1.基于药物靶点和核磁共振技术NMR的天然先导化合物发现及成药性评价。

2.资源植物的活性评价与开发  

2003-09--2008-07   中国科学技术大学   博士
1999-09--2003-06   四川大学   学士

​(1) Lin Jing; Dong Hao-Qi; Bao Mei-Fen; Liu Jiang-Xin *; Cai Xiang-Hai*. The First Kynurenine 3Monooxygenase Activator with an Undescribed Skeleton Provides Insight into the Toxicological Mechanism of Gelsemium elegans. Organic Letters, 2025, 27,3019-3023

(2) Pang Pan-Pan^#; Liu Jiangxin^#; Su Wen-Bin; Gao Wen-Cong; Qiao Guan-Rong; Yuan Jing; Zheng Yong-Tang; Zheng Chang-Bo*. Modulation of Abnormal Vasoconstriction Through 2-Hydroxyisobutyrylation of Tropomyosin 3 Lys141: Targeting Histone Deacetylase 3 as a Key Approach. J Am Heart Assoc. 2025;14:e037400.

(3) Dong Haoqi, Yang Xinni, Wang Peiying, Huang Weiya , Zhang Liang , Song Song, Liu Jiangxin*，Identification and verification of methylenetetrahydrofolate dehydrogenase 1-like protein as the binding target of natural product pseudolaric acid A. Natural Products and Bioprospecting. 15, 21 (2025)

(4) Yang Xinni, She Xianlan, Zhao Zhishuang, Ren Jian, Wang Peiying, Dong Haoqi, Zhao Qin-shi*, Liu Jiangxin*. In vitro and vivo anti-tumor activity and mechanisms of the new cryptotanshinone derivative 11 against hepatocellular carcinoma, European Journal of Pharmacology, 2024, 971, 176522

(5) Liu Jiangxin^#; Wu Xing-De^#; Li Wenyan^#; Yuan Zaifeng^#; Yang, Kun; Zhao, Qinshi*. Discovery of pseudolaric acid A as a new Hsp90 inhibitor uncovers its potential anticancer mechanism. Bioorganic Chemistry, 2021, 112: 104963.

(6) Bao Meifen, Yang Xinni, Wu Jing, Liu Jiangxin*, Cai Xianghai*. Discovery and biological evaluation of a new type of dual inhibitors of indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase from ethnomedicinal plant Dactylicapnos scandens. Phytochemistry 214 ,2023, 113794

(7) Liu Jiangxin^#; Ren Jian^#; Yang Kun^#; Chen Shuang; Yang Xinni; Zhao Qinshi*. Discovery and Biological Evaluation of tanshinone derivatives as potent dual inhibitors of indoleamine 2, 3-dioxygenase 1 and tryptophan 2, 3-dioxygenase. European Journal of Medicinal Chemistry, 2022, 235:114294. (IF 7.08, TOP10%)

(8) Li Meng^#; She Xianlan^#; Ou Yufei, Liu Jiangxin*, Yuan Zaifeng*, Zhao Qinshi*. Design, synthesis and biological evaluation of a new class of Hsp90 inhibitors vibsanin C derivatives. European Journal of Medicinal Chemistry, 2022, 244:114844. 

(9) Bi Ran; Yang Xinni; Zhou Haofeng; Peng Liyan; Liu Jiangxin*; Zhao Qinshi*. Eleven undescribed alkaloids from the rhizomes of Sinomenium acutum and their IDO1 and TDO inhibitory activities. Phytochemistry, 2022, 200: 113244. 

(10) Yang Emily ^#, Yoo Chan ^#, Liu Jiangxin^#, Wang He, Cao Jun, Li Fay-Wei, Pryer Kathleen M., Sun Tai-ping, Weigel Detlef, Zhou Pei*, Chen Meng*. NCP activates chloroplast transcription by controlling phytochrome-dependent dual nuclear and plastidial switches. Nature Communications, 2019, 10:2630 

(11) Nuan Ning, Zhao Qiyu, Duan Zilei, Ji Mengyao, Xing Meichen, Zhu Tengyu, Mwangi James, Rong Mingqiang*, Liu Jiangxin*, Lai Ren*. Identification and Characterization of ShSPI, a Kazal-Type Elastase Inhibitor from the Venom of Scolopendra Hainanum. Toxins, 2019, 11(12): 708.