General

Junfeng Wang

Ph.D., Associate Professor

South China Sea Institute of Oceanology

Chinese Academy of Sciences

 

No.164 West Xingang Road, Guangzhou, 510301, China

Tel: +86 2089023174, Mobile number: +86 13570918769

Email: wangjunfeng@scsio.ac.cn


Research Areas

1Bioactive natural products from marine microorganisms from extreme environmental sources

2Evaluation of natural products as antimicrobial and anticancer activity agents


Education

2009.9-2012.6, Ocean University of China, Ph.D., Medicinal Chemistry;

2006.9-2009.6, Qingdao University of Science & Technology, M.S., Organic Chemistry;

2002.9-2006.6, Qingdao University of Science & Technology, B.Sc., Chemistry


Experience

2016.12-current, Associate Professor, South China Sea Institute of Oceanology; 

2012.9-2016.12: Assistant Professor, South China Sea Institute of Oceanology


Publications

   
Papers

More than 80 papers have been published in Org. Lett., Org. Chem. Front., J. Nat. Prod., Org. Biomol. Chem., Bioorg. Med. Chem., et al.

The first/corresponding author' articles in the last five years:

30. Guo C, Wang P, Lin X, Salendra L, Kong F, Liao S, Yang B, Zhou X, Wang J*, Liu Y*. Phloroglucinol heterodimers and bis-indolyl alkaloids from the Sponge-Derived Fungus Aspergillus sp. SCSIO 41018Org Chem Front, 2019, doi: 10.1039/C9Qo00351G. (Cover paper)

29. Liu N, Peng S, Yang J, Cong Z, Lin X, Liao S, Yang B, Zhou X, Zhou X, Liu Y*, Wang J*. Structurally diverse sesquiterpenoids and polyketides from a sponge-associated fungus Aspergillus sydowii SCSIO41301Fitoterapia2019, doi: 10.1016/j.fitote.2019.03.031.

28. Guo C, Lin X, Liao S, Yang B, Zhou X, Yang X, Tian X, Wang J*, Liu Y.* Two new aromatic polyketides from a deep-sea fungus Penicillium sp. SCSIO 06720Nat Prod Res2019, doi: 10.1080/14786419.2018.1553880.

27. Cong Z, Huang X*, Liu Y, Liu Y, Wang P, Liao S, Yang B, Zhou X, Huang D, Wang J*. Cytotoxic anthracycline and antibacterial tirandamycin analoguesfrom a marine-derived Streptomyces sp. SCSIO 41399J Antibiot2019, 72: 45–49.

26Wang J, Qing L, Zhao B, Cai L, Zhong Z, Liu Y, Zhou X*. Crotonols A and B, two rare tigliane diterpenoid derivatives against K562 cells from Croton tigliumOrg Biomol Chem2019, 17(1): 195–202.

25Wang J, Cong Z, Huang X, Hou C, Chen W, Tu Z, Huang D, Liu Y*. Soliseptide A, acyclic hexapeptidepossessing piperazicacid groups from Streptomyces solisilvae HNM30702Org Lett2018,  20(5): 1371–1374.

24. Pang X, Lin X, Yang J, Zhou X, Yang B, Wang J*, Liu Y*. Spiro-Phthalides and isocoumarinsisolated from the marine-sponge-derived fungus Setosphaeria sp. SCSIO41009J Nat Prod2018, 81(8), 1860−1868. (Top 20 Most Read Articles in August, 2018)

23. Pang X, Lin X, Wang P, Zhou X, Yang B, Wang J*, Liu Y*. Perylenequione derivatives with anticancer activities isolated from the marine sponge-derived fungus, Alternaria sp. SCSIO41014Mar. Drugs2018, 16(8), 280.

22Wang J*, Zhou L, Chen S, Yang B, Liao S, Kong F, Lin X, Wang F, Zhou X, Liu Y*. New chlorinated diphenyl ethers and xanthones from a deep-sea-derivedfungus Penicillium chrysogenum SCSIO 41001Fitoterapia2018, 125, 49–54.

21. Pang X, Lin X, Wang J*, Liang R, Tian Y, Salendra L, Luo X, Zhou X, Yang B, Tu Z, Liu Y*. Three new highly oxygenated sterols and one new dihydroisocoumarin from the marine sponge-derived fungus Cladosporium sp. SCSIO41007Steroids2018, 129, 41–46.

