0710Z1-基因组学
0710J3-生物信息学

基因组学，生物信息学，群体遗传学
液体活检、肿瘤早筛
云计算与生命大数据

2010-09--2015-06   华南理工大学   博士学位
2006-09--2010-06   华南理工大学   学士学位

   

2020-03~现在, 深圳华大生命科学研究院, 精准健康研究所所长
2016-01~现在, 华南理工大学, 研究员
2015-07~2020-03,深圳华大基因股份有限公司, 大数据总监

2018-08-01-今,深圳市生物信息云计算促进会, 会长
2017-12-20-2021-12-30,广东省生物物理学会, 理事
2016-11-01-今,广东省生物信息学, 理事

实用生物统计

   

（1） 深圳市自然科学奖, 二等奖, 市地级, 2017

（ 1 ） 利用血浆游离DNA测序数据的reads覆盖情况进行肺癌预测的方法, 发明专利, 2020, 第 4 作者, 专利号: PCT/CN2021/071822
（ 2 ） 基于无创产前基因检测数据的亲缘关系判定方法和装置, 发明专利, 2020, 第 4 作者, 专利号: PCT/CN2020/124079
（ 3 ） 确定孕妇的孕期状态的方法, 发明专利, 2020, 第 3 作者, 专利号: PCT/CN2020/122214
（ 4 ） 一种统计DNA拷贝数信息的方法、装置及存储介质, 发明专利, 2017, 第 1 作者, 专利号: 201710685620.7
（ 5 ） SNRNP200基因突变体及其应用, 发明专利, 2012, 第 2 作者, 专利号: CN201210082413.X
（ 6 ） 一种检测高度近视的试剂盒, 发明专利, 2012, 第 2 作者, 专利号: CN201210057779.1
（ 7 ） 目标区域捕获方法及其生物信息处理方法和系统, 发明专利, 2011, 第 2 作者, 专利号: CN201180071091.2
（ 8 ） 遗传性疾病相关基因的鉴定方法, 发明专利, 2010, 第 3 作者, 专利号: CN201010286309.3

   

