Name: Shiwei Sun
Academic Title: associate professor
Primary Appointment: Bioinformatics
School: Institute of Computing Technology, Chinese Academy of Sciences
email: dwsun@ict.ac.cn
Lab Website: www.bioinfo.org.cn

Research Areas


Our research interest is focusing on the details of molecular glycosylation. The tools and instrumentation used in this effort revolve around mass measurement of fragments derived from multiple stage disassembly of molecular ions. This detailed analytical approach embraces the chemistry of carbohydrates, the principles and operation of ion trap mass spectrometry, and the physics of molecular fragmentation. We rely upon the detailed information yielded by the multistage mass spectrometer to determine glycans structure. We draw upon biology, chemistry, and computer science to increase the scope, sensitivity, and throughput of technologies for practical glycomics.



Education

2002~2007 Bioinformatics Research Group,
Institute of Computing Technology,
Chinese Academy of Sciences
Ph.D. Computer Sciense
1998~2001 Nankai University, Tianjin, China
Master. Physical Chemistry
1994~1998 Nankai University, Tianjin, China
bachelor. Physical Chemistry

Honors & Distinctions

employee of year 2006 of Institute of Computing&Technology.

Experience

   
Work Experience

2010~present  Associate Professor, Institute of Computing Technology, Chinese Academy of Sciences
2007~2010     Assistant Professor, Institute of Computing Technology, Chinese Academy of Sciences

Publications

arXiv preprint arXiv:1906.11196

2019

Ju, Fusong; Zhu, Jianwei; Wei, Guozheng; Zhang, Qi; Sun, Shiwei; Bu, Dongbo; 

Seq-SetNet: Exploring Sequence Sets for Inferring Structures




Carbohydrate Polymers

2019

Huang, Chuncui; Sun, Shiwei; Yan, Jingyu; Wang, Hui; Zhou, Jinyu; Gao, Huanyu; Xie, Wenchun; Li, Yan; Chai, Wengang; 

Identification of carbohydrate peripheral epitopes important for recognition by positive-ion MALDI multistage mass spectrometry



115528

BMC bioinformatics

2019

Wang, Chao; Wei, Yi; Zhang, Haicang; Kong, Lupeng; Sun, Shiwei; Zheng, Wei-Mou; Bu, Dongbo; 

Constructing effective energy functions for protein structure prediction through broadening attraction-basin and reverse Monte Carlo sampling

20

3

135

Computational biology and chemistry

2019

Ju, Fusong; Zhang, Jingwei; Bu, Dongbo; Li, Yan; Zhou, Jinyu; Wang, Hui; Wang, Yaojun; Huang, Chuncui; Sun, Shiwei; 

De novo glycan structural identification from mass spectra using tree merging strategy

80


217-224

Bioinformatics

2019

Wang, Yaojun; Bu, Dongbo; Huang, Chuncui; Wang, Hui; Zhou, Jinyu; Dong, Junchuan; Pan, Weiyi; Zhang, Jingwei; Zhang, Qi; Li, Yan; Shiwei Sun;

Best-first search guided multistage mass spectrometry-based glycan identification




BMC bioinformatics

2019

Zhang, Haicang; Zhang, Qi; Ju, Fusong; Zhu, Jianwei; Gao, Yujuan; Xie, Ziwei; Deng, Minghua; Sun, Shiwei; Zheng, Wei-Mou; Bu, Dongbo; 

Predicting protein inter-residue contacts using composite likelihood maximization and deep learning

20

1

537

Molecular Cellular&Proteomics

2019


NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods




Analytical chemistry

2018

Sun, Shiwei; Huang, Chuncui; Wang, Yaojun; Liu, Yaming; Zhang, Jingwei; Zhou, Jinyu; Gao, Feng; Yang, Fei; Chen, Runsheng; Mulloy, Barbara; 

Toward automated identification of glycan branching patterns using multistage mass spectrometry with intelligent precursor selection

90

24

14412-14422

Current Bioinformatics

2018

Wang, Yaojun; Zhang, Jingwei; Bu, Dongbo; Sun, Shiwei; 

