基本信息
梁伟 男 博导 中国科学院生物物理研究所
电子邮件： weixx@sun5.ibp.ac.cn
通信地址： 北京市朝阳区大屯路15号
邮政编码： 100101
电子邮件： weixx@sun5.ibp.ac.cn
通信地址： 北京市朝阳区大屯路15号
邮政编码： 100101
招生信息
招生专业
071009-细胞生物学
071011-生物物理学
071011-生物物理学
招生方向
生物大分子药物输送系统及免疫应答机制
溶酶体在维持蛋白质平衡中的作用
溶酶体在维持蛋白质平衡中的作用
教育背景
1997-09--2000-09 上海医药工业研究院 博士
1994-09--1997-06 沈阳药科大学 药剂学硕士
1994-09--1997-06 沈阳药科大学 药剂学硕士
工作经历
工作简历
2003-10~现在, 中科院生物物理研究所, 副研究员，研究员
2001-12~2003-10,Harvard University and Northeastern University, Research Associate
2000-11~2001-12,University of Minnesota, Postdoctoral fellow
2001-12~2003-10,Harvard University and Northeastern University, Research Associate
2000-11~2001-12,University of Minnesota, Postdoctoral fellow
社会兼职
2015-03-16-2019-03-16,中国药学会纳米药物专业委员会, 委员
2013-11-30-2017-10-31,中国生物物理学会第十届理事会, 理事
2011-06-01-今,生物物理学会分子影像学专业委员会, 副主任委员
2009-07-01-2013-06-30,生物物理学学会第九届理事会, 理事
2013-11-30-2017-10-31,中国生物物理学会第十届理事会, 理事
2011-06-01-今,生物物理学会分子影像学专业委员会, 副主任委员
2009-07-01-2013-06-30,生物物理学学会第九届理事会, 理事
教授课程
生物技术药物
SAXS在生物学中的应用
SAXS在生物学中的应用
专利与奖励
奖励信息
（1） 国家科学技术奖, 二等奖, 国家级, 2012
（2） 中国专利优秀奖, , 部委级, 2010
（3） 2009年中国科学院“优秀研究生指导教师”, , 院级, 2009
（4） 中国药学会科学技术奖，药物的新型纳米输送系统研究, 二等奖, 其他, 2008
（2） 中国专利优秀奖, , 部委级, 2010
（3） 2009年中国科学院“优秀研究生指导教师”, , 院级, 2009
（4） 中国药学会科学技术奖，药物的新型纳米输送系统研究, 二等奖, 其他, 2008
专利成果
（ 1 ） 一种PEG衍生化磷脂包载的前列腺素E1的胶束制剂, 发明, 2010, 第 1 作者, 专利号: ZL200810105113.2
（ 2 ） 聚乙二醇衍生化磷脂包载的蒽环类抗肿瘤抗生素纳米胶束制剂, 发明, 2010, 第 1 作者, 专利号: ZL200510059621.8
（ 3 ） 柚皮素和柚皮苷作为转化生长因子-β1信号通路抑制剂的应用, 发明, 2014, 第 1 作者, 专利号: 特许第5484320号
（ 4 ） Use of Naringenin and Naringin as Inhibitors for Transforming Growth Factor-β1 Signaling Pathway, 发明, 2014, 第 1 作者, 专利号: European Paten No 2163247
（ 2 ） 聚乙二醇衍生化磷脂包载的蒽环类抗肿瘤抗生素纳米胶束制剂, 发明, 2010, 第 1 作者, 专利号: ZL200510059621.8
（ 3 ） 柚皮素和柚皮苷作为转化生长因子-β1信号通路抑制剂的应用, 发明, 2014, 第 1 作者, 专利号: 特许第5484320号
（ 4 ） Use of Naringenin and Naringin as Inhibitors for Transforming Growth Factor-β1 Signaling Pathway, 发明, 2014, 第 1 作者, 专利号: European Paten No 2163247
出版信息
发表论文
[1] Li, Hao, Wang, Zihao, Fang, Xiaocui, Zeng, Wenfeng, Yang, Yanlian, Jin, Lingtao, Wei, Xiuli, Qin, Yan, Wang, Chen, Liang, Wei. Poroptosis: A form of cell death depending on plasma membrane nanopores formation. ISCIENCE[J]. 2022, 第 10 作者 通讯作者 25(6): http://dx.doi.org/10.1016/j.isci.2022.104481.
