General

        Jian Zhang,Ph.D,Professor/Doctoral Supervisor,Director of Center for Reproduction and Health Development.


“Hundred Talents Program” of CAS,2011,

Distinguished Younge Scholars of Shenzhen ,2012,

Shenzhen overseas high-level talents category C (Peacock plan),2014,

Shenzhen overseas high-level talents category B (Peacock plan),2016,

Member of American Diabetes Association, American Society for Endocrinology,

Member of reproductive biology branch of Chinese society of zoology


Research Achievements

1.   Prof. Zhang has discovered and successfully isolated and purified two peptide hormones: Obestatin and Neuronostatin; Applied for 34 international patents, 54 Chinese patents, of which 9 have been authorized.

2.    More than 75 papers have been published in domestic and foreign academic journals, including 59 SCI papers, including Science, J Hepatology,JBC, Molecular Endocrinology,Scientific Reports,Plos One and Molecular Human Reproduction, etc., with 1378 citations, and reviewers of many journals.

3.    Prof. Zhang now is the member of American Diabetes Association, American society for endocrinology, director of reproductive biology, branch of China zoological society.

4.    Fellowships: Graduate Innovation Grant of CAS, 2002; Excellence Award of CAS, 2003; the Best Posters of Weimar Germany, 2002.










Research Areas

Research interests include the discovery of active peptides and their roles in metabolism, reproduction and aging.


1) The role and mechanism of active peptides in the metabolic regulation of hypothalamic efficacious organ axis (adipose tissue, bone, muscle, etc.) and ovary;

2) The role and mechanism of active peptides in the regulation of maternal and fetal metabolic interaction between hypothalamic efficacious organ axis (adipose tissue, bone, muscle, etc.) and maternal metabolic risk.



Education

1999-2003,Ph.D. in Physiology , Institute of Zoology, Chinese Academy of Sciences (Supervisor: Prof. Duan Enkui)


Experience

   2003-2008,Postdoctoral Research in Stanford University（Supervisor: Prof. Aaron JW Hsueh）

   2008-2010,Stanford University Research ScientistDec,2010 till now, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences



Work Experience

2003-2008,Postdoctoral Research in Stanford University（Supervisor: Prof. Aaron JW Hsueh）

      2008-2010,Stanford University Research ScientistDec,2010 till now, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences

      2010-up to now，Shenzhen Institutes of Advanced Technology，Chinese Academy of Sciences，Researcher

Publications


Papers

1.        TAN L B#, OUYANG Z j#, CHEN Z L, SUN F, GUO H C, WANG F, MULDER M, SUN Y, LU XF, ZHANG JV, DANSER AHJ, VERDONK K, FAN X J*, YANG Q*.Adipokine chemerin overexpression in trophoblasts leads to dyslipidemia in pregnant mice: implications for preeclampsia[J]. Lipids Health Dis, 2023 Jan 25;22(1):12.

2.        YANG C#, ZENG QX#, LIU JC, YEUNG WS, ZHANG JV*(共通讯), DUAN YG*.Role of small RNAs harbored by sperm in embryonic development and offspring phenotype[J]. Andrology, 2022 Nov 23. doi: 10.1111/andr.13347.

3.        HUANG C,BIN C, CAI J X, CHEN J ,WANG B B, LI MX, ZHOU WEI, WANG J G,ZHANG P F,ZHANG J V*(通讯). Chondroitin sulfate Targeting Nanodrug Achieves Near-Infrared Fluorescence-guided Chemotherapy Against Triple Negative Breast Primary and Lung Metastatic Cancer[J]. Int J  Nanomed, 2022, 17：5547—5563.

4.        YU M#, YANG Y L#, ZHAO H , LI M X, CHEN J, WANG B B,XIAO T X, HUANG C,ZHAO HS ,ZHOU W*, ZHANG J V(通讯)*. Targeting the chemerin/CMKLR1 axis by small molecule antagonist α-NETA mitigates endometriosis progression[J]. Front Pharmacol, 2022, doi: 10.3389/fphar.2022.985618.

5.        GUAN X N#, YU M#, WU LL, CHEN J, TONG J N, WU X X, YIN A Q, XIAO T X, WANG B B, ZHANG J V*（共通讯）, NIU J M*. Elevated trophoblastic Siglec6 contributes to the impairment of vascular endothelial cell functions by downregulating Wnt6/beta-catenin signaling in preeclampsia [J]. Arch Biochem Biophys, 2022, 730: 109396.

6.        YU M#, YANG YL#,HUANG C,GE L,XUE L,XIAO ZL,XIAO TX,ZHAO HS,REN PG,ZHANG JV(通讯). Chemerin: a functional adipokine in reproductive health and diseases[J].Biomedicines,2022, 10(8), 1910.