[1] Yunyun An, Xin Zhao, Ziteng Zhang, Zhaohua Xia, Mengqi Yang, Li Ma, Yu Zhao, Gang Xu, Shunda Du, Xiangan Wu, Shuowen Zhang, Xin Hong, Xin Jin, Kun Sun. DNA methylation analysis explores the molecular basis of plasma cell-free DNA fragmentation. NATURE COMMUNICATIONS[J]. 2023, 第 13 作者  通讯作者  14(1): 1-12, https://doaj.org/article/b9632055ddd54a3f9f0a43ec3d13c260.
[2] Bai, Yong, Zheng, Fang, Zhang, Tongda, Luo, Qiuhong, Luo, Yuxue, Zhou, Ruilong, Jin, Yan, Shan, Ying, Cheng, Jiehui, Yang, Zhimin, Li, Lingguo, Zhang, Haiqiang, Zhang, Yan, Yin, Jianhua, Fang, Mingyan, Chen, Dongsheng, Cheng, Fanjun, Jin, Xin. Integrating plasma cell-free DNA with clinical laboratory results enhances the prediction of critically ill patients with COVID-19 at hospital admission. CLINICAL AND TRANSLATIONAL MEDICINE[J]. 2022, 第 18 作者  通讯作者  12(7): http://dx.doi.org/10.1002/ctm2.966.
[3] Li, Zhichao, Jiang, Xiaosen, Fang, Mingyan, Bai, Yong, Liu, Siyang, Huang, Shujia, Jin, Xin. CMDB: the comprehensive population genome variation database of China. NUCLEIC ACIDS RESEARCH. 2022, 第 7 作者  通讯作者  51(D1): D890-D895, http://dx.doi.org/10.1093/nar/gkac638.
[4] Wang, Yanqun, Li, Jie, Zhang, Lu, Sun, HaiXi, Zhang, Zhaoyong, Xu, Jinjin, Xu, Yonghao, Lin, Yu, Zhu, Airu, Luo, Yuxue, Zhou, Haibo, Wu, Yan, Lin, Shanwen, Sun, Yuzhe, Xiao, Fei, Chen, Ruiying, Wen, Liyan, Chen, Wei, Li, Fang, Ou, Rijing, Zhang, Yanjun, Kuo, Tingyou, Li, Yuming, Li, Lingguo, Sun, Jing, Sun, Kun, Zhuang, Zhen, Lu, Haorong, Chen, Zhao, Mai, Guoqiang, Zhuo, Jianfen, Qian, Puyi, Chen, Jiayu, Yang, Huanming, Wang, Jian, Xu, Xun, Zhong, Nanshan, Zhao, Jingxian, Li, Junhua, Zhao, Jincun, Jin, Xin. Plasma cell-free RNA characteristics in COVID-19 patients. GENOME RESEARCH[J]. 2022, 第 41 作者  通讯作者  32(2): 228-241, http://dx.doi.org/10.1101/gr.276175.121.
[5] Chen, Dongsheng, Tan, Cong, Ding, Peiwen, Luo, Lihua, Zhu, Jiacheng, Jiang, Xiaosen, Ou, Zhihua, Ding, Xiangning, Lan, Tianming, Zhu, Yixin, Jia, Yi, Wei, Yanan, Li, Runchu, Qin, Qiuyu, Sun, Chengcheng, Zhao, Wandong, Lv, Zhiyuan, Wang, Haoyu, Wu, Wendi, Yuan, Yuting, Pu, Mingyi, Li, Yuejiao, Zhang, Yanan, Chang, Ashley, Guo, Guoji, Bai, Yong, Jin, Xin, Liu, Huan. VThunter: a database for single-cell screening of virus target cells in the animal kingdom. NUCLEIC ACIDS RESEARCH[J]. 2022, 第 27 作者  通讯作者  50(D1): D934-D942, http://dx.doi.org/10.1093/nar/gkab894.
[6] Wu, Peng, Chen, Dongsheng, Ding, Wencheng, Wu, Ping, Hou, Hongyan, Bai, Yong, Zhou, Yuwen, Li, Kezhen, Xiang, Shunian, Liu, Panhong, Ju, Jia, Guo, Ensong, Liu, Jia, Yang, Bin, Fan, Junpeng, He, Liang, Sun, Ziyong, Feng, Ling, Wang, Jian, Wu, Tangchun, Wang, Hao, Cheng, Jin, Xing, Hui, Meng, Yifan, Li, Yongsheng, Zhang, Yuanliang, Luo, Hongbo, Xie, Gang, Lan, Xianmei, Tao, Ye, Li, Jiafeng, Yuan, Hao, Huang, Kang, Sun, Wan, Qian, Xiaobo, Li, Zhichao, Huang, Mingxi, Ding, Peiwen, Wang, Haoyu, Qiu, Jiaying, Wang, Feiyue, Wang, Shiyou, Zhu, Jiacheng, Ding, Xiangning, Chai, Chaochao, Liang, Langchao, Wang, Xiaoling, Luo, Lihua, Sun, Yuzhe, Yang, Ying, Zhuang, Zhenkun, Li, Tao, Tian, Lei, Zhang, Shaoqiao, Zhu, Linnan, Chang, Ashley, Chen, Lei, Wu, Yiquan, Ma, Xiaoyan, Chen, Fang, Ren, Yan, Xu, Xun, Liu, Siqi, Yang, Huanming, Wang, Lin, Sun, Chaoyang, Ma, Ding, Jin, Xin, Chen, Gang. The trans-omics landscape of COVID-19. NATURE COMMUNICATIONS[J]. 2021, 第 68 作者  通讯作者  12(1): http://dx.doi.org/10.1038/s41467-021-24482-1.
