主要从事细胞信号转导以及药物作用机理研究，具体方向包括以下几个方面：

1.   细胞信号转导途径的研究：

o   我们重点研究激酶和转录因子在细胞信号传导中的作用，关注激酶信号通路在细胞感知外界刺激、传递信号至细胞核并调控基因表达方面起关键作用。通过构建这些信号通路的模型，我们深入了解细胞如何对外界信号作出响应，并参与各种生理过程，如炎症、免疫反应和细胞凋亡等。

2.   离子共转运蛋白的功能研究：

o   离子共转运蛋白在维持细胞内环境的离子稳态方面起重要作用。我们研究这些蛋白的信号转导机制，探讨它们在调节细胞内离子平衡中的具体功能，揭示细胞在不同生理和病理状态下如何调控离子内稳态。

3.   炎症和免疫机制：

o   研究细胞如何通过特定信号通路感知和应对炎症及免疫反应,探讨其在免疫反应中的具体机制及其对细胞凋亡的调控作用。

4.   细胞凋亡的调控：

o   探讨细胞在凋亡过程中涉及的信号转导途径和关键蛋白。通过研究这些过程，我们希望理解细胞如何在受损或受刺激时通过凋亡途径清除自身，从而维持组织的健康。

5.   细胞内环境的稳态：

o   重点研究钠、钾、氯等离子的内稳态调控机制。离子稳态对于细胞的正常功能至关重要，我们通过研究这些过程，探讨其在生理和病理状态下的变化及其对细胞功能的影响。

6.   相关疾病的生物学特征研究：

o   通过上述研究，我们希望揭示多种疾病（如癌症、炎症性疾病、自身免疫疾病、神经退行性疾病等）的生物学特征，了解这些疾病的发生和发展机制，为疾病的早期诊断和治疗提供科学依据。

7.   小分子调控研究：

o   通过筛选和设计小分子药物，研究其对上述信号通路和离子共转运蛋白的调控作用。我们旨在开发新型小分子药物，用于干预和治疗相关疾病。这些研究不仅有助于理解药物作用的分子机制，也为新药研发提供重要的理论基础。

8.   天然微生物来源的产物的活性分析与鉴定：

o   通过对来自环境（如海洋、深海等）的微生物进行分离、培育、筛选和发酵，分析活性物质的富集、分离及其抗菌、抗病毒、抗人类疾病等活性；并进行活性物质基因簇的分子生物学研究，以及通过合成生物学手段提高活性物质的产量。

我们期待有志于细胞信号转导、药物作用机理及相关领域研究的同学加入我们，共同探索生命科学的奥秘，并为生物医学和生物医药的进步贡献力量。

   

0703Z1-化学生物学

生物化学与分子生物学、细胞信号转导、炎症和免疫机制、 细胞凋亡的调控、疾病生物学、药物研发、小分子调控研究

0703Z1-化学生物学 

071009-细胞生物学 

071010-生物化学与分子生物学 

071006-神经生物学

2008-03--2011-04   英国纽卡斯尔大学   博士研究生、生物技术专业、博士学位
2004-09--2007-06   自然资源部第三海洋研究所   硕士研究生、海洋生物学、硕士学位
1999-09--2003-06   福建师范大学生命科学学院   本科生、生物工程工科学位

   

2023-12~现在, 中国科学院上海有机化学研究所, 中国科学院上海有机所-生命过程小分子调控全国重点实验室, 研究员，课题组长
2017-07~2023-12,英国埃克塞特大学医学院（英格兰）, Principal Investigator，博士生导师，终身教职（高级职称）
2016-07~2017-06,英国邓迪大学，MRC-蛋白质磷酸化与泛素化研究所, Research Investigator
2015-07~2016-06,美国耶鲁大学医学院, Research Investigator
2011-07~2015-06,英国邓迪大学，MRC-蛋白质磷酸化与泛素化研究所, 博士后研究员
2007-07~2008-02,厦门大学医学院, 研究助理

2025-03-27-今,Journal of Advanced Research, Associate Editor
2023-08-29-今,Medicinal Research Reviews, Editorial Board
2022-12-30-今,Frontiers in Microbiology, Associate Editor
2022-12-30-今,Journal of Modern Biology and Drug Discovery, Editor in Chief
2022-05-30-今,Frontiers in Physiology, Associate Editor
2021-12-30-今,Frontiers in Pharmacology, Associate Editor
2019-02-27-今,厦门大学医学院附属心血管病医院, 特聘教授、博士生导师

   

（1） Biochemical Society (英国生物化学学会) Travel Award 参加国际会议旅行奖, 其他, 2024
（2） 中国科学院率先行动“人才项目”A类 (****), , 部委级, 2024
（3） 国家海外高层次人才计划 "科技部-创新长期项目", , 国家级, 2021
（4） 2019年在‘学术团队建设’方面获得超越奖，英国埃克塞特大学 (由医学院院长提名), , 其他, 2019
（5） 福建省"闽江学者奖励计划", , 省级, 2019
（6） 2019年在'科研原创性，重要性和严谨性方面处于世界领先的质量'方面获得超越奖， 英国埃克塞特大学 (由医学院院长提名), 其他, 2019
（7） 美国油化学学会优秀论文一等奖, 一等奖, 其他, 2010
（8） 美国油化学学会欧洲分会优秀青年科学家奖, 其他, 2010
（9） 英国政府‘多萝西·霍奇金博士研究生奖(DHPA), 全额博士奖学金’（多萝西·霍奇金，（英国首位女科学家）在1964年获得诺贝尔化学奖）, 其他, 2008
（10） 国家海洋局极地研究优秀论文三等奖, 三等奖, 部委级, 2008
（11） 福建海洋学会优秀论文二等奖, 二等奖, 其他, 2005
（12） 中国酶工程学会优秀青年论文奖, , 其他, 2005
（13） 国家海洋局第三海洋研究所第二届青年海洋科学研讨会优秀论文一等奖, 一等奖, 研究所（学校）, 2005
（14） 福建师范大学校优秀学生奖学金, , 研究所（学校）, 2003
（15） 福建省大学生创业大赛三等奖（作为团队负责人）, 三等奖, 省级, 2002
（16） 福建师范大学校优秀学生干部, , 研究所（学校）, 2002
（17） 福建师范大学校优秀学生奖学金, , 研究所（学校）, 2001
（18） 大学生记念建党八十周年暨第五次邓小平理论研讨会优秀论文三等奖, , 省级, 2001
（19） 福建师范大学校优秀学生奖学金, , 研究所（学校）, 2000

