2002年毕业于内蒙古大学化学系，获理学学士学位。2008年毕业于中国科学院成都生物研究所药物化学专业，获理学博士学位。2015年，瑞士洛桑联邦理工大学（école Polytechnique Fédérale de Lausanne, EPFL），生物有机化学专业学习。现就职于中科院成都生物研究所，副研究员。主要从事天然药物活性成分的构效关系研究和释药系统构建，以获得可成药的候选药物分子；活性分子特殊母核的合成方法学及计算化学反应机理研究；计算机辅助药物设计和药物活性机制研究。现在国际TOP期刊J. Med. Chem.，Chem. Commun.，Adv. Synth. Catal.等发表论文40余篇，申请发明专利5项。 

1. 药物先导化合物的构效关系研究和释药系统构建；

2. 活性分子特殊母核的合成方法学研究； 

3. 计算机辅助药物设计和机理研究。 

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100701-药物化学
086000-生物与医药

药物化学
生物有机化学
药物合成

[1] 焦威. 异喹啉酮类化合物及其合成方法. CN115197137A, 2022-10-18.
[2] 焦威. 一种肉苁蓉有效成分提取富集方法及设备. CN112999265A, 2022-06-22.
[3] 焦威. 一种制备2-吲哚全氢呋喃[2,3-b]并吡喃的方法. CN114315849A, 2022-04-12.
[4] 焦威. 一种制备全氢呋喃 [2,3-b] 并吡喃的方法. 202111510192.7, 2021-11-05.
[5] 焦威. 一种芍药苷衍生物的合成方法. CN113336812A, 2021-09-03.
[6] 焦威, 向玲, 邵华武, 王飞, 张中辉. 一类千金子二萜衍生物及其应用. CN: CN113200950A, 2021-08-03.
[7] 李姝, 焦威, 贾俊杰, 邵华武, 王松涛, 沈才洪. 一种苦荞麸皮总黄酮的提取纯化方法. CN: CN110787220A, 2020-02-14.
[8] 王晓玲, 官家发, 彭树林, 范成英, 焦威, 丁立生. 短乳杆菌发酵生产芍药苷代谢素－Ⅰ的方法. CN: CN101074447A, 2007-11-21.

   