[7] Xu, Huixin, Zhen, Qi, Bai, Mingzhou, Fang, Lin, Zhang, Yong, Li, Bao, Ge, Huiyao, Moon, Sunjin, Chen, Weiwei, Fu, Wenqing, Xu, Qiongqiong, Zhou, Yuwen, Yu, Yafeng, Lin, Long, Yong, Liang, Zhang, Tao, Chen, Shirui, Liu, Siyang, Zhang, Hui, Chen, Ruoyan, Cao, Lu, Zhang, Yuanwei, Zhang, Ruixue, Yang, Huanjie, Hu, Xia, Akey, Joshua M, Jin, Xin, Sun, Liangdan. Deep sequencing of 1320 genes reveals the landscape of protein-truncating variants and their contribution to psoriasis in 19,973 Chinese individuals. GENOME RESEARCH[J]. 2021, 第 27 作者  通讯作者  31(7): 1150-+, http://dx.doi.org/10.1101/gr.267963.120.
[8] Sun, Chaoyang, Bai, Yong, Chen, Dongsheng, He, Liang, Zhu, Jiacheng, Ding, Xiangning, Luo, Lihua, Ren, Yan, Xing, Hui, Jin, Xin, Chen, Gang. Accurate classification of COVID-19 patients with different severity via machine learning. CLINICAL AND TRANSLATIONAL MEDICINE[J]. 2021, 第 10 作者  通讯作者  11(3): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908044/.
[9] Wang, Fang, Huang, Shujia, Gao, Rongsui, Zhou, Yuwen, Lai, Changxiang, Li, Zhichao, Xian, Wenjie, Qian, Xiaobo, Li, Zhiyu, Huang, Yushan, Tang, Qiyuan, Liu, Panhong, Chen, Ruikun, Liu, Rong, Li, Xuan, Tong, Xin, Zhou, Xuan, Bai, Yong, Duan, Gang, Zhang, Tao, Xu, Xun, Wang, Jian, Yang, Huanming, Liu, Siyang, He, Qing, Jin, Xin, Liu, Lei. Initial whole-genome sequencing and analysis of the host genetic contribution to COVID-19 severity and susceptibility. CELL DISCOVERY[J]. 2020, 第 26 作者  通讯作者  6(1): https://doaj.org/article/96e1882855ca428ab13f3847bacc028a.
[10] Panhong Liu, Zilong Li, Xihong Lin, Yan Jin, Yu Yan, Kai Wang, Minghui Jiang, Xian Shi, Xingjie Hao, Minghan Qu, Lin Ding, Degang Wu, Shanshan Cheng, Fanjun Cheng, Wencheng Ding, Yu Fu, Kezhen Li, Chaoyang Sun, Peng Wu, Gang Chen, Ping Wu, Fang Zheng, Zuoyu Shao, Jingzhi Wang, Mingzhong Xiao, Xi Xu, Wei Ni, Xiaodong Li, Yana Zhou, Qing Zhang, Jia Ke, Linlin Liu, Xixiang Huo, Yingchun Zeng, Shi Han, Tingting Mo, Ziyue Geng, Limei Shi, Xuedan Xu, Wending Li, Xuanwen Mu, Hao Wang, Qin Jiang, Gaokun Qiu, Yuhui Lin, Kang Liu, Rong Peng, Pinpin Long, Hui Gao, Huan Guo, Chaolong Wang, Hongyan Hou, Feng Wang, Ziyong Sun, Xin Jin, Siyang Liu, Qing He, Lei Liu, Fang Wang. Trans-ethnic genome-wide association study of severe COVID-19. COMMUNICATIONS BIOLOGY. 202, 第 55 作者http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA202110141500372ZK.
[11] Ji, Xing, Li, Jia, Huang, Yonghua, Sung, PiLin, Yuan, Yuying, Liu, Qiang, Chen, Yan, Ju, Jia, Zhou, Yafeng, Huang, Shujia, Chen, Fang, Han, Yuan, Yuan, Wen, Fan, Cheng, Zhao, Qiang, Wu, Haitao, Feng, Suihua, Liu, Weiqiang, Li, Zhihua, Chen, Jingsi, Chen, Min, Yao, Hong, Zeng, Li, Ma, Tao, Fan, Shushu, Zhang, Jinman, Yuen, Ka Yiu, Cheng, So Hin, Chik, Irene Wing Shan, Liu, NienTzu, Zhu, Jianyu, Lin, Siyuan, Cao, Jeremy, Tong, Steve, Shan, Zhiyuan, Li, Wenyan, Hekmat, Mohammad Reza, Garshasbi, Masoud, Suela, Javier, Torres, Yaima, Cigudosa, Juan C, Perez Ruiz, F J, Rodriguez, Laura, Garcia, Monica, Bernik, Janez, Traven, Eva, Res, Ursula, Tul, Natasa, Tseng, ChingFong, Zhao, Depeng, Sun, Luming, Pan, Qiong, Shen, Li, Dai, Mengyao, Wang, Yuying, Wang, Jian, Yang, Huanming, Yin, Ye, Duan, Tao, Zhu, Baosheng, Choolani, Mahesh, Jin, Xin, Chen, Yingwei, Mao, Mao. Identifying occult maternal malignancies from 1.93 million pregnant women undergoing noninvasive prenatal screening tests. GENETICS IN MEDICINE[J]. 2019, 第 62 作者  通讯作者  21(10): 2293-2302, https://www.webofscience.com/wos/woscc/full-record/WOS:000488530100018.