（ 1 ） SPAK kinase inhibitors as neuroprotective agents, 2022, 第 3 作者, 专利号: US11414379B2

（ 2 ） SPAK KINASE INHIBITORS AS NEUROPROTECTIVE AGENTS, 发明专利, 2021, 第 3 作者, 专利号: US20210261497(A1)

（ 3 ） SPAK kinase inhibitors as neuroprotective agents 【南非专利： 2021/02261】, 发明专利, 2022, 第 3 作者, 专利号: 2021/02261

（ 4 ） SPAK kinase inhibitors as neuroprotective agents 【欧洲专利EP3873439A1】, 发明专利, 2021, 第 3 作者, 专利号: EP3873439A1

（ 5 ） SPAK kinase inhibitors as neuroprotective agents【澳大利亚专利：AU2019351731A1】, 发明专利, 2021, 第 3 作者, 专利号: AU2019351731A1

（ 6 ） SPAK kinase inhibitors as neuroprotective agents【加拿大专利： CA-3115075-A1】, 发明专利, 2021, 第 3 作者, 专利号: CA-3115075-A1

（ 7 ） 作为神经保护剂的SPAK激酶抑制剂, 发明专利, 2021, 专利号: CN113365614A

   

[1] Jinwei Zhang. Decoding a Million Genomes: Unveiling the Protein-Coding Landscape and Its Implications for Precision Medicine. Current Genomics[J]. 2025, 第 1 作者  通讯作者  null(null): 
[2] Jinwei Zhang. Epilepsy. Exploration of Neuroscience[J]. 2025, 第 1 作者  通讯作者  4(null): 100670, 
[3] Jinwei Zhang. Role of 1,25-Dihydroxyvitamin D₃ in alleviating hepatic steatosis: targeting M1 macrophage polarization in non-alcoholic fatty liver disease. World Journal of Gastrointestinal Oncology[J]. 2025, 第 1 作者  通讯作者  17(3): 102424, 
[4] Jinwei Zhang. FDA Approves Inavolisib Combo for PIK3CA-Mutated, HR+ Breast Cancer. CURRENT MEDICINAL CHEMISTRY[J]. 2025, 第 1 作者  通讯作者  null(null): 
[5] Zhang, Jinwei. Navigating the challenges of laparoscopic anatomical SVIII resection: A step forward in hepatobiliary surgery. WORLD JOURNAL OF GASTROINTESTINAL SURGERY[J]. 2025, 第 1 作者  通讯作者  17(2): 308-311, http://dx.doi.org/10.4240/wjgs.v17.i2.100847.
[6] Wen, Chaowei, Gajjala, Prathibha R, Liu, Yihan, Chen, Bingzhong, Bal, Mehtab S, Sutaria, Payal, Qiao, Yuanyuan, Zheng, Yang, Zhou, Yang, Zhang, Jinwei, Huang, Weixue, Ren, Xiaomei, Wang, Zhen, Ding, Ke, Chinnaiyan, Arul M, Zhou, Fengtao. Discovery of the first selective and potent PROTAC degrader for the pseudokinase TRIB2. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2025, 第 10 作者281: http://dx.doi.org/10.1016/j.ejmech.2024.117016.
[7] Li, Jinlin, Li, Lin, Hou, Caiyun, Tian, Zhaodi, Zhou, Yang, Zhang, Jinwei, Ren, Xiaomei, Wang, Zhen, Huang, Weixue, Ding, Ke, Zhou, Fengtao. Discovery of the first potent ROR1 degrader for the treatment of non-small cell lung cancer. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2025, 第 6 作者286: http://dx.doi.org/10.1016/j.ejmech.2025.117325.
[8] Zhang, Jinwei. Impact of miR-214-5p and miR-21-5p from hypoxic endometrial exosomes on human umbilical cord mesenchymal stem cell function. WORLD JOURNAL OF STEM CELLS[J]. 2025, 第 1 作者  通讯作者  17(2): http://dx.doi.org/10.4252/wjsc.v17.i2.102404.
[9] Trinder, Amelia, Ding, Ke, Zhang, Jinwei. The Therapeutic Significance of HER3 in Non-small Cell Lung Cancer (NSCLC): A Review Study. CURRENT MEDICINAL CHEMISTRY[J]. 2025, 第 3 作者  通讯作者  32(3): 434-446, http://dx.doi.org/10.2174/0109298673269305231115102542.
[10] Wujun Geng, Holly Thomas, Zhixiu Yan, Zhiyuan Chen, Pujuan Zhang, Meiying Zhang, Weixue Huang, Xiaomei Ren, Zhen Wang, Ke Ding, Jinwei Zhang. Mechanisms of Acquired Resistance to HER2-Positive Breast Cancer Therapies Induced by HER3: A Comprehensive Review. European Journal of Pharmacology[J]. 2024, 第 11 作者  通讯作者  977(null): 176725, https://www.sciencedirect.com/science/article/pii/S0014299924004138?via%3Dihub.
[11] Mira Hamze, Cathy Brier, Emmanuelle Buhler, Jinwei Zhang, Igor Medina, Christophe Porcher. Regulation of Neuronal Chloride Homeostasis by Pro- and Mature Brain-Derived Neurotrophic Factor (BDNF) via KCC2 Cation–Chloride Cotransporters in Rat Cortical Neurons. International Journal of Molecular Sciences[J]. 2024, 第 4 作者25(11): 6253, https://www.mdpi.com/1422-0067/25/11/6253.
[12] Lin Li, Weixue Huang, Xiaomei Ren, Zhen Wang, Ke Ding, zhao linxiang, Jinwei Zhang. Unlocking the Potential: Advancements and Future Horizons in ROR1-Targeted Cancer Therapies. 中国科学:生命科学(英文版)[J]. 2024, 第 7 作者  通讯作者  null(null): 
[13] Xiaorong Qiu, Rong Liu, Huan Ling, Yang Zhou, Xiaomei Ren, Fengtao Zhou, Jinwei Zhang, Weixue Huang, Zhen Wang, Ke Ding. Discovery of 5-aminopyrido[2,3-d]pyrimidin-7(8H)-one derivatives as new hematopoietic progenitor kinase 1 (HPK1) inhibitors. European Journal of Medicinal Chemistry[J]. 2024, 第 7 作者269(null): 116310, https://doi.org/10.1016/j.ejmech.2024.116310.
[14] Jinwei Zhang. Microbial stars: shedding light on gut microbes’ role in insulin resistance and innovative diabetes therapies. GUT MICROBES[J]. 2024, 第 1 作者  通讯作者  16(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10824143/.
[15] Amelia Trinder, Ding Ke, Zhang JinWei. The Therapeutic Significance of HER3 in Non-small Cell Lung Cancer (NSCLC): A Review Study. CURRENT TOPICS IN MEDICINAL CHEMISTRY[J]. 2024, 第 3 作者  通讯作者  31(null): CMC-EPUB, 
[16] Zhang Jinwei. Hereditary Causes of Hypertension Due to Increased Sodium Transport. CURRENT OPINION IN PEDIATRICS[J]. 2024, 第 1 作者  通讯作者  36(2): 211-218, https://journals.lww.com/co-pediatrics/abstract/2024/04000/hereditary_causes_of_hypertension_due_to_increased.13.aspx.
