with tumor development. Oncology Letters. 2010; 1(3): 457- 463.
59. Differential effects of recombinant fusion proteins TAT-OCT4 and TAT-NANOG on adult human fibroblasts. Frontiers in Biology. 2010; 5 (5): 424- 430.
60. The promotion of neural regeneration in an extreme rat spinal cord injury model using a collagen scaffold containing a collagen binding neuroprotective protein and an EGFR neutralizing antibody. Biomaterials. 2010; 31(35): 9212- 9220.
61. The promotion of neurological recovery in the rat spinal cord crushed injury model by collagen-binding BDNF. Biomaterials. 2010; 31(33): 8634- 8641.
62. Acceleration of diabetic wound healing by collagen-binding vascular endothelial growth factor in diabetic rat model. Diabetes Research and Clinical Practice. 2010; 90(1): 66- 72.
63. Linear ordered collagen scaffolds loaded with collagen-binding neurotrophin-3 promotes axonal regeneration and partial functional recovery after complete spinal cord transaction. J Neurotrauma. 2010; 27(9): 1671- 1683.
64. Stem cell research is coming of age in China. J Genet Genomics. 2010; 37(7): 413.
65. The novel OCT4 spliced variant OCT4B1 can generate three protein isoforms by alternative splicing into OCT4B. J Genet Genomics. 2010; 37(7): 461- 465.
66. Bladder regeneration by collagen scaffolds with collagen binding human basic fibroblast growth factor. J Urol. 2010; 183(6): 2432- 2439.
67. Isoforms of OCT4 contribute to the confusing diversity in stem cell biology. Stem Cells. 2010; 28(5): 885- 893.
68. Mapping of the minimal internal ribosome entry site element in the human embryonic stem cell gene OCT4B mRNA. Biochem Biophys Res Commun. 2010; 394(3): 750- 754.
69. Loading of VEGF to the heparin cross-linked demineralized bone matrix improves vascularization of the scaffold. J Mater Sci Mater Med. 2010; 21(1): 309- 317.
70. Nogo-66 regulates nanog expression through stat3 pathway in murine embryonic stem cells. Stem Cells Dev. 2010; 19(1): 53- 60.
71. Collagen scaffolds loaded with collagen-binding NGF-beta accelerate ulcer healing. J Biomed Mater Res A. 2010; 92(3): 887- 895.
72. The osteogenic effect of bone morphogenetic protein-2 on the collagen scaffold conjugated with antibodies. J Controlled Release. 2010; 141(1): 30- 37.
73. Direct chemical cross-linking of platelet-derived growth factor-BB to the demineralized bone matrix improves cellularization and vascularization. Biomacromolecules. 2009; 10(12): 3193- 3198.
74. Collagen-binding human epidermal growth factor promotes cellularization of collagen scaffolds. Tissue Eng Part A. 2009; 15(11): 3589- 3596.
75. Improvement of sciatic nerve regeneration using laminin-binding human NGF-beta. PLoS One. 2009; 4(7): e6180.
76. Erk1/2 promotes proliferation and inhibits neuronal differentiation of neural stem cells. Neurosci Lett. 2009; 461(3): 252- 257.
77. The effect of collagen-binding NGF-beta on the promotion of sciatic nerve regeneration in a rat sciatic nerve crush injury model. Biomaterials. 2009; 30(27): 4649- 4656.
78. Effects of splice sites on the intron retention in histamine H3 receptors from rats and mice. J Genet Genomics. 2009; 36(8): 475- 482.
79. Multiple sequence elements determine the intron retention in histamine H3 receptors in rats and mice. Int J Biochem Cell Biol. 2009; 41(11): 2281- 2286.
80. Effect of different regions of Nogo-A on the differentiation of neural progenitors. Neurosci Lett. 2009; 458(3): 132- 135.
81. Linear ordered collagen scaffolds loaded with collagen-binding brain-derived neurotrophic factor improve the recovery of spinal cord injury in rats. Tissue Eng Part A. 2009; 15(10): 2927- 2935.
82. Alternative translation of OCT4 by an internal ribosome entry site and its novel function in stress response. Stem Cells. 2009; 27(6): 1265- 1275.
83. Collagen-targeting vascular endothelial growth factor improves cardiac performance after myocardial infarction. Circulation. 2009; 119(13): 1776- 1784.
84. Crosslinking heparin to collagen scaffolds for the delivery of human platelet-derived growth factor. J Biomed Mater Res B Appl Biomater. 2009; 91(1): 366- 372.
85. Human basic fibroblast growth factor fused with kringle4 Peptide binds to a fibrin scaffold and enhances angiogenesis. Tissue Eng Part A. 2009; 15(5): 991- 998.