[1] Li, Pinyi, Fu, Xue, Zhou, Qiang, Fu, Xuewen, Wang, An, Zhang, Guolin, Jiao, Wei, Wang, Chun. Mechanistic understanding and the rational design of a SiO2@CD catalyst for selective protection of l-lysine. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2023, 21(3): 551-563, [2] 焦威. Enantioselective Cu-Catalyzed Nucleophilic Substitutions of Polyfluoroarenes: Synthesis of Chiral Polyfluoroaryl Diarylmethanes. Organic Letters[J]. 2023, [3] Yang, Chunmei, Zhang, Guoqing, Tang, Senling, Pan, Yang, Shao, Huawu, Jiao, Wei. Dess-Martin Periodinane-Mediated Oxidative Coupling Reaction of Isoquinoline with Benzyl Bromide. MOLECULES[J]. 2023, 28(3): http://dx.doi.org/10.3390/molecules28030923.
[4] 陈泳洁, 李攀, 向玲, 杨春梅, 张帆, 焦威. 多奈哌齐和美金刚与千金子活性P-糖蛋白调控剂联用的药代动力学. 应用与环境生物学报[J]. 2022, 28(2): 372-378, http://lib.cqvip.com/Qikan/Article/Detail?id=7107199028.
[5] Zhang Guoqing, Tang Senling, Yang Chunmei, Cheng Yongjie, Xiang Ling, Shao Huawu, Ma Xiaofeng, Zhang Fan, Jiao Wei. Synthesis of 2,2-Disubstituted Perhydrofuro[2,3-b]-pyran Derivatives containing Indole catalyzed by BF3.Et2O. ASIAN JOURNAL OF ORGANIC CHEMISTRY[J]. 2022, [6] Yuwen Sheng, Yuwen Chen, Zhongqiu Zeng, Wenbi Wu, Jing Wang, Yuling Ma, Yuan Lin, Jichao Zhang, Yulan Huang, Wenhua Li, Qiyu Zhu, Xiao Wei, Suiyan Li, Wisanee Wisanwattana, Fu Li, Wanli Liu, Apichart Suksamrarn, Guolin Zhang, Wei Jiao, Fei Wang. Identification of pyruvate carboxylase as the cellular target of natural bibenzyls with potent anticancer activity against hepatocellular carcinoma via metabolic reprogramming. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2022, 65: 460-484, [7] 向玲, 陈一鸣, 王松涛, 陈泳洁, 李姝, 焦威. 大孔树脂串联富集沙漠肉苁蓉苯乙醇苷的工艺. 食品工业[J]. 2022, 43(6): 39-43, http://lib.cqvip.com/Qikan/Article/Detail?id=7107602583.
[8] Wang, Haibo, Tang, Senling, Zhang, Guoqing, Pan, Yang, Jiao, Wei, Shao, Huawu. Synthesis of N-Substituted Iminosugar C-Glycosides and Evaluation as Promising alpha-Glucosidase Inhibitors. MOLECULES[J]. 2022, 27(17): [9] Shao, Huawu, Ma, Xiaofeng, Shen, Zhongke, Tang, China Qin, Jiao, Wei. One-Pot Synthesis of 2-C-Branched Glycosyl Triazoles by Integrating 1,2-Cyclopropanated Sugar Ring-Opening Azidation and CuAAC Reaction. JOURNAL OF ORGANIC CHEMISTRY. 2022, [10] Lin, Huaxin, Tang, Senling, Pan, Yang, Liang, Peng, Ma, Xiaofeng, Jiao, Wei, Shao, Huawu. A Novel Method to Construct 2-Aminobenzofurans via 4+1 Cycloaddition Reaction of In Situ Generated Ortho-Quinone Methides with Isocyanides. MOLECULES[J]. 2022, 27(23): http://dx.doi.org/10.3390/molecules27238538.
[11] 李姝, 王松涛, 吴萌萌, 邵华武, 赵建, 焦威. 不同大孔树脂苦荞黄酮富集品中4种主要黄酮的定量检测. 食品工业[J]. 2021, 42(2): 328-331, http://lib.cqvip.com/Qikan/Article/Detail?id=7104289064.
[12] Zhang, Xiaoke, Pan, Yang, Wang, Haibo, Liang, Chong, Ma, Xiaofeng, Jiao, Wei, Shao, Huawu. Strategy to Construct 1,2,3-Triazoles by K2CO3-Mediated 4+1 Annulation Reactions of N-Acetyl Hydrazones with Bifunctional Amino Reagents. ADVANCED SYNTHESIS & CATALYSIS[J]. 2021, 363(2): 459-463, https://www.webofscience.com/wos/woscc/full-record/WOS:000596586300001.
[13] Liang, Peng, Zhao, Hang, Zhou, Tingting, Zeng, Kaiyun, Jiao, Wei, Pan, Yang, Liu, Yazhou, Fang, Dongmei, Ma, Xiaofeng, Shao, Huawu. Rapid Oxidation Indoles into 2-Oxindoles Mediated by PIFA in Combination with n-Bu4NCl center dot H2O. ADVANCED SYNTHESIS & CATALYSIS[J]. 2021, 363(14): 3532-3538, http://dx.doi.org/10.1002/adsc.202100234.
