基本信息
任捷  女  博导  中国科学院北京基因组研究所
电子邮件: renjie@big.ac.cn
通信地址: 北京市朝阳区北辰西路1号院104号楼
邮政编码: 100101

研究领域

        遗传和表观遗传信息在子代精确稳定传递,是维持真核生物体生存的关键。基因组不稳定性影响衰老进程、肿瘤发生和肿瘤细胞异质性,其中表观遗传调控也起着重要作用。有别于DNA损伤修复机制的传统研究,课题组致力于拓展生物体如何通过对不同层次分子事件的调控来避免DNA发生损伤这一前沿领域新方向,阐明维护基因组稳定性的新机制。基因组转录和复制作为染色质生命活动的两个核心事件,传统方法上多作为独立的事件被分别研究,而这两者之间相互作用的重要性正在得到学界越来越广泛的重视。当转录和复制发生碰撞时,被阻滞的复制叉需要被稳定以便再次激活而完成复制,同时被滞留的RNA聚合酶(RNAP)需要被释放而不再成为复制叉前行的阻碍。在病理学上,两者碰撞导致染色体断裂而产生多种脆性位点,是其对基因组不稳定性发生作用的直接反映。在这一新兴的交叉领域,有许多亟待研究和解答的问题,其中通过表观遗传机机制化解复制和转录碰撞是一个创新型角度,其机制也是关键科学问题。对其深入探讨不仅在基础生命科学研究领域,同时对于人类疾病防治策略都具有重要的意义。

  课题组研究方向主要包括:

1. 解析转录和复制碰撞中维护基因组稳定性的表观遗传机理及在精准医学中的应用;

2. 探索RNA介导的染色质调控在干细胞和衰老中的应用;

