基本信息
屠洁      中国科学院深圳先进技术研究院
电子邮件: jie.tu@siat.ac.cn
通信地址: 深圳市南山区西丽学苑大道1068号
邮政编码: 518055

研究领域

中国科学院深圳先进技术研究院研究员,博士生导师,脑认知与脑疾病研究所副所长,深港脑科学创新研究院副院长,享受中科院特聘岗位研究员待遇。主要从事焦虑的神经和细胞机制研究,包括星型胶质细胞对脑功能神 经网络的调控。担任中国神经科学学会女科学家工作委员会副秘书长,应激分会、神经胶质细胞分会委员;受聘为国际期刊《Glia》 等杂志的编委。以通讯或第一作者身份发表了包括Neuron、Molecular Psychiatry、Nature Communications、 Advanced Science等国际主流期刊论文20篇,获授权国家发明专利10余项。主持或承担包括国家自然科学基金面上项目、国际(地区)合作项目;中国科学院国际合作重点项目;科技部重点研发计划课题;广东省重点领域研发计划等。

招生信息

   
招生专业
071006-神经生物学
071009-细胞生物学
071010-生物化学与分子生物学
招生方向
神经生物学
细胞生物学
分子生物学及基因工程

教育背景

2004-10--2008-09   香港大学   博士
2001-09--2004-06   浙江大学   理学硕士
1997-09--2001-06   浙江大学   理学学士

工作经历

   
工作简历
2016-01~现在, 中国科学院深圳先进技术研究院, 研究员
2010-02~2015-12,中国科学院深圳先进技术研究院, 副研究员
2008-10~2010-01,中国科学院深圳先进技术研究院, 助理研究员
社会兼职
2025-01-01-今,中国神经科学学会, 女科学家工作委员会副秘书长
2024-10-18-今,中国神经科学学会, 胶质细胞分会委员
2024-04-01-今,中国神经科学学会, 应激神经生物学委员
2022-09-01-今,Glia杂志, 编委

