071009-细胞生物学
071011-生物物理学

生物大分子药物输送系统及免疫应答机制
溶酶体在维持蛋白质平衡中的作用

1997-09--2000-09   上海医药工业研究院   博士
1994-09--1997-06   沈阳药科大学   药剂学硕士

   

2003-10~现在, 中科院生物物理研究所, 副研究员，研究员
2001-12~2003-10,Harvard University and Northeastern University, Research Associate
2000-11~2001-12,University of Minnesota, Postdoctoral fellow

2015-03-16-2019-03-16,中国药学会纳米药物专业委员会, 委员
2013-11-30-2017-10-31,中国生物物理学会第十届理事会, 理事
2011-06-01-今,生物物理学会分子影像学专业委员会, 副主任委员
2009-07-01-2013-06-30,生物物理学学会第九届理事会, 理事

生物技术药物
SAXS在生物学中的应用

   

（1） 国家科学技术奖, 二等奖, 国家级, 2012
（2） 中国专利优秀奖, , 部委级, 2010
（3） 2009年中国科学院“优秀研究生指导教师”, , 院级, 2009
（4） 中国药学会科学技术奖，药物的新型纳米输送系统研究, 二等奖, 其他, 2008

（ 1 ）  一种PEG衍生化磷脂包载的前列腺素E1的胶束制剂, 发明, 2010, 第 1 作者, 专利号: ZL200810105113.2
（ 2 ） 聚乙二醇衍生化磷脂包载的蒽环类抗肿瘤抗生素纳米胶束制剂, 发明, 2010, 第 1 作者, 专利号: ZL200510059621.8
（ 3 ） 柚皮素和柚皮苷作为转化生长因子-β1信号通路抑制剂的应用, 发明, 2014, 第 1 作者, 专利号: 特许第5484320号
（ 4 ） Use of Naringenin and Naringin as Inhibitors for Transforming Growth Factor-β1 Signaling Pathway, 发明, 2014, 第 1 作者, 专利号: European Paten No 2163247

   