86. Crosslinked three-dimensional demineralized bone matrix for the adipose-derived stromal cell proliferation and differentiation. Tissue Eng Part A. 2009; 15(1): 13- 21.
87. The bone-derived collagen containing mineralized matrix for the loading of collagen-binding bone morphogenetic protein-2. J Biomed Mater Res A. 2009; 88(3): 725- 734.
2. Urethral tissue regeneration using collagen scaffold modified with collagen binding VEGF in a beagle model. Biomaterials. 2015; 69: 45- 55.
3. Electrospun Collagen Fibers with Spatial Patterning of SDF1α for the Guidance of Neural Stem Cells. Adv Healthc Mater. 2015; 4(12): 1869- 1876.
4. Transplantation of hBMSCs Loaded on Collagen Scaffolds for the Regeneration of Canine Tissue-Engineered Urethras. J Genet Genome Res. 2015; 2: 1
5. Modified VEGF targets the ischemic myocardium and promotes functional recovery after myocardial infarction. J Control Release. 2015; 213: 27- 35
6. Functionalized Collagen Scaffold Neutralizing the Myelin-Inhibitory Molecules Promoted Neurites Outgrowth in Vitro and Facilitated Spinal Cord Regeneration in Vivo. ACS Appl Mater Interfaces. 2015; 7(25): 13960-13971.
7. A collagen-binding EGFR single-chain Fv antibody fragment for the targeted cancer therapy. J Control Release. 2015; 209: 101- 109.
8. Enhanced proliferation and osteogenic differentiation of mesenchymal stem cells on graphene oxide-incorporated electrospun poly (lactic-co-glycolic acid) nanofibrous mats. ACS Appl Mater Interfaces. 2015; 7(11): 6331- 6339.
9. The linear-ordered collagen scaffold-BDNF complex significantly promotes functional recovery after completely transected spinal cord injury in canine. Biomaterials. 2015; 41: 89- 96.
10. Collagen scaffolds combined with collagen-binding ciliary neurotrophic factor facilitate facial nerve repair in mini-pigs. J Biomed Mater Res A. 2015; 103(5): 1669- 1676
11. Repair of Extrahepatic Bile Duct Defect Using a Collagen Patch in a Swine Model. Artif Organs. 2015; 39(4): 352- 360
12. Paracrine factors from mesenchymal stem cells attenuate epithelial injury and lung fibrosis. Mol Med Rep. 2015; 11(4): 2831- 2837.
13. Nerve regeneration and functional recovery by collagen-binding BDNF in an intracerebral hemorrhage model. Tissue Eng Part A. 2015; 21(1-2): 62- 74.
14. The collagen scaffold with collagen binding BDNF enhances functional recovery by facilitating peripheral nerve infiltrating and ingrowth in canine complete spinal cord transaction. Spinal Cord. 2014; 52(12): 867- 873
15. Acceleration of wound healing in acute full-thickness skin wounds using a collagen-binding peptide with an affinity for MSCs. Burns & Trauma. 2014; 2(4): 181- 186.
16. Use of natural neural scaffolds consisting of engineered vascular endothelial growth factor immobilized on ordered collagen fibers filled in a collagen tube for peripheral nerve regeneration in rats. Int J Mol Sci. 2014 15(10): 18593- 18609.
17. The inhibition effects of insulin on BMP2-induced muscle heterotopic ossification. Biomaterials. 2014; 35(34): 9322- 9331.
18. The importance of three-dimensional scaffold structure on stemness maintenance of mouse embryonic stem cells. Biomaterials. 2014; 35(27): 7724- 7733.
19. Collagen scaffolds modified with CNTF and bFGF promote facial nerve regeneration in minipigs. Biomaterials. 2014; 35(27): 7819- 7827.
20. Accelerated postero-lateral spinal fusion by collagen scaffolds modified with engineered collagen-binding human bone morphogenetic protein-2 in rats. PLoS One. 2014; 9(5): e98480.
21. Methods for detecting transcribed pseudogenes: PCR on regions of high sequence similarity followed by cloning and sequencing. Methods Mol Biol. 2014; 1167: 103- 115.
22. Methods for detecting transcribed pseudogenes: PCR on regions of high sequence similarity followed by cloning and sequencing. Methods Mol Biol. 2014; 1167: 103- 115.
23. Transplantation of bone marrow mesenchymal stem cells on collagen scaffolds for the functional regeneration of injured rat uterus. Biomaterials. 2014; 35(18): 4888- 4900.