[17] Jinwei Zhang, JeanMarc Sabatier, Mohamed Chahine, Domenico Tricarico. Editorial: Reviews in pharmacology of ion channels and channelopathies. FRONTIERS IN PHARMACOLOGY[J]. 2024, 第 1 作者  通讯作者  15(null): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11368837/.
[18] McMoneagle, Erin, Zhou, Jin, Zhang, Shiyao, Huang, Weixue, Josiah, Sunday Solomon, Ding, Ke, Wang, Yun, Zhang, Jinwei. Neuronal K + -Cl - cotransporter KCC2 as a promising drug target for epilepsy treatment. ACTA PHARMACOLOGICA SINICA[J]. 2024, 第 8 作者  通讯作者  45(1): 1-22, http://dx.doi.org/10.1038/s41401-023-01149-9.
[19] Jinwei Zhang. Early pirfenidone treatment enhances lung function in idiopathic pulmonary fibrosis patients. WORLD JOURNAL OF CLINICAL CASES[J]. 2024, 第 1 作者  通讯作者  12(28): 6247-6249, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11362896/.
[20] Zhou, Licheng, Zhou, Kaijie, Chang, Yu, Yang, Jianzhang, Fan, Bohai, Su, Yuhan, Li, Zilu, Mannan, Rahul, Mahapatra, Somnath, Ding, Ming, Zhou, Fengtao, Huang, Weixue, Ren, Xiaomei, Xu, Jian, Wang, George Xiaoju, Zhang, Jinwei, Wang, Zhen, Chinnaiyan, Arul M, Ding, Ke. Discovery of ZLC491 as a Potent, Selective, and Orally Bioavailable CDK12/13 PROTAC Degrader. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2024, 第 16 作者67(20): 18247-18264, http://dx.doi.org/10.1021/acs.jmedchem.4c01596.
[21] Li, Chungen, Chen, Yihan, Huang, Weixue, Qiu, Yudi, Huang, Shengjie, Zhou, Yang, Zhou, Fengtao, Xu, Jian, Ren, Xiaomei, Zhang, Jinwei, Wang, Zhen, Ding, Ming, Ding, Ke. Structure-Based Design of "Head-to-Tail" Macrocyclic PROTACs. JACS AU[J]. 2024, 第 10 作者4(12): 4866-4882, http://dx.doi.org/10.1021/jacsau.4c00831.
[22] Bhuiyan, Mohammad Iqbal H, Fischer, Sydney, Patel, Shivani M, Oft, Helena, Zhang, Ting, Foley, Lesley M, Zhang, Jinwei, Hitchens, T Kevin, Molyneaux, Bradley J, Deng, Xianming, Sun, Dandan. Efficacy of novel SPAK inhibitor ZT-1a derivatives (1c, 1d, 1g & 1h) on improving post-stroke neurological outcome and brain lesion in mice. NEUROCHEMISTRY INTERNATIONAL[J]. 2023, 第 7 作者162: http://dx.doi.org/10.1016/j.neuint.2022.105441.
[23] Robert, Stephanie M, Reeves, Benjamin C, Kiziltug, Emre, Duy, Phan Q, Karimy, Jason K, Mansuri, M Shahid, Marlier, Arnaud, Allington, Garrett, Greenberg, Ana B W, DeSpenza Jr, Tyrone, Singh, Amrita K, Zeng, Xue, Mekbib, Kedous Y, Kundishora, Adam J, NelsonWilliams, Carol, Hao, Le Thi, Zhang, Jinwei, Lam, TuKiet T, Wilson, Rashaun, Butler, William E, Diluna, Michael L, Feinberg, Philip, Schafer, Dorothy P, Movahedi, Kiavash, Tannenbaum, Allen, Koundal, Sunil, Chen, Xinan, Benveniste, Helene, Limbrick Jr, David D, Schiff, Steven J, Carter, Bob S, Gunel, Murat, Simard, J Marc, Lifton, Richard P, Alper, Seth L, Delpire, Eric, Kahle, Kristopher T. The choroid plexus links innate immunity to CSF dysregulation in hydrocephalus. CELL[J]. 2023, 第 17 作者186(4): 764-+, http://dx.doi.org/10.1016/j.cell.2023.01.017.
[24] Zhang, Jinwei. Commentaries: Lecanemab: pioneering the way as the first approved drug for Alzheimer's disease treatment. INFLAMMATION RESEARCH. 2023, 第 1 作者  通讯作者  72(9): 1873-1876, http://dx.doi.org/10.1007/s00011-023-01788-y.
[25] Pracucci, Enrico, Graham, Robert T, Alberio, Laura, Nardi, Gabriele, Cozzolino, Olga, Pillai, Vinoshene, Pasquini, Giacomo, Saieva, Luciano, Walsh, Darren, Landi, Silvia, Zhang, Jinwei, Trevelyan, Andrew J, Ratto, GianMichele. Daily rhythm in cortical chloride homeostasis underpins functional changes in visual cortex excitability. NATURE COMMUNICATIONS[J]. 2023, 第 11 作者14(1): http://dx.doi.org/10.1038/s41467-023-42711-7.
[26] Shiyao Zhang, Nur Farah Meor Azlan, Sunday Solomon Josiah, Jing Zhou, Xiaoxia Zhou, Lingjun Jie, Yanhui Zhang, Cuilian Dai, Dong Liang, Peifeng Li, Zhengqiu Li, Zhen Wang, Yun Wang, Ke Ding, Yan Wang, Jinwei Zhang. The role of SLC12A family of cation-chloride cotransporters and drug discovery methodologies. JOURNAL OF PHARMACEUTICAL ANALYSIS[J]. 2023, 第 16 作者  通讯作者  13(12): 1471-1495, http://dx.doi.org/10.1016/j.jpha.2023.09.002.
[27] Zhang, Jinwei, Siew, Keith, Sun, Dandan. Editorial: Targeting pumps, channels and transporters for the treatments of vascular, cardiovascular and kidney diseases. FRONTIERS IN PHARMACOLOGY[J]. 2023, 第 1 作者  通讯作者  14: http://dx.doi.org/10.3389/fphar.2023.1130882.
[28] Zhang, Jinwei, Wang, Jianxin, Labes, Antje, Zeng, Runying. Marine microbial-derived molecules and their potential medical and cosmetic applications, volume II. FRONTIERS IN MICROBIOLOGY. 2023, 第 1 作者  通讯作者  14: http://dx.doi.org/10.3389/fmicb.2023.1188008.
[29] Stephanie M Robert, Benjamin C Reeves, Emre Kiziltug, Phan Q Duy, Jason K Karimy, M Shahid Mansuri, Arnaud Marlier, Garrett Allington, Ana B W Greenberg, Tyrone DeSpenza, Amrita K Singh, Xue Zeng, Kedous Y Mekbib, Adam J Kundishora, Carol NelsonWilliams, Le Thi Hao, Jinwei Zhang, TuKiet T Lam, Rashaun Wilson, William E Butler, Michael L Diluna, Philip Feinberg, Dorothy P Schafer, Kiavash Movahedi, Allen Tannenbaum, Sunil Koundal, Xinan Chen, Helene Benveniste, David D Limbrick, Steven J Schiff, Bob S Carter, Murat Gunel, J Marc Simard, Richard P Lifton, Seth L Alper, Eric Delpire, Kristopher T Kahle. The choroid plexus links innate immunity to CSF dysregulation in hydrocephalus. CELL[J]. 2023, 第 17 作者186(4): 764-785.e21, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10069664/.
