Metalloenzymes catalyze some of the most challenging reactions, such as the conversion of H2O to O2, O2 to H2O, N2 to NH3 and H+ to H2, under mild physiological conditions. As these reactions are of tremendous importance for energy production and green chemistry, they are currently intensively investigated by biophysical chemists. However, these metalloenzymes are usually huge membrane protein complexes, and are hard to produce in large amount for performing biochemical studies, and are difficult to engineer to suit for industrial applications. The central aim in our laboratory is to use small, soluble protein scaffold, and the genetic incorporation of unnatural amino acid to design easy-to-characterize, easy-to-produce, and easy-to-optimize metalloenzymes which catalyze these important reactions with equal or greater efficiency/selectivity than that of the natural systems.

Univ. of Illinois at Urbana Champaign -- 博士

   

2003-2007 Postdoctoral training, Dept. of Chemistry (Advisor: Prof. Peter G. Schultz) The Scripps Research Institute

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