[2] Fayun Zhang, Zifeng Zheng, Apurba Kumar Barman, Zihao Wang, Luyao Wang, Wenfeng Zeng, Luoyang Wang, Yan Qin, Asmita Pandey, Chunling Zhang, Wei Liang. Optimal combination treatment regimens of vaccine and radiotherapy augment tumor-bearing host immunity. COMMUNICATIONS BIOLOGY[J]. 2021, 第 11 作者 通讯作者 4(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000613509200002.
[3] Yin, Xiaozhe, Zeng, Wenfeng, Wu, Bowen, Wang, Luoyang, Wang, Zihao, Tian, Hongjian, Wang, Luyao, Jiang, Yunhan, Clay, Ryan, Wei, Xiuli, Qin, Yan, Zhang, Fayun, Zhang, Chunling, Jin, Lingtao, Liang, Wei. PPAR alpha Inhibition Overcomes Tumor-Derived Exosomal Lipid-Induced Dendritic Cell Dysfunction. CELL REPORTS[J]. 2020, 第 15 作者 通讯作者 33(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000582719300008.
[4] Wang, Luyao, Wang, Zihao, Qin, Yan, Liang, Wei. Delivered antigen peptides to resident CD8 alpha(+) DCs in lymph node by micelle-based vaccine augment antigen-specific CD8(+) effector T cell response. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS[J]. 2020, 第 4 作者 通讯作者 147: 76-86, https://www.webofscience.com/wos/woscc/full-record/WOS:000510313900008.
[5] Wang, Luoyang, Zeng, Wenfeng, Wang, Luyao, Wang, Zihao, Yin, Xiaozhe, Qin, Yan, Zhang, Fayun, Zhang, Chunling, Liang, Wei. Naringenin Enhances the Antitumor Effect of Therapeutic Vaccines by Promoting Antigen Cross-Presentation. JOURNAL OF IMMUNOLOGY[J]. 2020, 第 9 作者 通讯作者 204(3): 622-631, https://www.webofscience.com/wos/woscc/full-record/WOS:000508649800014.
[6] Wang, Luoyang, Jiang, Guoqiang, Jing, Nan, Liu, Xuerun, Li, Qicheng, Liang, Wei, Liu, Zheng. Bilberry anthocyanin extracts enhance anti-PD-L1 efficiency by modulating gut microbiota. FOOD & FUNCTION[J]. 2020, 第 6 作者11(4): 3180-3190, https://www.webofscience.com/wos/woscc/full-record/WOS:000556523100030.
[7] Zhang, Chao, Zeng, Wenfeng, Yao, Yi, Xu, Bin, Wei, Xiuli, Wang, Luoyang, Yin, Xiaozhe, Barman, Apurba Kumar, Zhang, Fayun, Zhang, Chunling, Song, Qibin, Liang, Wei. Naringenin Ameliorates Radiation-Induced Lung Injury by Lowering IL-1 beta Level. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS[J]. 2018, 第 12 作者 通讯作者 366(2): 341-348, https://www.webofscience.com/wos/woscc/full-record/WOS:000442126300012.