[30] Zhang, Jinwei, Hartmann, AnnaMaria, Guo, Jiangtao. Editorial: Chloride homeostasis in animal cell physiology. FRONTIERS IN PHYSIOLOGY[J]. 2023, 第 1 作者  通讯作者  14: http://dx.doi.org/10.3389/fphys.2023.1227565.
[31] Zhang, Shiyao, Azlan, Nur Farah Meor, Josiah, Sunday Solomon, Zhou, Jing, Zhou, Xiaoxia, Jie, Lingjun, Zhang, Yanhui, Dai, Cuilian, Liang, Dong, Li, Peifeng, Li, Zhengqiu, Wang, Zhen, Wang, Yun, Ding, Ke, Wang, Yan, Zhang, Jinwei. The role of SLC12A family of cation-chloride cotransporters and drug discovery methodologies. JOURNAL OF PHARMACEUTICAL ANALYSIS. 2023, 第 16 作者  通讯作者  13(12): 1471-1495, http://dx.doi.org/10.1016/j.jpha.2023.09.002.
[32] Mohammad Iqbal H Bhuiyan, Sydney Fischer, Shivani M Patel, Helena Oft, Ting Zhang, Lesley M Foley, Jinwei Zhang, T Kevin Hitchens, Bradley J Molyneaux, Xianming Deng, Dandan Sun. Efficacy of novel SPAK inhibitor ZT-1a derivatives (1c, 1d, 1g & 1h) on improving post-stroke neurological outcome and brain lesion in mice. NEUROCHEMISTRY INTERNATIONAL. 2022, 第 7 作者162: 105441-105441, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839627/.
[33] Wang, Jun, Liu, Ruijia, Hasan, Md Nabiul, Fischer, Sydney, Chen, Yang, Como, Matt, Fiesler, Victoria M, Bhuiyan, Mohammad Iqbal H, Dong, Shuying, Li, Eric, Kahle, Kristopher T, Zhang, Jinwei, Deng, Xianming, Subramanya, Arohan R, Begum, Gulnaz, Yin, Yan, Sun, Dandan. Role of SPAK-NKCC1 signaling cascade in the choroid plexus blood-CSF barrier damage after stroke. JOURNAL OF NEUROINFLAMMATION[J]. 2022, 第 12 作者19(1): http://dx.doi.org/10.1186/s12974-022-02456-4.
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[36] Zhong, Chunlian, Zhao, Huan, Xie, Xinwen, Qi, Zhi, Li, Yumei, Jia, Lee, Zhang, Jinwei, Lu, Yusheng. Protein Kinase C-Mediated Hyperphosphorylation and Lateralization of Connexin 43 Are Involved in Autoimmune Myocarditis-Induced Prolongation of QRS Complex. FRONTIERS IN PHYSIOLOGY[J]. 2022, 第 7 作者  通讯作者  13: http://dx.doi.org/10.3389/fphys.2022.815301.
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[38] Josiah, Sunday Solomon, Azlan, Nur Farah Meor, OguroAndo, Asami, Zhang, Jinwei. Study of the Functions and Activities of Neuronal K-Cl Co-Transporter KCC2 Using Western Blotting. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS[J]. 2022, 第 4 作者  通讯作者  http://dx.doi.org/10.3791/64179.
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[41] DSilva, Elvira, Azlan, Nur Farah Meor, Zhang, Jinwei. Angiotensin II Receptor Blockers in the Management of Hypertension in Preventing Cognitive Impairment and Dementia-A Systematic Review. PHARMACEUTICS. 2022, 第 3 作者  通讯作者  14(10): http://dx.doi.org/10.3390/pharmaceutics14102123.
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[46] Brown, Archie, Meor Azlan, Nur Farah, Wu, Zhijuan, Zhang, Jinwei. WNK-SPAK/OSR1-NCC kinase signaling pathway as a novel target for the treatment of salt-sensitive hypertension. ACTA PHARMACOLOGICA SINICA[J]. 2021, 第 4 作者  通讯作者  42(4): 508-517, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6936572&detailType=1.
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[76] Zhang, Jinwei, Karimy, Jason K, Delpire, Eric, Kahle, Kristopher T. Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport. EXPERT OPINION ON THERAPEUTIC TARGETS. 2017, 第 1 作者  通讯作者  21(8): 795-804, https://www.webofscience.com/wos/woscc/full-record/WOS:000406019900005.
[77] Heubl, Martin, Zhang, Jinwei, Pressey, Jessica C, Al Awabdh, Sana, Renner, Marianne, GomezCastro, Ferran, Moutkine, Imane, Eugene, Emmanuel, Russeau, Marion, Kahle, Kristopher T, Poncer, Jean Christophe, Levi, Sabine. GABA A receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl - -sensitive WNK1 kinase. NATURE COMMUNICATIONS[J]. 2017, 第 2 作者8: http://dx.doi.org/10.1038/s41467-017-01749-0.
[78] Zhang, Jinwei, Gao, Geng, Begum, Gulnaz, Wang, Jinhua, Khanna, Arjun R, Shmukler, Boris E, Daubner, Gerrit M, de los Heros, Paola, Davies, Paul, Varghese, Joby, Bhuiyan, Mohammad Iqbal H, Duan, Jinjing, Zhang, Jin, Duran, Daniel, Alper, Seth L, Sun, Dandan, Elledge, Stephen J, Alessi, Dario R, Kahle, Kristopher T. Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain. SCIENTIFIC REPORTS[J]. 2016, 第 1 作者  通讯作者  6: http://dx.doi.org/10.1038/srep35986.
[79] Kahle, Kristopher T, Schmouth, JeanFrancois, Lavastre, Valerie, Latremoliere, Alban, Zhang, Jinwei, Andrews, Nick, Omura, Takao, Laganiere, Janet, Rochefort, Daniel, Hince, Pascale, Castonguay, Genevieve, Gaudet, Rebecca, Mapplebeck, Josiane C S, Sotocinal, Susana G, Duan, JingJing, Ward, Catherine, Khanna, Arjun R, Mogil, Jeffrey S, Dion, Patrick A, Woolf, Clifford J, Inquimbert, Perrine, Rouleau, Guy A. Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition. SCIENCE SIGNALING[J]. 2016, 第 5 作者9(421): https://www.webofscience.com/wos/woscc/full-record/WOS:000373165700002.
