100706-药理学

基于多组学的胃癌、胰腺癌的新靶标发现研究
胃癌、胰腺癌新靶标的功能与分子机制研究
基于胃癌胰腺癌新靶标的干预策略与创新药物研究

2006-09--2011-06   上海交通大学药学院   博士
2002-09--2006-06   上海交通大学药学院   学士

   

（1） 基于人工智能数据库的胃癌诊疗关键技术创新及推广应用, 一等奖, 省级, 2022
（2） 上海市优秀博士学位论文, 一等奖, 省级, 2012
（3） 教育部博士研究生学术新人奖, 一等奖, 部委级, 2010

（ 1 ） 一种富勒醇接枝高分子载体的合成及应用, 发明专利, 2023, 第 2 作者, 专利号: ZL202110394445.2

（ 2 ） 一种具有抗肿瘤活性的嗜氮酮生物碱、制备方法及其用途, 发明专利, 2020, 第 2 作者, 专利号: ZL202010078082.7

（ 3 ） 一种具有抗肿瘤活性的苯并二呋喃酮类化合物、制备方法及其用途, 发明专利, 2021, 第 2 作者, 专利号: ZL202010439985.3

   

（1） Peptide-based strategies for overcoming multidrug-resistance in cancer therapy., Chinese Chemical Letters, 2024, 通讯作者
（2） ML162 derivatives incorporating a naphthoquinone unit as ferroptosis/apoptosis inducers: Design, synthesis, anti-cancer activity, and drug-resistance reversal evaluation., European Journal of Medicinal Chemistry, 2024, 通讯作者
（3） Nanomaterial-encapsulated STING agonists for immune modulation in cancer therapy., Biomarker Research, 2024, 通讯作者
（4） Targeting Ferroptosis in Gastric Cancer: Strategies and Opportunities., Immunological Reviews, 2024, 通讯作者
（5） Role of F-Box Proteins in Human Upper Gastrointestinal Tumors, Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 2024, 通讯作者
（6） Progress in RAS-targeted therapeutic strategies: From small molecule inhibitors to proteolysis targeting chimeras., Medicinal Research Review, 2024, 通讯作者
（7） Expanding the Ubiquitin Code in Pancreatic Cancer, Biochim Biophys Acta Molecular Basis of Disease, 2024, 通讯作者
（8） Radioiodine-refractory thyroid cancer: Molecular mechanisms and therapeutic strategies for radioiodine resistance., Drug Resistance Updates, 2024, 通讯作者
（9） Blocking Ubiquitin-Specific Protease 7 Induces Ferroptosis in Gastric Cancer via Targeting Stearoyl-CoA Desaturase., Advanced Science, 2024, 通讯作者
（10） Integrated proteogenomic characterization of adenocarcinoma of esophagogastric junction, Nature Communications, 2023, 通讯作者
（11） Evolution of immune and stromal cell states and ecotypes during gastric adenocarcinoma progression., Cancer Cell, 2023, 第 1 作者
（12） Dual inhibition of MYC and SLC39A10 by a novel natural product STAT3 inhibitor derived from Chaetomium globosum suppresses tumor growth and metastasis in gastric cancer., Pharmacological Research, 2023, 通讯作者
（13） Pan-cancer T cell atlas links a cellular stress response state to immunotherapy resistance., Nature Medicine, 2023, 第 8 作者
（14） Glutathione peroxidase 2 knockdown suppresses gastric cancer progression and metastasis via regulation of kynurenine metabolism., Oncogene, 2023, 通讯作者
（15） Strategies to overcome cancer multidrug resistance (MDR) through targeting P-glycoprotein (ABCB1): an updated review., Pharmacology & Therapeutics, 2023, 通讯作者
（16） Polyphyllin B suppresses gastric tumor growth by modulating iron metabolism and inducing ferroptosis., International Journal of Biological Sciences, 2023, 通讯作者
