基本信息

刘将新  女  研究员,博士生导师,中国科学院昆明植物研究所
电子邮件: liujiangxin@mail.kib.ac.cn
通信地址: 昆明植物研究所华立楼
邮政编码:

研究领域

1. 活性天然产物新靶点的鉴定和确证

2. 基于药物靶点和核磁共振技术NMR的活性天然产物筛选。

3. 活性天然产物的成药性评价。

教育背景

2003-09--2008-07   中国科学技术大学   博士
1999-09--2003-06   四川大学   学士

出版信息

   

科研活动

1)国家自然科学基金面上项目,HSP90 CTD天然产物抑制剂的发现和基于复合物结构的优化研究, 负责人国家任务, 2018-01--2021-12
2)云南省万人计划青年拔尖人才项目, 负责人地方任务, 2019-01--2023-12

3)云南省基础研究专项面上项目,202201AT070183,土荆皮甲酸作用新靶点和新活性研究,2022/06-2025/5, 主持。

科研项目
( 1 ) HSP90 CTD天然产物抑制剂的发现和基于复合物结构的优化研究, 负责人, 国家任务, 2018-01--2021-12
( 2 ) 云南省“万人计划”青年拔尖人才项目, 负责人, 地方任务, 2019-01--2023-12

已完成的科研项目

1.  国家自然科学基金青年项目,肿瘤相关抗原ROR1的结构及其与功能性抗体和配体的作用、2015/01-2017/12、结题

2.  云南省科技计划基础研究项目,2015/01-2017/12 、结题 

3.  中国科学院“西部之光”一般人才项目, 2015/01-2017/12、 结题 

4.  昆明植物所引进海外“青年骨干人才”,结题

已发表论文

(1) Liu, Jiangxin, Ren, Jian, Yang, Kun, Chen, Shuang, Yang, Xinni, Zhao, Qin-Shi*. Discovery and biological evaluation of tanshinone derivatives as potent dual inhibitors of indoleamine 2, 3-dioxygenase 1 and tryptophan 2, 3-dioxygenase. European Journal of Medicinal Chemistry, 2022, 235:114294.

(2) Liu, Jiangxin; Wu, Xing-De; Li, Wenyan; Yuan, Zaifeng; Yang, Kun; Zhao, Qin-Shi*; Discovery of pseudolaric acid A as a new Hsp90 inhibitor uncovers its potential anticancer mechanism. Bioorganic Chemistry, 2021, 112: 104963

(3) Bi, Ran; Yang, Xinni; Zhou, Haofeng; Peng Liyan; Liu, Jiangxin*; Zhao Qin-Shi*. Eleven undescribed alkaloids from the rhizomes of Sinomenium acutum and their IDO1 and TDO inhibitory activities. Phytochemistry, 2022, 200: 113244

(4) Yang Emily #, Yoo Chan #, Liu Jiangxin#, Wang He, Cao Jun, Li Fay-Wei, Pryer Kathleen M., Sun Tai-ping, Weigel Detlef, Zhou Pei*, Chen Meng*. NCP activates chloroplast transcription by controlling phytochrome-dependent dual nuclear and plastidial switches. Nature Communications, 2019, 10:2630 (共第一作者)

(5) Nuan Ning, Zhao Qiyu, Duan Zilei, Ji Mengyao, Xing Meichen, Zhu Tengyu, Mwangi James, Rong Mingqiang*, Liu Jiangxin*, Lai Ren*. Identification and Characterization of ShSPI, a Kazal-Type Elastase Inhibitor from the Venom of Scolopendra Hainanum. Toxins, 2019, 11(12): 0-708.

(6) Rong, Mingqiang#; Liu, Jiangxin#; Zhang, Meilin#; Wang, Gan; Zhao,Gang; Wang, Guodong; Zhang, Yaping; Hu, Kaifeng*; Lai, Ren*. A sodium channel inhibitor ISTX-I with a novel structure provides a new hint at the evolutionary link between two toxin folds. Scientific Reports, 2016, 6:29691 (共第一作者)

(7) Shao, Li-Dong#; Su, Jia#; Ye, Baixin#; Liu, Jiang-Xin#; Zuo, Zhi-Li, Li, Yan; Wang, Yue-Ying*; Xia, Chengfeng*; Zhao, Qin-Shi*. Design, Synthesis, and Biological Activities of Vibsanin B Derivatives:A New Class of HSP90 CTerminal Inhibitors. Journal of Medicinal Chemistry. 2017, 60, 9053-9066 (共第一作者

(8) Liu, Jiangxin; Fan, Shilong; Lee, Chul-Jin; Arno, L Greenleaf; Zhou, Pei*. Specific interaction of the transcription elongation regulator TCERG1 with RNA polymerase II requires simultaneous phosphorylation at Ser2, Ser5, and Ser7 within the carboxyl-terminal domain repeat. The Journal of Biological Chemistry, 2013, 288:10890-10901

(9) Wojtaszek, Jessica#; Liu, Jiangxin#; Souza, Sanjay#; Wang, Su; Xue, yaohua; Walker, Graham C; Zhou, Pei*. Multifaceted recognition of vertebrate Rev1 by translesion polymerases zeta and kappa. The Journal of Biological Chemistry, 2013,287: 26400-26408 (共第一作者)

(10) Liu, Jiangxin; Zhang, Jiahai; Yang, Yinshan; Huang, Hongda; Shen, Weiqun; Hu, Qi; Wang, Xingsheng; Wu, Jihui; Shi, Yunyu, Conformational change upon ligand binding and dynamics of the PDZ domain from leukemia-associated Rho guanine nucleotide exchange factor.  Protein Science, 2008.17(6): 1003~1014