[80] Zhang, Jinwei, Deng, Xianming, Kahle, Kristopher T. Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition. SCIENCE SIGNALING[J]. 2016, 第 1 作者9(450): https://www.webofscience.com/wos/woscc/full-record/WOS:000387029300003.
[81] Kahle, Kristopher T, Flores, Bianca, BharuchaGoebel, Diana, Zhang, Jinwei, Donkervoort, Sandra, Hegde, Madhuri, Hussain, Gulnaz, Duran, Daniel, Liang, Bo, Sun, Dandan, Bonnemann, Carsten G, Delpire, Eric. Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter. SCIENCE SIGNALING[J]. 2016, 第 4 作者9(439): ra77-ra77, https://www.webofscience.com/wos/woscc/full-record/WOS:000380779400001.
[82] Emami, Kaveh, Nelson, Andrew, Hack, Ethan, Zhang, Jinwei, Green, David H, Caldwell, Gary S, Mesbahi, Ehsan. MALDI-TOF Mass Spectrometry Discriminates Known Species and Marine Environmental Isolates of Pseudoalteromonas. FRONTIERS IN MICROBIOLOGY[J]. 2016, 第 4 作者7: https://doaj.org/article/b669ef70a45a4d54916624827ca901ee.
[83] Schumacher, FrancesRose, Siew, Keith, Zhang, Jinwei, Johnson, Clare, Wood, Nicola, Cleary, Sarah E, Al Maskari, Raya S, Ferryman, James T, Hardege, Iris, Yasmin, Figg, Nichola L, Enchev, Radoslav, Knebel, Axel, OShaughnessy, Kevin M, Kurz, Thimo. Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia. EMBO MOLECULAR MEDICINE[J]. 2015, 第 3 作者7(10): 1285-1306, https://www.doi.org/10.15252/emmm.201505444.
[84] Hatcher, John M*, Zhang, Jinwei*, Choi, Hwan Geun*, Ito, Genta, Alessi, Dario R, Gray, Nathanael S. Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor. ACS MEDICINAL CHEMISTRY LETTERS[J]. 2015, 6(5): 584-589, http://dx.doi.org/10.1021/acsmedchemlett.5b00064.
[85] Friedel, Perrine*, Kahle, Kristopher T*, Zhang, Jinwei*, Hertz, Nicholas, Pisella, Lucie I, Buhler, Emmanuelle, Schaller, Fabienne, Duan, JingJing, Khanna, Arjun R, Bishop, Paul N, Shokat, Kevan M, Medina, Igor. WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons. SCIENCE SIGNALING[J]. 2015, 8(383): http://dx.doi.org/10.1126/scisignal.aaa0354.
[86] Zhang, Jinwei, Burgess, J Grant. Shewanella electrodiphila sp nov., a psychrotolerant bacterium isolated from Mid-Atlantic Ridge deep-sea sediments. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY[J]. 2015, 第 1 作者65: 2882-2889, http://dx.doi.org/10.1099/ijs.0.000345.
[87] Kazlauskaite, Agne, MartinezTorres, R Julio, Wilkie, Scott, Kumar, Atul, Peltier, Julien, Gonzalez, Alba, Johnson, Clare, Zhang, Jinwei, Hope, Anthony G, Peggie, Mark, Trost, Matthias, van Aalten, Daan M F, Alessi, Dario R, Prescott, Alan R, Knebel, Axel, Walden, Helen, Muqit, Miratul M K. Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation. EMBO REPORTS[J]. 2015, 第 8 作者16(8): 939-954, https://www.doi.org/10.15252/embr.201540352.
[88] Zhang, Jinwei, Siew, Keith, Macartney, Thomas, OShaughnessy, Kevin M, Alessi, Dario R. Critical role of the SPAK protein kinase CCT domain in controlling blood pressure. HUMAN MOLECULAR GENETICS[J]. 2015, 第 1 作者  通讯作者  24(16): 4545-4558, http://dx.doi.org/10.1093/hmg/ddv185.
[89] Alessi, Dario R, Zhang, Jinwei, Khanna, Arjun, Hochdoerfer, Thomas, Shang, Yuze, Kahle, Kristopher T. The WNK-SPAK/OSR1 pathway: Master regulator of cation-chloride cotransporters. SCIENCE SIGNALING. 2014, 第 2 作者7(334): http://dx.doi.org/10.1126/scisignal.2005365.
[90] de los Heros, Paola, Alessi, Dario R, Gourlay, Robert, Campbell, David G, Deak, Maria, Macartney, Thomas J, Kahle, Kristopher T, Zhang, Jinwei. The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters. BIOCHEMICAL JOURNAL[J]. 2014, 第 8 作者  通讯作者  458: 559-573, http://dx.doi.org/10.1042/BJ20131478.
[91] de los Heros, Paola, Alessi, Dario R, Gourlay, Robert, Campbell, David G, Deak, Maria, Macartney, Thomas J, Kahle, Kristopher T, Zhang, Jinwei. The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K + -Cl - co-transporters. BIOCHEMICAL JOURNAL[J]. 2014, 第 8 作者458: 559-573, http://dx.doi.org/10.1042/BJ20131478.
[92] Deng, Xianming, Elkins, Jonathan M, Zhang, Jinwei, Yang, Qingkai, Erazo, Tatiana, Gomez, Nestor, Choi, Hwan Geun, Wang, Jinhua, Dzamko, Nicolas, Lee, JiingDwan, Sim, Taebo, Kim, NamDoo, Alessi, Dario R, Lizcano, Jose M, Knapp, Stefan, Gray, Nathanael S. Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzoepyrimido-5,4-bdiazepine-6(11H)-ones. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2013, 第 3 作者70: 758-767, http://dx.doi.org/10.1016/j.ejmech.2013.10.052.
[93] Delbroek, Lore, Van Kolen, Kristof, Steegmans, Liesbeth, da Cunha, Raquel, Mandemakers, Wim, Daneels, Guy, De Bock, PieterJan, Zhang, Jinwei, Gevaert, Kris, De Strooper, Bart, Alessi, Dario R, Verstreken, Patrik, Moechars, Diederik W. Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS[J]. 2013, 第 8 作者76: 49-58, http://dx.doi.org/10.1016/j.jpba.2012.12.002.
