General

Hui xiao，Professor
Email: huixiao@ips.ac.cn
Telephone: 021-54923127
Address: 320 Yueyang Road, The New Life  Science Research  Building B-211,Shanghai, China 

Postcode: 200031

Research Areas

The major goal of our research is to decipher the signaling mechanisms by which the pattern-recognition receptors (PRRs, such as TLRs, CLRs, RLR and cGAS/STING) induce the expression of cytokines (including IL-12, IL-10, and IL-23) and IFN-a/b, reprogram cell metabolism, and coordinate cell death/survival. To delineate the molecular and cellular mechanisms underlying the innate immune regulation of T cell responses to microbes and cancers, we aim to study the complex interactions between PRRs and metabolic pathways in the host immune system, focusing on epithelium, macrophages/DCs and T cells, whereby understanding how the innate immune system manages to coordinate the adequate innate and adaptive immune responses to combat pathogens and cancer while tolerate commensals.


 


Education

1994.09-1997.08: Molecular Genetics, Shanghai Institute of Plant Physiology, Ph.D.
1991.09-1994.07: Dept. of Microbiology and Immunology, Wuhan University, M.S.
1987.09-1991.07: Dept. of Microbiology and Immunology, Wuhan University, B.S.

Publications

  1.     Zhou C, Chen X, Planells-Cases R, Chu J, Wang L, Cao L, Li Z, López-Cayuqueo KI, Xie Y, Ye S, Wang X, Ullrich F, Ma S, Fang Y, Zhang X, Qian Z, Liang X, Cai SQ, Jiang Z, Zhou D, Leng Q, Xiao TS, Lan K, Yang J, Li H, Peng C, Qiu Z, Jentsch TJ, Xiao H. Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity. Immunity. 2020 Apr 7. pii: S1074-7613(20)30129-1.

  2.     Xie Y, Zhao Y, Shi L, Li W, Chen K, Li M, Chen X, Zhang H, Li T, Matsuzawa-Ishimoto Y, Yao X, Shao D, Ke Z, Li J, Chen Y, Zhang X, Cui J, Cui S, Leng Q, Cadwell K, Li X, Wei H, Zhang H, Li H, Xiao H. Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer. J Clin Invest. 2020 Apr 1;130(4):2111-2128. 

  3.     Shi L, Chen X, Zang A, Li T, Hu Y, Ma S, Lü M, Yin H, Wang H, Zhang X, Zhang B, Leng Q, Yang J, Xiao H. TSC1/mTOR-controlled metabolic-epigenetic cross talk underpins DC control of CD8+ T-cell homeostasis. PLoS Biol. 2019 Aug 21;17(8):e3000420.

  4.     Wang W, Deng Z, Wu H, Zhao Q, Li T, Zhu W, Wang X, Tang L, Wang C, Cui SZ, Xiao H, Chen J.A small secreted protein triggers a TLR2/4-dependent inflammatory response during invasive Candida albicans infection. Nat Commun. 2019 Mar 4;10(1):1015. 

  5.     Zhou P, Ding X, Wan X, Liu L, Yuan X, Zhang W, Hui X, Meng G, Xiao H, Li B, Zhong J, Hou F, Deng L, Zhang Y. MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation. Nat Commun. 2018 Mar 28;9(1):1243. 

  6.     Liu L, Wan X, Zhou P, Zhou X, Zhang W, Hui X, Yuan X, Ding X, Zhu R, Meng G, Xiao H, Ma F, Huang H, Song X, Zhou B, Xiong S, Zhang Y. The chromatin remodeling subunit Baf200 promotes normal hematopoiesis and inhibits leukemogenesis. J Hematol Oncol. 2018 Feb 26;11(1):27. 

  7.     Zhang WC, Du LJ, Zheng XJ, Chen XQ, Shi C, Chen BY, Sun XN, Li C, Zhang YY, Liu Y, Xiao H, Leng Q, Jiang X, Zhang Z, Sun S, Duan SZ. Elevated sodium chloride drives type I interferon signaling in macrophages and increases antiviral resistance. J Biol Chem. 2018 Jan 19;293(3):1030-1039. 

