基本信息
胡志远 男 博导 国家纳米科学中心
电子邮件: huzy@nanoctr.cn
通信地址: 北京市海淀区中关村北一条11号
邮政编码: 100190
电子邮件: huzy@nanoctr.cn
通信地址: 北京市海淀区中关村北一条11号
邮政编码: 100190
研究领域
胡志远课题组研究方向为新型纳米材料和纳米技术在生物医学上的应用,重点探索疾病标志物的发现及临床应用,尤其在精准医疗方面。
主要的研究方向为:
1)肿瘤多肽探针筛选和循环肿瘤细胞的纳米检测;
2)微流控单细胞操控和分子分析。
其它研究包括蛋白诊断芯片、肿瘤免疫治疗和蛋白质组学研究。
主要的研究方向为:
1)肿瘤多肽探针筛选和循环肿瘤细胞的纳米检测;
2)微流控单细胞操控和分子分析。
其它研究包括蛋白诊断芯片、肿瘤免疫治疗和蛋白质组学研究。
招生信息
招生专业
071010-生物化学与分子生物学100214-肿瘤学
招生方向
纳米生物学蛋白质组学转化医学
教育背景
2000-04--2005-04 美国约翰霍普金斯大学 生物化学博士1990-09--1995-06 复旦大学 遗传学本科
学历
研究生
学位
博士
工作经历
工作简历
2010-12~现在, 国家纳米科学中心, 研究员2007-04~2010-11,美国系统生物学研究所, 研究科学家2006-04~2007-04,美国系统生物学研究所, 博士后2005-04~2006-04,美国约翰霍普金斯大学, 博士后1995-06~1999-12,军事医学科学院, 实习研究员
社会兼职
2012-02-01-2015-01-01,广州华南生物芯片研究中心专家顾问委员会委员,
2011-11-01-2016-10-31,华东理工大学兼职教授,
2010-10-01-2014-09-30,美国FDA免疫学仪器专家委员会, 投票委员
2011-11-01-2016-10-31,华东理工大学兼职教授,
2010-10-01-2014-09-30,美国FDA免疫学仪器专家委员会, 投票委员
教授课程
纳米生物技术
专利与奖励
奖励信息
(1) 中国科学院北京分院2016年度科技成果转化奖, 二等奖, 院级, 2016(2) “医疗合伙人”创新合作方案大赛总决赛医疗技术类, 一等奖, 国家级, 2016(3) 中科创赛, 一等奖, 国家级, 2016(4) 中国创新创业大赛新材料行业团队一等奖, 一等奖, 国家级, 2015(5) “纳米之星”首届新材料主题赛, 一等奖, 国家级, 2015(6) “众创杯”北京创新创业大赛新材料主题赛, 一等奖, 市地级, 2015(7) 黑马大赛全球新材料行业总决赛, 一等奖, 国家级, 2015(8) 中国人民解放军科学技术进步奖, 二等奖, 省级, 1997
专利成果
[1] 胡志远, 王子华, 孙梦琦. 一种靶向Aβ42纤维体的类肽及其制备方法与应用. CN: CN113929744A, 2022-01-14.[2] 于志颖, 王子华, 傅林萍, 钱怡霞, 王蔚芝, 胡志远. 靶向DDR2的多肽及其应用. CN: CN111548419B, 2021-11-16.[3] 胡志远, 范林洋, 王子华. 用于检测CLDN18.2基因表达的分子探针及检测方法. CN: CN110331199A, 2019-10-15.[4] 胡志远. 一种靶向PD-L1的多肽及其应用. CN: CN114163495A, 2022-03-11.[5] 胡志远, 钱怡霞, 王蔚芝, 王月华. 一种靶向PD-L1的共价多肽抑制剂及其制备方法和应用. CN: CN112028982B, 2022-02-08.[6] 胡志远, 钱怡霞. 一种靶向PD-L1的多肽及其应用. CN: CN114163496B, 2023-08-08.[7] 胡志远. 