基本信息

陆炯明 男 中国科学院上海营养与健康研究所
电子邮件: jmlu@sibs.ac.cn
通信地址: 上海市徐汇区岳阳路320号
邮政编码: 200031
电子邮件: jmlu@sibs.ac.cn
通信地址: 上海市徐汇区岳阳路320号
邮政编码: 200031
研究领域
衰老是人体机能随着时间衰退的一个过程,是许多疾病的首要风险因素。当前世界人口老龄化的急剧增加,给我们整个社会带来了巨大的挑战。现代衰老学研究表明,衰老过程是可以通过营养干预得到改善。营养干预,特别是饮食限制,是目前延长动物健康和寿命最有效的干预措施,也是改善人类健康的最有潜力的手段。食物中的不同营养成分,比如蛋白质或其组成成分氨基酸、脂肪、碳水化合物等,在饮食限制中发挥的效果是不一样的。氨基酸是其中最为关键的成分,但是氨基酸如何发挥其作用的目前仍然未知。因此,我们课题组的工作将聚焦于阐述氨基酸诱导健康衰老的分子机制,同时开发新型的延长健康跨度和寿命的干预方式。
本课题组将使用全化学食物和遗传学工具,同时结合代谢和基因组分析,以体外细胞、果蝇和小鼠为实验模型,围绕以下三个方面展开研究:
1. 全面系统地解析单氨基酸干预在应激反应和健康衰老中的作用,
2. 研究氨基酸翻译、代谢和感应机制介导健康衰老的分子机理,
3. 揭示Sestrin活性调控机制,推进以Sestrin为靶点的转化研究。
上述三个方面的研究内容相互独立又相互关联,研究结果将使衰老相关慢性疾病患者和正常衰老的人都受益,从而改善人口老龄化对医疗系统的挑战。
招生信息
招生专业
071003-生理学
071007-遗传学
071009-细胞生物学
071007-遗传学
071009-细胞生物学
招生方向
衰老
营养干预
干细胞
营养干预
干细胞
教育背景
2009-01--2013-12 瑞士伯尔尼大学 博士
2005-09--2008-07 中国科学院上海生命科学研究院 硕士
2001-09--2005-06 南京大学 学士
2005-09--2008-07 中国科学院上海生命科学研究院 硕士
2001-09--2005-06 南京大学 学士
工作经历
工作简历
2023-01~现在, 中国科学院上海营养与健康研究所, 研究员, 博士生导师
2015-07~2022-11,德国马普衰老研究所, 博士后
2014-01~2015-06,瑞士伯尔尼大学, 博士后
2015-07~2022-11,德国马普衰老研究所, 博士后
2014-01~2015-06,瑞士伯尔尼大学, 博士后
专利与奖励
奖励信息
(1) 瑞士自然科学基金博士后奖学金, 国家级, 2015
专利成果
( 1 ) 雷公藤活性成分调控热休克蛋白和视黄醇X受体α的应用, 发明专利, 2012, 第 1 作者, 专利号: CN101574386B
出版信息
发表论文
[1] Anchal Srivastava, Jiongming Lu, Dennis Said Gadalla, Oliver Hendrich, Sebastian Grnke, Linda Partridge. The Role of GCN2 Kinase in Mediating the Effects of Amino Acids on Longevity and Feeding Behaviour in Drosophila. FRONTIERS IN AGING[J]. 2022, 第 2 作者3: https://doaj.org/article/5cadd427e10948988df37e4225517bec.
[2] Manh Tin Ho, Jiongming Lu, Paula VazquezPianzola, Beat Suter. α-Phenylalanyl tRNA synthetase competes with Notch signaling through its N-terminal domain. PLOS GENETICS[J]. 2022, 第 2 作者18(4): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9094542/.
[3] Paula Juricic, Yu-Xuan Lu, Thomas Leech, Lisa F. Drews, Jonathan Paulitz, Jiongming Lu, Tobias Nespital, Sina Azami, Jennifer C. Regan, Emilie Funk, Jenny Fröhlich, Sebastian Grönke, Linda Partridge. Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy. Nature Aging[J]. 2022, https://www.nature.com/articles/s43587-022-00278-w.
[4] Lu Jiongming, Ulrike Temp, Andrea Müller-Hartmann, Jacqueline Esser, Sebastian Grönke, Linda Partridge. Sestrin is a key regulator of stem cell function and lifespan in response to dietary amino acids. Nature Aging[J]. 2021, 第 1 作者1(1): 60-72, https://www.nature.com/articles/s43587-020-00001-7.
[5] Manh Tin Ho, Lu, Jiongming, Brunssen, Dominique, Suter, Beat. A translation-independent function of PheRS activates growth and proliferation in Drosophila. DISEASE MODELS & MECHANISMS[J]. 2021, 第 2 作者14(3): http://dx.doi.org/10.1242/dmm.048132.
