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Junfeng Wang
Ph.D., Associate Professor
South China Sea Institute of Oceanology
Chinese Academy of Sciences
No.164 West Xingang Road, Guangzhou, 510301, China
Tel: +86 2089023174, Mobile number: +86 13570918769
Email: wangjunfeng@scsio.ac.cn
Research Areas
1. Bioactive natural products from marine microorganisms from extreme environmental sources
2. Evaluation of natural products as antimicrobial and anticancer activity agents
Education
2009.9-2012.6, Ocean University of China, Ph.D., Medicinal Chemistry;
2006.9-2009.6, Qingdao University of Science & Technology, M.S., Organic Chemistry;
2002.9-2006.6, Qingdao University of Science & Technology, B.Sc., Chemistry
Experience
2016.12-current, Associate Professor, South China Sea Institute of Oceanology;
2012.9-2016.12: Assistant Professor, South China Sea Institute of Oceanology
Publications
Papers
More than 80 papers have been published in Org. Lett., Org. Chem. Front., J. Nat. Prod., Org. Biomol. Chem., Bioorg. Med. Chem., et al.
The first/corresponding author' articles in the last five years:
30. Guo C, Wang P, Lin X, Salendra L, Kong F, Liao S, Yang B, Zhou X, Wang J*, Liu Y*. Phloroglucinol heterodimers and bis-indolyl alkaloids from the Sponge-Derived Fungus Aspergillus sp. SCSIO 41018. Org Chem Front, 2019, doi: 10.1039/C9Qo00351G. (Cover paper)
29. Liu N, Peng S, Yang J, Cong Z, Lin X, Liao S, Yang B, Zhou X, Zhou X, Liu Y*, Wang J*. Structurally diverse sesquiterpenoids and polyketides from a sponge-associated fungus Aspergillus sydowii SCSIO41301. Fitoterapia, 2019, doi: 10.1016/j.fitote.2019.03.031.
28. Guo C, Lin X, Liao S, Yang B, Zhou X, Yang X, Tian X, Wang J*, Liu Y.* Two new aromatic polyketides from a deep-sea fungus Penicillium sp. SCSIO 06720. Nat Prod Res, 2019, doi: 10.1080/14786419.2018.1553880.
27. Cong Z, Huang X*, Liu Y, Liu Y, Wang P, Liao S, Yang B, Zhou X, Huang D, Wang J*. Cytotoxic anthracycline and antibacterial tirandamycin analoguesfrom a marine-derived Streptomyces sp. SCSIO 41399. J Antibiot, 2019, 72: 45–49.
26. Wang J, Qing L, Zhao B, Cai L, Zhong Z, Liu Y, Zhou X*. Crotonols A and B, two rare tigliane diterpenoid derivatives against K562 cells from Croton tiglium. Org Biomol Chem, 2019, 17(1): 195–202.
25. Wang J, Cong Z, Huang X, Hou C, Chen W, Tu Z, Huang D, Liu Y*. Soliseptide A, acyclic hexapeptidepossessing piperazicacid groups from Streptomyces solisilvae HNM30702. Org Lett, 2018, 20(5): 1371–1374.
24. Pang X, Lin X, Yang J, Zhou X, Yang B, Wang J*, Liu Y*. Spiro-Phthalides and isocoumarinsisolated from the marine-sponge-derived fungus Setosphaeria sp. SCSIO41009. J Nat Prod, 2018, 81(8), 1860−1868. (Top 20 Most Read Articles in August, 2018)
23. Pang X, Lin X, Wang P, Zhou X, Yang B, Wang J*, Liu Y*. Perylenequione derivatives with anticancer activities isolated from the marine sponge-derived fungus, Alternaria sp. SCSIO41014. Mar. Drugs, 2018, 16(8), 280.
22. Wang J*, Zhou L, Chen S, Yang B, Liao S, Kong F, Lin X, Wang F, Zhou X, Liu Y*. New chlorinated diphenyl ethers and xanthones from a deep-sea-derivedfungus Penicillium chrysogenum SCSIO 41001. Fitoterapia, 2018, 125, 49–54.
21. Pang X, Lin X, Wang J*, Liang R, Tian Y, Salendra L, Luo X, Zhou X, Yang B, Tu Z, Liu Y*. Three new highly oxygenated sterols and one new dihydroisocoumarin from the marine sponge-derived fungus Cladosporium sp. SCSIO41007. Steroids, 2018, 129, 41–46.