TagDict: Prediction of Theoretical Spectra of Peptides Based on A Tag Dictionary

13

5

444-449

2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

2018

Hao, Yu; Han, Renmin; Wan, Xiaohua; Zhang, Fa; Sun, Shiwei; 

Fiducial marker detection via deep learning approach for electron tomography



642-645

Bioinformatics

2018

Zhu, Jianwei; Wang, Sheng; Bu, Dongbo; Xu, Jinbo; 

Protein threading using residue co-variation and deep learning

34

13

i263-i273

Bioinformatics

2017

Zhu, Jianwei; Zhang, Haicang; Li, Shuai Cheng; Wang, Chao; Kong, Lupeng; Sun, Shiwei; Zheng, Wei-Mou; Bu, Dongbo; 

Improving protein fold recognition by extracting fold-specific features from predicted residue–residue contacts

33

23

3749-3757

BMC bioinformatics

2017

Zhang, Haicang; Zhu, Jianwei; Wang, Chao; Sun, Shiwei; Zheng, Wei-Mou; Bu, Dongbo; 

Improving prediction of burial state of residues by exploiting correlation among residues

18

3

70

Progress in Biochemistry and Biophysics

2017

王耀君; 黄纯翠; 高枫; 张敬玮; 李岩; 卜东波; 孙世伟

串联质谱寡糖结构解析方法评介

44

10

830-847

第三届全国质谱分析学术报告会摘要集

2017

黄纯翠; 孙世伟; 王耀君; 刘亚名; 张敬玮; 周巾煜; 高枫; 杨飞; 陈润生; 柴文刚

基于多级质谱技术高通量鉴定糖链分支结构




Scientific reports

2016

Huang, Chunlin; Liu, Xingwu; Sun, Shiwei; Li, Shuai Cheng; Deng, Minghua; He, Guangxue; Zhang, Haicang; Wang, Chao; Zhou, Yang; Zhao, Yanlin; 

Insights into the transmission of respiratory infectious diseases through empirical human contact networks

6


31484

Bioinformatics

2015

Wang, Chao; Zhang, Haicang; Zheng, Wei-Mou; Xu, Dong; Zhu, Jianwei; Wang, Bing; Ning, Kang; Sun, Shiwei; Li, Shuai Cheng; Bu, Dongbo; 

FALCON@ home: a high-throughput protein structure prediction server based on remote homologue recognition

32

3

462-464

BMC bioinformatics

2015

Sun, Shiwei; Wang, Xuetao; Gao, Xin; Ren, Lihui; Su, Xiaoquan; Bu, Dongbo; Ning, Kang; 

Condensing Raman spectrum for single-cell phenotype analysis

16

18

S15

BMC bioinformatics

2015

Wang, Yaojun; Yang, Fei; Wu, Peng; Bu, Dongbo; Sun, Shiwei; 

OpenMS-Simulator: an open-source software for theoretical tandem mass spectrum prediction

16

1

110

arXiv preprint arXiv:1507.03197

2015

Zhu, Jianwei; Zhang, Haicang; Wang, Chao; Ling, Bin; Zheng, Wei-Mou; Bu, Dongbo; 

Topo: Improving remote homologue recognition via identifying common protein structure framework




arXiv preprint arXiv:1509.03434

2015

Zhang, Haicang; Shao, Mingfu; Wang, Chao; Zhu, Jianwei; Zheng, Wei-Mou; Bu, Dongbo; 

Improving protein threading accuracy via combining local and global potential using treecrf model




Journal of proteome research

2012

Sun, Shiwei; Yang, Fuquan; Yang, Qing; Zhang, Hong; Wang, Yaojun; Bu, Dongbo; Ma, Bin; 

MS-simulator: predicting y-ion intensities for peptides with two charges based on the intensity ratio of neighboring ions