[1] Li, Hao, Wang, Zihao, Fang, Xiaocui, Zeng, Wenfeng, Yang, Yanlian, Jin, Lingtao, Wei, Xiuli, Qin, Yan, Wang, Chen, Liang, Wei. Poroptosis: A form of cell death depending on plasma membrane nanopores formation. ISCIENCE[J]. 2022, 第 10 作者  通讯作者  25(6): http://dx.doi.org/10.1016/j.isci.2022.104481.
[2] Fayun Zhang, Zifeng Zheng, Apurba Kumar Barman, Zihao Wang, Luyao Wang, Wenfeng Zeng, Luoyang Wang, Yan Qin, Asmita Pandey, Chunling Zhang, Wei Liang. Optimal combination treatment regimens of vaccine and radiotherapy augment tumor-bearing host immunity. COMMUNICATIONS BIOLOGY[J]. 2021, 第 11 作者  通讯作者  4(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000613509200002.
[3] Yin, Xiaozhe, Zeng, Wenfeng, Wu, Bowen, Wang, Luoyang, Wang, Zihao, Tian, Hongjian, Wang, Luyao, Jiang, Yunhan, Clay, Ryan, Wei, Xiuli, Qin, Yan, Zhang, Fayun, Zhang, Chunling, Jin, Lingtao, Liang, Wei. PPAR alpha Inhibition Overcomes Tumor-Derived Exosomal Lipid-Induced Dendritic Cell Dysfunction. CELL REPORTS[J]. 2020, 第 15 作者  通讯作者  33(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000582719300008.
[4] Wang, Luyao, Wang, Zihao, Qin, Yan, Liang, Wei. Delivered antigen peptides to resident CD8 alpha(+) DCs in lymph node by micelle-based vaccine augment antigen-specific CD8(+) effector T cell response. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS[J]. 2020, 第 4 作者  通讯作者  147: 76-86, https://www.webofscience.com/wos/woscc/full-record/WOS:000510313900008.
[5] Wang, Luoyang, Zeng, Wenfeng, Wang, Luyao, Wang, Zihao, Yin, Xiaozhe, Qin, Yan, Zhang, Fayun, Zhang, Chunling, Liang, Wei. Naringenin Enhances the Antitumor Effect of Therapeutic Vaccines by Promoting Antigen Cross-Presentation. JOURNAL OF IMMUNOLOGY[J]. 2020, 第 9 作者  通讯作者  204(3): 622-631, https://www.webofscience.com/wos/woscc/full-record/WOS:000508649800014.
[6] Wang, Luoyang, Jiang, Guoqiang, Jing, Nan, Liu, Xuerun, Li, Qicheng, Liang, Wei, Liu, Zheng. Bilberry anthocyanin extracts enhance anti-PD-L1 efficiency by modulating gut microbiota. FOOD & FUNCTION[J]. 2020, 第 6 作者11(4): 3180-3190, https://www.webofscience.com/wos/woscc/full-record/WOS:000556523100030.
[7] Zhang, Chao, Zeng, Wenfeng, Yao, Yi, Xu, Bin, Wei, Xiuli, Wang, Luoyang, Yin, Xiaozhe, Barman, Apurba Kumar, Zhang, Fayun, Zhang, Chunling, Song, Qibin, Liang, Wei. Naringenin Ameliorates Radiation-Induced Lung Injury by Lowering IL-1 beta Level. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS[J]. 2018, 第 12 作者  通讯作者  366(2): 341-348, https://www.webofscience.com/wos/woscc/full-record/WOS:000442126300012.
[8] Guan, Xiaoyang, Chaffey, Patrick K, Wei, Xiuli, Gulbranson, Daniel R, Ruan, Yuan, Wang, Xinfeng, Li, Yaohao, Ouyang, Yan, Chen, Liqun, Zeng, Chen, Koelsch, Theo N, Tran, Amy H, Liang, Wei, Shen, Jingshi, Tan, Zhongping. Chemically Precise Glycoengineering Improves Human Insulin. ACS CHEMICAL BIOLOGY[J]. 2018, 第 13 作者  通讯作者  13(1): 73-81, https://www.webofscience.com/wos/woscc/full-record/WOS:000423252600008.
[9] Zeng WenFeng, Zhang FaYun, Du GangJun, Jin LingTao, Qin Lei, Dong WenJuan, Zhang Chao, Wang LuoYang, Yin XiaoZhe, Zhang ChunLing, Liang Wei. Research Updates on a Novel Immunomodulator, Naringenin. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2018, 第 11 作者  通讯作者  45(9): 915-925, https://www.webofscience.com/wos/woscc/full-record/WOS:000445847600003.
[10] Zeng, Wenfeng, Jin, Lingtao, Zhang, Fayun, Zhang, Chunling, Liang, Wei. Naringenin as a potential immunomodulator in therapeutics. PHARMACOLOGICAL RESEARCH. 2018, 第 5 作者  通讯作者  135: 122-126, http://dx.doi.org/10.1016/j.phrs.2018.08.002.