  8.     Wang J, He N, Zhang N, Quan D, Zhang S, Zhang C, Yu RT, Atkins AR, Zhu R, Yang C, Cui Y, Liddle C, Downes M, Xiao H, Zheng Y, Auwerx  J,   Evans       RM, Leng Q. NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing  positive selection. Nat Commun. 2017 Oct 16;8(1):959. 

  9.     Ma S, Wan X, Deng Z, Shi L, Hao C, Zhou Z, Zhou C, Fang Y, Liu J, Yang J, Chen X, Li T, Zang A, Yin S, Li B, Plumas J, Chaperot L, Zhang X, Xu G, Jiang L, Shen N, Xiong S, Gao X, Zhang Y, Xiao H*. Epigenetic regulator CXXC5 recruit DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs. J Exp Med. 2017, 214(5):1471-1491. (*Corresponding author)

  10.        Javed N, Xue G, Lu A, Xing Y, Iwakura Y, Xiao H, Lecoeur H, Späth GF, Meng G. Cross reactivity of S. aureus to murine cytokine assays: A source of discrepancy. Cytokine. 2016, 81:101-108.

  11.        Gong Q, Hu Z, Zhang F, Cui A, Chen X, Jiang H, Gao J, Chen X, Han Y, Liang Q, Ye D, Shi L, Chin YE, Wang Y, Xiao H, Guo F, Liu Y, Zang M, Xu A, Li Y. Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice. Hepatology. 2016, 64(2):425-438.

  12.         Zhu X, Shi D, Li X, Gong W, Wu F, Guo X, Xiao H, Liu L, Zhou H. TLR signaling affects sperm mitochondrial function and motility via phosphatidylinositol 3-kinase and glycogen synthase kinase-3α. Cell Signal. 2016, 28(3):148-156.

  13.        Deng Z, Ma S, Zhou H, Zang A, Fang Y, Li T, Shi H, Liu M, Du M, Taylor PR, Zhu HH, Chen J, Meng G, Li F, Chen C, Zhang Y, Jia XM, Lin X, Zhang X, Pearlman E, Li X, Feng GS, Xiao H*. Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses. Nat Immunol. 2015,16:642-652. (*Corresponding author)

  14.        Du M, Liu J, Chen X, Xie Y, Yuan C, Xiang Y, Sun B, Lan K, Chen M, James SJ, Zhang Y, Zhong J, Xiao H*.  Casein Kinase II Controls TBK1/IRF3 Activation in IFN Response against Viral Infection. J Immunol. 2015, 194:4477-4488. (*Corresponding author)

  15.         He L, Zang A, Du M, Ma D, Yuan C, Zhou C, Mu J, Shi H, Li D, Huang H, Deng Q, Xiao J, Yan H, Hui L, Lan K, Xiong S, Li X, Huang Z, Xiao H*. mTOR regulates TLR-induced c-fos and Th1 responses to HBV and HCV vaccines. Virologica Sinica. 2015, 30:1-16. (*Corresponding author)

  16.         Yang C, Guo L, Liu J, Yang J, Zhu K, Xiao H*, Leng Q*. Non-Classical MHC I-E negatively regulates macrophage activation and Th17 cells in NOD mice. Sci Rep. 2015, 5:12941-12949. (*Co-Corresponding author)

  17.         James SJ, Jiao H, Teh HY, Takahashi H, Png CW, Phoon MC, Suzuki Y, Sawasaki T, Xiao H, Chow VT, Yamamoto N, Reynolds JM, Flavell RA, Dong C, Zhang Y. MAPK Phosphatase 5 Expression Induced by Influenza and Other RNA Virus Infection Negatively Regulates IRF3 Activation and Type I Interferon Response. Cell Rep. 2015, pii: S2211-1247(15)00176-X.

  18.        Zhao Q, Liang D, Sun R, Jia B, Xia T, Xiao H, Lan K. Kaposi's sarcoma-associated herpesvirus-encoded replication and transcription activator impairs innate immunity via ubiquitin-mediated degradation of myeloid differentiation factor 88. J Virol. 2015, 89:415-427.

  19.        Wang C, Wu L, Bulek K, Martin BN, Zepp JA, Kang Z, Liu C, Herjan T, Misra S, Carman JA, Gao J, Dongre A, Han S, Bunting KD, Ko JS, Xiao H, Kuchroo VK, Ouyang W, Li X. Thepsoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90. Nat Immunol. 2013, 14:72-81.