11

9

4509-4516

计算机工程

2012

王耀君; 孙世伟; 卜东波; 刘金刚

串联质谱谱库搜索鉴定技术综述


2012 07

269-272

BMC bioinformatics

2011

Qiao, Yantao; Zhang, Hong; Bu, Dongbo; Sun, Shiwei; 

PI: An open-source software package for validation of the SEQUEST result and visualization of mass spectrum

12

1

234

BMC bioinformatics

2011

Zhang, Shenghui; Wang, Yaojun; Bu, Dongbo; Zhang, Hong; Sun, Shiwei; 

ProbPS: A new model for peak selection based on quantifying the dependence of the existence of derivative peaks on primary ion intensity

12

1

346

计算机科学与探索

2010

乔彦涛; 缪佳铮; 孙世伟; 刘金刚; 卜东波

串联质谱的蛋白质序列鉴定技术综述

4

2

97-107

Annual International Conference on Research in Computational Molecular Biology

2008

Lin, Yu; Qiao, Yantao; Sun, Shiwei; Yu, Chungong; Dong, Gongjin; Bu, Dongbo; 

A fragmentation event model for peptide identification by mass spectrometry



154-166

Trends in Genetics

2008

Zhao, Yi; He, Shunmin; Liu, Changning; Ru, Songwei; Zhao, Haitao; Yang, Zhen; Yang, Pengcheng; Yuan, Xiongyin; Sun, Shiwei; Bu, Dongbo; 

MicroRNA regulation of messenger-like noncoding RNAs: a network of mutual microRNA control

24

7

323-327

Research in Computational Molecular Biology: 12th Annual International Conference, RECOMB 2008, Singapore, March 30-April 2, 2008, Proceedings

2008

Bu, Dongbo; 

A Fragmentation Event Model for Peptide Identification by Mass Spectrometry

4955


154

Journal of bioinformatics and computational biology

2007

Yu, Chungong; Lin, Yu; Sun, Shiwei; Cai, Jinjin; Zhang, Jingfen; Bu, Dongbo; Zhang, Zhuo; Chen, Runsheng; 

An iterative algorithm to quantify factors influencing peptide fragmentation during tandem mass spectrometry

5

02a

297-311

Journal of proteome research

2007

Sun, Shiwei; Yu, Chungong; Qiao, Yantao; Lin, Yu; Dong, Gongjin; Liu, Changning; Zhang, Jingfen; Zhang, Zhuo; Cai, Jinjin; Zhang, Hong; 

Deriving the probabilities of water loss and ammonia loss for amino acids from tandem mass spectra

7

1

202-208

FEBS letters

2006

Sun, Shiwei; Zhao, Yi; Jiao, Yishan; Yin, Yifei; Cai, Lun; Zhang, Yong; Lu, Hongchao; Chen, Runsheng; Bu, Dongbo; 

Faster and more accurate global protein function assignment from protein interaction networks using the MFGO algorithm

580

7

1891-1896

BMC bioinformatics

2006

Zhang, Yong; Li, Shaojuan; Skogerbø, Geir; Zhang, Zhihua; Zhu, Xiaopeng; Zhang, Zefeng; Sun, Shiwei; Lu, Hongchao; Shi, Baochen; Chen, Runsheng; 

Phylophenetic properties of metabolic pathway topologies as revealed by global analysis

7

1

252

Journal of theoretical biology

2006

Zhang, Zhihua; Sun, Hong; Zhang, Yong; Zhao, Yi; Shi, Baochen; Sun, Shiwei; Lu, Hongchao; Bu, Dongbo; Ling, Lunjiang; Chen, Runsheng; 

Genome-wide analysis of mammalian DNA segment fusion/fission

240

2

200-208

Computational Systems Bioinformatics: CSB2006 Conference Proceedings, Stanford CA, 14-18 August 2006

2006

Yir, Chungong; Lhv, Yu; Sun, Shiwei; Cai, Jinjin; Zhang, Jingfen; Zhang, Zhuo; Chen, Runsheng; Bu, Dongbo; 