[12] Wu, Jinyu, Yu, Ping, Jin, Xin, Xu, Xiu, Li, Jinchen, Li, Zhongshan, Wang, Mingbang, Wang, Tao, Wu, Xueli, Jiang, Yi, Cai, Wanshi, Mei, Junpu, Min, Qingjie, Xu, Qiong, Zhou, Bingrui, Guo, Hui, Wang, Ping, Zhou, Wenhao, Hu, Zhengmao, Li, Yingrui, Cai, Tao, Wang, Yi, Xia, Kun, Jiang, YongHui, Sun, Zhong Sheng. Genomic landscapes of Chinese sporadic autism spectrum disorders revealed by whole-genome sequencing. JOURNAL OF GENETICS AND GENOMICS[J]. 2018, 第 3 作者45(10): 527-538, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6374940&detailType=1.
[13] Liu, Siyang, Huang, Shujia, Chen, Fang, Zhao, Lijian, Yuan, Yuying, Francis, Stephen Starko, Fang, Lin, Li, Zilong, Lin, Long, Liu, Rong, Zhang, Yong, Xu, Huixin, Li, Shengkang, Zhou, Yuwen, Davies, Robert W, Liu, Qiang, Walters, Robin G, Lin, Kuang, Ju, Jia, Komeliussen, Thorfinn, Yang, Melinda A, Fu, Qiaomei, Wang, Jun, Zhou, Lijun, Krogh, Anders, Zhang, Hongyun, Wang, Wei, Chen, Zhengming, Cai, Zhiming, Yin, Ye, Yang, Huanming, Mao, Mao, Shendure, Jay, Wang, Jian, Albrechtsen, Anders, Jin, Xin, Nielsen, Rasmus, Xu, Xun. Genomic Analyses from Non-invasive Prenatal Testing Reveal Genetic Associations, Patterns of Viral Infections, and Chinese Population History. CELL[J]. 2018, 第 36 作者  通讯作者  175(2): 347-+, http://119.78.100.205/handle/311034/8995.
[14] Bataillon, Thomas, Duan, Jinjie, Hvilsom, Christina, Jin, Xin, Li, Yingrui, Skov, Laurits, Glemin, Sylvain, Munch, Kasper, Jiang, Tao, Qian, Yu, Hobolth, Asger, Wang, Jun, Mailund, Thomas, Siegismund, Hans R, Schierup, Mikkel H. Inference of Purifying and Positive Selection in Three Subspecies of Chimpanzees (Pan troglodytes) from Exome Sequencing. GENOME BIOLOGY AND EVOLUTION[J]. 2015, 第 4 作者7(4): 1122-1132, http://dx.doi.org/10.1093/gbe/evv058.
[15] HuertaSanchez, Emilia, Jin, Xin, Asan, Bianba, Zhuoma, Peter, Benjamin M, Vinckenbosch, Nicolas, Liang, Yu, Yi, Xin, He, Mingze, Somel, Mehmet, Ni, Peixiang, Wang, Bo, Ou, Xiaohua, Huasang, Luosang, Jiangbai, Cuo, Zha Xi Ping, Li, Kui, Gao, Guoyi, Yin, Ye, Wang, Wei, Zhang, Xiuqing, Xu, Xun, Yang, Huanming, Li, Yingrui, Wang, Jian, Wang, Jun, Nielsen, Rasmus. Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA. NATURE[J]. 2014, 第 2 作者512(7513): 194-+, http://dx.doi.org/10.1038/nature13408.
[16] Sheng, Yujun, Jin, Xin, Xu, Jinhua, Gao, Jinping, Du, Xiaoqing, Duan, Dawei, Li, Bing, Zhao, Jinhua, Zhan, Wenying, Tang, Huayang, Tang, Xianfa, Li, Yang, Cheng, Hui, Zuo, Xianbo, Mei, Junpu, Zhou, Fusheng, Liang, Bo, Chen, Gang, Shen, Changbing, Cui, Hongzhou, Zhang, Xiaoguang, Zhang, Change, Wang, Wenjun, Zheng, Xiaodong, Fan, Xing, Wang, Zaixing, Xiao, Fengli, Cui, Yong, Li, Yingrui, Wang, Jun, Yang, Sen, Xu, Lei, Sun, Liangdan, Zhang, Xuejun. Sequencing-based approach identified three new susceptibility loci for psoriasis. NATURE COMMUNICATIONS[J]. 2014, 第 2 作者5: http://www.corc.org.cn/handle/1471x/2216406.