3. 研发表观遗传、基因组功能分析的多维组学体系和单分子测序新技术

招生信息

   
招生专业
071022-基因组学
071007-遗传学
071010-生物化学与分子生物学
招生方向
基因组稳定性,表观遗传,精准医学,单分子测序

教育工作经历

2000-2004 南京大学 学士

2005-2010 美国纽约州立大学石溪分校 博士

2011-2018 美国冷泉港实验室 博士后

2019-至今 中科院北京基因组研究所 研究员

出版信息

   
发表论文
[1] Bao, Hainan, Cao, Jiani, Chen, Mengting, Chen, Min, Chen, Wei, Chen, Xiao, Chen, Yanhao, Chen, Yu, Chen, Yutian, Chen, Zhiyang, Chhetri, Jagadish K, Ding, Yingjie, Feng, Junlin, Guo, Jun, Guo, Mengmeng, He, Chuting, Jia, Yujuan, Jiang, Haiping, Jing, Ying, Li, Dingfeng, Li, Jiaming, Li, Jingyi, Liang, Qinhao, Liang, Rui, Liu, Feng, Liu, Xiaoqian, Liu, Zuojun, Luo, Oscar Junhong, Lv, Jianwei, Ma, Jingyi, Mao, Kehang, Nie, Jiawei, Qiao, Xinhua, Sun, Xinpei, Tang, Xiaoqiang, Wang, Jianfang, Wang, Qiaoran, Wang, Siyuan, Wang, Xuan, Wang, Yaning, Wang, Yuhan, Wu, Rimo, Xia, Kai, Xiao, FuHui, Xu, Lingyan, Xu, Yingying, Yan, Haoteng, Yang, Liang, Yang, Ruici, Yang, Yuanxin, Ying, Yilin, Zhang, Le, Zhang, Weiwei, Zhang, Wenwan, Zhang, Xing, Zhang, Zhuo, Zhou, Min, Zhou, Rui, Zhu, Qingchen, Zhu, Zhengmao, Cao, Feng, Cao, Zhongwei, Chan, Piu, Chen, Chang, Chen, Guobing, Chen, HouZao, Chen, Jun, Ci, Weimin, Ding, BiSen, Ding, Qiurong, Gao, Feng, Han, JingDong J, Huang, Kai, Ju, Zhenyu, Kong, QingPeng, Li, Ji, Li, Jian, Li, Xin, Liu, Baohua, Liu, Feng, Liu, Lin, Liu, Qiang, Liu, Qiang, Liu, Xingguo, Liu, Yong, Luo, Xianghang, Ma, Shuai, Ma, Xinran, Mao, Zhiyong, Nie, Jing, Peng, Yaojin, Qu, Jing, Ren, Jie, Ren, Ruibao, Song, Moshi, Zhou Songyang, Sun, Yi Eve, Sun, Yu, Tian, Mei, Wang, Shusen, Wang, Si, Wang, Xia, Wang, Xiaoning, Wang, YanJiang, Wang, Yunfang, Wong, Catherine C L, Xiang, Andy Peng, Xiao, Yichuan, Xie, Zhengwei, Xu, Daichao, Ye, Jing, Yue, Rui, Zhang, Cuntai, Zhang, Hongbo, Zhang, Liang, Zhang, Weiqi, Zhang, Yong, Zhang, YunWu, Zhang, Zhuohua, Zhao, Tongbiao, Zhao, Yuzheng, Zhu, Dahai, Zou, Weiguo, Pei, Gang, Liu, GuangHui, Aging Biomarker Consortium. Biomarkers of aging. SCIENCE CHINA-LIFE SCIENCES[J]. 2023, 66(5): 893-1066, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7491049&detailType=1.
[2] Shuhui Sun, Shuai Ma, Yusheng Cai, Si Wang, Jie Ren, Yuanhan Yang, Jiale Ping, Xuebao Wang, Yiyuan Zhang, Haoteng Yan, Wei Li, Concepcion Rodriguez Esteban, Yan Yu, Feifei Liu, Juan Carlos Izpisua Belmonte, Weiqi Zhang, Jing Qu, GuangHui Liu. A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body. THE INNOVATION[J]. 2023, 4(1): http://dx.doi.org/10.1016/j.xinn.2023.100380.
[3] Zeming Wu, Mingming Lu, Di Liu, Yue Shi, Jie Ren, Si Wang, Ying Jing, Sheng Zhang, Qian Zhao, Hongyu Li, Zhihui Yu, Zunpeng Liu, Shijia Bi, Tuo Wei, YunGui Yang, Jingfa Xiao, Juan Carlos Izpisua Belmonte, Jing Qu, Weiqi Zhang, Weimin Ci, GuangHui Liu. m6A epitranscriptomic regulation of tissue homeostasis during primate aging.. Nat Aging[J]. 2023, [4] Ma Shuai, Chi Xu, Cai Yusheng, Ji Zhejun, Wang Si, Ren Jie, Liu Guang-Hui. Decoding aging hallmarks at the single-cell level. Annual Review of Biomedical Data Science[J]. 