1、多靶点抗肿瘤化合物的设计、合成及其作用机理研究

2、药物相互作用研究新方法，

3、基于多功能分子探针的化学生物学研究

接受过化学类、生物类或药学类的本科教育，专业基础扎实、较强的科研能力和创新能力的优秀青年学者。英语基础较好，身心健康，人际交往和谐，具有团队精神。年招生计划1-2人

070302-分析化学

分析化学
蛋白质组学
化学生物学

2001-09--2007-02   中国科学院理化技术研究所   博士学位
1988-09--1992-06   湖南师范大学   学士学位

博士

博士

   

2007-06~现在, 中国科学院化学研究所, 助研/副研
2007-03~2007-06,中国科学院化学研究所, 博士后工作
1992-06~1999-11,空军长沙航空职业技术学院, 讲师

分析化学1

   

（1） 获得2014年中国分析测试协会科学技术奖( CAIA奖 ), 二等奖, 省级, 2014

[1] 汪福意, 侯垠竹, 罗群, 房田田, 甘铁梁, 赵耀, 张燕燕. 吡啶抑素或其衍生物和反式铂类化合物的组合或配合物在制备治疗癌症的药物中的应用. CN: CN115463131A, 2022-12-13.

[2] 罗群, 汪福意, 石慧霞, 唐朝, 孟祥超, 章一鸣, 季安全, 朱军, 王明直, 姜懿璇, 戚鲁豫, 侯垠竹. 鉴定外周血和月经血的应用以及鉴定方法. CN: CN114518414A, 2022-05-20.

[3] 汪福意, 戚鲁豫, 罗群, 赵耀, 张燕燕, 贾菲菲, 房田田. 生物标志物及其应用. CN: CN114262739A, 2022-04-01.

[4] 汪福意, 姜懿璇, 罗群, 赵耀, 张燕燕, 唐朝, 贾菲菲. 一种含5-氨基荧光素类配体的Pt配合物及其制备方法和应用. CN: CN113372393A, 2021-09-10.

[5] 汪福意, 曾文娟, 罗群, 赵耀. 药物损伤DNA功能化磁性纳米亲和探针及其制备方法和应用. CN: CN111812315A, 2020-10-23.

[6] 徐艳, 汪福意, 罗群, 赵耀, 王媛媛, 李向军. 蛋白质功能化磁珠亲和探针及其制备方法与应用. CN: CN110389216B, 2020-07-14.

[7] 徐艳, 汪福意, 罗群, 赵耀, 王媛媛, 李向军. 蛋白质功能化磁珠亲和探针及其制备方法与应用. CN: CN110389216A, 2019-10-29.

[8] 汪福意, 梁祖青, 罗群. 黄酮糖苷功能化磁性纳米亲和探针及其制备方法和应用以及细胞内靶标蛋白捕获方法. CN: CN108693354A, 2018-10-23.

[9] 汪福意, 梁塑, 罗群. 含黄酮类药物活性分子的荧光探针及其制备方法和应用. CN: CN108690033A, 2018-10-23.

[10] 汪福意, 王朝英, 罗群, 吴魁. 一种微流控反应器及其应用以及检测系统和检测液相界面离子分布的方法. CN: CN107345935A, 2017-11-14.

[11] 汪福意, 张扬, 罗群, 赵耀, 郑伟, 张二龙, 吴魁, 王朝英. 含喹唑啉类配体的Pt配合物及其制备方法和应用. CN: CN106188147A, 2016-12-07.

[12] 汪福意, 刘素彦, 吴魁, 罗群, 赵耀. 一种可寻址的样品板及其在单细胞显微成像中的应用. CN: CN106153538A, 2016-11-23.

[13] 汪福意, 杜支凤, 罗群, 郭伟. 一种损伤DNA-纳米金复合物及其制备方法与应用. CN: CN104861037A, 2015-08-26.

[14] 汪福意, 郭伟, 罗群, 李鲜婵. 一种有机金属钌缀合蛋白及其制备方法与应用. CN: CN104072607A, 2014-10-01.