一种靶向PD-L1的多肽及其应用. CN: CN114031670B, 2023-08-08.[8] 胡志远. 一种靶向PD-L1的多肽及其应用. CN: CN114031670A, 2022-02-11.[9] 胡志远. 一种靶向PD-L1的多肽及其应用. CN: CN114163495B, 2023-08-08.[10] 胡志远, 钱怡霞. 一种靶向PD-L1的多肽及其应用. CN: CN114163497B, 2023-08-08.[11] 胡志远, 钱怡霞. 一种靶向PD-L1的多肽及其应用. CN: CN114163498B, 2023-08-08.[12] 胡志远, 钱怡霞, 王月华, 王蔚芝. 一种靶向PD-L1的多肽及其应用. CN: CN112028968B, 2022-02-08.[13] 胡志远, 钱怡霞, 王蔚芝. 一种靶向PD-L1的多肽及其制备方法和应用. CN: CN112028969B, 2022-02-01.[14] 张卫凯, 李仁, 李勤, 魏泽文, 胡志远. 用于单细胞捕获和筛选的微流控芯片及其应用. CN: CN111349541A, 2020-06-30.[15] 王月华, 钱怡霞, 王蔚芝, 胡志远. 一种靶向人N-cadherin蛋白的多肽及其应用. CN: CN109467588A, 2019-03-15.[16] 杨延莲, 高厚乾, 朱凌, 赵子健, 胡志远, 王琛. 一种类肽纳米片层、其制备方法及应用. CN: CN110818777A, 2020-02-21.[17] 王浩, 胡志远, 丛勇, 乔增莹. 一种多肽聚合物及其制备方法和应用. CN: CN110507825A, 2019-11-29.[18] 史方浩, 马艳, 张卫凯, 范林洋, 胡志远. 一种PLS3-ABD2重组蛋白的制备方法. CN: CN108611368A, 2018-10-02.[19] 岳春燕, 李仁, 马艳, 朱光宇, 胡志远. 一种检测单细胞EGFR基因突变的引物组合及其应用. CN: CN107475392A, 2017-12-15.[20] 马艳, 岳春燕, 李仁, 胡志远. PLS3重组蛋白真核表达质粒及其构建方法和应用. CN: CN107446949A, 2017-12-08.[21] 李仁, 马艳, 胡志远, 魏泽文. 用于研究肿瘤单细胞侵袭和上皮间质转化的微流控芯片. CN: CN107497503A, 2017-12-22.[22] 王子华, 胡志远. 一种肿瘤免疫治疗预测生物标志物PD‑L2靶向多肽及其应用. CN: CN107556367A, 2018-01-09.[23] 王子华, 胡志远. 一种肿瘤免疫治疗预测生物标志物PD‑L1靶向多肽及其应用. CN: CN107459559A, 2017-12-12.[24] 王子华, 王蔚芝, 胡志远. 一种靶向肿瘤干细胞标志物CD133的多肽及其应用. CN: CN107286222A, 2017-10-24.[25] 赵子健, 朱凌, 高厚乾, 刘明珠, 杨延莲, 胡志远. 一种类肽及其制备方法和应用. CN: CN106854233A, 2017-06-16.[26] 朱凌, 高厚乾, 赵子健, 杨延莲, 胡志远, 刘长亮. 一种类肽及其制备方法和应用. CN: CN106866794A, 2017-06-20.[27] 胡志远, 郑晖, 李永, 吴佳涛, 潘玉霖. 一种基于人工智能的细胞荧光图像分类方法和系统. CN: CN106650796A, 2017-05-10.[28] 王凡, 董诚岩, 胡志远, 史继云, 贾兵, 王子华, 李立强, 吴越, 刘昭飞, 赵慧云. 一种靶向HER2的新型多肽放射性药物及其制备方法和应用. CN: CN106581700A, 2017-04-26.