  20.       Gulen MF, Bulek K, Xiao H, Yu M, Gao J, Sun L, Beurel E, Kaidanovich-Beilin O, Fox PL, DiCorleto PE, Wang JA, Qin J, Wald DN, Woodgett JR, Jope RS, Carman J, Dongre A, Li X. Inactivation of the enzyme GSK3α by the kinase IKKi promotes AKT-mTOR signaling pathway that mediates interleukin-1-induced Th17 cell maintenance. Immunity 2012, 37:800-812.

  21.      Cui W, Xiao N, Xiao H, Zhou H, Yu M, Gu J, Li X.β-TrCP-mediated IRAK1 degradation releases TAK1-TRAF6 from the membrane to the cytosol for TAK1-dependent NF-κB activation. Mol Cell Biol. 2012, 32:3990-00.

  22.       Kim TW, Yu M, Zhou H, Cui W, Wang J, DiCorleto P, Fox P, Xiao H, Li X. Pellino 2 is critical for Toll-like receptor/interleukin-1 receptor (TLR/IL-1R)-mediated post-transcriptional control. J Biol Chem. 2012, 287:25686-95.

  23.      Chan ER, Hester J, Kalady M, Xiao H, Li X, Serre D. A novel method for determining microflora composition using dynamic phylogenetic analysis of 16S ribosomal RNA deep sequencing data. Genomics. 2011, 98:253-59.

  24.      Yin W, Wan Y, Kim TW, Yao P, Xiao H, Zhou H, Xiao J, Fox P, Li X. The kinase activity of interleukin-1 receptor-associated kinase 2 is essential for lipopolysaccharide-mediated cytokine and chemokine mRNA stability and translation. J Interferon Cytokine Res. 2011), 31:415-22.

  25.       Gulen MF, Kang Z, Bulek K, Youzhong W, Chen Y, Sass Bak-Jensen K, Do JS, Xiao H, Delgoffe GM, Powell JD, Tuohy VK, Cua DJ, Li X. The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation. Immunity 2010, 32:54-66.

  26.       Xiao H#, Yin W, Khan M, Gulen MF, Zhou H, Sham HP, Jacobson K, Vallance BA and Li X. Loss of SIGIRR leads to enhanced colonic polyposis in Apcmin mice. Gastroenterology 2010, 139:574-585. 

  27.       Wan Y#, Xiao H#, Affolter J, Kim TW, Bulek K, Chaudhuri S, Carlson D, Hamilton T, Mazumder B, Stark GR, Thomas J, Li X. IRAK2 is critical for LPS-mediated post-transcriptional control. J Biol Chem. 2009, 284:10367-10375. （#Equal contributors）

  28.       Xiao H#, Qian W, Staschke K, Jiang Z, Qian Y, Cui G, Deng L, Chen ZJ, Gilmour R, Li X. Pellino 3b negatively regulates IL-1-induced TAK1-dependent NFkB activation. J Biol Chem. 2008, 283:14654-64.

  29.      von Bernuth H, Picard C, Jin Z, Pankla R, Xiao H, Ku CL, Chrabieh M, Mustapha IB, Ghandil P, Camcioglu Y, Vasconcelos J, Sirvent N, Guedes M, Vitor AB, Herrero-Mata MJ, Aróstegui JI, Rodrigo C, Alsina L, Ruiz-Ortiz E, Juan M, Fortuny C, Yagüe J, Antón J, Pascal M, Chang HH, Janniere L, Rose Y, Garty BZ, Chapel H, Issekutz A, Maródi L, Rodriguez-Gallego C, Banchereau J, Abel L, Li X, Chaussabel D, Puel A, Casanova JL. Pyogenic bacterial infections in humans with MyD88 deficiency. Science 2008, 321:691-96.

  30.       Fraczek J, Kim TW, Xiao H, Yao J, Wen Q, Li Y, Casanova JL, Pryjma J, Li X. The kinase activity of IRAK4 is required for TLR-IL-1R-induced TAK1-dependent NFkB activation. J Biol Chem. 2008, 283:31697-705.

  31.       Xiao H#, Gulen MF, Qin J, Yao J, Bulek K, Kish D, Altuntas CZ, Walde D, Ma C, Zhou H, Tuohy VK, Fairchild R, de la Motte C, Cua D, Vallance BA, and Li X. The Toll-Interleukin-1 receptor member SIGIRR regulates colonic epithelia homeostasis, inflammation and tumorigenesis. Immunity 2007, 26:461-75. 