[15] 汪福意, 韩玉苗, 罗群, 郑伟, 吴魁, 李鲜婵. 抑制蛋白酪氨酸磷酸酶1B活性的含钌配合物及其制备方法和蛋白酪氨酸磷酸酶1B抑制剂. CN: CN103360428A, 2013-10-23.

[16] 汪福意, 罗群, 纪丽云, 郑伟, 吕爽. 一种喹唑啉衍生物及其制备方法. CN: CN102452988A, 2012-05-16.

[17] 汪福意, 罗群, 吕爽, 吴魁, 胡文兵, 纪丽云, 韩玉苗. 一种含有钌的配合物及其制备方法. CN: CN101891627A, 2010-11-24.

[18] 汪福意, 罗群, 吕爽, 纪丽云, 胡文兵, 吴魁, 韩玉苗. 一种酪氨酸蛋白激酶抑制剂及其制备方法. CN: CN101890018A, 2010-11-24.

   

[1] Zhu, Li, Liu, Hui, Dou, Yang, Luo, Qun, Gu, Liangzhen, Liu, Xingkai, Zhou, Qianxiong, Han, Juanjuan, Wang, Fuyi. A Photoactivated Ru (II) Polypyridine Complex Induced Oncotic Necrosis of A549 Cells by Activating Oxidative Phosphorylation and Inhibiting DNA Synthesis as Revealed by Quantitative Proteomics. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2023, 24(9): http://dx.doi.org/10.3390/ijms24097756.
[2] Zhang, Yanyan, Jin, Jing, Xue, Yifei, Zhao, Yao, Luo, Qun, Mao, Lanqun, Wang, Fuyi. Molecular unravelling of the mechanism of overpotential change at the carbon nanotubes-modified gold electrode surface. CHEMICAL COMMUNICATIONS[J]. 2023, 59(54): 8412-8415, http://dx.doi.org/10.1039/d3cc01818k.
[3] Xingkai Liu, Qian Chen, Xuming Ji, Wanchen Yu, Tong Wang, Juanjuan Han, Shumu Li, Jianan Liu, Fangang Zeng, Yao Zhao, Yanyan Zhang, Qun Luo, Shijun Wang, Fuyi Wang. Astragaloside IV promotes pharmacological effect of Descurainia sophia seeds on isoproterenol-induced cardiomyopathy in rats by synergistically modulating the myosin motor. FRONTIERS IN PHARMACOLOGY[J]. 2022, 13: https://doaj.org/article/a719a78de5234a28a64f5c2968cdaff2.
[4] Hou, Yinzhu, Liang, Zuqing, Qi, Luyu, Tang, Chao, Liu, Xingkai, Tang, Jilin, Zhao, Yao, Zhang, Yanyan, Fang, Tiantian, Luo, Qun, Wang, Shijun, Wang, Fuyi. Baicalin Targets HSP70/90 to Regulate PKR/PI3K/AKT/eNOS Signaling Pathways. MOLECULES[J]. 2022, 27(4): http://dx.doi.org/10.3390/molecules27041432.
[5] Hou, Yinzhu, Gan, Tieliang, Fang, Tiantian, Zhao, Yao, Luo, Qun, Liu, Xingkai, Qi, Luyu, Zhang, Yanyan, Jia, Feifei, Han, Juanjuan, Li, Shumu, Wang, Shijun, Wang, Fuyi. G-quadruplex inducer/stabilizer pyridostatin targets SUB1 to promote cytotoxicity of a transplatinum complex. NUCLEIC ACIDS RESEARCH[J]. 2022, 50(6): 3070-3082, http://dx.doi.org/10.1093/nar/gkac151.
[6] Wang, Lailiang, Luo, Qun, Zhou, Fangfang, Zhu, Beixia. Serum 25-hydroxyvitamin D status was associated with brachial-ankle pulse wave velocity and mortality among peritoneal dialysis patients. EUROPEAN JOURNAL OF CLINICAL NUTRITION[J]. 2021, 75(5): 754-758, http://dx.doi.org/10.1038/s41430-020-00787-0.
[7] Chai, Lingxiong, Cai, Kedan, Wang, Kaiyue, Luo, Qun. Relationship between blood neutrophil-lymphocyte ratio and renal tubular atrophy/interstitial fibrosis in IgA nephropathy patients. JOURNAL OF CLINICAL LABORATORY ANALYSIS[J]. 2021, 35(6): http://dx.doi.org/10.1002/jcla.23774.