教授课程

神经生物学基础
神经生理学

出版信息

发表论文
(1) Palatable-Food–Driven Top-Down Circuit Inhibits PVNCRF Activity to Mitigate Stress via peri-PVNCRFR1 Neurons, Advanced Science, 2026, 第 13 作者  通讯作者
(2) MLKL-USP7-UBA52 signaling is indispensable for autophagy in brain through maintaining ubiquitin homeostasis, AUTOPHAGY, 2024, 第 10 作者  通讯作者
(3) Astrocyte-mediated regulation of BLAWFS1 neurons alleviates risk-assessment deficits in DISC1-N mice, Neuron, 2024, 第 13 作者  通讯作者
(4) Increased EAAT2 levels in BLA astrocytes mediated chronic stress-induced anxiety-like behavior., Neural Regeneration Research, 2024, 第 6 作者  通讯作者
(5) Sugar Beverage Habitation Relieves Chronic Stress-Induced Anxiety-like Behavior but Elicits Compulsive Eating Phenotype via vLS(GAD2) Neurons, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 第 5 作者  通讯作者
(6) The Central Nervous Mechanism of Stress-Promoting Cancer Progression, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 第 6 作者  通讯作者
(7) Diverse risk-avoidance behaviors in DISC1 mice are associated with different neuronal firing patterns in BLA neurons, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2022, 第 3 作者  通讯作者
(8) Reduced firing of accumbal parvalbumin interneurons causes impairment of risk avoidance in DISC1 transgenic mice, Neuroscience Bulletin, 2021, 第 14 作者  通讯作者
(9) Autophagy in Alzheimer's disease pathogenesis: Therapeutic potential and future perspectives, AGEING RESEARCH REVIEWS, 2021, 第 4 作者  通讯作者
(10) A new GABAergic somatostatin projection from the BNST onto accumbal parvalbumin neurons controls anxiety, MOLECULAR PSYCHIATRY, 2021, 第 9 作者  通讯作者
(11) Activation of dopaminergic VTA inputs to the mPFC ameliorates chronic stress-induced breast tumor progression, CNS NEUROSCIENCE & THERAPEUTICS, 2021, 第 6 作者  通讯作者
(12) Astrocyte, a Promising Target for Mood Disorder Interventions, FRONTIERS IN MOLECULAR NEUROSCIENCE, 2019, 第 6 作者  通讯作者
(13) Astrocytes in the ventromedial hypothalamus modulate anxiety behavior through regulating SF-1 neuron activities, GLIA, 2019, 第 5 作者
(14) The interplay between depression and tuberculosis, JOURNAL OF LEUKOCYTE BIOLOGY, 2019, 第 3 作者
(15) Ultra-soft and highly stretchable hydrogel optical fibers for in vivo optogenetic modulations, ADVANCED OPTICAL MATERIALS, 2018, 第 5 作者
(16) Astrocytic L-Lactate Signaling Facilitates Amygdala-Anterior Cingulate Cortex Synchrony and Decision Making in Rats, CELL REPORTS, 2017, 第 2 作者
(17) The role of astrocytes in modulation of neural circuits for brain diseases., GLIA, 2017, 第 7 作者
(18) Pharmacogenetic inhibiting VMH astrocytes induced anxiolytic behaviors in mice., GLIA, 2017, 第 7 作者
(19) Direct modulation of the astrocytes in ventromedial hypothalamus regulate the bone metabolism., GLIA, 2017, 第 6 作者
(20) Light activation of astrocytes promotes neuronal differentiation of stem cells and improves neurological deficit in stroke rats, GLIA, 2015, 第 1 作者
(21) Astrocytes enhance the dopaminergic differentiation of stem cells and promote brain repair through bFGF, GLIA, 2015, 第 3 作者
(22) 用于光遗传技术的体外细胞光刺激系统, In Vitro Cell Culture Light Stimulation System for Optogenetics, 集成技术, 2015, 第 6 作者
(23) Light-controlled inhibition of malignant glioma by opsin gene transfer, GLIA, 2015, 第 3 作者
(24) Light-Controlled Astrocytes Promote Human Mesenchymal Stem Cells Toward Neuronal Differentiation and Improve the Neurological Deficit in Stroke Rats, GLIA, 2014, 第 1 作者
(25) Activated astrocytes enhance the dopaminergic differentiation of stem cells and promote brain repair through bFGF, NATURE COMMUNICATIONS, 2014, 第 3 作者
(26) Light-controlled niche-astrocytes promote neuronal differentiation of human mesenchymal stem cells and improve the neurological deficit in rats with stroke, EUROPEAN JOURNAL OF NEUROLOGY, 2014, 第 1 作者
(27) Optogenetic inhibition of primary human malignant glioma, EUROPEAN JOURNAL OF NEUROLOGY, 2014, 第 2 作者
(28) Light-controlled niche-astrocytes promote neuronal differentiation of human mesenchymal stem cells and improve the neurological deficit in stroke rats, JOURNAL OF NEUROLOGY, 2014, 第 1 作者
(29) Optogenetic inhibition of primary human malignant glioma, JOURNAL OF NEUROLOGY, 2014, 第 2 作者
(30) Light-controlled inhibition of malignant glioma by opsin gene transfer, CELL DEATH & DISEASE, 2013, 第 2 作者
(31) Tunneling-nanotube direction determination in neurons and astrocytes, CELL DEATH & DISEASE, 2012, 第 4 作者
(32) cAMP/Protein Kinase A Activates Cystic Fibrosis Transmembrane Conductance Regulator for ATP Release from Rat Skeletal Muscle during Low pH or Contractions, PLOS ONE, 2012, 第 1 作者
(33) Strontium Enhances Osteogenic Differentiation of Mesenchymal Stem Cells and In Vivo Bone Formation by Activating Wnt/Catenin Signaling, STEM CELLS, 2011, 第 3 作者
(34) Involvement of the cystic fibrosis transmembrane conductance regulator in the acidosis-induced efflux of ATP from rat skeletal muscle, JOURNAL OF PHYSIOLOGY-LONDON, 2010, 第 1 作者
(35) Osteogenic differentiation of mesenchymal stem cells could be enhanced by strontium, 2010 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), 2010, 第 2 作者
(36) Therapeutic potential of extracellular ATP and P2 receptors in nervous system diseases, NEUROSCIENCE BULLETIN, 2009, 第 1 作者  通讯作者
(37) 细胞外ATP及其P2受体在神经系统疾病中的治疗潜能(英文), Therapeutic potential of extracellular ATP and P2 receptors in nervous system diseases, 神经科学通报:英文版, 2009, 第 1 作者
(38) Expression of Neuronal and Astroglial Markers of Differentiated Human Umbilical Mesenchymal Stem Cells in vitro, Glia, 2009, 第 1 作者
(39) EXPRESSION OF NEURAL AND ASTROGLIAL MARKERS OF DIFFERENTIATED HUMAN UMBILICAL MESENCHYMAL STEM CELLS IN VITRO, GLIA, 2009, 第 1 作者
(40) 深部脑刺激对神经精神疾病的治疗与未来展望, Deep Brain Stimulation for Neuropsychiatric Disorders and its Perspective in Therapeutics, 中国生物医学工程学报, 2009, 第 2 作者
(41) Analysis of interstitial concentrations of ATP from rat soleus muscle using microdialysis combined with ion-pairing high performance liquid chromatography (HPLC), 2009 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-20, 2009, 第 1 作者  通讯作者
(42) Increase in interstitial ATP of rat soleus muscle during lactic acid infusion, FASEBJOURNAL, 2007, 第 1 作者
(43) Cardioprotection of preconditioning with interleukin-2 is mediated via k- but not δ-opioid receptors., Journal of Pharmacology and Experimental Therapeutics, 2004, 第 1 作者
(44) Endothelin-1-mediated coronary vasoconstriction deteriorates myocardial depression in isolated hearts from lipopolysaccharide-treated rats: interaction with nitric oxide., Cli Exp Pharmacol Physiol, 2004, 第 1 作者
(45) ALTERATIONS OF CORONARY PERFUSION PRESSURE AND CARDIAC CONTRACTION DURING LIPOPOLYSACCHARIDE CHALLENGE., Conf Proc IEEE Eng Med Biol Soc, 2003, 第 1 作者
发表著作
(1) 脑科学常用研究技术, 科学出版社, 2023-11, 第 其他 作者

指导学生

已指导学生

李娟  硕士研究生  085208-电子与通信工程  

周辛夷  博士研究生  071006-神经生物学  

肖倩  博士研究生  071006-神经生物学  

徐锡荣  硕士研究生  071009-细胞生物学  

洪育川  博士研究生  071006-神经生物学  

郭琼  硕士研究生  085211-计算机技术  

徐锡荣  博士研究生  071006-神经生物学  

现指导学生

陈钰洁  博士研究生  071006-神经生物学