  32.       Kim TW, Staschke K, Bulek K, Yao J, Peters K, Oh KH, Vendenburg Y, Xiao H, Qian W, Hamilton T, Min B, Sen G, Gilmour R, Li X. A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity. J Exp Med. 2007, 204:1025-36.

  33.       Yao J, Kim TW, Qin J, Jiang Z, Qian Y, Xiao H, Lu Y, Qian W, Gulen MF, Sizemore N, DiDonato J, Sato S, Akira S, Su B, Li X. Interleukin-1 (IL-1)-induced TAK1-dependent Versus MEKK3-dependent NFkB activation pathways bifurcate at IRAK modification. J Biol Chem. 2007, 282:6075-89.

  34.       Qin J, Yao J, Cui G, Xiao H, Kim TW, Fraczek J, Wightman P, Sato S, Akira S, Puel A, Casanova JL, Su B, Li X. TLR8-mediated NFkB and JNK activation are TAK1-independent and MEKK3-dependent. J Biol Chem. 2006, 281:21013-21.

  35.        Xiao H#, Chung J, Kao HY, and Yang YC. Tip60 is a co-repressor for STAT3. J Biol Chem. 2003, 278:11197-204.

  36.        Xiao H#, Yin T, Wang X, Uchida T, Chung J, Morris WF, and Yang YC. Specificity of IL-2 receptor gamma chain superfamily cytokines is mediated by insulin receptor substrate-dependent pathway. J Biol Chem. 2002, 277:8091-98. 

  37.         Xiao H#, Shen SC and Zhu JB. NifL, an antagonistic regulator of NifA, directly interacts with transcription activator NifA and NtrC. Science inChina. 1998, 6:453-57. 

  38.         Xiao H#, Shen SC and Zhu JB. The Binding site and model of transcription activator SyrM to nodD3 promoter region. Science inChina. 1998, 4:343-49. 



Conferences

（1）Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs, AAI meeting,2017-5-13

（2）TRAF1 negatively regulates C-type lectin receptor-induced proinflammatory response to fungal infection . AAI meeting .2016-5-13

（3）The Regulation of C-type Lectin Receptor Signaling and Anti-fungal immunity   .Forum on advancements in immunology research.   2015-11-24
（4）Multi-layered regulator mechanisms underlie viruses-induced IFN response.   ,The 11th annual meeting of chinese society for virology & the 6th Wuhan international symposium on Modern Virology. 2015-10-24
（5）Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses  . Journees du Department d'immunoloie de l'Institut pasteur.2015-09-23
（6）天然免疫受体信号调节T细胞应答和宿主防御的机制   2015年度中国细胞生物学会免疫细胞生物学分会年会   2015-09-14
（7）SHP2 Mediates Dectin-induced SYK Activation and Anti-fungal TH17 Response  .The 4th international conference on regulatory T cells and T helper cell subsets and clinical application in human diseases.   2014-11-01
（8）Casine kinase II is a novel regulator of TBK1/IRF3 and type I interferon induction by various innate receptors   .The cytokines2014-10-25
（9）Adjuvant in vaccine development   中国新型疫苗研发和产业化前景   2014-06-07
（10）Blockade of mTOR in innate immune system represents an effective strategy boosting Toll-like Receptor-induced Th1 response for vaccine   .    AAI annual  meeting .2014-05-02
（11）Blockade of mTOR in Innate System Represents an Effective Strategy to Boost TLR-induced Th1 Response for HBV and HCV Vaccine   The 5th Wuhan international symposium on Modern virology.  2013-11-16
（12）The key role of Toll-like receptors in inflammation and host defense   中国微生物学会人畜共患传染性疾病研讨会 .2010-11-18
（13）Commensal microflora-dependent colonic polyposis in Apcmin/+SIGIRR-/- compound mutant mice  .   2009-01-29
（14）IRAK2 is critical for LPS-mediated post-transcriptional Control.   2008-10-16
（15）The regulatory role of SIGIRR in inflammation-associated cancer.   2007-10-15
（16）The regulatory role of SIGIRR in colonic epithelial homeostasis, inflammation and tumorigenesis   .2007-07-04