基本信息
刘将新  女  硕导  中国科学院昆明植物研究所
电子邮件: liujiangxin@mail.kib.ac.cn
通信地址: 昆明植物研究所华立楼B305
邮政编码:

研究领域

1. 综合利用植物化学与西部植物资源持续利用国家重点实验室独特的药用植物天然化合物,针对特定靶标蛋白质,深入发掘天然产物活性和功能。

2. 天然产物小分子发挥功能的分子生物学机制。

3. 靶标蛋白质-天然产物小分子相互作用的分子机制。

教育背景

2003-09--2008-07   中国科学技术大学   博士
1999-09--2003-06   四川大学   学士

出版信息

   

科研活动

1)国家自然科学基金面上项目,HSP90 CTD天然产物抑制剂的发现和基于复合物结构的优化研究, 负责人国家任务, 2018-01--2021-12
2)云南省万人计划青年拔尖人才项目, 负责人地方任务, 2019-01--2023-12

3)云南省基础研究专项面上项目,202201AT070183,土荆皮甲酸作用新靶点和新活性研究,2022/06-2025/5, 10万,主持。

科研项目
( 1 ) HSP90 CTD天然产物抑制剂的发现和基于复合物结构的优化研究, 负责人, 国家任务, 2018-01--2021-12
( 2 ) 云南省“万人计划”青年拔尖人才项目, 负责人, 地方任务, 2019-01--2023-12

已完成的科研项目

1.  国家自然科学基金青年项目,肿瘤相关抗原ROR1的结构及其与功能性抗体和配体的作用、2015/01-2017/12、27万、结题

2.  云南省科技计划基础研究项目,2015/01-2017/12 、10万、结题 

3.  中国科学院“西部之光”一般人才项目, 2015/01-2017/12、 30万、结题 

4.  昆明植物所引进海外“青年骨干人才”,结题

已发表论文

(1) Liu, Jiangxin, Ren, Jian, Yang, Kun, Chen, Shuang, Yang, Xinni, Zhao, Qin-Shi*. Discovery and biological evaluation of tanshinone derivatives as potent dual inhibitors of indoleamine 2, 3-dioxygenase 1 and tryptophan 2, 3-dioxygenase. European Journal of Medicinal Chemistry, 2022, 235:114294.

(2) Liu, Jiangxin; Wu, Xing-De; Li, Wenyan; Yuan, Zaifeng; Yang, Kun; Zhao, Qin-Shi*; Discovery of pseudolaric acid A as a new Hsp90 inhibitor uncovers its potential anticancer mechanism. Bioorganic Chemistry, 2021, 112: 104963

(3) Bi, Ran; Yang, Xinni; Zhou, Haofeng; Peng Liyan; Liu, Jiangxin*; Zhao Qin-Shi*. Eleven undescribed alkaloids from the rhizomes of Sinomenium acutum and their IDO1 and TDO inhibitory activities. Phytochemistry, 2022, 200: 113244

(4) Yang Emily #, Yoo Chan #, Liu Jiangxin#, Wang He, Cao Jun, Li Fay-Wei, Pryer Kathleen M., Sun Tai-ping, Weigel Detlef, Zhou Pei*, Chen Meng*. NCP activates chloroplast transcription by controlling phytochrome-dependent dual nuclear and plastidial switches. Nature Communications, 2019, 10:2630 (共第一作者)

(5) Nuan Ning, Zhao Qiyu, Duan Zilei, Ji Mengyao, Xing Meichen, Zhu Tengyu, Mwangi James, Rong Mingqiang*, Liu Jiangxin*, Lai Ren*. Identification and Characterization of ShSPI, a Kazal-Type Elastase Inhibitor from the Venom of Scolopendra Hainanum. Toxins, 2019, 11(12): 0-708.

(6) Rong, Mingqiang#; Liu, Jiangxin#; Zhang, Meilin#; Wang, Gan; Zhao,Gang; Wang, Guodong; Zhang, Yaping; Hu, Kaifeng*; Lai, Ren*. A sodium channel inhibitor ISTX-I with a novel structure provides a new hint at the evolutionary link between two toxin folds. Scientific Reports, 2016, 6:29691 (共第一作者)

(7) Shao, Li-Dong#; Su, Jia#; Ye, Baixin#; Liu, Jiang-Xin#; Zuo, Zhi-Li, Li, Yan; Wang, Yue-Ying*; Xia, Chengfeng*; Zhao, Qin-Shi*. Design, Synthesis, and Biological Activities of Vibsanin B Derivatives:A New Class of HSP90 CTerminal Inhibitors. Journal of Medicinal Chemistry. 2017, 60, 9053-9066 (共第一作者

(8) Liu, Jiangxin; Fan, Shilong; Lee, Chul-Jin; Arno, L Greenleaf; Zhou, Pei*. Specific interaction of the transcription elongation regulator TCERG1 with RNA polymerase II requires simultaneous phosphorylation at Ser2, Ser5, and Ser7 within the carboxyl-terminal domain repeat. The Journal of Biological Chemistry, 2013, 288:10890-10901

(9) Wojtaszek, Jessica#; Liu, Jiangxin#; Souza, Sanjay#; Wang, Su; Xue, yaohua; Walker, Graham C; Zhou, Pei*. Multifaceted recognition of vertebrate Rev1 by translesion polymerases zeta and kappa. The Journal of Biological Chemistry, 2013,287: 26400-26408 (共第一作者)

(10) Liu, Jiangxin; Zhang, Jiahai; Yang, Yinshan; Huang, Hongda; Shen, Weiqun; Hu, Qi; Wang, Xingsheng; Wu, Jihui; Shi, Yunyu, Conformational change upon ligand binding and dynamics of the PDZ domain from leukemia-associated Rho guanine nucleotide exchange factor.  Protein Science, 2008.17(6): 1003~1014