[11] Zeng WenFeng, Zhang FaYun, Du GangJun, Jin LingTao, Qin Lei, Dong WenJuan, Zhang Chao, Wang LuoYang, Yin XiaoZhe, Zhang ChunLing, Liang Wei. Research Updates on a Novel Immunomodulator, Naringenin. PROGRESSINBIOCHEMISTRYANDBIOPHYSICS[J]. 2018, 第 11 作者  通讯作者  45(9): 915-925, https://www.webofscience.com/wos/woscc/full-record/WOS:000445847600003.
[12] Guan, Xiaoyang, Chaffey, Patrick K, Chen, Huan, Feng, Wei, Wei, Xiuli, Yang, LiuMeng, Ruan, Yuan, Wang, Xinfeng, Li, Yaohao, Barosh, Kimberly B, Tran, Amy H, Zhu, Jaimie, Liang, Wei, Zheng, YongTang, Wang, Xu, Tan, Zhongping. O-GaINAcylation of RANTES Improves Its Properties as a Human Immunodeficiency Virus Type 1 Entry Inhibitor. BIOCHEMISTRY[J]. 2018, 第 13 作者57(1): 136-148, https://www.webofscience.com/wos/woscc/full-record/WOS:000419999100017.
[13] Han, Qiusen, Wang, Xinhuan, Jia, Xinghang, Cai, Shuangfei, Liang, Wei, Qin, Yan, Yang, Rong, Wang, Chen. CpG loaded MoS2 nanosheets as multifunctional agents for photothermal enhanced cancer immunotherapy. NANOSCALE[J]. 2017, 第 5 作者9(18): 5927-5934, http://dx.doi.org/10.1039/c7nr01460k.
[14] Liu, Zhida, Zhou, Chang, Qin, Yan, Wang, Zihao, Wang, Luyao, Wei, Xiuli, Zhou, Yinjian, Li, Qicheng, Zhou, Hang, Wang, Wenjun, Fu, YangXin, Zhu, Mingzhao, Liang, Wei. Coordinating antigen cytosolic delivery and danger signaling to program potent cross-priming by micelle-based nanovaccine. CELL DISCOVERY[J]. 2017, 第 13 作者  通讯作者  3: 17007, http://dx.doi.org/10.1038/celldisc.2017.7.
[15] Wei Liang. Naringenin Ameliorates Acute Inflammation by Regulating Intracellular Cytokine Degradatio. the Journal of Immunology. 2017, 第 1 作者  通讯作者  
[16] Jin, Lingtao, Zeng, Wenfeng, Zhang, Fayun, Zhang, Chunling, Liang, Wei. Naringenin Ameliorates Acute Inflammation by Regulating Intracellular Cytokine Degradation. JOURNAL OF IMMUNOLOGY[J]. 2017, 第 5 作者  通讯作者  199(10): 3466-3477, https://www.webofscience.com/wos/woscc/full-record/WOS:000414660600008.
[17] Fang, Xiaocui, Yang, Tao, Wang, Luoyang, Yu, Jibing, Wei, Xiuli, Zhou, Yinjian, Wang, Chen, Liang, Wei. Nano-cage-mediated refolding of insulin by PEG-PE micelle. BIOMATERIALS[J]. 2016, 第 8 作者77: 139-148, http://www.corc.org.cn/handle/1471x/2176433.
[18] Fayun Zhang, Wenjuan Dong, Wenfeng Zeng, Lei Zhang, Chao Zhang, Yuqi Qiu, Luoyang Wang, Xiaozhe Yin, Chunling Zhang, Wei Liang. Naringenin prevents TGF-β1 secretion from breast cancer and suppresses pulmonary metastasis by inhibiting PKC activation. BREAST CANCER RESEARCH : BCR. 2016, 第 10 作者18: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818388/.
[19] Zhou, Yinjian, Dong, Ying, Huang, Gang, Wang, Yiguang, Huang, Xiaonan, Zhang, Fayun, Boothman, David A, Gao, Jinming, Liang, Wei. Lysosome-oriented, dual-stage pH-responsive polymeric micelles for beta-lapachone delivery. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2016, 第 9 作者  通讯作者  4(46): 7429-7440, http://dx.doi.org/10.1039/c6tb02049f.
[20] Li, Nan, Yang, Yong, He, Kangmin, Zhang, Fayun, Zhao, Libo, Zhou, Wei, Yuan, Jinghe, Liang, Wei, Fang, Xiaohong. Single-Molecule Imaging Reveals the Activation Dynamics of Intracellular Protein Smad3 on Cell Membrane. SCIENTIFIC REPORTS[J]. 2016, 第 8 作者  通讯作者  6: http://ir.iccas.ac.cn/handle/121111/35259.
[21] Tang, Haidong, Wang, Yang, Chlewicki, Lukasz K, Zhang, Yuan, Guo, Jingya, Liang, Wei, Wang, Jieyi, Wang, Xiaoxiao, Fu, YangXin. Facilitating T Cell Infiltration in Tumor Microenvironment Overcomes Resistance to PD-L1 Blockade. CANCER CELL[J]. 2016, 第 6 作者29(3): 285-296, http://dx.doi.org/10.1016/j.ccell.2016.02.004.