[14] 焦威. UPLC-MS/MS测定大鼠血浆中多奈哌齐和美金刚在两种活性大戟二萜类化合物作用下的含量及其在药代动力学研究中的应用. 应用与环境生物学报. 2020, [15] Pan, Yang, Li, Jiangtao, Li, Zhefeng, Huang, Feng, Ma, Xiaofeng, Jiao, Wei, Shao, Huawu. An efficient and facile strategy for trifluoromethylation and perfluoroalkylation of isoquinolines and heteroarenes. CHEMICAL COMMUNICATIONS[J]. 2020, 56(56): 7813-7816, https://www.webofscience.com/wos/woscc/full-record/WOS:000548421300028.
[16] Zhang, Xiaoke, Pan, Yang, Liang, Peng, Ma, Xiaofeng, Jiao, Wei, Shao, Huawu. An Effective Method for the Synthesis of 1,3-Dihydro-2H-indazoles via N-N Bond Formation. ADVANCED SYNTHESIS & CATALYSIS[J]. 2019, 361(24): 5552-5557, [17] Liang, Peng, Pan, Yang, Ma, Xiaofeng, Jiao, Wei, Shao, Huawu. A facile method for the synthesis of fused perhydropyrano2,3-bpyrans promoted by Yb(OTf)(3). CHEMICAL COMMUNICATIONS[J]. 2018, 54(30): 3763-3766, https://www.webofscience.com/wos/woscc/full-record/WOS:000429592700019.
[18] 但春, 焦威. 丁香的化学成分研究. 中药材[J]. 2018, 1108-1113, http://lib.cqvip.com/Qikan/Article/Detail?id=90896765504849564853485049.
[19] Zhang, Xiaoke, Pan, Yang, Liang, Peng, Pang, Lu, Ma, Xiaofeng, Jiao, Wei, Shao, Huawu. Oxadiazepine Synthesis by Formal 4+3 Cycloaddition of o-Chloromethyl Arylsulfonamides with Nitrones Promoted by NaHCO3. ADVANCED SYNTHESIS & CATALYSIS[J]. 2018, 360(16): 3015-3019, https://www.webofscience.com/wos/woscc/full-record/WOS:000441874400004.
[20] Liang, Peng, Pan, Yang, Ma, Xiaofeng, Jiao, Wei, Shao, Huawu. A facile method for the synthesis of fused perhydropyrano2,3-bpyrans promoted by Yb(OTf)(3). JOURNAL OF MATERIALS CHEMISTRY B[J]. 2018, 6(14): 3763-3766, [21] Yuan, Wen, Pan, Yang, Zhang, Xiaoke, Liang, Peng, Zhang, Jichao, Jiao, Wei, Shao, Huawu. Direct and highly stereoselective synthesis of quinolizidine iminosugars promoted by L-proline-Et3N. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2018, 16(47): 9230-9236, http://ir.imde.ac.cn/handle/131551/24731.
[22] Igbe, Ighodaro, Shen, XiaoFei, Jiao, Wei, Qiang, Zhe, Deng, Teng, Li, Sheng, Liu, WanLi, Liu, HanWei, Zhang, GuoLin, Wang, Fei. Dietary quercetin potentiates the antiproliferative effect of interferon-alpha in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase. ONCOTARGET[J]. 2017, 8(69): 113734-113748, http://dx.doi.org/10.18632/oncotarget.22556.
[23] Fei Wang. Dietary quercetin potentiates the antiproliferative effect of interferon-α in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase. Oncotarget. 2017, [24] Yuan, Wen, Xia, Jianhui, Zhang, Xiaoke, Liang, Peng, Zhang, Jichao, Jiao, Wei, Shao, Huawu. An efficient method for the stereoselective synthesis of N-substituted trihydroxypiperidine derivatives promoted by p-TsOH. TETRAHEDRON[J]. 2016, 72(27-28): 3994-4000, http://dx.doi.org/10.1016/j.tet.2016.05.023.
[25] Shen, Xudong, Xia, Jianhui, Liang, Peng, Ma, Xiaofeng, Jiao, Wei, Shao, Huawu. Zn(OTf)(2) promoted rearrangement of 1,2-cyclopropanated sugars with amines: a convenient method for the synthesis of 3-polyhydroxyalkyl-substituted pyrrole derivatives. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2015, 13(44): 10865-10873, http://210.75.237.14/handle/351003/27600.