（17） Targeting E2 ubiquitin-conjugating enzyme UbcH5c by small molecule inhibitor suppresses pancreatic cancer growth and metastasis., Molecular Cancer, 2022, 通讯作者
（18） Targeting KRAS mutant cancers: From druggable therapy to drug resistance., Molecular Cancer, 2022, 通讯作者
（19） Inhibiting STAT3 Signaling Pathway by Natural Products for Cancer Prevention and Therapy: In Vitro and In Vivo Activity and Mechanisms of Action., Pharmacological Research, 2022, 通讯作者
（20） Discovery of benzochalcone derivative as a potential antigastric cancer agent targeting signal transducer and activator of transcription 3 (STAT3), Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, 通讯作者
（21） p-MEK Expression Predicts Prognosis of Patients with Adenocarcinoma of Esophagogastric Junction (AEG) and Plays a Role in Anti-AEG Efficacy of Huaier., Pharmacological Research, 2021, 通讯作者
（22） Protein degradation technology: A strategic paradigm shift in drug discovery, Journal of Hematology & Oncology, 2021, 通讯作者
（23） Recent Update on Development of Small-Molecule STAT3 Inhibitors for Cancer Therapy: From Phosphorylation Inhibition to Protein Degradation., Journal of Medicinal Chemistry, 2021, 通讯作者
（24） Integrative analysis reveals clinically relevant molecular fingerprints in pancreatic cancer., Molecular Therapy-Nucleic Acids, 2021, 通讯作者
（25） Medicinal chemistry strategies to discover P-glycoprotein inhibitors: An update., Drug Resistance Updates, 2020, 通讯作者
（26） Long non-coding RNAs towards precision medicine in gastric cancer: Early diagnosis, treatment, and drug resistance., Molecular Cancer, 2020, 通讯作者
（27） UbcH5c: An emerging target in cancer and immune disorders., Drug Discovery Today, 2020, 通讯作者
（28） MDM2-NFAT1 Dual Inhibitor, MA242: Effective against Hepatocellular Carcinoma, Independent of p53, Cancer Letters, 2019, 第 1 作者
（29） Dual roles and therapeutic potential of Keap1-Nrf2 pathway in pancreatic cancer: A systematic review., Cell Communication and Signaling, 2019, 通讯作者
（30） STAT3 as a potential therapeutic target in triple negative breast cancer: a systematic review., Journal of Experimental & Clinical Cancer Research, 2019, 通讯作者
（31） Is CDK9 a Promising Target for Both Primary And Metastatic Osteosarcoma?, EBioMedicine, 2019, 通讯作者
（32） Discovery and characterization of dual inhibitors of MDM2 and NFAT1 for pancreatic cancer therapy., Cancer Research, 2018, 第 1 作者

   

（ 1 ） 重大疾病标志物分子识别元件的筛选及识别机制研究, 负责人, 国家任务, 2021-12--2026-11
（ 2 ） 基于中药多靶标协同作用特性的大花旋覆花内酯抗胰腺癌分子机制研究, 负责人, 地方任务, 2021-01--2023-12
（ 3 ） 基于多维组学的食管胃结合部恶性肿瘤分子分型、疗效预测及预后评估研究, 负责人, 地方任务, 2022-01--2024-12
（ 4 ） 靶向E2泛素结合酶UbcH5c的抗胰腺癌中药小分子的发现与作用机制研究, 负责人, 地方任务, 2024-01--2026-12
（ 5 ） 中药旋覆花倍半萜内酯靶向UbcH5c/cIAP1复合物调控多信号通路协同治疗胰腺癌的作用机制研究, 负责人, 国家任务, 2024-01--2027-12
（ 6 ） 胃癌胰腺癌新靶标发现与创新药物开发, 负责人, 地方任务, 2023-01--2025-12

现指导学生

彭缇  硕士研究生  105500-药学  

严丽  硕士研究生  105500-药学  

朱春晓  硕士研究生  105500-药学  

张澈  硕士研究生  105500-药学