AN ITERATIVE ALGORITHM TO QUANTIFY THE FACTORS INFLUENCING PEPTIDE FRAGMENTATION FOR MS/MS SPECTRUM

4


353

Genome research

2006

Deng, Wei; Zhu, Xiaopeng; Skogerbø, Geir; Zhao, Yi; Fu, Zhuo; Wang, Yudong; He, Housheng; Cai, Lun; Sun, Hong; Liu, Changning; 

Organization of the Caenorhabditis elegans small non-coding transcriptome: genomic features, biogenesis, and expression

16

1

20-29

Computational Systems Bioinformatics

2006

Yu, Chungong; Lin, Yu; Sun, Shiwei; Cai, Jinjin; Zhang, Jingfen; Zhang, Zhuo; Chen, Runsheng; Bu, Dongbo; 

An iterative algorithm to quantify the factors influencing peptide fragmentation for MS/MS spectrum



353-360

BMC bioinformatics

2006

Zhang, Zhuo; Sun, Shiwei; Zhu, Xiaopeng; Chang, Suhua; Liu, Xiaofei; Yu, Chungong; Bu, Dongbo; Chen, Runsheng; 

A novel scoring schema for peptide identification by searching protein sequence databases using tandem mass spectrometry data

7

1

222

Biochemical and biophysical research communications

2006

Zhang, Yong; Sun, Shiwei; Wu, Tao; Wang, Jie; Liu, Changning; Chen, Lan; Zhu, Xiaopeng; Zhao, Yi; Zhang, Zhihua; Shi, Baochen; 

Identifying Hfq-binding small RNA targets in Escherichia coli

343

3

950-955

BMC Infectious Diseases

2004

Lu, Hongchao; Zhao, Yi; Zhang, Jingfen; Wang, Yuelan; Li, Wei; Zhu, Xiaopeng; Sun, Shiwei; Xu, Jingyi; Ling, Lunjiang; Cai, Lun; 

Date of origin of the SARS coronavirus strains

4

1

3

Nucleic acids research

2004

Lu, Hongchao; Zhu, Xiaopeng; Liu, Haifeng; Skogerbø, Geir; Zhang, Jingfen; Zhang, Yong; Cai, Lun; Zhao, Yi; Sun, Shiwei; Xu, Jingyi; 

The interactome as a tree—an attempt to visualize the protein–protein interaction network in yeast

32

16

4804-4811

Nucleic acids research

2003

Bu, Dongbo; Zhao, Yi; Cai, Lun; Xue, Hong; Zhu, Xiaopeng; Lu, Hongchao; Zhang, Jingfen; Sun, Shiwei; Ling, Lunjiang; Zhang, Nan; 

Topological structure analysis of the protein–protein interaction network in budding yeast

31

9

2443-2450

Chinese Science Bulletin

2003

Qi, Zhen; Hu, Yu; Li, Wei; Chen, Yanjun; Zhang, Zhihua; Sun, Shiwei; Lu, Hongchao; Zhang, Jingfen; Bu, Dongbo; Ling, Lunjiang; 

Phylogeny of SARS-CoV as inferred from complete genome comparison

48

12

1175-1178

高等学校化学学报

2001

唐祥海; 温新; 孙世伟; 蒋海燕; 陈铁红

高钛含量钛硅中孔材料的合成及理化性质研究


z1

200-203

燃料化学学报

2001

唐祥海; 孙世伟; 蒋海燕; 陈铁红; 王敬中

高钛含量钛硅 mcmr41 中孔结构材料的合成及表征

29


52



Sun, Shiwei; Yu, Chungong; Zhang, Jingfen; Lin, Yu; Zhang, Zhuo; Cai, Jinjin; Bu, Dongbo; 

An EM Method to Learn the Probability of Neutral Losses from Ions during Low-energy CID






Zhao, Yi; He, Shunmin; Liu, Changning; Ru, Songwei; Zhao, Haitao; Yang, Zhen; Yang, Pengcheng; Yuan, Xiongyin; Sun, Shiwei; Bu, Dongbo; 

Online Supplementary material MicroRNA regulation of messenger-like non-coding RNAs––a network of mutual microRNA control