[26] 濮生财, 鲁璐, 焦威, 邵华武, 阳小成. 不同品种苦荞中的4种活性黄酮含量. 应用与环境生物学报[J]. 2015, 21(3): 470-476, http://210.75.237.14/handle/351003/27717.
[27] Jiao, Wei, Wan, Zhongmin, Chen, Shuang, Lu, Runhua, Chen, Xiaozhen, Fang, Dongmei, Wang, Jiufeng, Pu, Shengcai, Huang, Xin, Gao, Haixiang, Shao, Huawu. Lathyrol Diterpenes as Modulators of P-Glycoprotein Dependent Multidrug Resistance: Structure-Activity Relationship Studies on Euphorbia Factor L-3 Derivatives. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2015, 58(9): 3720-3738, http://210.75.237.14/handle/351003/27584.
[28] Wang, Cong, Ma, Xiaofeng, Zhang, Jichao, Tang, Qin, Jiao, Wei, Shao, Huawu. Methanesulfonic-Acid-Catalysed Ring Opening and Glycosylation of 1,2-(Acetylcyclopropane)-Annulated D-Lyxofuranose. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY[J]. 2014, 2014(21): 4592-4599, http://210.75.237.14/handle/351003/26675.
[29] 焦威, 万忠民, 濮生财, 焦威, 阳小成, 邵华武. 减压内沸腾和响应面分析优化苦荞总黄酮提取工艺. 应用与环境生物学报[J]. 2014, 20(4): 633-638, http://www.irgrid.ac.cn/handle/1471x/1028569.
[30] Chen, XiaoZhen, Lu, ShengMing, Li, GuoYou, Jiao, Wei, Huang, TianFang, Yang, Tao, Fang, DongMei. Biphenyls from aerial parts of Ribes takare. CHINESE CHEMICAL LETTERS[J]. 2014, 25(1): 127-130, http://dx.doi.org/10.1016/j.cclet.2013.07.019.
[31] 万忠民, 安坤, 焦威, 焦威, 邵华武, 阳小成. 太子参红外指纹图谱的双指标序列分析. 天然产物研究与开发[J]. 2013, 25(5): 594-599, http://210.75.237.14/handle/351003/24054.
[32] Jiao, Wei, Fang, DongMei, Wu, ZhiJun, Chen, JianZhong, Shao, HuaWu, Zhang, GuoLin. Analysis of lathyrane diterpenes using electrospray ionization quadrupole time-of-flight mass spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY. 2013, 27(1): 276-280, http://www.irgrid.ac.cn/handle/1471x/900505.
[33] Jiao, Wei, Wu, Zhijun, Chen, Xiaozhen, Lu, Runhua, Shao, Huawu. Rhopeptin A: First Cyclopeptide Isolated from Rhodobryum giganteum. HELVETICA CHIMICA ACTA[J]. 2013, 96(1): 114-118, http://www.irgrid.ac.cn/handle/1471x/900516.
[34] Jiao, Wei, Chen, Xiaozhen, Wang, Haibo, Lu, Runhua, Shao, Huawu. A new hepatotoxic triterpenoid ketone from Curculigo orchioides. FITOTERAPIA[J]. 2013, 84: 1-5, http://www.irgrid.ac.cn/handle/1471x/900510.
[35] 安坤, 何静, 万忠民, 邵华武, 阳小成, 焦威. 不同产区太子参氨基酸含量测定及多元统计分析. 天然产物研究与开发[J]. 2012, 24(5): 594-598, http://lib.cqvip.com/Qikan/Article/Detail?id=42073356.
[36] 焦威, 鲁改丽, 邵华武, 鲁润华. 暖地大叶藓化学成分的研究. 天然产物研究与开发[J]. 2010, http://lib.cqvip.com/Qikan/Article/Detail?id=1001202406.
[37] 焦威, 鲁璐, 邓美彩, 邵华武, 鲁润华. 千金子化学成分的研究. 中草药[J]. 2010, 181-187, http://lib.cqvip.com/Qikan/Article/Detail?id=33142013.
[38] Wang, Zhizhong, Jiao, Wei, He, Guangyun, Lu, Runhua. One-step regioselective green synthesis of 2,3-mannoepoxy-beta-cyclodextrin under aqueous conditions. MONATSHEFTE FUR CHEMIE[J]. 2009, 140(1): 79-81, http://www.irgrid.ac.cn/handle/1471x/256564.
[39] 邓美彩, 焦威, 董玮玮, 鲁润华. 蹄叶橐吾根的化学成分研究. 天然产物研究与开发[J]. 2009, 776-778, http://lib.cqvip.com/Qikan/Article/Detail?id=31969395.
[40] 杨淳彬, 邓美彩, 董玮玮, 焦威, 鲁润华. 细叶草乌的化学成分研究. 应用与环境生物学报[J]. 2009, 15(3): 323-325, http://lib.cqvip.com/Qikan/Article/Detail?id=30797263.
[41] 邓美彩, 焦威, 董玮玮, 杨淳彬, 鲁润华. 钩藤化学成分的研究. 天然产物研究与开发[J]. 2009, 21(2): 242-245, http://lib.cqvip.com/Qikan/Article/Detail?id=30283007.