7.        YIN A Q, GUAN X N, ZHANG JV*(共通讯), NIU J M*.Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental development and preeclampsia[J]. Front Cell Dev Biol, 2022 Sep 14;10:959239.

8.   SONG Q Y, XIAO B, HUANG H L, MA L Y, ZHANG JV*(共通讯), ZHU Y F*.Influences of gestational diabetes mellitus on the oral microbiota in offspring from birth to 1 month old[J]. BMC Pregnancy Childbirth,2022 Apr 6;22(1):289.

9.   ZHANG QQ #,XIAO Z L#, LEE C K, DUAN Y G, FAN X J, YEUNG W S B, CHIU P C N*, ZHANG J V*(通讯). The Regulatory Roles of Chemerin-Chemokine-Like Receptor 1 Axis in Placental Development and Vascular Remodeling During Early Pregnancy[J]. Front Cell Dev Biol, 2022 May 17;10:883636.

10. MA CY#, XIONG Y#, HAN P#, ZHANG X Y, CAO Y J, WANG B B ,ZHAO H S,DUAN E K, ZHANG J V*(共通讯), LEI X H*. Simulated microgravity potentiates hematopoietic differention of human pluripotent stem cells and supports formation of 3D hematopoietic cluster[J]. Front Cell Dev Biol, 2022 Jan 10;9:797060.

11. LIU H P, ZHANG J V, WANG DW,ALBRECHT A, STEINHÖFEL K, LAI HM. Extended endocrine therapy in breastcancer:A basket of length-constraint  feature selection metaheuristics to balance Type I againstType II errors[J]. J Biomed Inform. 2022 Jun 6;131:104112.

12. LEE CL*, CHEN ZL, ZHANG Q Q, GUO Y, NG VWY, ZHANG B Z, BAI KF, RUAN DG, KAN ASY, CHEUNG KW, MAK ASL, YEUNG WSB, SU R, YANG Q, CHEN M, DU MR, ZHANG J, FAN XJ*, CHIU PCN*. Dysregulation of the CD147 complex confers defective placental development: A pathogenesis of early-onset preeclampsia[J]. Clin Transl Med, 2022 Jun;12(6):e826.

13. TAN L B#, CHEN Z L#, SUN F, ZHOU  Z Q, Zhang B Z, WANG B B, CHEN J, LI M X, XIAO T X, NEUMAN RI, NIU J M, VERDONK K, LU X F, ZHANG J V, DANSER AHJ, YANG Q*, FAN X J*. Placental trophoblast-specific overexpression of chemerin induces preeclampsia-like symptoms[J]. Clin Sci (Lond),2022 Feb 25;136(4):257-72.

14. SUN F#, CAI H#, TAN L B, QIN D Z, ZHANG J, HUA J L, FAN X J*, PENG S*. Placenta-Specific miR-125b Overexpression Leads to Increased Rates of Pregnancy Loss in Mice[J]. Int J Mol Sci, 2022 Jan 15;23(2):943.

15. 黄容，张键，车旭. SLC4A10表达水平对肝癌患者预后的影响[J].基础医学与临床. 2022, 42(3):461-6.

16. ZHOU X S#,ZHAO J#,ZHANG J V*(共通讯),WU Y L,WANG L,CHEN X Q,JI D M,ZHOU G G Y*.Enhancing Therapeutic Efficacy of Oncolytic Herpes Simplex Virus with MEK Inhibitor Trametinib in Some BRAF or KRAS-Mutated Colorectal or Lung Carcinoma Models[J]. Viruses, 2021, 13(9), 1758.

17. LI R R, MA C Y, XIONG Y, ZHAO H S, YANG Y L, XUE L,WANG B B,XIAO T X ,CHEN J,LEI X H*, MA B H *,ZHANG J V*(通讯). An Antagonistic Peptide of Gpr1 Ameliorates LPS-Induced Depression through the Hypothalamic -Pituitary- Ovarian Axis [J].Biomolecules, 2021,11(6):857.

18. SUN LF#, YANG Y L#, WANG M Y, ZHAO H S, XIAO T X, LI M X, WANG B B, HUANG C, REN P G*, ZHANG JV*(通讯).Inhibition of Col6a5 improve lipid metabolism disorder in Dihydrotestosterone-induced hyperandrogenic mice [J].Front Cell Dev Biol，2021 , doi: 10.3389/fcell.2021.669189.

19. WANG H F, HUANG B B, HOU A L, XUE L, WANG B B, CHEN J, LI M X, ZHANG J V(通讯). High NOV/CCN3 expression during high-fat diet pregnancy in mice affects GLUT3 expression and the mTOR pathway[J]. Am J Physiol-Endocrinol Metab,2021, DOI: 10.1152/ajpendo.00230.2020

20. ZHANG J Z#, CHEN Z L#, WANG B B, CHEN J, XIAO TX, ZHANG J V*(共同通讯), CHEN S L*, FAN XJ*. Reduction of pl-CSA through ChSy-2 knockout inhibits tumorigenesis  and metastasis of choriocarcinoma in JEG3 cells[J]. Int J Mol Sci, 2021 2021;18(1):207-215.