[29] 周明行, 郑晖, 李仁, 魏泽文, 胡志远. 用于捕获和鉴定循环肿瘤细胞的微流控芯片. CN: CN106754240A, 2017-05-31.[30] 李仁, 胡志远, 魏泽文. 用于单细胞分选和单细胞全基因组扩增的微流控芯片. CN: CN106065391A, 2016-11-02.[31] 李仁, 周明行, 胡志远, 魏泽文. 用于表达EGFR的单细胞分选和多基因位点检测的微流控芯片. CN: CN106148187A, 2016-11-23.[32] 李仁, 周明行, 胡志远, 魏泽文. 用于表达EGFR的单细胞分选和多基因位点检测的微流控芯片. CN: CN206052034U, 2017-03-29.[33] 李仁, 胡志远, 魏泽文. 用于单细胞分选和单细胞全基因组扩增的微流控芯片. CN: CN206033771U, 2017-03-22.[34] 朱凌, 赵子健, 覃茂昌, 杨延莲, 胡志远. 一种类肽抑制剂、其制备方法及应用. CN: CN105753940A, 2016-07-13.[35] 钱怡霞, 王蔚芝, 王子华, 胡志远. 一种pH响应且靶向人肿瘤血管标记物VEGFR2的多肽及其应用. CN: CN105330725A, 2016-02-17.[36] 胡志远, 王子华, 王蔚芝, 钱怡霞. 一种肿瘤靶向多肽、其制备方法及应用. CN: CN105198964A, 2015-12-30.[37] 胡志远, 钟业腾, 王子华. 一种稀土上转换纳米颗粒及其制备方法和用途. CN: CN105176515A, 2015-12-23.[38] 胡志远, 覃茂昌, 赵子建, 朱凌, 郑晖. 一种自动化类肽纳米片层合成装置及其应用. CN: CN105061551A, 2015-11-18.[39] 魏泽文, 胡志远. 一种用于细胞电穿孔的微针尖阵列芯片及其应用. CN: CN104531524A, 2015-04-22.[40] 王子华, 王蔚芝, 胡志远. 一种靶向人乳腺癌细胞的多肽及其应用. CN: CN104262460A, 2015-01-07.[41] 王蔚芝, 王子华, 胡志远. 一种靶向人癌细胞的多肽及其应用. CN: CN104177476A, 2014-12-03.[42] 耿令令, 方巧君, 胡志远, 连文玺, 杨小亮. 一种特异靶向HER2蛋白的多肽. CN: CN104130315A, 2014-11-05.[43] 魏泽文, 胡志远. 一种单细胞分析用微流控芯片和系统及单细胞分析方法. CN: CN103894248A, 2014-07-02.[44] 王蔚芝, 李梦林, 魏泽文, 胡志远. 一种微腔阵列质谱靶板及其制作方法和应用. CN: CN103868982A, 2014-06-18.[45] 郑晖, 王蔚芝, 胡志远. 一种气控固相多肽合成微流控芯片装置及其应用. CN: CN103755777A, 2014-04-30.[46] 胡志远, 雷春妮. 一种人肺腺癌多药耐药细胞株、其制备方法及用途. CN: CN103627674A, 2014-03-12.[47] 胡志远, 崔健, 王坤. 一种检测液体样品中外囊体的方法. CN: CN104237168A, 2014-12-24.[48] 胡志远, 郑晖, 王蔚芝. 一种全氟聚合物微反应器及其应用. CN: CN104096526A, 2014-10-15.[49] 胡志远, 傅林萍, 王子华. 一种靶向PD-L1的多肽及其应用. CN: CN118324852A, 2024-07-12.[50] 胡志远, 王子华, 孙梦琦. 一种靶向Aβ42纤维体的类肽及其制备方法与应用. CN: CN113929744B, 2024-05-10.