[6] Lu, Jiongming, Marygold, Steven J, Gharib, Walid H, Suter, Beat. The aminoacyl-tRNA synthetases of Drosophila melanogaster. FLY. 2015, 第 1 作者9(2): 53-61, https://www.webofscience.com/wos/woscc/full-record/WOS:000371287400001.
[7] Lu, Jiongming, Bergert, Martin, Walther, Anita, Suter, Beat. Double-sieving-defective aminoacyl-tRNA synthetase causes protein mistranslation and affects cellular physiology and development. NATURE COMMUNICATIONS[J]. 2014, 第 1 作者5: http://dx.doi.org/10.1038/ncomms6650.
[8] Liu, Jie, Zhou, Wen, Li, ShaoShun, Sun, Zhe, Lin, Bingzhen, Lang, YuanYuan, He, JiaYou, Cao, Xihua, Yan, Tingdong, Wang, Li, Lu, Jiongming, Han, YoungHoon, Cao, Yu, Zhang, Xiaokun, Zeng, JinZhang. Modulation of Orphan Nuclear Receptor Nur77-Mediated Apoptotic Pathway by Acetylshikonin and Analogues. CANCER RESEARCH[J]. 2008, 第 11 作者68(21): 8871-8880, https://www.webofscience.com/wos/woscc/full-record/WOS:000260698900029.
[2] Manh Tin Ho, Jiongming Lu, Paula VazquezPianzola, Beat Suter. α-Phenylalanyl tRNA synthetase competes with Notch signaling through its N-terminal domain. PLOS GENETICS[J]. 2022, 第 2 作者18(4): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9094542/.
[3] Paula Juricic, Yu-Xuan Lu, Thomas Leech, Lisa F. Drews, Jonathan Paulitz, Jiongming Lu, Tobias Nespital, Sina Azami, Jennifer C. Regan, Emilie Funk, Jenny Fröhlich, Sebastian Grönke, Linda Partridge. Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy. Nature Aging[J]. 2022, https://www.nature.com/articles/s43587-022-00278-w.
[4] Lu Jiongming, Ulrike Temp, Andrea Müller-Hartmann, Jacqueline Esser, Sebastian Grönke, Linda Partridge. Sestrin is a key regulator of stem cell function and lifespan in response to dietary amino acids. Nature Aging[J]. 2021, 第 1 作者1(1): 60-72, https://www.nature.com/articles/s43587-020-00001-7.
[5] Manh Tin Ho, Lu, Jiongming, Brunssen, Dominique, Suter, Beat. A translation-independent function of PheRS activates growth and proliferation in Drosophila. DISEASE MODELS & MECHANISMS[J]. 2021, 第 2 作者14(3): http://dx.doi.org/10.1242/dmm.048132.
[6] Lu, Jiongming, Marygold, Steven J, Gharib, Walid H, Suter, Beat. The aminoacyl-tRNA synthetases of Drosophila melanogaster. FLY. 2015, 第 1 作者9(2): 53-61, https://www.webofscience.com/wos/woscc/full-record/WOS:000371287400001.
[7] Lu, Jiongming, Bergert, Martin, Walther, Anita, Suter, Beat. Double-sieving-defective aminoacyl-tRNA synthetase causes protein mistranslation and affects cellular physiology and development. NATURE COMMUNICATIONS[J]. 2014, 第 1 作者5: http://dx.doi.org/10.1038/ncomms6650.
[8] Liu, Jie, Zhou, Wen, Li, ShaoShun, Sun, Zhe, Lin, Bingzhen, Lang, YuanYuan, He, JiaYou, Cao, Xihua, Yan, Tingdong, Wang, Li, Lu, Jiongming, Han, YoungHoon, Cao, Yu, Zhang, Xiaokun, Zeng, JinZhang. Modulation of Orphan Nuclear Receptor Nur77-Mediated Apoptotic Pathway by Acetylshikonin and Analogues. CANCER RESEARCH[J]. 2008, 第 11 作者68(21): 8871-8880, https://www.webofscience.com/wos/woscc/full-record/WOS:000260698900029.
科研活动
参与会议
(1)Sestrin is a key regulator of stem cell function and lifespan in response to dietary amino acids 2021-02-18
(2)TORC1 amino-acid sensing pathway in lifespan regulation of Drosophila melanogaster 2016-09-26
(3)Double-sieving defective tRNA synthetase causes protein mistranslation and affects cellular physiology in Drosophila 2015-02-22
(2)TORC1 amino-acid sensing pathway in lifespan regulation of Drosophila melanogaster 2016-09-26
(3)Double-sieving defective tRNA synthetase causes protein mistranslation and affects cellular physiology in Drosophila 2015-02-22