21. ZHENG X L, ZHANG J V, BAI Y F, WANG J Q, JIANG M F, ZENG S, WANG L H. Upregulation of OATP1A2 in Human Esophageal Squamous Cell Carcinoma Cells via the HDAC6-GCN5/PCAF-H3K9Ac Axis[J]. Xenobiotica, 2021 Nov 25;1-10.  doi: 10.1080/00498254.2021.2001076

22. TAN L B, CHEN Z L, SUN F, ZHOU Z Q, ZHANG B Z, WANG B B, CHEN J, LI MX, XIAO TX, NEUMAN R I, NIU J M, VERDONK K, LU X F, ZHANG J, JAN DANSER A.H., YANG Q, FAN X J. Placental Trophoblast Specific Overexpression of Chemerin Induces Preeclampsia-like Symptoms[J]. Placenta, 2021,112,Page e56.

23. HONG H, CHEN H C, ZHANG Y X, WU Z M,  ZHANG Y Y, ZHANG Y Y,  HU Z, ZHANG J V, LING K,  HU J H, WEI Q. DYF-4 regulates patched-related/ DAF-6-mediated sensory compartment formation in C. elegans[J].  PLoS Genet.2021 17(6): e1009618.

24. ZHAO Y#*, FENG H W#, ZHANG Y H#, ZHANG J V, WANG X H, LIU D T, WANG T R, LI R H W, NG E H Y, YEUNG W S B, RODRIGUEZ-WALLBERG K A, LIU K. Current Understandings of Core Pathways for the Activation of Mammalian Primordial Follicles [J].Cells, 2021, 10(6): 1491.

25. CHEN Y Q#, UDDUTTULA A#, XIE X L, ZHOU M, SHENG W B, YU F, WENG J, WANG D L, TENG B, MANIVASAGAM G, ZHANG J V, REN P G*, KANG B*, ZENG H*.A novel photocrosslinked phosphate functionalized Chitosan-Sr5(PO4)2SiO4 composite hydrogels and in vitro biomineralization, osteogenesis, angiogenesis for bone regeneration application [J]. Compos Part B-Eng, 2021,109057,ISSN 1359-8368.

26. HUANG C#, DAI X Y#, CAI J X#, CHEN J, WANG B B,ZHU W, WANG E, WEI W*, ZHANG J V*(通讯). A screened GPR1 peptide exerts antitumor effects on triple-negative breast cancer[J]. Mol Ther-oncolytics,2020,18:602-12.

27. HUANG B B#, ZHU W#, ZHAO H S#, ZENG F, WANG E, WANG H F, CHEN J, LI M X, HUANG C,REN L R*, NIU J M*, ZHANG J V*(通讯). Placenta-derived Osteoprotegerin is Required for Glucose Homeostasis in Gestational Diabetes Mellitus[J]. Front Cell Dev Biol, 2020 Sep 1;8:563509.

28. TENG B#, HUANG C#, CHENG C L, UDDUTTULA A, YU X F, LIU C, LI J, YAO Z Y, LONG J, MIAO L F, ZOU C, CHU J, ZHANG J V*（共同通讯）, REN P G*. Newly identified peptide hormone inhibits intestinal fat absorption and improves NAFLD through its receptor GPRC6A [J]. J Hepatol, 2020,73(2):383-93.

29. UDDUTTULA A#, TENG B#, CHANDRASHEKAR B N, LI J, YU X F, LIU C, SHI R, CHENG C, ZHANG J V*（共同通讯）, REN P G*. Novel Sr5(PO4)2SiO4-graphene nanocomposites for applications in bone regeneration in vitro [J]. Appl Surf Sci, Volume 507, 30 March 2020, 145176.

30. HUANG B B#, ZHAO H S#, HUANG C#, WU L L, XIANG L, CHEN J, WANG B B, XIAO T X, LI M X, REN L R*, NIU J M*, ZHANG J V*(通讯). CMKLR1 deficiency attenuates androgen-induced lipid accumulation in mice [J]. Am J Physiol-Endocrinol Metab, 2020, 318(3): E371-E80.

31. LI N, HE F, GAO H, GE Y, FAN X J, ZHANG J V, QI H, REN L L. Elevated cell-free fetal DNA contributes to placental inflammation and antiangiogenesis via AIM2 and IFI16 during pre-eclampsia [J]. J Cell Physiol, 2020 May 7. doi: 10.1002/jcp.29766.