[22] Fayun Zhang, Wenjuan Dong, Wenfeng Zeng, Lei Zhang, Chao Zhang, Yuqi Qiu, Luoyang Wang, Xiaozhe Yin, Chunling Zhang, Wei Liang. Naringenin prevents TGF-β1 secretion from breast cancer and suppresses pulmonary metastasis by inhibiting PKC activation. BREAST CANCER RESEARCH. 2016, 第 10 作者18(1): http://dx.doi.org/10.1186/s13058-016-0698-0.
[23] Zhang, Fayun, Dong, Wenjuan, Zeng, Wenfeng, Zhang, Lei, Zhang, Chao, Qiu, Yuqi, Wang, Luoyang, Yin, Xiaozhe, Zhang, Chunling, Liang, Wei. Naringenin prevents TGF-beta 1 secretion from breast cancer and suppresses pulmonary metastasis by inhibiting PKC activation. BREAST CANCER RESEARCH[J]. 2016, 第 10 作者  通讯作者  18: http://dx.doi.org/10.1186/s13058-016-0698-0.
[24] Meng, Jie, Guo, Fangqin, Xu, Haiyan, Liang, Wei, Wang, Chen, Yang, XianDa. Combination Therapy using Co-encapsulated Resveratrol and Paclitaxel in Liposomes for Drug Resistance Reversal in Breast Cancer Cells in vivo. SCIENTIFIC REPORTS[J]. 2016, 第 4 作者6: http://www.corc.org.cn/handle/1471x/2176542.
[25] Han, Zhou, Wang, Xinhuan, Heng, Chenglin, Han, Qiusen, Cai, Shuanfei, Li, Jingying, Qi, Cui, Liang, Wei, Yang, Rong, Wang, Chen. Synergistically enhanced photocatalytic and chemotherapeutic effects of aptamer-functionalized ZnO nanoparticles towards cancer cells. PHYSICAL CHEMISTRY CHEMICAL PHYSICS[J]. 2015, 第 8 作者17(33): 21576-21582, https://www.webofscience.com/wos/woscc/full-record/WOS:000359596600064.
[26] Dong, Wenjuan, Wei, Xiuli, Zhang, Fayun, Hao, Junfeng, Huang, Feng, Zhang, Chunling, Liang, Wei. A dual character of flavonoids in influenza A virus replication and spread through modulating cell-autonomous immunity by MAPK signaling pathways. SCIENTIFIC REPORTS[J]. 2014, 第 7 作者  通讯作者  4: https://www.webofscience.com/wos/woscc/full-record/WOS:000346254800002.
[27] Wei Liang. Poly(ethylene glycol)-mediated conformational alteration of α-chymotrypsin prevents inactivation of insulin by stabilizing active intermediates. Mol Pharm. Mol Pharm. 2014, 第 1 作者  通讯作者  
[28] 赵宇亮. Progress of nanoscience in China. FRONTIERS OF PHYSICS[J]. 2014, 9(3): 257-288, http://ir.ihep.ac.cn/handle/311005/225016.
[29] Yu, Jibing, Wei, Xiuli, Zhang, Li, Fang, Xiaocui, Yang, Tao, Huang, Feng, Liang, Wei. Poly(ethylene glycol)-Mediated Conformational Alteration of alpha-Chymotrypsin Prevents Inactivation of Insulin by Stabilizing Active Intermediates. MOLECULAR PHARMACEUTICS[J]. 2014, 第 7 作者11(10): 3361-3370, http://dx.doi.org/10.1021/mp500001n.
[30] 张发云, 秦蕾, 梁伟. 活体自发光成像监测长春瑞滨纳米胶束抗乳腺癌转移机制研究. 中国肿瘤临床[J]. 2014, 第 3 作者41(1): 13-17, http://lib.cqvip.com/Qikan/Article/Detail?id=48353473.
[31] Yi, Cunjian, Zhang, Lei, Zhang, Fayun, Li, Li, Ling, Shengrong, Wang, Xiaowen, Liu, Xiangqiong, Liang, Wei. Methodologies for the establishment of an orthotopic transplantation model of ovarian cancer in mice. FRONTIERS OF MEDICINE[J]. 2014, 第 8 作者8(1): 101-105, https://www.webofscience.com/wos/woscc/full-record/WOS:000209571500013.
[32] Zhou, Yinjian, Zhang, Chunling, Liang, Wei. Development of RNAi technology for targeted therapy - A track of siRNA based agents to RNAi therapeutics. JOURNAL OF CONTROLLED RELEASE[J]. 2014, 第 3 作者  通讯作者  193: 270-281, http://dx.doi.org/10.1016/j.jconrel.2014.04.044.
[33] Yi, Cunjian, Zhang, Lei, Li, Li, Liu, Xiangqiong, Ling, Shengrong, Zhang, Fayun, Liang, Wei. Establishment of an orthotopic transplantation tumor model in nude mice using a drug-resistant human ovarian cancer cell line with a high expression of c-Kit. ONCOLOGY LETTERS[J]. 2014, 第 7 作者8(6): 2611-2615, https://www.webofscience.com/wos/woscc/full-record/WOS:000345948600050.