24. Accelerating proliferation of neural stem/progenitor cells in collagen sponges immobilized with engineered basic fibroblast growth factor for nervous system tissue engineering. Biomacromolecules. 2014; 15(3): 1062- 1068.
25. Regulation of human mesenchymal stem cells differentiation into chondrocytes inextracellular matrix-based hydrogel scaffolds. Colloids Surf B Biointerfaces. 2014; 114: 316- 323.
26. Collagen scaffolds modified with collagen-binding bFGF promotes the neural regeneration in a rat hemisected spinal cord injury model. Sci China Life Sci. 2014; 57(2): 232- 240.
27. The miR-7 identified from collagen biomaterial based 3-D cultured cells regulates neural stem cell differentiation. Stem Cells Dev. 2014; 23(4): 393- 405.
28. Linear ordered collagen scaffolds loaded with collagen-binding basic fibroblast growth factor facilitate recovery of sciatic nerve injury in rats. Tissue Eng Part A. 20(7-8):1253-62. 2014
29. Three-dimensional culture may promote cell reprogramming. Organogenesis. 2013; 9: 118 – 120.
30. Effect of collagen scaffold with adipose-derived stromal vascular fraction cells on diabetic wound healing: A study in a diabetic porcine model. Tissue Engineering and Regenerative Medicine. 2013; 10(4): 192- 199.
31. Assembled 3D cell niches in chitosan hydrogel network to mimic extracellular matrix. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2013; 434: 78– 87.
32. Transplantation of human mesenchymal stem cells loaded on collagen scaffolds for the treatment of traumatic brain injury in rats. Biomaterials. 2013; 34（24）: 5937- 5946.
33. Direct conversion of fibroblasts into neural progenitor-like cells by forced growth into 3D spheres on low attachment surfaces. Biomaterials. 2013; 34(24): 5897- 5906.
34. Promotion of neuronal differentiation of neural progenitor cells by using EGFR antibody functionalized collagen scaffolds for spinal cord injury repair. Biomaterials. 2013; 34(21): 5107- 5116.
45. Promotion of diabetic wound healing by collagen scaffold with collagen-binding vascular endothelial growth factor in diabetic rat model. J Tissue Eng Regen Med. 2013; 8(3): 195- 201.
36. Three-dimensional graphene foam as a biocompatible and conductive scaffold for neural stem cells. Sci. Rep. 2013; 3: 1604.
37. The effect of forced growth of cells into 3D spheres using low attachment surfaces on the acquisition of stemness properties. Biomaterials. 2013; 34(13): 3215- 3222.
38. Maintenance of the self-renewal properties of neural progenitor cells cultured in three-dimensional collagen scaffolds by the REDD1-mTOR signal pathway. Biomaterials. 2013; 34(8): 1921- 1928.
39. Induction of rat facial nerve regeneration by functional collagen scaffolds. Biomatierials. 2013; 34(4): 1302- 1310.
40. The three-dimensional collagen scaffold improves the stemness of rat bone marrow mesenchymal stem cells. J Genet Genomics. 2012; 39(12): 633- 641.
41. Extrahepatic bile duct regeneration in pigs using collagen scaffolds loaded with human collagen-binding bFGF. Biomaterials. 2012; 33(17): 4298- 4308.
42. MiR-125b orchestrates cell proliferation, differentiation and migration in neural stem/progenitor cells by targeting Nestin. BMC Neurosci. 2012; 13(1): 116.
43. The novel function of OCT4B isoform-265 in genotoxic stress. Stem Cells. 2012; 30(4): 665- 672.
44. Collagen-based Functional Biomaterials for Tissue Regeneration. Regenerative Medicine in China, S. Sanders Ed. A Sponsored supplement to Science (Science/AAAS, Washington, DC, 2012):43-5. Science. 2012; 336(6080): 497.
45. The effect of collagen-binding vascular endothelial growth factor on the remodeling of scarred rat uterus following full-thickness injury. Biomaterials. 2012; 33(6): 1801- 1807.
46. Controllable synthesis of monodispersed silver nanoparticles as standards for quantitative assessment of their cytotoxicity. Biomaterials. 2012; 33(6): 1714- 1721.
47. Neuronal regeneration and protection by collagen-binding BDNF in the rat middle cerebral artery occlusion model. Biomaterials. 2012; 33(5): 1386- 1395.
48. The enhancement of cancer stem cell properties of MCF-7 cells in 3D collagen scaffolds for modeling of cancer and anti-cancer drugs. Biomaterials. 2012; 33(5): 1437- 1444.
49. A Myocardial Patch Made of Collagen Membranes Loaded with Collagen-Binding Human Vascular Endothelial Growth Factor Accelerates Healing of the Injured Rabbit Heart. Tissue Engineering Part A. 2011; 17(21-22): 2739- 2747.