20. Wang J, He W, Kong F, Tian T, Wang P, Zhou X*, Liu Y*. Ochracenes A−I, Humulane-Derived Sesquiterpenoids from the Antarctic Fungus Aspergillus ochraceopetaliformis. J Nat Prod, 2017, 80(6): 1725–1733. (Highlighted by Natural Products Reports)
19. Wang J, Liang R, Liao S, Yang B, Tu Z, Lin X, Wang B, Liu Y*. Vaccinols J–S, ten new salicyloid derivatives from the marine mangrove-derived endophytic fungus Pestalotiopsis vaccinii. Fitoterapia, 2017, 120: 164–170.
18. He W, Zhou X, Qin X, Mai Y, Lin X, Liao S, Yang B, Zhang T, Tu Z, Wang J*, Liu Y*. Quinone/hydroquinone meroterpenoids with antitubercular and cytotoxic activities produced by the sponge-derivedfungus Gliomastix sp. ZSDS1-F7. Nat Prod Res, 2017, 31(5): 604–609.
17. Wang J, Wei X, Qin X, Tian X, Liao L, Li K, Zhou X, Yang X, Wang F, Tu Z, Chen B, Liu Y*. Antiviral Merosesquiterpenoids Produced by the Antarctic Fungus Aspergillus ochraceopetaliformis SCSIO 05702, J Nat Prod, 2016, 79(1): 59–65. (Highlighted by Natural Products Reports)
16. Wang J, He W, Huang X, Tian X, Liao S, Yang B, Wang F, Zhou X, Liu Y*. Antifungal New Oxepine-Containing Alkaloids and Xanthones from the Deep-Sea-Derived Fungus Aspergillus versicolor SCSIO 05879, J Agric Food Chem, 2016, 64(16): 2910–2916.
15. Wang J, Qin X, Chen Z, Ju Z, He W, Tan Y, Zhou X, Tu Z, Lu F*, Liu Y*. Two new anthraquinones with antiviral activities from the barks of Morinda citrifolia (Noni), Phytochem Lett, 2016, 15: 13–15.
14. Zhao B#, Peng S#, He W, Liu Y, Wang J*, Zhou X*. Antitubercular and cytotoxic tigliane-type diterpenoidsfrom Croton tiglium, Bioorg Med Chem Lett, 2016, 26(20): 4996–4999.
13. Xu G#, Wang Z#, Zhao B, Liu N, Yang S, Liu Y, Wang J*, Zhou X*. Saniculamins A and B, two new flavonoids from Sanicula lamelligera Hance inhibiting LPS-inducednitric oxide release, Phytochem Lett, 2016, 18: 35–38.
12. Wang J, Wei X, Qin X, Lin X, Zhou X, Liao S, Yang B, Liu J, Tu Z, Liu Y*. Arthpyrones A–C, pyridine alkaloids from a sponge-derivied fungus Arthrinium arundinis ZSDS1-F3. Org Lett, 2015, 17(3): 656–659. (ACS Editors' Choice, Highlighted by Natural Products Reports)
11. Wang J, He W, Qin X, Wei X, Tian X, Liao L, Liao S, Yang B, Tu Z, Chen B, Wang F, Zhou X*, Liu Y*. Three new indolyl diketopiperazine metabolites from the antarctic soil-derived fungus Penicillium sp. SCSIO 05705, RSC Adv, 2015, 5(84): 68736–68742.
10. Wang J, Wang Z, Ju Z, Wan J, Liao S, Lin X, Zhang T, Zhou X, Chen H, Tu Z*, Liu Y*. Cytotoxic cytochalasins from marine-derived fungus Arthrinium arundinis. Planta Med, 2015, 81(2): 160–166.
9. Wang J, He W, Zhang X, Zhao B, Liu Y, Zhou X*. Dicarabrol, a new dimer icsesquiterpene from Carpesium abrotaoides L. Bioorg Med Chem Lett, 2015, 25(19): 4082–4084.
8. Wang J#, Yang S#, Liu Y, Li D, He W, Zhang X, Liu Y*, Zhou X*. Five new phorbol esters with cytotoxic and selective anti-inflammatory activities from Croton tiglium. Bioorg Med Chem Lett, 2015, 25(9): 1986–1989.