32. ZHAO K#*, CHENG G G#, ZHANG B Z#, LI D, HAN J Y, CHEN J, WANG B B, LI M X, XIAO T X, LE A W, SUN B N, JIN Z, ZHANG J V, FAN X J. Targeting delivery of partial VAR2CSA peptide guided N-2-Hydroxypropyl trimethyl ammonium chloride chitosan nanoparticles for multiple cancer types [J]. Mater Sci Eng C-Mater Biol Appl, 2020, 106:110171.

33. ZHAO H S#, YAN D W#, XIANG L#, HUANG C, LI J, YU X F, HUANG B B, WANG B B, CHEN J, XIAO T X, REN P G*, ZHANG J V*（通讯）. Chemokine-like receptor 1 deficiency leads to lower bone mass in male mice [J]. Cell Mol Life Sci, 2019, 76(2): 355-67.

34. YAO Z Y#, LIU C#, YU X F, MENG J, TENG B, SUN Y T, KEREM O E, ISMAYIL A, FANG P, ZHANG J V *(共同通讯), REN P G*. Microarray Profiling and Coexpression Network Analysis of Long Noncoding RNAs in Adipose Tissue of Obesity-T2DM Mouse [J]. Obesity, 2019, 27(10): 1644-51.

35. UDDUTTULA A#, LI J#, ZHAO P Y, WANG G C, ZHANG J V*（共同通讯）, REN P G*. Sol-gel derived nanosized Sr5(PO4)2SiO4 powder with enhanced in vitro osteogenesis and angiogenesis for bone regeneration applications [J]. Ceramics International, 2019, 45(3): 3148-58.

36. SUN L F#, YANG Y L#, XIAO T X, LI M X, ZHANG J V（通讯）. Removal of DHT can relieve polycystic ovarian but not metabolic abnormalities in DHT-induced hyperandrogenism in mice [J]. Reprod Fertil Dev, 2019, 31(10): 1597-606.

37. JIN P#*, CHEN X F#, YU G Y, LI Z Y, ZHANG Q Q, ZHANG J V*（共同通讯）. The Clinical and Experimental Research on the Treatment of Endometriosis with Thiostrepton [J]. Anti-Cancer Agents Med Chem, 2019, 19(3): 323-9.

38. HUANG B B, LIU X C, QIN X Y, CHEN J, REN P G, DENG W F*, ZHANG J V *（通讯）. Effect of High-Fat Diet on Immature Female Mice and Messenger and Noncoding RNA Expression Profiling in Ovary and White Adipose Tissue [J]. Reprod Sci, 2019, 26(10): 1360-72.

39. HUANG B B#, ZHU W#, CHANG J L#, DAI X Y, YU G Y, HUANG C, WANG E, LI Z H, LIN L L, WANG B B, CHEN J, XIAO T X, NIU J M*, ZHANG J V *（通讯）. Role of G protein-coupled receptor 1 in choriocarcinoma progression [J]. Am J Physiol-Cell Physiol, 2019, 317(3): C556-C65.

40. HUANG B B#, HUANG C#, ZHAO H S#, ZHU W, WANG B B, WANG H F, CHEN J, XIAO T X, NIU J M*, ZHANG J V *（通讯）. Impact of GPR1 signaling on maternal high-fat feeding and placenta metabolism in mice [J]. Am J Physiol-Endocrinol Metab, 2019, 316(6): E987-E97.

41. 李荣荣, 薛丽, 马保华*, 张键*（共同通讯）. Adipsin相关疾病的研究进展 [J]. 公共卫生与预防医学, 2019, 30(02): 74-8.

42. ZHAO K#, LI D, CHENG G G, ZHANG B Z, HAN J Y, CHEN J, WANG B B, LI M X, XIAO T X, ZHANG J V, ZHOU D P, JIN Z, FAN X J#. Targeted Delivery Prodigiosin to Choriocarcinoma by Peptide-Guided Dendrigraft Poly-l-lysines Nanoparticles [J]. Int J Mol Sci, 2019, 20(21):5458.

43. QIU C#, LI J#, ZHANG J V, HE Q, WANG L, WENG X, GUAN M. Modulation of the airway smooth muscle phenotype in a murine asthma model and effects of nuclear factor-κB inhibition [J]. Journal of Asthma, 2019, 56(12): 1247-56.

44. ZHANG B Z#, TAN L B#, YU Y#, WANG B B, CHEN Z L, HAN J Y, LI M X, CHEN J, XIAO T X, AMBATI B K, CAI L T, YANG Q, NAYAK N R, ZHANG J V *(共同通讯), FAN X J*. Placenta-specific drug delivery by trophoblast-targeted nanoparticles in mice [J]. Theranostics, 2018, 8(10): 2765-81.