50. Regeneration of uterine horns in rats by collagen scaffolds loaded with collagen-binding human basic fibroblast growth factor. Biomaterials. 2011; 32(32): 8172- 8181.
51. The promotion of cerebral ischemia recovery in rats by laminin-binding BDNF. Biomaterials. 2011; 32(22): 5077- 5085.
52. The use of laminin modified linear ordered collagen scaffolds loaded with laminin-binding ciliary neurotrophic factor for sciatic nerve regeneration in rats. Biomaterials. 2011; 32(16): 3939- 3948.
53. Neural regrowth induced by PLGA nerve conduits and neurotrophin-3 in rats with complete spinal cord transaction. JBMRB. 2011; 97(2): 271- 277.
54. The promotion of neurological recovery in an intracerebral hemorrhage model using fibrin-binding brain derived neurotrophic factor. Biomaterials. 2011; 32(12): 3244- 3252.
55. Stem-cell-capturing collagen scaffold promotes cardiac tissue regeneration. Biomaterials. 2011; 32(10): 2508- 2515.
56. Regeneration of full-thickness abdominal wall defects in rats using collagen scaffolds loaded with collagen-binding basic fibroblast growth factor. Biomaterials. 2011; 32(3): 753- 759.
57. Improved cellularization and angiogenesis using collagen scaffolds chemically conjugated with vascular endothelial growth factor. Acta Biomaterialia. 2011; 7(3): 1084- 1093.
58. The human pluripotency gene NANOG/NANOGP8 is expressed in gastric cancer and associated with tumor development. Oncology Letters. 2010; 1(3): 457- 463.
59. Differential effects of recombinant fusion proteins TAT-OCT4 and TAT-NANOG on adult human fibroblasts. Frontiers in Biology. 2010; 5 (5): 424- 430.
60. The promotion of neural regeneration in an extreme rat spinal cord injury model using a collagen scaffold containing a collagen binding neuroprotective protein and an EGFR neutralizing antibody. Biomaterials. 2010; 31(35): 9212- 9220.
61. The promotion of neurological recovery in the rat spinal cord crushed injury model by collagen-binding BDNF. Biomaterials. 2010; 31(33): 8634- 8641.
62. Acceleration of diabetic wound healing by collagen-binding vascular endothelial growth factor in diabetic rat model. Diabetes Research and Clinical Practice. 2010; 90(1): 66- 72.
63. Linear ordered collagen scaffolds loaded with collagen-binding neurotrophin-3 promotes axonal regeneration and partial functional recovery after complete spinal cord transaction. J Neurotrauma. 2010; 27(9): 1671- 1683.
64. Stem cell research is coming of age in China. J Genet Genomics. 2010; 37(7): 413.
65. The novel OCT4 spliced variant OCT4B1 can generate three protein isoforms by alternative splicing into OCT4B. J Genet Genomics. 2010; 37(7): 461- 465.
66. Bladder regeneration by collagen scaffolds with collagen binding human basic fibroblast growth factor. J Urol. 2010; 183(6): 2432- 2439.
67. Isoforms of OCT4 contribute to the confusing diversity in stem cell biology. Stem Cells. 2010; 28(5): 885- 893.
68. Mapping of the minimal internal ribosome entry site element in the human embryonic stem cell gene OCT4B mRNA. Biochem Biophys Res Commun. 2010; 394(3): 750- 754.
69. Loading of VEGF to the heparin cross-linked demineralized bone matrix improves vascularization of the scaffold. J Mater Sci Mater Med. 2010; 21(1): 309- 317.
70. Nogo-66 regulates nanog expression through stat3 pathway in murine embryonic stem cells. Stem Cells Dev. 2010; 19(1): 53- 60.
71. Collagen scaffolds loaded with collagen-binding NGF-beta accelerate ulcer healing. J Biomed Mater Res A. 2010; 92(3): 887- 895.
72. The osteogenic effect of bone morphogenetic protein-2 on the collagen scaffold conjugated with antibodies. J Controlled Release. 2010; 141(1): 30- 37.
73. Direct chemical cross-linking of platelet-derived growth factor-BB to the demineralized bone matrix improves cellularization and vascularization. Biomacromolecules. 2009; 10(12): 3193- 3198.
74. Collagen-binding human epidermal growth factor promotes cellularization of collagen scaffolds. Tissue Eng Part A. 2009; 15(11): 3589- 3596.