[8] Guan, Xiaoyang, Chaffey, Patrick K, Wei, Xiuli, Gulbranson, Daniel R, Ruan, Yuan, Wang, Xinfeng, Li, Yaohao, Ouyang, Yan, Chen, Liqun, Zeng, Chen, Koelsch, Theo N, Tran, Amy H, Liang, Wei, Shen, Jingshi, Tan, Zhongping. Chemically Precise Glycoengineering Improves Human Insulin. ACS CHEMICAL BIOLOGY[J]. 2018, 第 13 作者 通讯作者 13(1): 73-81, https://www.webofscience.com/wos/woscc/full-record/WOS:000423252600008.
[9] Zeng WenFeng, Zhang FaYun, Du GangJun, Jin LingTao, Qin Lei, Dong WenJuan, Zhang Chao, Wang LuoYang, Yin XiaoZhe, Zhang ChunLing, Liang Wei. Research Updates on a Novel Immunomodulator, Naringenin. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2018, 第 11 作者 通讯作者 45(9): 915-925, https://www.webofscience.com/wos/woscc/full-record/WOS:000445847600003.
[10] Zeng, Wenfeng, Jin, Lingtao, Zhang, Fayun, Zhang, Chunling, Liang, Wei. Naringenin as a potential immunomodulator in therapeutics. PHARMACOLOGICAL RESEARCH. 2018, 第 5 作者 通讯作者 135: 122-126, http://dx.doi.org/10.1016/j.phrs.2018.08.002.
[11] Zeng WenFeng, Zhang FaYun, Du GangJun, Jin LingTao, Qin Lei, Dong WenJuan, Zhang Chao, Wang LuoYang, Yin XiaoZhe, Zhang ChunLing, Liang Wei. Research Updates on a Novel Immunomodulator, Naringenin. PROGRESSINBIOCHEMISTRYANDBIOPHYSICS[J]. 2018, 第 11 作者 通讯作者 45(9): 915-925, https://www.webofscience.com/wos/woscc/full-record/WOS:000445847600003.
[12] Guan, Xiaoyang, Chaffey, Patrick K, Chen, Huan, Feng, Wei, Wei, Xiuli, Yang, LiuMeng, Ruan, Yuan, Wang, Xinfeng, Li, Yaohao, Barosh, Kimberly B, Tran, Amy H, Zhu, Jaimie, Liang, Wei, Zheng, YongTang, Wang, Xu, Tan, Zhongping. O-GaINAcylation of RANTES Improves Its Properties as a Human Immunodeficiency Virus Type 1 Entry Inhibitor. BIOCHEMISTRY[J]. 2018, 第 13 作者57(1): 136-148, https://www.webofscience.com/wos/woscc/full-record/WOS:000419999100017.
[13] Han, Qiusen, Wang, Xinhuan, Jia, Xinghang, Cai, Shuangfei, Liang, Wei, Qin, Yan, Yang, Rong, Wang, Chen. CpG loaded MoS2 nanosheets as multifunctional agents for photothermal enhanced cancer immunotherapy. NANOSCALE[J]. 2017, 第 5 作者9(18): 5927-5934, http://dx.doi.org/10.1039/c7nr01460k.
[14] Liu, Zhida, Zhou, Chang, Qin, Yan, Wang, Zihao, Wang, Luyao, Wei, Xiuli, Zhou, Yinjian, Li, Qicheng, Zhou, Hang, Wang, Wenjun, Fu, YangXin, Zhu, Mingzhao, Liang, Wei. Coordinating antigen cytosolic delivery and danger signaling to program potent cross-priming by micelle-based nanovaccine. CELL DISCOVERY[J]. 2017, 第 13 作者 通讯作者 3: 17007, http://dx.doi.org/10.1038/celldisc.2017.7.
[15] Wei Liang. Naringenin Ameliorates Acute Inflammation by Regulating Intracellular Cytokine Degradatio. the Journal of Immunology. 2017, 第 1 作者 通讯作者
[16] Jin, Lingtao, Zeng, Wenfeng, Zhang, Fayun, Zhang, Chunling, Liang, Wei. Naringenin Ameliorates Acute Inflammation by Regulating Intracellular Cytokine Degradation. JOURNAL OF IMMUNOLOGY[J]. 2017, 第 5 作者 通讯作者 199(10): 3466-3477, https://www.webofscience.com/wos/woscc/full-record/WOS:000414660600008.