45. YANG Y L#, SUN L F#, YU Y, XIAO T X, WANG B B, REN P G, TANG H R*, ZHANG J V*(通讯). Deficiency of Gpr1 improves steroid hormone abnormality in hyperandrogenized mice [J]. Reprod Biol Endocrinol, 2018, 16(1): 50.

46. HUANG C#, HUANG B B#, NIU J M#, YU Y, QIN X Y, YANG Y L, XIAO T X, CHEN J, REN L R*, ZHANG J V*（通讯）. Global mRNA and Long Non-Coding RNA Expression in the Placenta and White Adipose Tissue of Mice Fed a High-Fat Diet During Pregnancy [J]. Cell Physiol Biochem, 2018, 50(6): 2260-71.

47. XUE L, YU Y, ZENG F, TANG H R, XIANG L, CHEN J, XIAO T X, REN PG, ZHANG J V（通讯）. Alleviation of Diet-Induced Fat Accumulation by a Small Molecule CMKLR1 Antagonist in Mice [J]. Journal of Steroids & Hormonal Science, 2018, 09(01): 10.4172 / 2157-7536.1000191.

48. 范秀军, 黄晨, 陈指龙, 王鹤霏, 黄斌斌, 张键（通讯）. 妊娠期代谢性疾病与胎盘发育 [J]. 中国实用妇科与产科杂志, 2018, 34(09): 959-63.

49. ZHANG B Z#, CHENG G G#, ZHENG M B, HAN J Y, WANG B B, LI M X, CHEN J, XIAO T X, ZHANG J V, CAI L T, LI S J, FAN X J. Targeted delivery of doxorubicin by CSA-binding nanoparticles for choriocarcinoma treatment [J]. Drug Deliv, 2018, 25(1): 461-71.

50. XIAO Z L, LI S J, YU Y, LI M X, CHEN J, WANG F, ZHANG J V, DENG W F*, YANG Q*, FAN X J*. VEGF-A regulates sFlt-1 production in trophoblasts through both Flt-1 and KDR receptors [J]. Mol Cell Biochem, 2018, 449(1-2): 1-8.

51. 余贵媛, 代小勇, 张键, 李秋霞, 曹冠姝, 金平. CMKLR1对子宫内膜癌细胞增殖和迁移特性的影响 [J]. 现代妇产科进展, 2018, 27(07): 512-7.

52. CHEN Z L, ZHANG J V, YANG Q*, FAN X J*. A Secreted Protein in the Wnt Signaling Pathway-R-Spondin3: A Mini-Review [J]. Significances of Bioengineering & Biosciences, 2018, 1(4): 10.31031/SBB.2018.01.000518.

53. LI J#, XIANG L#, JIANG X T#, TENG B, SUN Y T, CHEN G L, CHEN J, ZHANG J V*（共同通讯）, REN P G*. Investigation of bioeffects of G protein-coupled receptor 1 on bone turnover in male mice [J]. J Orthop Translat, 2017, 10:42-51.

54. WANG L W#, LI J#, ZHANG J V#（共一）, HE Q, WENG X W, HUANG Y M, GUAN M J, QIU C. Inhibition of TRPC3 downregulates airway hyperresponsiveness, remodeling of OVA-sensitized mouse [J]. Biochem Biophys Res Commun, 2017, 484(1): 209-17.

55. 孙立峰, 杨雅莉, 黄晨, 薛丽, 张键（通讯）. 脂肪因子Chemerin与多囊卵巢综合征的研究进展综述 [J]. 集成技术, 2017, 6(06): 59-71.

56. 孙立峰, 薛丽, 杨雅莉, 张键（通讯）. 鸢尾素(Irisin)与能量代谢相关研究进展 [J]. 生理科学进展, 2017, 48(06): 409-16.

57. 姜晓彤, 向亮, 范秀军, 葛利江*, 张键*（通讯）. Chemokine-Like Receptor 1信号通路对双氢睾酮诱导小鼠骨密度增加的影响  [J]. 集成技术,2017, 6(02): 32-40.

58. 黄斌斌, 秦逍云, 汤惠茹, 金平, 张键（通讯）. 长链非编码RNA及其在代谢疾病中研究进展  [J]. 公共卫生与预防医学, 2017, 28(02): 80-4.

59. YANG Y L#, REN L R#, SUN L F#, HUANG C, XIAO T X, WANG B B, CHEN J, ZABEL B A, REN P G*, ZHANG J V*（通讯）. The role of GPR1 signaling in mice corpus luteum [J]. J Endocrinol, 2016, 230(1): 55-65.

60. TANG M#, HUANG C#, WANG Y F, REN P G, CHEN L, XIAO T X, WANG B B, PAN Y F, TSANG B K, ZABEL B A, MA B H*, ZHAO H Y*, ZHANG J V*（通讯）. CMKLR1 deficiency maintains ovarian steroid production in mice treated chronically with dihydrotestosterone [J]. Sci Rep, 2016, 6:21328.