[17] Huayang Tang, Xin Jin, Yang Li, Hui Jiang, Xianfa Tang, Xu Ya. A large-scale screen for coding variants predisposing to psoriasis. 2013, 第 2 作者http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201804160009346LZ.
[18] Jiang, Yonghui, Yuen, Ryan K C, Wang, Mingbang, Jin, Xin, Chen, Nong, Wu, Xueli, Ju, Jia, Mei, Junpu, Shi, Yujian, He, Mingze, Wang, Guangbiao, Liang, Jieqin, Wang, Zhe, Cao, Dandan, Carter, Melissa T, Chrysler, Christina, Drmic, Irene E, Howe, Jennifer L, Lau, Lynette, Marshall, Christian R, Merico, Daniele, Nalpathamkalam, Thomas, Thiruvahindrapuram, Bhooma, Thompson, Ann, Uddin, Mohammed, Walker, Susan, Luo, Jun, Anagnostou, Evdokia, Zwaigenbaum, Lonnie, Ring, Robert H, Wang, Jian, Lajonchere, Clara, Wang, Jun, Shih, Andy, Szatmari, Peter, Yang, Huanming, Dawson, Geraldine, Li, Yingrui, Scherer, Stephen W. Detection of Clinically Relevant Genetic Variants in Autism Spectrum Disorder by Whole-Genome Sequencing. AMERICAN JOURNAL OF HUMAN GENETICS[J]. 2013, 第 4 作者93(2): 249-263, http://www.corc.org.cn/handle/1471x/2221533.
[19] Michaelson, Jacob J, Shi, Yujian, Gujral, Madhusudan, Zheng, Hancheng, Malhotra, Dheeraj, Jin, Xin, Jian, Minghan, Liu, Guangming, Greer, Douglas, Bhandari, Abhishek, Wu, Wenting, Corominas, Roser, Peoples, Aine, Koren, Amnon, Gore, Athurva, Kang, Shuli, Lin, Guan Ning, Estabillo, Jasper, Gadomski, Therese, Singh, Balvindar, Zhang, Kun, Akshoomoff, Natacha, Corsello, Christina, McCarroll, Steven, Iakoucheva, Lilia M, Li, Yingrui, Wang, Jun, Sebat, Jonathan. Whole-Genome Sequencing in Autism Identifies Hot Spots for De Novo Germline Mutation. CELL[J]. 2012, 第 6 作者151(7): 1431-1442, http://dx.doi.org/10.1016/j.cell.2012.11.019.
[20] Yi, Xin, Liang, Yu, HuertaSanchez, Emilia, Jin, Xin, Cuo, Zha Xi Ping, Pool, John E, Xu, Xun, Jiang, Hui, Vinckenbosch, Nicolas, Korneliussen, Thorfinn Sand, Zheng, Hancheng, Liu, Tao, He, Weiming, Li, Kui, Luo, Ruibang, Nie, Xifang, Wu, Honglong, Zhao, Meiru, Cao, Hongzhi, Zou, Jing, Shan, Ying, Li, Shuzheng, Yang, Qi, Asan, Ni, Peixiang, Tian, Geng, Xu, Junming, Liu, Xiao, Jiang, Tao, Wu, Renhua, Zhou, Guangyu, Tang, Meifang, Qin, Junjie, Wang, Tong, Feng, Shuijian, Li, Guohong, Huasang, Luosang, Jiangbai, Wang, Wei, Chen, Fang, Wang, Yading, Zheng, Xiaoguang, Li, Zhuo, Bianba, Zhuoma, Yang, Ge, Wang, Xinping, Tang, Shuhui, Gao, Guoyi, Chen, Yong, Luo, Zhen, Gusang, Lamu, Cao, Zheng, Zhang, Qinghui, Ouyang, Weihan, Ren, Xiaoli, Liang, Huiqing, Zheng, Huisong, Huang, Yebo, Li, Jingxiang, Bolund, Lars, Kristiansen, Karsten, Li, Yingrui, Zhang, Yong, Zhang, Xiuqing, Li, Ruiqiang, Li, Songgang, Yang, Huanming, Nielsen, Rasmus, Wang, Jun, Wang, Jian. Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude. SCIENCE[J]. 2010, 第 4 作者329(5987): 75-78, http://www.corc.org.cn/handle/1471x/2406221.
[21] Qiya Huang, Xianmei Lan, Hebing Chen, Hao Li, Yu Sun, Chao Ren, Chao Xing, Xiaochen Bo, Jizheng Wang, Xin Jin, Lei Song. Association between genetic predisposition and disease burden of stroke in China: a genetic epidemiological study. THE LANCET REGIONAL HEALTH - WESTERN PACIFIC. 第 10 作者http://dx.doi.org/10.1016/j.lanwpc.2023.100779.