[8] 罗群. 活细胞荧光成像揭示汉黄芩素靶向线粒体. talanta. 2021, [9] Kammer, Lisa Marie, Badir, Shorouk O, Hu, RenMing, Molander, Gary A, Xiaohong Fang. Single cell imaging reveals cisplatin regulating interactions between transcription (co)factors and DNA. CHEMICAL SCIENCE[J]. 2021, 12(15): 5419-5429, http://dx.doi.org/10.1039/d0sc06760a.
[10] KeDan Cai, BeiXia Zhu, HaiXue Lin, Qun Luo. Successful application of roxadustat in the treatment of patients with anti-erythropoietin antibody-mediated renal anaemia: a case report and literature review. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH[J]. 2021, 49(4): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054214/.
[11] 黄超, 梁祖君, 赵耀, 房田田, 吴魁, 罗群, 汪福意. 铂基抗癌药物与蛋白质配位键相互作用质谱研究新进展. 质谱学报[J]. 2021, 42(5): 819-844, http://lib.cqvip.com/Qikan/Article/Detail?id=7105604776.
[12] Zhou, Fangfang, Luo, Qun, Han, Lina, Shen, Gen, Huang, Lulu, Ye, Honghua. Proteomics reveals urine apolipoprotein A-I as a potential biomarker of acute kidney injury following percutaneous coronary intervention in elderly patients. EXPERIMENTAL AND THERAPEUTIC MEDICINE[J]. 2021, 22(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141962/.
[13] Liang, Su, Wang, Zeyu, Qi, Luyu, Tang, Chao, Zhang, Yiming, Luo, Qun, Wu, Yayun, Yuan, Jinghe, Zhao, Yao, Zhang, Yanyan, Fang, Xiaohong, Wang, Shijun, Wang, Fuyi. Fluorescence live cell imaging revealed wogonin targets mitochondria. TALANTA[J]. 2021, 230: http://dx.doi.org/10.1016/j.talanta.2021.122328.
[14] 陈易欣, 周芳芳, 罗群. 急性肾损伤集束化治疗的研究进展. 临床荟萃[J]. 2021, 36(4): 370-373, http://lib.cqvip.com/Qikan/Article/Detail?id=7104565951.
[15] Zhao, Yao, Kang, Yan, Xu, Fengmin, Zheng, Wei, Luo, Qun, Zhang, Yanyan, Jia, Feifei, Wang, Fuyi, Sadler, PJ, VanEldik, R. Pharmacophore conjugation strategy for multi-targeting metal-based anticancer complexes. MEDICINAL CHEMISTRYnull. 2020, 75: 257-285, http://dx.doi.org/10.1016/bs.adioch.2019.10.002.
[16] 戴智威, 蔡珂丹, 周芳芳, 王来亮, 邵宁俊, 罗群. 慢性肾脏病患者血中性粒细胞/淋巴细胞比与动脉僵硬度相关性研究. 现代实用医学[J]. 2020, 32(9): 1054-1057, http://lib.cqvip.com/Qikan/Article/Detail?id=7102998389.
[17] 朱蓓霞, 周芳芳, 叶红华, 薛聪平, 卢梦凡, 罗群. 维持性腹膜透析患者肌少症的患病率及其相关因素研究. 中华全科医师杂志[J]. 2020, 19(10): 913-917, http://lib.cqvip.com/Qikan/Article/Detail?id=7103201901.
[18] 罗科娜, 蔡珂丹, 罗群. 肠道菌群代谢产物短链脂肪酸在慢性肾脏病中的研究进展. 中国微生态学杂志[J]. 2020, 32(8): 983-987, http://lib.cqvip.com/Qikan/Article/Detail?id=7102929769.
[19] 罗群, 陈易欣. 钠-葡萄糖共转运蛋白2抑制剂肾脏保护作用的研究进展. 现代实用医学[J]. 2020, 32(12): 1448-1450, http://lib.cqvip.com/Qikan/Article/Detail?id=7103710868.
[20] Bai, Xu, Luo, Qun, Tan, Kuibi, Guo, Liming. Diagnostic value of VDBP and miR-155-5p in diabetic nephropathy and the correlation with urinary microalbumin. EXPERIMENTAL AND THERAPEUTIC MEDICINE[J]. 2020, 20(5): https://www.webofscience.com/wos/woscc/full-record/WOS:000590182400086.
[21] Li, Chaoyang, Xu, Fengmin, Zhao, Yao, Zheng, Wei, Zeng, Wenjuan, Luo, Qun, Wang, Zhaoying, Wu, Kui, Du, Jun, Wang, Fuyi. Platinum(II) Terpyridine Anticancer Complexes Possessing Multiple Mode of DNA Interaction and EGFR Inhibiting Activity. FRONTIERS IN CHEMISTRY[J]. 2020, 8: https://doaj.org/article/f16506b376664349877e8c6e392ec4f4.
[22] 陈易欣, 李梦, 罗群. 基于容量管理自动化腹膜透析处方的调整. 中华全科医师杂志[J]. 2020, 19(1): 72-75, http://lib.cqvip.com/Qikan/Article/Detail?id=7101121122.
[23] Zhang, Yanyan, Zeng, Wenjuan, Jia, Feifei, Ye, Juan, Zhao, Yao, Luo, Qun, Zhu, Zihua, Wang, Fuyi. Cisplatin-induced alteration on membrane composition of A549 cells revealed by ToF-SIMS. SURFACE AND INTERFACE ANALYSIS[J]. 2020, 52(5): 256-263, https://www.webofscience.com/wos/woscc/full-record/WOS:000494540900001.
[24] Fangfang Zhou, Yi Yang, Lianxin Luo, Yixin Chen, Qun Luo, Jianghua Chen. Impact of Prolonged Mechanical Ventilation on Ferroptosis in Renal Ischemia/Reperfusion Injury in Rats. BIOMED RESEARCH INTERNATIONAL[J]. 2020, 2020: https://doaj.org/article/1759f485b32a49c89010e6cf407c78db.
[25] Jia, Feifei, Wang, Jie, Zhao, Yao, Zhang, Yanyan, Luo, Qun, Qi, Luyu, Hou, Yinzhu, Du, Jun, Wang, Fuyi. In Situ Visualization of Proteins in Single Cells by Time-of-Flight-Secondary Ion Mass Spectrometry Coupled with Genetically Encoded Chemical Tags. ANALYTICAL CHEMISTRY[J]. 2020, 92(23): 15517-15525, https://www.webofscience.com/wos/woscc/full-record/WOS:000596727600033.
[26] Guo, Liming, Tan, Kuibi, Luo, Qun, Bai, Xu. Dihydromyricetin promotes autophagy and attenuates renal interstitial fibrosis by regulating miR-155-5p/PTEN signaling in diabetic nephropathy. BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES[J]. 2020, 20(3): 372-380, https://www.webofscience.com/wos/woscc/full-record/WOS:000544365100011.
[27] Jia, Feifei, Wu, Kui, Che, Yanli, Zhang, Yanyan, Zeng, Fangang, Luo, Qun, Yu, XiaoYing, Zhu, Zihua, Zhao, Yao, Wang, Fuyi. ToF-SIMS analysis of chemical composition of atmospheric aerosols in Beijing. SURFACE AND INTERFACE ANALYSIS[J]. 2020, 52(5): 272-282, https://www.webofscience.com/wos/woscc/full-record/WOS:000494527400001.
[28] Qi, Luyu, Luo, Qun, Zhang, Yanyan, Jia, Feifei, Zhao, Yao, Wang, Fuyi. Advances in Toxicological Research of the Anticancer Drug Cisplatin. CHEMICAL RESEARCH IN TOXICOLOGYnull. 2019, 32(8): 1469-1486, https://www.webofscience.com/wos/woscc/full-record/WOS:000482173200003.
[29] Wang, Lailiang, Luo, Qun, Zhu, Beixia, Zhou, Fangfang. Relation of Serum 25-Hydroxyvitamin D Status with Skeletal Muscle Mass and Grip Strength in Patients on Peritoneal Dialysis. JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY[J]. 2019, 65(6): 477-482, https://www.webofscience.com/wos/woscc/full-record/WOS:000504880200003.
[30] Zeng, Wenjuan, Zhang, Yanyan, Zheng, Wei, Luo, Qun, Han, Juanjuan, Liu, Jianan, Zhao, Yao, Jia, Feifei, Wu, Kui, Wang, Fuyi. Discovery of Cisplatin Binding to Thymine and Cytosine on a Single-Stranded Oligodeoxynucleotide by High Resolution FT-ICR Mass Spectrometry. MOLECULES[J]. 2019, 24(10): https://doaj.org/article/4d08fd48b125440da84939bd273a00b7.
[31] Han, Yumiao, Guo, Wei, Zheng, Wei, Luo, Qun, Wu, Kui, Zhao, Yao, Wang, Fuyi. Mass spectrometric quantification of the binding ratio of metal-based anticancer complexes with protein thiols. RAPID COMMUNICATIONS IN MASS SPECTROMETRY[J]. 2019, 33(10): 951-958, [32] Lin, Yu, Wang, Jie, Zheng, Wei, Luo, Qun, Wu, Kui, Du, Jun, Zhao, Yao, Wang, Fuyi. Organometallic ruthenium anticancer complexes inhibit human peroxiredoxin I activity by binding to and inducing oxidation of its catalytic cysteine residue. METALLOMICS[J]. 2019, 11(3): 546-555, https://www.webofscience.com/wos/woscc/full-record/WOS:000463840800018.
[33] Du, Jun, Wei, Yuanyuan, Zhao, Yao, Xu, Fengmin, Wang, Yuanyuan, Zheng, Wei, Luo, Qun, Wang, Ming, Wang, Fuyi. A Photoactive Platinum(IV) Anticancer Complex Inhibits Thioredoxin-Thioredoxin Reductase System Activity by Induced Oxidization of the Protein. INORGANIC CHEMISTRY[J]. 2018, 57(9): 5575-5584, https://www.webofscience.com/wos/woscc/full-record/WOS:000431833500089.
[34] 梁祖青, 罗群, 郑伟, 赵耀, 汪福意. 生物质谱鉴定中药活性成分靶标蛋白质的研究进展. 中国科学：生命科学[J]. 2018, 48(2): 140-150, http://lib.cqvip.com/Qikan/Article/Detail?id=674812393.
[35] Zhang, Yang, Luo, Qun, Zheng, Wei, Wang, Zhaoying, Lin, Yu, Zhang, Erlong, Lu, Shuang, Xiang, Junfeng, Zhao, Yao, Wang, Fuyi. Luminescent cyclometallated platinum(II) complexes: highly promising EGFR/DNA probes and dual-targeting anticancer agents. INORGANIC CHEMISTRY FRONTIERS[J]. 2018, 5(2): 413-424, https://www.webofscience.com/wos/woscc/full-record/WOS:000425032100016.
[36] Shao ChangFang, Zhao Yao, Wu Kui, Jia FeiFei, Luo Qun, Liu Zhe, Wang FuYi. Correlated Secondary Ion Mass Spectrometry-Laser Scanning Confocal Microscopy Imaging for Single Cell-Principles and Applications. CHINESEJOURNALOFANALYTICALCHEMISTRY[J]. 2018, 46(7): 1005-1016, http://dx.doi.org/10.1016/S1872-2040(18)61095-3.
[37] Liu, Suyan, Liang, Aihua, Wu, Kui, Zeng, Wenjuan, Luo, Qun, Wang, Fuyi. Binding of Organometallic Ruthenium Anticancer Complexes to DNA: Thermodynamic Base and Sequence Selectivity. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2018, 19(7): https://doaj.org/article/35e1484673a84a00834c1ab1864bbca5.