61. HUANG C#, WANG M M#, REN L R, XIANG L, CHEN J, LI M X, XIAO T X, REN P G, XIONG L K*, ZHANG J V*(通讯). CMKLR1 deficiency influences glucose tolerance and thermogenesis in mice on high fat diet [J]. Biochem Biophys Res Commun, 2016, 473(2): 435-41.

62. GUO C Z#, LI J#, SHE C, SHAO X Z, TENG B, FENG J, ZHANG J V*（共同通讯）, REN P G*. Bioeffects of micron-size magnesium particles on inflammatory cells and bone turnover in vivo and in vitro [J]. J Biomed Mater Res Part B, 2016, 104(5): 923-31.

63. 肖仲琳, 杨青*, 张键, 范秀军*. 子痫前期动物模型的研究进展 [J]. 生物化学与生物物理进展, 2016, 43(06): 563-9.

64. LIU H D, XIONG W, LIU Q Y, ZHANG J V, DONG S H. Chemokine-Like Receptor 1 Regulates the Proliferation and Migration of Vascular Smooth Muscle Cells [J]. Med Sci Monitor, 2016, 22:4054-61.

65. LI J, XU Q, TENG B, YU C, LI J, SONG L, LAI Y X, ZHANG J V, ZHENG W, REN P G. Investigation of angiogenesis in bioactive 3-dimensional poly(d,l-lactide-co-glycolide)/ nano-hydroxyapatite scaffolds by in vivo multiphoton microscopy in murine calvarial critical bone defect [J]. Acta Biomater, 2016, 42:389-99.

66. LE A W, SHAN L L, DAI X Y, XIAO T H, LI X R, WANG Z H, ZHANG J V*(共同通讯), CHEN X Y*. PI3K, AKT, and P-AKT levels in thin endometrium [J]. Genet Mol Res, 2016, 15(1): doi: 10.4238/gmr.15017184.

67. 熊玮, 董少红, 张键, 李江华, 廖碧红, 庞新利, 罗林杰. 趋化素促进小鼠血管平滑肌细胞增殖的实验研究 [J]. 临床心血管病杂志, 2016, 32(01): 66-9.

68. 刘华东, 熊玮, 刘启云, 李江华, 吴美善, 张键, 董少红. 沉默人趋化因子受体1基因对小鼠血管平滑肌细胞增殖的作用 [J]. 医学研究杂志, 2016, 45(04): 76-9+84.

69. 刘华东, 熊玮, 刘启云, 李江华, 吴美善, 张键, 董少红. 人趋化因子受体1促进小鼠血管平滑肌细胞增殖的机制研究  [J]. 中华心血管病杂志, 2016, 44(07): 605-9.

70. 刘华东, 熊玮, 董少红, 吴美善, 李江华, 张键. 趋化素上调丝裂原活化蛋白激酶的表达促进大鼠球囊损伤后颈动脉重塑 [J]. 中国介入心脏病学杂志, 2016, 24(11): 651-4.

71. LI J#, TENG B#, LIN R Q, SHE C, YAO Z Y, ZHANG J V, SONG L, REN P G. Neovasculature in 3D-PLGA/nHAp Scaffolds for Murine Critical Sized Bone Defect Regeneration by Photoacoustic Imaging: A Preliminary Study [J]. Iarjset, 2016, 3(4): 162-70.

72. 田小飞, 马玮娟, 方光光, 肖天霞, 陈杰, 张键(通讯). 干预GPR1通路对实验性小鼠脂肪累积的影响 [J]. 生物化学与生物物理进展, 2015, 42(05): 457-67.

73. ZHANG Q Q, FAN X J*, ZHANG J V*（通讯）. The Role of Adipokine Chemerin in Pregnancy Complications [J]. Prog Biochem Biophys, 2015, 42(10): 962-8.

74. QIU C*, ZHANG J V*（共同通讯）, SU M P, FAN X J. Nuclear factor-kappa B mediates the phenotype switching of airway smooth muscle cells in a murine asthma model [J]. International Journal of Clinical and Experimental Pathology, 2015, 8(10): 12115-28.

75. JIA Q Y#, CHENG W X#, YUE Y, HU Y P, ZHANG J V, PAN X H, XU Z W*, ZHANG P*. Cucurbitacin E inhibits TNF-alpha-induced inflammatory cytokine production in human synoviocyte MH7A cells via suppression of PI3K/Akt/NF-kappa B pathways [J]. Int Immunopharmacol, 2015, 29(2): 884-90.