[42] Deng, Meicai, Dong, Weiwei, Jiao, Wei, Lu, Runhua. New Eremophilane Sesquiterpenes from the Roots of Ligularia fischeri. HELVETICA CHIMICA ACTA[J]. 2009, 92(3): 495-501, [43] Jiao, Wei, Dong, Weiwei, Li, Zhefeng, Deng, Meicai, Lu, Runhua. Lathyrane diterpenes from Euphorbia lathyris as modulators of multidrug resistance and their crystal structures. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2009, 17(13): 4786-4792, http://dx.doi.org/10.1016/j.bmc.2009.04.041.
[44] Lu, Runhua, Yang, Cheng, Cao, Yujuan, Tong, Linhui, Jiao, Wei, Wada, Takehiko, Wang, Zhizhong, Mori, Tadashi, Inoue, Yoshihisa. Enantiodifferentiating photoisomerization of cyclooctene included and sensitized by aroyl-beta-cyclodextrins: A critical enantioselectivity control by substituents. JOURNAL OF ORGANIC CHEMISTRY[J]. 2008, 73(19): 7695-7701, http://www.irgrid.ac.cn/handle/1471x/256478.
[45] 焦威, 王燕军, 白冰如, 鲁润华. 四川产暖地大叶藓挥发油成分分析. 天然产物研究与开发[J]. 2008, 20(B05): 29-31, http://lib.cqvip.com/Qikan/Article/Detail?id=29162193.
[46] 焦威. 千金子和暖地大叶藓的化学成分研究. 2008, 128-, http://210.75.237.14/handle/351003/2453.
[47] JIAO Wei, YU Kai-Bei, LU Run-Hua. Configuration Confirmation of Euphorbia Factor L1 by Single-crystal X-ray Diffraction. 结构化学[J]. 2008, 27(12): 1431-1434, http://lib.cqvip.com/Qikan/Article/Detail?id=28961597.
[48] 焦威. 千金子和暖地大叶藓的化学成分研究. 2008, 128-, http://210.75.237.14/handle/351003/2453.
[49] Jiao Wei, Yu KaiBei, Lu RunHua. Configuration Confirmation of Euphorbia Factor L-1 by Single-crystal X-ray Diffraction. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY[J]. 2008, 27(12): 1431-1434, http://lib.cqvip.com/Qikan/Article/Detail?id=28961597.
[50] Jiao, Wei, Mao, Zhihua, Dong, Weiwei, Deng, Meicai, Lu, Runhua. Euphorbia factor L-8: a diterpenoid from the seeds of Euphorbia lathyris. ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS[J]. 2008, 64: O331-U5588, https://www.webofscience.com/wos/woscc/full-record/WOS:000252049300510.
[51] Dong, WeiWei, Jiao, Wei, Deng, MeiCai, Yang, ChunBin, Yue, JianMin, Lu, RunHua. A New Steroid Glycoside Derivative from Acorus calamus L.. JOURNAL OF THE CHINESE CHEMICAL SOCIETY[J]. 2008, 55(6): 1277-1279, http://www.irgrid.ac.cn/handle/1471x/256461.
[52] Xlao-Ling Wang, Suo-Lang Gesang, Wei Jiao, Xun Liao, Li-Sheng Ding. Two New Sesquiterpenoid Glucosides from the Aerial Parts of Saussurea involucrate. 植物学报：英文版[J]. 2007, 49(5): 609-614, http://lib.cqvip.com/Qikan/Article/Detail?id=24397208.
[53] Wang, XiaoLing, Gesang, SuoLang, Jiao, Wei, Liao, Xun, Ding, LiSheng. Two new sesquiterpenoid glucosides from the aerial parts of Saussurea involucrate. JOURNAL OF INTEGRATIVE PLANT BIOLOGY[J]. 2007, 49(5): 609-614, http://lib.cqvip.com/Qikan/Article/Detail?id=24397208.
[54] Wang, Xiao Ling, Jiao, Wei, Liao, Xun, Peng, Shu Ling, Ding, Li Sheng. Monoterpene glycosides from the roots of Paeonia lactiflora. CHINESE CHEMICAL LETTERS[J]. 2006, 17(7): 916-918, http://lib.cqvip.com/Qikan/Article/Detail?id=22284851.
[55] Xiao Ling WANG, Wei JIAO, Xun LIAO, Shu Ling PENG, Li Sheng DING. Monoterpene Glycosides from the Roots of Paeonia lactiflora. 中国化学快报：英文版[J]. 2006, 17(7): 916-918, http://lib.cqvip.com/Qikan/Article/Detail?id=22284851.

   

现指导学生

向玲  硕士研究生  085235-制药工程  

杨春梅  硕士研究生  085238-生物工程  

唐森铃  硕士研究生  086000-生物与医药