[17] Fang, Xiaocui, Yang, Tao, Wang, Luoyang, Yu, Jibing, Wei, Xiuli, Zhou, Yinjian, Wang, Chen, Liang, Wei. Nano-cage-mediated refolding of insulin by PEG-PE micelle. BIOMATERIALS[J]. 2016, 第 8 作者77: 139-148, http://www.corc.org.cn/handle/1471x/2176433.
[18] Fayun Zhang, Wenjuan Dong, Wenfeng Zeng, Lei Zhang, Chao Zhang, Yuqi Qiu, Luoyang Wang, Xiaozhe Yin, Chunling Zhang, Wei Liang. Naringenin prevents TGF-β1 secretion from breast cancer and suppresses pulmonary metastasis by inhibiting PKC activation. BREAST CANCER RESEARCH : BCR. 2016, 第 10 作者18: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818388/.
[19] Zhou, Yinjian, Dong, Ying, Huang, Gang, Wang, Yiguang, Huang, Xiaonan, Zhang, Fayun, Boothman, David A, Gao, Jinming, Liang, Wei. Lysosome-oriented, dual-stage pH-responsive polymeric micelles for beta-lapachone delivery. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2016, 第 9 作者 通讯作者 4(46): 7429-7440, http://dx.doi.org/10.1039/c6tb02049f.
[20] Li, Nan, Yang, Yong, He, Kangmin, Zhang, Fayun, Zhao, Libo, Zhou, Wei, Yuan, Jinghe, Liang, Wei, Fang, Xiaohong. Single-Molecule Imaging Reveals the Activation Dynamics of Intracellular Protein Smad3 on Cell Membrane. SCIENTIFIC REPORTS[J]. 2016, 第 8 作者 通讯作者 6: http://ir.iccas.ac.cn/handle/121111/35259.
[21] Tang, Haidong, Wang, Yang, Chlewicki, Lukasz K, Zhang, Yuan, Guo, Jingya, Liang, Wei, Wang, Jieyi, Wang, Xiaoxiao, Fu, YangXin. Facilitating T Cell Infiltration in Tumor Microenvironment Overcomes Resistance to PD-L1 Blockade. CANCER CELL[J]. 2016, 第 6 作者29(3): 285-296, http://dx.doi.org/10.1016/j.ccell.2016.02.004.
[22] Fayun Zhang, Wenjuan Dong, Wenfeng Zeng, Lei Zhang, Chao Zhang, Yuqi Qiu, Luoyang Wang, Xiaozhe Yin, Chunling Zhang, Wei Liang. Naringenin prevents TGF-β1 secretion from breast cancer and suppresses pulmonary metastasis by inhibiting PKC activation. BREAST CANCER RESEARCH. 2016, 第 10 作者18(1): http://dx.doi.org/10.1186/s13058-016-0698-0.
[23] Zhang, Fayun, Dong, Wenjuan, Zeng, Wenfeng, Zhang, Lei, Zhang, Chao, Qiu, Yuqi, Wang, Luoyang, Yin, Xiaozhe, Zhang, Chunling, Liang, Wei. Naringenin prevents TGF-beta 1 secretion from breast cancer and suppresses pulmonary metastasis by inhibiting PKC activation. BREAST CANCER RESEARCH[J]. 2016, 第 10 作者 通讯作者 18: http://dx.doi.org/10.1186/s13058-016-0698-0.
[24] Meng, Jie, Guo, Fangqin, Xu, Haiyan, Liang, Wei, Wang, Chen, Yang, XianDa. Combination Therapy using Co-encapsulated Resveratrol and Paclitaxel in Liposomes for Drug Resistance Reversal in Breast Cancer Cells in vivo. SCIENTIFIC REPORTS[J]. 2016, 第 4 作者6: http://www.corc.org.cn/handle/1471x/2176542.