76. 田小飞, 马玮娟, 张键（通讯）. 脂肪因子Chemerin与非酒精性脂肪肝病的关系 [J]. 公共卫生与预防医学, 2015, 26(02): 75-8.

77. 孙立峰, 杨雅莉, 张键（通讯）. 肥胖引起的氧化应激及其对两性生殖的影响 [J]. 公共卫生与预防医学, 2015, 26(04): 71-3.

78. 熊玮, 董少红, 张键, 李江华, 吴美善, 廖碧红, 庞新利, 罗林杰. 慢病毒载体构建小鼠CMKLR1基因缺陷性血管平滑肌细胞系  [J]. 中国组织工程研究, 2015, 19(20): 3195-9.

79. 熊玮, 董少红, 张键, 李江华, 吴美善, 廖碧红, 庞新利, 罗林杰. Chn1基因缺陷性小鼠血管平滑肌细胞株的构建和鉴定 [J]. 广东医学, 2015, 36(16): 2495-8.

80. 熊玮, 董少红, 张键, 李江华, 廖碧红, 庞新利, 罗林杰. 趋化素通过上调磷酸化JNK促进小鼠血管平滑肌细胞的增殖[J]. 中国病理生理杂志, 2015, 31(12): 2282-6.

81. LI L#, MA P#, HUANG C, LIU Y J, ZHANG Y, GAO C, XIAO T X, REN P G, ZABEL B A, ZHANG J V (通讯). Expression of chemerin and its receptors in rat testes and its action on testosterone secretion [J]. J Endocrinol, 2014, 220(2): 155-63.

82. LI L#, HUANG C#, ZHANG X, WANG J B, MA P, LIU Y J, XIAO T X, ZABEL B A, ZHANG J V (通讯). Chemerin-Derived Peptide C-20 Suppressed Gonadal Steroidogenesis [J]. Am J Reprod Immunol, 2014, 71(3): 265-77.

83. 黄庆生, 肖天霞, 张键*(共同通讯), 魏彦杰*. 内皮素-1在均匀流中构象改变的分子动力学模拟 [J]. 集成技术, 2014, 3(02): 17-26.

84. 陈曾, 徐展望, 向亮, 张鹏, 张键(通讯). 脂肪因子chemerin与骨质疏松症的关系展望 [J]. 中国骨质疏松杂志, 2014, 20(12): 1506-10.

85. PANDEY V#, WU Z S#, ZHANG M, LI R, ZHANG J V, ZHU T*, LOBIE P E*. Trefoil factor 3 promotes metastatic seeding and predicts poor survival outcome of patients with mammary carcinoma [J]. Breast Cancer Research, 2014, 16(5): 429.

86. GRAHAM K L, ZHANG J V , LEWEN S, BURKE T M, DANG T, ZOUDILOVA M, SOBEL R A, BUTCHER E C, ZABEL B A. A Novel CMKLR1 Small Molecule Antagonist Suppresses CNS Autoimmune Inflammatory Disease [J]. Plos One, 2014, 9(12): e112925.

87. ZHANG J V #*（通讯）, LI L#, HUANG Q S#, REN P G*. Obestatin receptor in energy homeostasis and obesity pathogenesis [J]. Prog Mol Biol Transl Sci, 2013, 114: 89-107.

88. LI L#, MA P#, LIU Y J, HUANG C, O W S, TANG F, ZHANG J V (通讯). Intermedin Attenuates LPS-induced Inflammation in the Rat Testis [J]. Plos One, 2013, 8(6): e65278.

89. ZHAO L M, PURANDARE B, ZHANG J V, HANTASH B M. beta 2-Microglobulin-free HLA-G activates natural killer cells by increasing cytotoxicity and proinflammatory cytokine production [J]. Hum Immunol, 2013, 74(4): 417-24.

90. ZHANG J V , JAHR H, LUO C W, KLEIN C, VAN KOLEN K, VER DONCK L, DE A, BAART E, LI J, MOECHARS D, HSUEH A J. Obestatin induction of early-response gene expression in gastrointestinal and adipose tissues and the mediatory role of G protein-coupled receptor, GPR39 [J]. Mol Endocrinol, 2008, 22(6): 1464-75.

91. SAMSON W K*#, ZHANG J V #(共一), AVSIAN-KRETCHMER O, CUI K, YOSTEN G L, KLEIN C, LYU R M, WANG Y X, CHEN X Q, YANG J, PRICE C J, HOYDA T D, FERGUSON A V, YUAN X B, CHANG J K, HSUEH A J*. Neuronostatin encoded by the somatostatin gene regulates neuronal, cardiovascular, and metabolic functions [J]. J Biol Chem, 2008, 283(46): 31949-59.

92. ZHANG J V , KLEIN C, REN P G, KASS S, DONCK L V, MOECHARS D, HSUEH A J W. Response to Comment on "Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake" [J]. Science, 2007, 315(5813): 766d-d.