[94] Yao, Chen, Johnson, William M, Gao, Yue, Wang, Wen, Zhang, Jinwei, Deak, Maria, Alessi, Dario R, Zhu, Xiongwei, Mieyal, John J, Roder, Hanno, WilsonDelfosse, Amy L, Chen, Shu G. Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity. HUMAN MOLECULAR GENETICS[J]. 2013, 第 5 作者22(2): 328-344, https://www.webofscience.com/wos/woscc/full-record/WOS:000312651800011.
[95] Yao, Chen, Johnson, William M, Gao, Yue, Wang, Wen, Zhang, Jinwei, Deak, Maria, Alessi, Dario R, Zhu, Xiongwei, Mieyal, John J, Roder, Hanno, WilsonDelfosse, Amy L, Chen, Shu G. Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity. HUMAN MOLECULAR GENETICS[J]. 2013, 第 5 作者22(2): 328-344, http://dx.doi.org/10.1093/hmg/dds431.
[96] Zhang, Jinwei, Zhang, Enren, Scott, Keith, Burgess, J Grant. Enhanced Electricity Production by Use of Reconstituted Artificial Consortia of Estuarine Bacteria Grown as Biofilms. ENVIRONMENTAL SCIENCE & TECHNOLOGY[J]. 2012, 第 1 作者46(5): 2984-2992, http://dx.doi.org/10.1021/es2020007.
[97] Reith, Alastair D, Bamborough, Paul, Jandu, Karamjit, Andreotti, Daniele, Mensah, Lucy, Dossang, Pamela, Choi, Hwan Geun, Deng, Xianming, Zhang, Jinwei, Alessi, Dario R, Gray, Nathanael S. GSK2578215A; A potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2012, 第 9 作者22(17): 5625-5629, http://dx.doi.org/10.1016/j.bmcl.2012.06.104.
[98] Zhang, Jinwei, Deng, Xianming, Choi, Hwan Geun, Alessi, Dario R, Gray, Nathanael S. Characterization of TAE684 as a potent LRRK2 kinase inhibitor. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2012, 第 1 作者22(5): 1864-1869, http://dx.doi.org/10.1016/j.bmcl.2012.01.084.
[99] Choi, Hwan Geun*, Zhang, Jinwei*, Deng, Xianming*, Hatcher, John M, Patricelli, Matthew P, Zhao, Zheng, Alessi, Dario R, Gray, Nathanael S. Brain Penetrant LRRK2 Inhibitor. ACS MEDICINAL CHEMISTRY LETTERS[J]. 2012, 3(8): 658-662, http://dx.doi.org/10.1021/ml300123a.
[100] Zhang, Jinwei, Zeng, Runying. Molecular cloning and expression of an extracellular alpha-amylase gene from an Antarctic deep sea psychrotolerant Pseudomonas stutzeri strain 7193. WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY[J]. 2011, 第 1 作者27(4): 841-850, http://dx.doi.org/10.1007/s11274-010-0526-0.
[101] Zhang, Jinwei, Zeng, Runying. Molecular cloning and expression of an extracellular α-amylase gene from an Antarctic deep sea psychrotolerant Pseudomonas stutzeri strain 7193. WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY[J]. 2011, 第 1 作者  通讯作者  27(4): 841-850, http://dx.doi.org/10.1007/s11274-010-0526-0.
[102] Zhang JinWei, Zeng Runying. Purification and Characterization of a Cold-Adapted α-Amylase Produced by Nocardiopsis sp. 7326 Isolated from Prydz Bay, Antarctic. Marine Biotechnology[J]. 2008, 第 1 作者10(1): 75-82, https://link.springer.com/article/10.1007/s10126-007-9035-z.
[103] Zhang JinWei, Zeng Runying. Molecular cloning and expression of a cold-adaptive lipase gene from an Antarctic deep dea psychrotrophic bacterium Pseudomonas sp. 7323. Marine Biotechnology[J]. 2008, 第 1 作者10(5): 612-621, https://link.springer.com/article/10.1007/s10126-008-9099-4.
[104] 张金伟, 曾润颖. 南极嗜冷假单胞菌7197的分离和无机焦磷酸酯酶（PPase）基因ppa的克隆. 高技术通讯[J]. 2007, 第 1 作者17(10): 1067-1071, http://lib.cqvip.com/Qikan/Article/Detail?id=25832145.
[105] Zhang, Jinwei, Lin, Shu, Zeng, Runying. Cloning, expression, and characterization of a cold-adapted lipase gene from an Antarctic deep-sea psychrotrophic bacterium, Psychrobacter sp 7195. JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2007, 第 1 作者17(4): 604-610, https://www.webofscience.com/wos/woscc/full-record/WOS:000246096700008.
[106] Zhang, J W, Zeng, R Y. Psychrotrophic amylolytic bacteria from deep sea sediment of Prydz Bay, Antarctic: diversity and characterization of amylases. WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY[J]. 2007, 23(11): 1551-1557, https://www.webofscience.com/wos/woscc/full-record/WOS:000249921800007.
[107] 张金伟, 曾润颖. 南极嗜冷假单胞菌7197 S-腺苷同型半胱氨酸水解酶（SAHH）基因的克隆与序列分析. 现代生物医学进展[J]. 2006, 第 1 作者6(4): 5-7, http://lib.cqvip.com/Qikan/Article/Detail?id=21968316.
[108] 张锋, 黄硕芩, 张金伟. 一株南极嗜冷杆菌产丙酮酸脱氢酶的性质研究及基因克隆. 现代生物医学进展[J]. 2006, 第 3 作者  通讯作者  6(12): 40-43, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=2789977&detailType=1.
[109] 张金伟, 曾润颖. 南极产低温脂肪酶菌株Psychrobacter sp. 7195的选育、发酵条件及酶学性质研究. 生物磁学[J]. 2006, 第 1 作者6(1): 6-10, http://lib.cqvip.com/Qikan/Article/Detail?id=21559022.
[110] 张金伟, 连明珠, 曾润颖. 产冷适应复合酶菌株Pseudomonas sp.NJ197的选育、发酵条件及酶学性质. 应用与环境生物学报[J]. 2006, 第 1 作者12(5): 683-687, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=2608627&detailType=1.
[111] Zhang JinWei, Zeng RunYing. Cloning, expression and characterization of the cold active lipase (Lip3) from metagenomic DNA of an Antarctic deep sea sediment. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2006, 第 1 作者  通讯作者  33(12): 1207-1214, https://www.webofscience.com/wos/woscc/full-record/WOS:000243097200009.
[112] 张金伟, 曾润颖. 产复合酶菌株Pseudomonas sp．NJ197产酶发酵条件的研究. 台湾海峡[J]. 2005, 第 1 作者24(4): 520-525, http://lib.cqvip.com/Qikan/Article/Detail?id=20335166.
[113] 王水顺, 林进哲, 张金伟, 施巧琴, 谢必峰. 复合酶高产菌株选育的研究. 药物生物技术[J]. 2001, 第 3 作者8(6): 317-321, http://lib.cqvip.com/Qikan/Article/Detail?id=5853640.