出版信息
发表论文
[1] Zhou, Ying, Cai, Guoen, Wang, Yuanzhuo, Guo, Yuxin, Yang, Zhimin, Wang, Anqi, Chen, Yongshou, Li, Xuejie, Chen, Xiaochun, Hu, Zhiyuan, Wang, Zihua. Microarray Chip-Based High-Throughput Screening of Neurofilament Light Chain Self-Assembling Peptide for Noninvasive Monitoring of Alzheimer's Disease. ACS NANO[J]. 2024, 第 10 作者 通讯作者 18(28): 18160-18175, http://dx.doi.org/10.1021/acsnano.3c09642.[2] fang zhiguo, wang chenlei, Yang Jingrun , Song Zhizheng, Xie Chunyu, Ji Yu , Wang Zhongliang , Du Xiaohui , Zheng Qiang , Chen, Chunying, Hu Zhiyuan, Zhong Yeteng. Oxyhaemoglobin saturation NIR-IIb imaging for assessing cancer metabolism and predicting the response to immunotherapy. Nature Nanotechnology[J]. 2024, 第 11 作者 通讯作者 19(1): 124-130, [3] Jiang, Sujun, Cai, Guoen, Yang, Zhimin, Shi, Haoyuan, Zeng, Huajie, Ye, Qinyong, Hu, Zhiyuan, Wang, Zihua. Biomimetic Nanovesicles as a Dual Gene Delivery System for the Synergistic Gene Therapy of Alzheimer's Disease. ACS NANO[J]. 2024, 第 7 作者 通讯作者 18(18): 11753-11768, http://dx.doi.org/10.1021/acsnano.3c13150.[4] Li, Xuejie, Wang, Yuanzhuo, Yang, Qi, Song, Lele, Kang, Lei, Hu, Zhiyuan, Wang, Zihua. Microarray-Based CD38 Peptide Probe Screening for Multiple Myeloma Imaging. MOLECULAR PHARMACEUTICS[J]. 2023, 第 6 作者 通讯作者 21(1): 245-254, http://dx.doi.org/10.1021/acs.molpharmaceut.3c00808.[5] Zhou, Ying, Zhou, Jinmei, Hao, Xiaopeng, Shi, Haoyuan, Li, Xuejie, Wang, Anqi, Hu, Zhiyuan, Yang, Yanlian, Jiang, Zefei, Wang, Tao. Efficacy relevance of PD-L1 expression on circulating tumor cells in metastatic breast cancer patients treated with anti-PD-1 immunotherapy. BREAST CANCER RESEARCH AND TREATMENT[J]. 2023, 第 7 作者 通讯作者 200(2): 281-291, http://dx.doi.org/10.1007/s10549-023-06972-6.[6] Hong, Baoan, Zhang, Xuezhou, Du, Xin, Yang, Dazhi, Hu, Zhiyuan, Zhang, Xiuli, Zhang, Ning. Exploring the Potential Driver Gene Mutations That Promote Renal Cancer Cell Metastasis and Implantation Based on Circulating Tumor Cells Culture. DIAGNOSTICS[J]. 2023, 第 5 作者13(11): http://dx.doi.org/10.3390/diagnostics13111855.[7] Yang, Zhimin, Shi, Haoyuan, Cai, Guoen, Jiang, Sujun, Hu, Zhiyuan, Wang, Zihua. A Reactive Oxygen Species-Responsive Targeted Nanoscavenger to Promote Mitophagy for the Treatment of Alzheimer's Disease. SMALL[J]. 2023, 第 5 作者 通讯作者 19(42): http://dx.doi.org/10.1002/smll.202302284.[8] Wang, Mengting, Xu, Ting, Shen, Lin, Li, Jian, Zhu, Ling, Wang, Chen, Hu, Zhiyuan, Li, Ping, Yang, Yanlian, Wang, Xicheng. HER2 Expression in Circulating Tumor Cells as Prognostic and Predictive Biomarkers for Anti-HER2 Therapy in Previously Treated Metastatic Colorectal Cancer. ADVANCED THERAPEUTICS[J]. 2023, 第 7 作者 通讯作者 http://dx.doi.org/10.1002/adtp.202300044.[9] Ying Zhou, Long Wang, Lufei Chen, Wei Wu, Zhimin Yang, Yuanzhuo Wang, Anqi Wang, