遗传和表观遗传信息在子代精确稳定传递，是维持真核生物体生存的关键。基因组不稳定性影响衰老进程、肿瘤发生和肿瘤细胞异质性，其中表观遗传调控也起着重要作用。有别于DNA损伤修复机制的传统研究，课题组致力于拓展生物体如何通过对不同层次分子事件的调控来避免DNA发生损伤这一前沿领域新方向，阐明维护基因组稳定性的新机制。基因组转录和复制作为染色质生命活动的两个核心事件，传统方法上多作为独立的事件被分别研究，而这两者之间相互作用的重要性正在得到学界越来越广泛的重视。当转录和复制发生碰撞时，被阻滞的复制叉需要被稳定以便再次激活而完成复制，同时被滞留的RNA聚合酶（RNAP）需要被释放而不再成为复制叉前行的阻碍。在病理学上，两者碰撞导致染色体断裂而产生多种脆性位点，是其对基因组不稳定性发生作用的直接反映。在这一新兴的交叉领域，有许多亟待研究和解答的问题，其中通过表观遗传机机制化解复制和转录碰撞是一个创新型角度，其机制也是关键科学问题。对其深入探讨不仅在基础生命科学研究领域，同时对于人类疾病防治策略都具有重要的意义。

　　课题组研究方向主要包括：

1. 解析转录和复制碰撞中维护基因组稳定性的表观遗传机理及在精准医学中的应用；

2. 探索RNA介导的染色质调控在干细胞和衰老中的应用；

3. 研发表观遗传、基因组功能分析的多维组学体系和单分子测序新技术

   

071022-基因组学
071007-遗传学
071010-生物化学与分子生物学

基因组稳定性，表观遗传，精准医学，单分子测序

2000-2004 南京大学 学士

2005-2010 美国纽约州立大学石溪分校 博士

2011-2018 美国冷泉港实验室 博士后

2019-至今 中科院北京基因组研究所 研究员

   

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