[25] Han, Zhou, Wang, Xinhuan, Heng, Chenglin, Han, Qiusen, Cai, Shuanfei, Li, Jingying, Qi, Cui, Liang, Wei, Yang, Rong, Wang, Chen. Synergistically enhanced photocatalytic and chemotherapeutic effects of aptamer-functionalized ZnO nanoparticles towards cancer cells. PHYSICAL CHEMISTRY CHEMICAL PHYSICS[J]. 2015, 第 8 作者17(33): 21576-21582, https://www.webofscience.com/wos/woscc/full-record/WOS:000359596600064.
[26] Dong, Wenjuan, Wei, Xiuli, Zhang, Fayun, Hao, Junfeng, Huang, Feng, Zhang, Chunling, Liang, Wei. A dual character of flavonoids in influenza A virus replication and spread through modulating cell-autonomous immunity by MAPK signaling pathways. SCIENTIFIC REPORTS[J]. 2014, 第 7 作者 通讯作者 4: https://www.webofscience.com/wos/woscc/full-record/WOS:000346254800002.
[27] Wei Liang. Poly(ethylene glycol)-mediated conformational alteration of α-chymotrypsin prevents inactivation of insulin by stabilizing active intermediates. Mol Pharm. Mol Pharm. 2014, 第 1 作者 通讯作者
[28] 赵宇亮. Progress of nanoscience in China. FRONTIERS OF PHYSICS[J]. 2014, 9(3): 257-288, http://ir.ihep.ac.cn/handle/311005/225016.
[29] Yu, Jibing, Wei, Xiuli, Zhang, Li, Fang, Xiaocui, Yang, Tao, Huang, Feng, Liang, Wei. Poly(ethylene glycol)-Mediated Conformational Alteration of alpha-Chymotrypsin Prevents Inactivation of Insulin by Stabilizing Active Intermediates. MOLECULAR PHARMACEUTICS[J]. 2014, 第 7 作者11(10): 3361-3370, http://dx.doi.org/10.1021/mp500001n.
[30] 张发云, 秦蕾, 梁伟. 活体自发光成像监测长春瑞滨纳米胶束抗乳腺癌转移机制研究. 中国肿瘤临床[J]. 2014, 第 3 作者41(1): 13-17, http://lib.cqvip.com/Qikan/Article/Detail?id=48353473.
[31] Yi, Cunjian, Zhang, Lei, Zhang, Fayun, Li, Li, Ling, Shengrong, Wang, Xiaowen, Liu, Xiangqiong, Liang, Wei. Methodologies for the establishment of an orthotopic transplantation model of ovarian cancer in mice. FRONTIERS OF MEDICINE[J]. 2014, 第 8 作者8(1): 101-105, https://www.webofscience.com/wos/woscc/full-record/WOS:000209571500013.
[32] Zhou, Yinjian, Zhang, Chunling, Liang, Wei. Development of RNAi technology for targeted therapy - A track of siRNA based agents to RNAi therapeutics. JOURNAL OF CONTROLLED RELEASE[J]. 2014, 第 3 作者 通讯作者 193: 270-281, http://dx.doi.org/10.1016/j.jconrel.2014.04.044.
[33] Yi, Cunjian, Zhang, Lei, Li, Li, Liu, Xiangqiong, Ling, Shengrong, Zhang, Fayun, Liang, Wei. Establishment of an orthotopic transplantation tumor model in nude mice using a drug-resistant human ovarian cancer cell line with a high expression of c-Kit. ONCOLOGY LETTERS[J]. 2014, 第 7 作者8(6): 2611-2615, https://www.webofscience.com/wos/woscc/full-record/WOS:000345948600050.
[34] Qin, Lei, Zhang, Fayun, Lu, Xiaoyan, Wei, Xiuli, Wang, Jing, Fang, Xiaocui, Si, Duanyun, Wang, Yiguang, Zhang, Chunling, Yang, Rong, Liu, Changxiao, Liang, Wei. Polymeric micelles for enhanced lymphatic drug delivery to treat metastatic tumors. JOURNAL OF CONTROLLED RELEASE[J]. 2013, 第 12 作者171(2): 133-142, http://dx.doi.org/10.1016/j.jconrel.2013.07.005.
[35] Zhang, Min, Mao, Xiaobo, Wang, Chenxuan, Zeng, Wenfeng, Zhang, Chunling, Li, Zhongjun, Fang, Ying, Yang, Yanlian, Liang, Wei, Wang, Chen. The effect of graphene oxide on conformation change, aggregation and cytotoxicity of HIV-1 regulatory protein (Vpr). BIOMATERIALS[J]. 2013, 第 9 作者34(4): 1383-1390, http://dx.doi.org/10.1016/j.biomaterials.2012.10.067.
[36] Wang, Jing, Xing, Xueqing, Fang, Xiaocui, Zhou, Chang, Huang, Feng, Wu, Zhonghua, Lou, Jizhong, Liang, Wei. Cationic amphiphilic drugs self-assemble to the core-shell interface of PEGylated phospholipid micelles and stabilize micellar structure. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES[J]. 2013, 第 8 作者371(2000): http://ir.ihep.ac.cn/handle/311005/224718.
[37] Zeng, Wenfeng, Yan, Yan, Zhang, Fayun, Zhang, Chunling, Liang, Wei. Chrysin promotes osteogenic differentiation via ERK/MAPK activation. PROTEIN & CELL[J]. 2013, 第 5 作者4(7): 539-547, http://www.irgrid.ac.cn/handle/1471x/756659.
[38] Yan, Yan, Zeng, Wenfeng, Song, Shujun, Zhang, Fayun, He, Wenxi, Liang, Wei, Niu, Zhongying. Vitamin C induces periodontal ligament progenitor cell differentiation via activation of ERK pathway mediated by PELP1. PROTEIN & CELL[J]. 2013, 第 6 作者 通讯作者 4(8): 620-627, http://www.irgrid.ac.cn/handle/1471x/756664.
[39] Wei XiuLi, Liang Wei. Nanostructrue and Function of PEGylated Phospholipid Micelles Encapsulation Drugs. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2013, 第 2 作者 通讯作者 40(10): 948-954, https://www.webofscience.com/wos/woscc/full-record/WOS:000326312500007.
[40] Wei XiuLi, Liang Wei. Nanostructrue and Function of PEGylated Phospholipid Micelles Encapsulation Drugs. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2013, 第 2 作者 通讯作者 40(10): 948-954, https://www.webofscience.com/wos/woscc/full-record/WOS:000326312500007.
[41] Zhang, Fayun, Shan, Liang, Liu, Yuanyi, Neville, David, Woo, JungHee, Chen, Yue, Korotcov, Alexandru, Lin, Stephen, Huang, Sophia, Sridhar, Rajagopalan, Liang, Wei, Wang, Paul C. An Anti-PSMA Bivalent Immunotoxin Exhibits Specificity and Efficacy for Prostate Cancer Imaging and Therapy. ADVANCED HEALTHCARE MATERIALS[J]. 2013, 第 11 作者2(5): 736-744, http://www.irgrid.ac.cn/handle/1471x/756512.
[42] Wang, Jing, Wang, Yiguang, Liang, Wei. Delivery of drugs to cell membranes by encapsulation in PEG-PE micelles. JOURNAL OF CONTROLLED RELEASE[J]. 2012, 第 3 作者 通讯作者 160(3): 637-651, http://dx.doi.org/10.1016/j.jconrel.2012.02.021.