   

（ 1 ） 基于十四万人基因大数据的中国人群遗传结构与等位基因频率库构建与研究, 主持, 省级, 2017-05--2021-05
（ 2 ） 免疫性肾病易感基因的验证和临床关联研究, 主持, 省级, 2020-01--2022-12
（ 3 ） 基于大型自然人群队列示范项目的高精度中国人群单倍型参考序列集构建与研究, 主持, 国家级, 2021-01--2023-12

（1）Genomic analyses from non-invasive prenatal testing reveal genetic associations, patterns of viral infections, and Chinese population history   中国遗传学会第十届全国会员代表大会暨学术讨论会   2018-11-26
（2）Discovery and challenges in low-pass whole genome sequencing of over 140,000 individuals from throughout China   美国人类遗传学年会   2016-10-18
（3）Deep exome sequencing of psoriasis identified new association signals contribute by INDELs, CNVs and rare SNPs   美国人类遗传学年会   2012-11-06

现指导学生

陈璇  硕士研究生  071007-遗传学  

曾圣印  硕士研究生  086000-生物与医药  

颜硕  硕士研究生  086000-生物与医药  

叶庆实  硕士研究生  0710Z1-基因组学  

周鑫兰  博士研究生  071007-遗传学  

王晴晴  博士研究生  071007-遗传学  

唐庄媛  博士研究生  071007-遗传学  

李志超  博士研究生  071007-遗传学  

万尊敏  博士研究生  071007-遗传学