20Wang J, He W, Kong F, Tian T, Wang P, Zhou X*, Liu Y*. Ochracenes A−I, Humulane-Derived Sesquiterpenoids from the Antarctic Fungus Aspergillus ochraceopetaliformisJ Nat Prod2017, 80(6): 1725–1733. (Highlighted by Natural Products Reports)

19Wang J, Liang R, Liao S, Yang B, Tu Z, Lin X, Wang B, Liu Y*. Vaccinols J–S, ten new salicyloid derivatives from the marine mangrove-derived endophytic fungus Pestalotiopsis vacciniiFitoterapia2017, 120: 164–170.

18. He W, Zhou X, Qin X, Mai Y, Lin X, Liao S, Yang B, Zhang T, Tu Z, Wang J*, Liu Y*. Quinone/hydroquinone meroterpenoids with antitubercular and cytotoxic activities produced by the sponge-derivedfungus Gliomastix sp. ZSDS1-F7Nat Prod Res2017, 31(5): 604–609.

17Wang J, Wei X, Qin X, Tian X, Liao L, Li K, Zhou X, Yang X, Wang F, Tu Z, Chen B, Liu Y*. Antiviral Merosesquiterpenoids Produced by the Antarctic Fungus Aspergillus ochraceopetaliformis SCSIO 05702, J Nat Prod2016, 79(1): 59–65. (Highlighted by Natural Products Reports)

16Wang J, He W, Huang X, Tian X, Liao S, Yang B, Wang F, Zhou X, Liu Y*. Antifungal New Oxepine-Containing Alkaloids and Xanthones from the Deep-Sea-Derived Fungus Aspergillus versicolor SCSIO 05879J Agric Food Chem2016, 64(16): 2910–2916.

15Wang J, Qin X, Chen Z, Ju Z, He W, Tan Y, Zhou X, Tu Z, Lu F*, Liu Y*. Two new anthraquinones with antiviral activities from the barks of Morinda citrifolia (Noni)Phytochem Lett2016, 15: 13–15.

14. Zhao B#, Peng S#, He W, Liu Y, Wang J*, Zhou X*. Antitubercular and cytotoxic tigliane-type diterpenoidsfrom Croton tigliumBioorg Med Chem Lett2016, 26(20): 4996–4999.

13. Xu G#, Wang Z#, Zhao B, Liu N, Yang S, Liu Y, Wang J*, Zhou X*. Saniculamins A and B, two new flavonoids from Sanicula lamelligera Hance inhibiting LPS-inducednitric oxide releasePhytochem Lett2016, 18: 35–38.

12Wang J, Wei X, Qin X, Lin X, Zhou X, Liao S, Yang B, Liu J, Tu Z, Liu Y*. Arthpyrones A–C, pyridine alkaloids from a sponge-derivied fungus Arthrinium arundinis ZSDS1-F3Org Lett2015, 17(3): 656–659. (ACS Editors' Choice, Highlighted by Natural Products Reports)

11Wang J, He W, Qin X, Wei X, Tian X, Liao L, Liao S, Yang B, Tu Z, Chen B, Wang F, Zhou X*, Liu Y*. Three new indolyl diketopiperazine metabolites from the antarctic soil-derived fungus Penicillium sp. SCSIO 05705RSC Adv2015, 5(84): 68736–68742.

10Wang J, Wang Z, Ju Z, Wan J, Liao S, Lin X, Zhang T, Zhou X, Chen H, Tu Z*, Liu Y*. Cytotoxic cytochalasins from marine-derived fungus Arthrinium arundinisPlanta Med2015, 81(2): 160–166.

9Wang J, He W, Zhang X, Zhao B, Liu Y, Zhou X*. Dicarabrol, a new dimer icsesquiterpene from Carpesium abrotaoides LBioorg Med Chem Lett2015, 25(19): 4082–4084.

8. Wang J#, Yang S#, Liu Y, Li D, He W, Zhang X, Liu Y*, Zhou X*. Five new phorbol esters with cytotoxic and selective anti-inflammatory activities from Croton tigliumBioorg Med Chem Lett2015, 25(9): 1986–1989.