[34] Qin, Lei, Zhang, Fayun, Lu, Xiaoyan, Wei, Xiuli, Wang, Jing, Fang, Xiaocui, Si, Duanyun, Wang, Yiguang, Zhang, Chunling, Yang, Rong, Liu, Changxiao, Liang, Wei. Polymeric micelles for enhanced lymphatic drug delivery to treat metastatic tumors. JOURNAL OF CONTROLLED RELEASE[J]. 2013, 第 12 作者171(2): 133-142, http://dx.doi.org/10.1016/j.jconrel.2013.07.005.
[35] Zhang, Min, Mao, Xiaobo, Wang, Chenxuan, Zeng, Wenfeng, Zhang, Chunling, Li, Zhongjun, Fang, Ying, Yang, Yanlian, Liang, Wei, Wang, Chen. The effect of graphene oxide on conformation change, aggregation and cytotoxicity of HIV-1 regulatory protein (Vpr). BIOMATERIALS[J]. 2013, 第 9 作者34(4): 1383-1390, http://dx.doi.org/10.1016/j.biomaterials.2012.10.067.
[36] Wang, Jing, Xing, Xueqing, Fang, Xiaocui, Zhou, Chang, Huang, Feng, Wu, Zhonghua, Lou, Jizhong, Liang, Wei. Cationic amphiphilic drugs self-assemble to the core-shell interface of PEGylated phospholipid micelles and stabilize micellar structure. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES[J]. 2013, 第 8 作者371(2000): http://ir.ihep.ac.cn/handle/311005/224718.
[37] Zeng, Wenfeng, Yan, Yan, Zhang, Fayun, Zhang, Chunling, Liang, Wei. Chrysin promotes osteogenic differentiation via ERK/MAPK activation. PROTEIN & CELL[J]. 2013, 第 5 作者4(7): 539-547, http://www.irgrid.ac.cn/handle/1471x/756659.
[38] Yan, Yan, Zeng, Wenfeng, Song, Shujun, Zhang, Fayun, He, Wenxi, Liang, Wei, Niu, Zhongying. Vitamin C induces periodontal ligament progenitor cell differentiation via activation of ERK pathway mediated by PELP1. PROTEIN & CELL[J]. 2013, 第 6 作者  通讯作者  4(8): 620-627, http://www.irgrid.ac.cn/handle/1471x/756664.
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[52] Wang, Tiewei, Zhang, Chunling, Liang, XingJie, Liang, Wei, Wu, Yan. Hydroxypropyl-beta-Cyclodextrin Copolymers and Their Nanoparticles as Doxorubicin Delivery System. JOURNAL OF PHARMACEUTICAL SCIENCES[J]. 2011, 第 4 作者100(3): 1067-1079, http://www.irgrid.ac.cn/handle/1471x/757398.
[53] Qin, Lei, Jin, Lingtao, Lu, Linlin, Lu, Xiaoyan, Zhang, Chunling, Zhang, Fayun, Liang, Wei. Naringenin reduces lung metastasis in a breast cancer resection model. PROTEIN & CELL[J]. 2011, 第 7 作者  通讯作者  2(6): 507-516, http://lib.cqvip.com/Qikan/Article/Detail?id=7105128520.
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[57] Lu, Xiaoyan, Zhang, Fayun, Qin, Lei, Xiao, Fengying, Liang, Wei. Polymeric micelles as a drug delivery system enhance cytotoxicity of vinorelbine through more intercellular accumulation. DRUG DELIVERY[J]. 2010, 第 5 作者  通讯作者  17(4): 255-262, http://www.irgrid.ac.cn/handle/1471x/757162.
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（ 1 ） 药用生物纳米材料, Biological and Pharmaceutical Nanomaterials, 科学出版社, 2009-09, 第 1 作者

   

（ 1 ） 纳米材料的自组装及其在生物体内转运机制的研究, 主持, 国家级, 2008-12--2011-12
（ 2 ） 纳米药物的临床安全性和有效性评价, 主持, 部委级, 2014-07--2018-06
（ 3 ） YPS345治疗放化疗引起的肺损伤的合作开发, 主持, 院级, 2016-05--2019-12

（1）PEG-PE micelle based vaccine for treatment of HPV positive cervical carcinoma   2016-04-20
（2）PEG-PE micelle mediated refolding of insulin   2015年中国药物制剂大会   2015-09-26
（3）基于聚合物胶束的生物大分子药物纳米输送系统   2013年中国药物制剂大会   2013-10-26
（4）Fast crossing cell membrane of doxorubicin by encapsulated into PEG-PE micelles   的第十一次全国暨第二次国际膜生物学研讨会   Jiang Wang, Wei Liang   2010-11-09

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