7. Yang S#, Liu Y#, Wang J*, Wang Y, Pan W, Sheng W, Cai R, Zhou X*. Isoquinoline alkaloids from Zanthoxylum simulans and their biological evaluation, J Antibiot, 2015, 68(4): 289–292.
6. Wang J, Wei X, Qin X, Chen H, Lin X, Zhang T, Yang X, Liao S, Yang B, Liu J, Zhou X, Tu Z*, Liu Y*. Two new prenylated phenols from endogenous fungus Pestalotiopsis vaccinii of mangrove plant Kandelia candel (L.) Druce. Phytochem Lett, 2015, 12: 59–62.
5. Wang J#, Qin X#, Xu F, Zhang T, Liao S, Lin X, Yang B, Liu J, Wang L, Tu Z*, Liu Y*. Tetramic acid derivatives and polyphenols from sponge-derived fungus and their biological evaluation. Nat Prod Res, 2015, 29(18): 1761–1765.
4. Wang J, Wei X, Lu X, Xu F, Wan J, Lin X, Zhou X, Liao S, Yang B, Tu Z, Liu Y*. Eight new polyketide metabolites from the fungus Pestalotiopsis vaccinii endogenous with the mangrove plant Kandelia candel(L.) Druce. Tetrahedron, 2014, 70(51): 9695–9701.
3. Wang J, Deng Y, Yang S, Liu Y, Wang Y, Pan W, Zhou X*. Characterization and biological evaluation of six new dimericlignans with an unusual α,β-unsaturated ketone motif from Zanthoxylum simulans, Bioorg Med Chem Lett, 2014, 24(19): 4667–4671.
2. Wang J, Xu F, Wang Z, Lu X, Wan J, Yang B, Zhou X, Zhang T, Tu Z, Liu Y*. A new naphthalene glycoside from the sponge-derived fungus Arthrinium sp. ZSDS1-F3. Nat Prod Res, 2014, 28(14): 1070–1074.
1. Wang J#, Lin X#, Qin C, Liao S, Wan J, Zhang T, Liu J, Fredimoses M, Chen H, Yang B, Zhou X, Yang X, Tu Z*, Liu Y*. Antimicrobial and antiviral sesquiterpenoids from sponge-associated fungus, Aspergillus sydowii ZSDS1-F6. J Antibiot, 2014, 67(8): 581–583.
Patents
1. Junfeng Wang, Weijun He, Xiaolong Huang, XinpengTian, Yonghong Liu.Antibiotic versicoloids A and B: preparation and anti-phytopathogenic fungal application. CN 201610046509.9.
2. Junfeng Wang, Weijun He, XinpengTian, Yonghong Liu. α-pyronemerosesquiterpenoids : preparation and application. CN 201510244085.2.
3. Junfeng Wang, Yonghong Liu, Xuefeng Zhou, Shengrong Liao, Xianwen Yang, Bin Yang, Xiuping Lin, Juan Liu. Pyridone Alkaloids: preparation and anti-tumor application. CN 201410021280.4.
4. Junfeng Wang, Yonghong Liu, Xuefeng Zhou, Shengrong Liao, Xianwen Yang, Bin Yang, Xiuping Lin, Juan Liu. Pyridone Alkaloids: preparation, and anti-EV71 and anti-AChE application. CN 201410021315.4.
Projects
1. National Natural Science Foundation of China (No. 41776169); PI3K/Akt inhibitors from the sponge-derived fungi collected from the Xisha and Nansha Islands of China: discovery and action mechanism study (Wang), 2018.01–2021.12.
2. National Natural Science Foundation of China (for young scientist, No. 21502204); Discovery of anti-enterovirus 71 (EV71) compounds from three marine fungi associated with the sponge collected from the Xisha Islands (Wang), 2016.01–2018.12.
3. The Fund for Development of Science and Technology of Guangdong Province (No. 2016A020222010); The study of targeted antitumor secondary metabolites from sponge-derived fungi collected from the Xisha Islands (Wang), 2016.01–2018.12.
4. Pearl River S&T Nova Program of Guangzhou (No.201710010136); Akt/Erk/Casp inhibitors from the marine fungi isolated from South China Sea: discovery and action mechanism study (Wang), 2017.05–2020.04.