[43] Wang, Jing, Fang, Xiaocui, Liang, Wei. Pegylated Phospholipid Micelles Induce Endoplasmic Reticulum-Dependent Apoptosis of Cancer Cells but not Normal Cells. ACS NANO[J]. 2012, 第 3 作者 通讯作者 6(6): 5018-5030, http://www.irgrid.ac.cn/handle/1471x/756882.
[44] Dong WenJuan, Zhou YinJian, Liang Wei. Lipid-based siRNA Delivery Systems. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2012, 第 3 作者 通讯作者 39(5): 396-401, http://www.irgrid.ac.cn/handle/1471x/757024.
[45] Lou, Changjie, Zhang, Fayun, Yang, Ming, Zhao, Juan, Zeng, Wenfeng, Fang, Xiaocui, Zhang, Yanqiao, Zhang, Chunling, Liang, Wei. Naringenin Decreases Invasiveness and Metastasis by Inhibiting TGF-beta-Induced Epithelial to Mesenchymal Transition in Pancreatic Cancer Cells. PLOS ONE[J]. 2012, 第 9 作者7(12): http://dx.doi.org/10.1371/journal.pone.0050956.
[46] Li, Ruixing, Fan, Huirong, Gu, Yuan, Si, Duanyun, Liang, Wei. Determination of Boc5 in Rat Plasma by HPLC-MS/MS and Its Application to a Pharmacokinetic Study. CHROMATOGRAPHIA[J]. 2012, 第 5 作者75(13-14): 721-727, http://www.irgrid.ac.cn/handle/1471x/756768.
[47] Dong WenJuan, Zhou YinJian, Liang Wei. Lipid-based siRNA Delivery Systems. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2012, 第 3 作者 通讯作者 39(5): 396-401, http://www.irgrid.ac.cn/handle/1471x/757024.
[48] Wei, Xiuli, Wang, Yiguang, Zeng, Wenfeng, Huang, Feng, Qin, Lei, Zhang, Chunling, Liang, Wei. Stability Influences the Biodistribution, Toxicity, and Anti-tumor Activity of Doxorubicin Encapsulated in PEG-PE Micelles in Mice. PHARMACEUTICAL RESEARCH[J]. 2012, 第 7 作者29(7): 1977-1989, http://www.irgrid.ac.cn/handle/1471x/756932.
[49] Han, Qiusen, Yang, Rong, Li, Jingying, Liang, Wei, Zhang, Ying, Dong, Mingdong, Besenbacher, Flemming, Wang, Chen. Enhancement of biological activities of nanostructured hydrophobic drug species. NANOSCALE[J]. 2012, 第 4 作者4(6): 2078-2082, http://www.irgrid.ac.cn/handle/1471x/756785.
[50] Tiewei Wang, Chunling Zhang, Xing-Jie Liang, Wei Liang, Yan Wu. Hydroxypropyl-β-Cyclodextrin Copolymers and Their Nanoparticles as Doxorubicin Delivery System. JOURNAL OF PHARMACEUTICAL SCIENCES. 2011, 第 4 作者100(3): 1067-1079, http://dx.doi.org/10.1002/jps.22352.
[51] Yang, Yong, Xu, Yongchun, Xia, Tie, Chen, Fangjin, Zhang, Chunling, Liang, Wei, Lai, Luhua, Fang, Xiaohong. A single-molecule study of the inhibition effect of Naringenin on transforming growth factor-beta ligand-receptor binding. CHEMICAL COMMUNICATIONS[J]. 2011, 第 6 作者47(19): 5440-5442, http://www.irgrid.ac.cn/handle/1471x/757315.
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[52] Wang, Tiewei, Zhang, Chunling, Liang, XingJie, Liang, Wei, Wu, Yan. Hydroxypropyl-beta-Cyclodextrin Copolymers and Their Nanoparticles as Doxorubicin Delivery System. JOURNAL OF PHARMACEUTICAL SCIENCES[J]. 2011, 第 4 作者100(3): 1067-1079, http://www.irgrid.ac.cn/handle/1471x/757398.