93. ZHANG J V , REN P G, AVSIAN-KRETCHMER O, LUO C W, RAUCH R, KLEIN C, HSUEH A J. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake [J]. Science, 2005, 310(5750): 996-9.

94. LI J, ZHANG J V , CAO Y J, ZHOU J X, LIU W M, FAN X J, DUAN E K. Inhibition of the beta-catenin signaling pathway in blastocyst and uterus during the window of implantation in mice [J]. Biol Reprod, 2005, 72(3): 700-6.

95. MAZERBOURG S, BOULEY D M, SUDO S, KLEIN C A, ZHANG J V , KAWAMURA K, GOODRICH L V, RAYBURN H, TESSIER-LAVIGNE M, HSUEH A J. Leucine-rich repeat-containing, G protein-coupled receptor 4 null mice exhibit intrauterine growth retardation associated with embryonic and perinatal lethality [J]. Mol Endocrinol, 2004, 18(9): 2241-54.

96. 赵田夫#, 张键#（共一）, 李晶, 曹宇静, 李素敏, 周家喜, 李福洋, 药立波, 段恩奎. 血管生长抑素在小鼠胚泡中的调节作用 [J]. 生物化学与生物物理进展, 2003, 05): 778-83.

97. ZHANG J V, CAO Y J, LI F Y, LI J, YAO L B, DUAN E K. Effects of Fibronectin, VEGF and Angiostatin on the Expression of MMPs through Different Signaling Pathways in the JEG‐3 Cells [J]. American Journal of Reproductive Immunology, 2003, 50(4): 273-85.

98. ZHANG J V, ZHAO Y G, CAO Y J, SANG Q X A, DUAN EK. Expression and implications of tissue inhibitor of metalloproteinases-4 in mouse embryo [J]. Molecular human reproduction, 2003, 9(3): 143-49.

99. 赵田夫#, 张键#（共一） 李晶, 曹宇静, 李素敏, 周家喜, 段恩奎. 血管生长抑素抑制小鼠胚胎植入的最低有效量及其作用机理 [J]. 动物学报, 2003, 03: 332-8.

100.     DAI BJ C Y, WANG X C, ZHOU J X, ZHANG J V, CHEN D Y, DUAN EK. Expression of LIF, VEGF, CD57 and CD68 after the transfer of rat embryos to mouse uteri [J]. Chinese Science Bulletin, 2003, 06): 542-8.

101.     CAI L Q, ZHANG J V, DUAN E K. Dynamic distribution of epidermal growth factor during mouse embryo peri-implantation [J]. Cytokine, 2003, 23(6): 170-8.

102.     LI S M#, CAO Y J#, ZHANG J V#（共一）, TIAN Y Q, ZHENG X, DUAN E K. Effects of vascular endothelial growth factor on MMPs during embryo implantation in mice [J]. Chinese Science Bulletin, 2002, 47(24): 2071-4.

103.     ZHANG J V#, CAO Y J#, ZHAO Y J, SANG Q X A, DUAN EK. Expression of matrix metalloproteinase-26 and tissue inhibitor of metalloproteinase-4 in human normal cytotrophoblast cells and a choriocarcinoma cell line, JEG-3 [J]. Mol Hum Reprod, 2002, 8(7): 659-66.

104.     ZHANG J V, CAO Y J, LIU W M, ZHAO B S, ZENG G Q, DUAN E K. Expression of matrix metalloproteinase-28 in human normal cytotrophoblast cells and a choriocarcinoma cell line, JEG-3 [J]. Chinese Science Bulletin, 2002, 47(9): 732-6.

105.     张键, 段恩奎. 子宫珠蛋白的结构与功能 [J]. 生物化学与生物物理进展, 2001, 05: 627-30.

106.     ZHANG J V, TIE G D, CAO Y J, DUAN E K. Effect of fibronectin and leukaemia inhibitory factor on matrix metalloproteinases in mouse blastocyst [J]. Chinese Science Bulletin, 2001, 46(15): 1296-300.

107.     张键, 段恩奎. 空间生殖与发育生物学及组织工程研究展望 [J]. 中华航空航天医学杂志, 2001, 03: 57-9.

 


Patents

Applied 90 patents  and 40 have been authorized. Among them, 40 patents related to beauty/hair loss prevention,

 lipid and glucose reduction, fertility maintenance and anti-aging (10 have been authorized); 

23 health/functional food active ingredients and drugs patents (16 have been authorized); 

15 3D printing patents (3 have been authorized); 8 patents for gene and protein detection (2 have been authorized); 

2 device patents (2 have been authorized); 

2 patents for embryonic development and stem cells.

Research Interests

1、Physiology

2、Cytobiology

3、Biochemistry & Molecular Biology