2023, [5] Xiaoqian Liu, Zunpeng Liu, Zeming Wu, Jie Ren, Yanling Fan, Liang Sun, Gang Cao, Yuyu Niu, Baohu Zhang, Qianzhao Ji, Xiaoyu Jiang, Cui Wang, Qiaoran Wang, Zhejun Ji, Lanzhu Li, Concepcion Rodriguez Esteban, Kaowen Yan, Wei Li, Yusheng Cai, Si Wang, Aihua Zheng, Yong E Zhang, Shengjun Tan, Yingao Cai, Moshi Song, Falong Lu, Fuchou Tang, Weizhi Ji, Qi Zhou, Juan Carlos Izpisua Belmonte, Weiqi Zhang, Jing Qu, GuangHui Liu. Resurrection of endogenous retroviruses during aging reinforces senescence. CELL. 2023, 186(2): 287-304.e26, http://dx.doi.org/10.1016/j.cell.2022.12.017.
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[11] Chuqian Liang, Qiong Ke, Zunpeng Liu, Jie Ren, Weiqi Zhang, Jianli Hu, Zehua Wang, Hong Chen, Kai Xia, Xingqiang Lai, Qiaoran Wang, Kuan Yang, Wei Li, Zeming Wu, Chao Wang, Haoteng Yan, Xiaoyu Jiang, Zhejun Ji, Miyang Ma, Xiao Long, Si Wang, Huating Wang, Hao Sun, JuanCarlosIzpisua Belmonte, Jing Qu, AndyPeng Xiang, GuangHui Liu. BMAL1 moonlighting as a gatekeeper for LINE1 repression and cellular senescence in primates. NUCLEIC ACIDS RESEARCH[J]. 2022, 50(6): 3323-3347, [12] Li, He, Zhu, Lei, Wang, Rong, Xie, Lihui, Ren, Jie, Ma, Shuai, Zhang, Weiqi, Liu, Xiuxing, Huang, Zhaohao, Chen, Binyao, Li, Zhaohuai, Feng, Huyi, Liu, GuangHui, Wang, Si, Qu, Jing, Su, Wenru. Aging weakens Th17 cell pathogenicity and ameliorates experimental autoimmune uveitis in mice. Protein & Cell[J]. 2022, 13(6): 422-445, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7254564&detailType=1.
[13] Hongkai Zhao, Qianzhao Ji, Zeming Wu, Si Wang, Jie Ren, Kaowen Yan, Zehua Wang, Jianli Hu, Qun Chu, Huifang Hu, Yusheng Cai, Qiaoran Wang, Daoyuan Huang, Zhejun Ji,, Juan Carlos Izpisua Belmonte, Jingyi Li, Moshi Song, Weiqi Zhang, Jing Qu, Guang-Hui Liu. Destabilizing heterochromatin by APOE mediates senescence. Nature Aging[J]. 2022, [14] Ma Shuai, Si Wang, Yanxia Ye, Jie Ren, Ruiqing Chen, Wei Li, Jiaming Li, Liyun Zhao, Qian Zhao, Guoqiang Sun, Ying Jing, Yuesheng Zuo, Muzhao Xiong, Yuanhan Yang, Qiaoran Wang, Jinghui Lei, Shuhui Sun, Xiao Long, Moshi Song, shuyang yu, Piu Chan, Jianwei Wang, Qi Zhou, Juan Carlos Izpisua Belmonte, Jing qu, Weiqi Zhang, Guang-Hui Liu . Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues.. Cell Stem Cell[J]. 2022, 29(6): 990-1005, https://www.sciencedirect.com/science/article/pii/S1934590922001709.
[15] Wang, Kang, Liu, Huicong, Hu, Qinchao, Wang, Lingna, Liu, Jiaqing, Zheng, Zikai, Zhang, Weiqi, Ren, Jie, Zhu, Fangfang, Liu, GuangHui. Epigenetic regulation of aging: implications for interventions of aging and diseases. SIGNAL TRANSDUCTION AND TARGETED THERAPYnull. 2022, 7(1): 4283-4304, http://dx.doi.org/10.1038/s41392-022-01211-8.
[16] Zhang, Sheng, Wu, Zeming, Shi, Yue, Wang, Si, Ren, Jie, Yu, Zihui, Huang, Daoyuan, Yan, Kaowen, He, Yifang, Liu, Xiaoqian, Ji, Qianzhao, Liu, Beibei, Liu, Zunpeng, Qu, Jing, Liu, GuangHui, Ci, Weimin, Wang, Xiaoqun, Zhang, Weiqi. FTO stabilizes MIS12 and counteracts senescence. PROTEIN & CELL[J]. 2022, 13(12): 954-960, http://dx.doi.org/10.1007/s13238-022-00914-6.