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[54] Wang, Jing, Qu, Hui, Jin, Lingtao, Zeng, Wenfeng, Qin, Lei, Zhang, Fayun, Wei, Xiuli, Lu, Wanliang, Zhang, Chunling, Liang, Wei. Pegylated Phosphotidylethanolamine Inhibiting P-Glycoprotein Expression and Enhancing Retention of Doxorubicin in MCF7/ADR Cells. JOURNAL OF PHARMACEUTICAL SCIENCES[J]. 2011, 第 10 作者 通讯作者 100(6): 2267-2277, http://dx.doi.org/10.1002/jps.22461.
[55] 张发云, 陈萍, 梁伟. 活体光学成像技术在TGF-β1信号通路调控乳腺癌转移作用中的应用. 生物物理学报[J]. 2011, 第 3 作者27(11): 907-913, http://lib.cqvip.com/Qikan/Article/Detail?id=40126179.
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[57] Lu, Xiaoyan, Zhang, Fayun, Qin, Lei, Xiao, Fengying, Liang, Wei. Polymeric micelles as a drug delivery system enhance cytotoxicity of vinorelbine through more intercellular accumulation. DRUG DELIVERY[J]. 2010, 第 5 作者 通讯作者 17(4): 255-262, http://www.irgrid.ac.cn/handle/1471x/757162.
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发表著作
（ 1 ） 药用生物纳米材料, Biological and Pharmaceutical Nanomaterials, 科学出版社, 2009-09, 第 1 作者
科研活动
科研项目
（ 1 ） 纳米材料的自组装及其在生物体内转运机制的研究, 主持, 国家级, 2008-12--2011-12
（ 2 ） 纳米药物的临床安全性和有效性评价, 主持, 部委级, 2014-07--2018-06
（ 3 ） YPS345治疗放化疗引起的肺损伤的合作开发, 主持, 院级, 2016-05--2019-12
（ 2 ） 纳米药物的临床安全性和有效性评价, 主持, 部委级, 2014-07--2018-06
（ 3 ） YPS345治疗放化疗引起的肺损伤的合作开发, 主持, 院级, 2016-05--2019-12
参与会议
（1）PEG-PE micelle based vaccine for treatment of HPV positive cervical carcinoma 2016-04-20
（2）PEG-PE micelle mediated refolding of insulin 2015年中国药物制剂大会 2015-09-26
（3）基于聚合物胶束的生物大分子药物纳米输送系统 2013年中国药物制剂大会 2013-10-26
（4）Fast crossing cell membrane of doxorubicin by encapsulated into PEG-PE micelles 的第十一次全国暨第二次国际膜生物学研讨会 Jiang Wang, Wei Liang 2010-11-09
（2）PEG-PE micelle mediated refolding of insulin 2015年中国药物制剂大会 2015-09-26
（3）基于聚合物胶束的生物大分子药物纳米输送系统 2013年中国药物制剂大会 2013-10-26
（4）Fast crossing cell membrane of doxorubicin by encapsulated into PEG-PE micelles 的第十一次全国暨第二次国际膜生物学研讨会 Jiang Wang, Wei Liang 2010-11-09
指导学生
已指导学生
张玲 02 19184
曲卉 02 19183
唐宁 01 19183
陆晓燕 01 19184
金凌涛 01 19184
秦蕾 01 19184
曾文峰 01 19184
王静 01 19184
方小翠 01 19182
于继兵 01 19182
周畅 01 19182
现指导学生
张超 01 19182
尹晓哲 02 19183
路路 02 63228
王洛洋 01 19182
杨韬 01 19182
李浩 02 19182
郑楠 02 19182
王路瑶 01 19182
王子昊 01 19182
郑子峰 02 19182
何奕霏 02 19182