[38] Shao ChangFang, Zhao Yao, Wu Kui, Jia FeiFei, Luo Qun, Liu Zhe, Wang FuYi. Correlated Secondary Ion Mass Spectrometry-Laser Scanning Confocal Microscopy Imaging for Single Cell-Principles and Applications. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY[J]. 2018, 46(7): 1005-1016, http://dx.doi.org/10.1016/S1872-2040(18)61095-3.
[39] Zheng, Wei, Zhao, Yao, Luo, Qun, Zhang, Yang, Wu, Kui, Wang, Fuyi. Multi-Targeted Anticancer Agents. CURRENT TOPICS IN MEDICINAL CHEMISTRYnull. 2017, 17(28): 3084-3098, http://dx.doi.org/10.2174/1568026617666170707124126.
[40] Wu Kui, Jia Feifei, Zheng Wei, Luo Qun, Zhao Yao, Wang Fuyi. Visualization of metallodrugs in single cells by secondary ion mass spectrometry imaging. JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY[J]. 2017, https://www.webofscience.com/wos/woscc/full-record/WOS:000405434700003.
[41] Wang, Ping, Xia, YangLiu, Zou, LiWei, Qian, XingKai, Dou, TongYi, Jin, Qiang, Li, ShiYang, Yu, Yang, Wang, DanDan, Luo, Qun, Ge, GuangBo, Yang, Ling. An Optimized Two-Photon Fluorescent Probe for Biological Sensing and Imaging of Catechol-O-Methyltransferase. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2017, 23(45): 10800-10807, http://cas-ir.dicp.ac.cn/handle/321008/149799.
[42] Lei, Wei, Wang, DanDan, Dou, TongYi, Hou, Jie, Feng, Liang, Yin, Heng, Luo, Qun, Sun, Jie, Ge, GuangBo, Yang, Ling. Assessment of the inhibitory effects of pyrethroids against human carboxylesterases. TOXICOLOGY AND APPLIED PHARMACOLOGY[J]. 2017, 321: 48-56, http://cas-ir.dicp.ac.cn/handle/321008/169292.
[43] Wu, Kui, Jia, Feifei, Zheng, Wei, Luo, Qun, Zhao, Yao, Wang, Fuyi. Visualization of metallodrugs in single cells by secondary ion mass spectrometry imaging. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY[J]. 2017, 22(5): 653-661, http://dx.doi.org/10.1007/s00775-017-1462-3.
[44] Liu, Suyan, Zheng, Wei, Wu, Kui, Lin, Yu, Jia, Feifei, Zhang, Yang, Wang, Zhaoying, Luo, Qun, Zhao, Yao, Wang, Fuyi. Correlated mass spectrometry and confocal microscopy imaging verifies the dual-targeting action of an organoruthenium anticancer complex. CHEMICAL COMMUNICATIONS[J]. 2017, 53(29): 4136-4139, http://dx.doi.org/10.1039/c7cc01503h.
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（ 1 ） 微纳米DNA 探针捕获蛋白质-质谱分析联用研究肿瘤细胞对金属抗肿瘤药物的应答机制,, 主持, 国家级, 2013-01--2016-12
（ 2 ） 氢交换质谱研究蛋白质与DNA药物复合物之间的相互作用, 主持, 国家级, 2011-01--2011-12
（ 3 ） 生物活性荧光探针的构建及肿瘤活细胞成像分析研究，, 主持, 市地级, 2012-07--2014-06
（ 4 ） 调控蛋白与药物损伤DNA相互作用研究的分析新方法, 参与, 国家级, 2012-01--2016-12
（ 5 ） 基于利水功效的中药药性理论研究, 参与, 国家级, 2013-01--2017-12
（ 6 ） 中药黄芩活性成分靶标蛋白的捕获与鉴定新方法, 主持, 省级, 2018-01--2019-12

（1）生物活性荧光探针的构建及其在EGFR定量分析中的应用   第八届全国化学生物学学术会议   2013-09-15
（2）生物活性荧光探针的构建及肿瘤活细胞成像分析研究   第十一届全国分析化学年会   2012-10-26
（3）质谱研究碱金属离子对胸苷基T-四联体形成的尺寸效应   第31届中国质谱学会年会   2011-08-06

已指导学生

张扬  博士研究生  070302-分析化学  

梁祖青  硕士研究生  070302-分析化学  

梁塑  硕士研究生  070302-分析化学  

现指导学生

曾文娟  博士研究生  070302-分析化学