[17] Yusheng Cai, Wei Song, Jiaming Li, Ying Jing, Chuqian Liang, Liyuan Zhang, Xia Zhang, Wenhui Zhang, Beibei Liu, Yongpan An, Jingyi Li, Baixue Tang, Siyu Pei, Xueying Wu, Yuxuan Liu, ChengLe Zhuang, Yilin Ying, Xuefeng Dou, Yu Chen, FuHui Xiao, Dingfeng Li, Ruici Yang, Ya Zhao, Yang Wang, Lihui Wang, Yujing Li, Shuai Ma, Si Wang, Xiaoyuan Song, Jie Ren, Liang Zhang, Jun Wang, Weiqi Zhang, Zhengwei Xie, Jing Qu, Jianwei Wang, Yichuan Xiao, Ye Tian, Gelin Wang, Ping Hu, Jing Ye, Yu Sun, Zhiyong Mao, QingPeng Kong, Qiang Liu, Weiguo Zou, XiaoLi Tian, ZhiXiong Xiao, Yong Liu, JunPing Liu, Moshi Song, JingDong J Han, GuangHui Liu. The landscape of aging. Science China Life Sciences[J]. 2022, 1-101, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446657/.
[18] Xiao Han, Jia Guo, Mengke Wang, Nan Zhang, Jie Ren, Ying Yang, Xu Chi, Yusheng Chen, Huan Yao, YongLiang Zhao, YunGui Yang, Yingpu Sun, Jiawei Xu. Dynamic DNA 5-hydroxylmethylcytosine and RNA 5-methycytosine Reprogramming During Early Human Development. GENOMICS, PROTEOMICS & BIOINFORMATICS[J]. 2022, http://dx.doi.org/10.1016/j.gpb.2022.05.005.
[19] Lei, Jinghui, Jiang, Xiaoyu, Li, Wei, Ren, Jie, Wang, Datao, Ji, Zhejun, Wu, Zeming, Cheng, Fang, Cai, Yusheng, Yu, ZhengRong, Belmonte, Juan Carlos Izpisua, Li, Chunyi, Liu, GuangHui, Zhang, Weiqi, Qu, Jing, Wang, Si. Exosomes from antler stem cells alleviate mesenchymal stem cell senescence and osteoarthritis. PROTEIN & CELL[J]. 2022, 13(3): 220-226, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000680774700001.
[20] Kang, Wang, Jin, Tong, Zhang, Tao, Ma, Shuai, Yan, Haoteng, Liu, Zunpeng, Ji, Zhejun, Cai, Yusheng, Wang, Si, Song, Moshi, Ren, Jie, Hu, Baoyang, Zhou, Qi, Zhang, Weiqi, Qu, Jing, Bao, Yiming, Liu, GuangHui. Regeneration Roadmap: database resources for regenerative biology. Nucleic Acids Research[J]. 2022, 50(D1): D1085-D1090, https://doi.org/10.1093/nar/gkab870.
[21] Zhang, Hui, Li, Jiaming, Ren, Jie, Sun, Shuhui, Ma, Shuai, Zhang, Weiqi, Yu, Yang, Cai, Yusheng, Yan, Kaowen, Li, Wei, Hu, Baoyang, Chan, Piu, Zhao, GuoGuang, Belmonte, Juan Carlos Izpisua, Zhou, Qi, Qu, Jing, Wang, Si, Liu, GuangHui. Single-nucleus transcriptomic landscape of primate hippocampal aging. Protein & Cell[J]. 2021, 12(9): 695-716, http://dx.doi.org/10.1007/s13238-021-00852-9.
[22] He Ming, Chi Xu, Ren Jie. Applications of Oxford Nanopore Sequencing in Schizosaccharomyces pombe. Methods in Molecular Biology[J]. 2021, [23] Wu, Zeming, Shi, Yue, Lu, Mingming, Song, Moshi, Yu, Zihui, Wang, Jilu, Wang, Si, Ren, Jie, Yang, YunGui, Liu, GuangHui, Zhang, Weiqi, Ci, Weimin, Qu, Jing. METTL3 counteracts premature aging via m(6)A-dependent stabilization of MIS12 mRNA. NUCLEIC ACIDS RESEARCH[J]. 2020, 48(19): 11083-11096, https://www.webofscience.com/wos/woscc/full-record/WOS:000606018400039.
[24] Pengze Yan, Jie Ren, Weiqi Zhang, Jing Qu, GuangHui Liu. Protein quality control of cell stemness. 细胞再生(英文)[J]. 2020, 9(1): 1-11, http://lib.cqvip.com/Qikan/Article/Detail?id=7108164441.
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