（1） Zhang, J*., Labes, A., Zeng, R., eds. (2021). e-Book: Marine Microbial-Derived Molecules and Their Potential Medical and Cosmetic Applications. Lausanne: Frontiers Media SA. doi: 10.3389/978-2-88971-331-8, Lausanne: Frontiers Media SA, 2021-07, 第 1 作者
（2） Josiah S, Meor Azlan NF, Zhang J* (2021). Book chapter “Targeting the WNK-SPAK/OSR1 pathway and Cation-Chloride Cotransporters for the therapy of stroke”. In (Ed) Neuroprotection: Rescue from Neuronal Death in the Brain, by Bae Hwan Lee (Ed.) p27-48. MDPI (Basel, Switzerland). doi.org/10.3390/books978-3-0365-1995-1, MDPI (Basel, Switzerland), 2021-10, 第 3 作者
（3） Zhang, J*. (2023). Gitelman Syndrome. pp 1–4. In: Rezaei, N. (eds) Genetic Syndromes. Springer, Cham. https://doi.org/10.1007/978-3-319-66816-1_1333-1, eBook ISBN 978-3-319-66816-1, Springer Nature, 2024-01, 第 1 作者
（4） Jinwei Zhang, Hamideh P Fallah, Qian He, Dong Liang, Chapter 7: “TRP channel drug discovery strategies”, In (Ed) TRP Channels as Therapeutic Targets: Advances in basic science and clinical use. Arpad Szallasi (editor). P103-113. 2nd Edition 2024, Elsevier. https://doi.org/10.1016/B978-0-443-18653-0.00016-2, Elsevier, 2024-09, 第 1 作者