75. Improvement of sciatic nerve regeneration using laminin-binding human NGF-beta. PLoS One. 2009; 4(7): e6180.
76. Erk1/2 promotes proliferation and inhibits neuronal differentiation of neural stem cells. Neurosci Lett. 2009; 461(3): 252- 257.
77. The effect of collagen-binding NGF-beta on the promotion of sciatic nerve regeneration in a rat sciatic nerve crush injury model. Biomaterials. 2009; 30(27): 4649- 4656.
78. Effects of splice sites on the intron retention in histamine H3 receptors from rats and mice. J Genet Genomics. 2009; 36(8): 475- 482.
79. Multiple sequence elements determine the intron retention in histamine H3 receptors in rats and mice. Int J Biochem Cell Biol. 2009; 41(11): 2281- 2286.
80. Effect of different regions of Nogo-A on the differentiation of neural progenitors. Neurosci Lett. 2009; 458(3): 132- 135.
81. Linear ordered collagen scaffolds loaded with collagen-binding brain-derived neurotrophic factor improve the recovery of spinal cord injury in rats. Tissue Eng Part A. 2009; 15(10): 2927- 2935.
82. Alternative translation of OCT4 by an internal ribosome entry site and its novel function in stress response. Stem Cells. 2009; 27(6): 1265- 1275.
83. Collagen-targeting vascular endothelial growth factor improves cardiac performance after myocardial infarction. Circulation. 2009; 119(13): 1776- 1784.
84. Crosslinking heparin to collagen scaffolds for the delivery of human platelet-derived growth factor. J Biomed Mater Res B Appl Biomater. 2009; 91(1): 366- 372.
85. Human basic fibroblast growth factor fused with kringle4 Peptide binds to a fibrin scaffold and enhances angiogenesis. Tissue Eng Part A. 2009; 15(5): 991- 998.
86. Crosslinked three-dimensional demineralized bone matrix for the adipose-derived stromal cell proliferation and differentiation. Tissue Eng Part A. 2009; 15(1): 13- 21.
87. The bone-derived collagen containing mineralized matrix for the loading of collagen-binding bone morphogenetic protein-2. J Biomed Mater Res A. 2009; 88(3): 725- 734.
Patents
International Patents:
1. Activated collagen scaffold materials and their special fused active restoration factors. Patent No. US 8,802,396 B2
2. Activated collagen scaffold materials and their special fused active restoration factors. Patent No. EP 1970382 B1
3. Reprogramming cells by three-dimensional cultivation. Application No. PCT/CN2012/072284
4. Activated collagen scaffold materials and their special fused active restoration factors. Application No. 14/320,191
5. Activated collagen scaffold materials and their special fused active restoration factors. Application No. 14/320,105
1. Activated collagen scaffold materials and their special fused active restoration factors. Patent No. US 8,802,396 B2
2. Activated collagen scaffold materials and their special fused active restoration factors. Patent No. EP 1970382 B1
3. Reprogramming cells by three-dimensional cultivation. Application No. PCT/CN2012/072284
4. Activated collagen scaffold materials and their special fused active restoration factors. Application No. 14/320,191
5. Activated collagen scaffold materials and their special fused active restoration factors. Application No. 14/320,105
Students
Graduated students:
Suo Guangli, Ph.D. (SINANO, CAS)
Wang Xia, Ph.D. (Jackson Lab)
Wang Bin, Ph.D. (IGDB, CAS)
Zhao Wenxue, Ph.D. (UCSF)
Zhao Yanhong, Ph.D. (NIFDC)
Lin Hang, Ph.D. (Pittsburgh University)
Zhang Jingyu, Ph.D. (Thermo)
Chen Bing, Ph.D. (IGDB, CAS)
Sun Wenjie, Ph.D. (Shandong University)
Zhao Yannan, Ph.D. (IGDB, CAS)
Zhang Jing, Ph.D. (Capital Medical University)
Gao Jian, Ph.D. (P&G)
Gao Yuan, Ph.D. (P&G)
Han Jin, Ph.D. (IGDB, CAS)
Han Qianqian, Ph.D. (NIFDC)
Shi Chunying, Ph.D.
Cao Jiani, Ph.D. (IOZ, CAS)
Chen Lei, Ph.D. (Xinyang Normal University)
Han Sufang, Ph.D. (IGDB, CAS)
Su Guannan, Ph.D. (The University of Melbourne)
Xiao Hanshan, Ph.D.
Wei Jianshu, Ph.D. (The PLA Gernal Hospital)
Mu Chenchen, M.S.
Yang Yun, Ph.D.
Liang Hui, Ph.D.
Ph.D. candidates:
Li Xing
Fan Caixia
Liu Sumei
Xu Bai
Xue Weiwei
Yang Ying