7. Yang S#, Liu Y#Wang J*, Wang Y, Pan W, Sheng W, Cai R, Zhou X*. Isoquinoline alkaloids from Zanthoxylum simulans and their biological evaluationJ Antibiot2015, 68(4): 289–292.

6Wang J, Wei X, Qin X, Chen H, Lin X, Zhang T, Yang X, Liao S, Yang B, Liu J, Zhou X, Tu Z*, Liu Y*. Two new prenylated phenols from endogenous fungus Pestalotiopsis vaccinii of mangrove plant Kandelia candel (L.) DrucePhytochem Lett2015, 12: 59–62.

5Wang J#, Qin X#, Xu F, Zhang T, Liao S, Lin X, Yang B, Liu J, Wang L, Tu Z*, Liu Y*. Tetramic acid derivatives and polyphenols from sponge-derived fungus and their biological evaluationNat Prod Res2015, 29(18): 1761–1765.

4Wang J, Wei X, Lu X, Xu F, Wan J, Lin X, Zhou X, Liao S, Yang B, Tu Z, Liu Y*. Eight new polyketide metabolites from the fungus Pestalotiopsis vaccinii endogenous with the mangrove plant Kandelia candel(L.) DruceTetrahedron2014, 70(51): 9695–9701.

3Wang J, Deng Y, Yang S, Liu Y, Wang Y, Pan W, Zhou X*. Characterization and biological evaluation of six new dimericlignans with an unusual α,β-unsaturated ketone motif from Zanthoxylum simulansBioorg Med Chem Lett2014, 24(19): 4667–4671.

2Wang J, Xu F, Wang Z, Lu X, Wan J, Yang B, Zhou X, Zhang T, Tu Z, Liu Y*. A new naphthalene glycoside from the sponge-derived fungus Arthrinium sp. ZSDS1-F3Nat Prod Res2014, 28(14): 1070–1074.

1Wang J#, Lin X#, Qin C, Liao S, Wan J, Zhang T, Liu J, Fredimoses M, Chen H, Yang B, Zhou X, Yang X, Tu Z*, Liu Y*. Antimicrobial and antiviral sesquiterpenoids from sponge-associated fungus, Aspergillus sydowii ZSDS1-F6J Antibiot2014, 67(8): 581–583.



Patents

1. Junfeng Wang, Weijun He, Xiaolong Huang, XinpengTian, Yonghong Liu.Antibiotic versicoloids A and B: preparation and anti-phytopathogenic fungal application. CN 201610046509.9.

2. Junfeng Wang, Weijun He, XinpengTian, Yonghong Liu. α-pyronemerosesquiterpenoids : preparation and application. CN 201510244085.2. 

3. Junfeng Wang, Yonghong Liu, Xuefeng Zhou, Shengrong Liao, Xianwen Yang, Bin Yang, Xiuping Lin, Juan Liu. Pyridone Alkaloids: preparation and anti-tumor application. CN 201410021280.4.

4. Junfeng Wang, Yonghong Liu, Xuefeng Zhou, Shengrong Liao, Xianwen Yang, Bin Yang, Xiuping Lin, Juan Liu. Pyridone Alkaloids: preparation, and anti-EV71 and anti-AChE application. CN 201410021315.4.


Projects

1.  National Natural Science Foundation of China (No. 41776169); PI3K/Akt inhibitors from the sponge-derived fungi collected from the Xisha and Nansha Islands of China: discovery and action mechanism study (Wang), 2018.012021.12.

2.  National Natural Science Foundation of China (for young scientist, No. 21502204); Discovery of anti-enterovirus 71 (EV71) compounds from three marine fungi associated with the sponge collected from the Xisha Islands (Wang), 2016.012018.12.

3. The Fund for Development of Science and Technology of Guangdong Province (No. 2016A020222010); The study of targeted antitumor secondary metabolites from sponge-derived fungi collected from the Xisha Islands (Wang), 2016.01–2018.12.

4. Pearl River S&T Nova Program of Guangzhou (No.201710010136); Akt/Erk/Casp inhibitors from the marine fungi isolated from South China Sea: discovery and action mechanism study (Wang), 2017.05–2020.04.