   

（ 1 ） 中国科学院率先行动“人才项目”A类（****）, 负责人, 中国科学院计划, 2024-01--2026-12
（ 2 ） 创新长期项目, 负责人, 国家任务, 2024-01--2026-12
（ 3 ） 阳离子-氯离子共转运蛋白在动脉粥样硬化平滑肌炎性损伤中的作用及机制研究, 负责人, 国家任务, 2022-01--2025-12
（ 4 ） WNK-SPAK-KCC3信号通道调控心肌细胞氯离子稳态在心肌缺血损伤中的作用机制及靶向药物干预, 负责人, 国家任务, 2020-01--2023-12

（1）通过调节KCC2和NKCC1磷酸化的WNK-SPAK信号通路对癫痫的治疗方法   第二届国际SLC-NDD（KCC2相关脑神经发育疾病）研讨会   Jinwei Zhang   2025-03-13
（2）Advancing Disease Treatment by Targeting Cation-Chloride Cotransporters and the Upstream Kinase Signaling in the WNK-SPAK/OSR1 Pathway   第11届国际生物医学与制药会议（ICBP2023）   Jinwei Zhang   2023-08-24
（3）Targeting the WNK-SPAK/OSR1 Pathway and Cation-Chloride Cotransporters for Diseases Therapy   第11届国际生物医学工程与生物技术大会（ICBEB 2022）   Jinwei Zhang   2022-11-15
（4）Towards therapeutic ion transport modulation via pharmacological WNK-SPAK kinase inhibition   世界脑疾病和神经科学峰会（BDNS 2022）   Jinwei Zhang   2022-10-27
（5）Targeting the WNK-SPAK/OSR1 Pathway for the Therapy of Hypertension   第2届国际药理学和毒理学电子会议“药理学虚拟2021”   Jinwei Zhang   2021-12-21
（6）Activation of K+–Cl-–cotransporter KCC2 by inhibiting the WNK-SPAK kinase signalling as a novel therapeutic strategy for epilepsy.    第6届癫痫与治疗国际会议   Jinwei Zhang   2020-09-21
（7）Activation of K+–Cl-–cotransporter KCC2 by inhibiting the WNK-SPAK kinase signalling as a novel therapeutic strategy for epilepsy   第23届神经病学与神经生理学国际会议   Jinwei Zhang   2019-03-18
（8）KCC2 ion transporter as a novel therapeutic target for epilepsy   第16届精准医疗暨离子通道论坛,邀请口头报告   Jinwei Zhang   2018-11-14
（9）Restoration of brain water homeostasis and neurological function via a novel kinase-cotransporter modulator   Cell 国际前沿论坛（衰老和代谢）   J Zhang*, MIH Bhuiyan, T Zhang, J Karimy, Z Wu, KT Kahle, D Sun, X Deng   2018-09-23
（10）The gut microbiome and Parkinson's disease   （第三届）海峡两岸暨世界华人微生态高峰论坛   Jinwei Zhang   2017-05-19
（11）Disruption of STE20/SPS1-related proline/alanine-rich kinase (SPAK) targeted mouse model of Gitelman　Syndrome   2014年‘英国高血压学会’主办的科学年会   Jinwei Zhang, Keith Siew, Kevin M O'Shaughnessy and Dario R. Alessi   2014-09-11
（12）Systems Biology of Fatty Acid Biosynthesis in Marine Microorganisms   ‘美国油类化学家学会’第101届研讨会   Jinwei Zhang   2010-05-17
（13）Systems Biology of Omega 3 Fatty Acid Biosynthesis by Marine Microorganisms as Route to Their Sustainable Production   美国油类化学家学会欧洲分会   Jinwei Zhang   2010-05-16
（14）微生物低温酶的应用   中国酶制剂及生物催化产品技术开发与产业化会议   张金伟，曾润颖   2006-08-24
（15）南极深海低温脂肪酶的选育，克隆，表达和酶学性质研究   第五届中国酶工程学术研讨会   张金伟，曾润颖   2005-11-15

现指导学生

耿午珺  硕士研究生  0703Z1-化学生物学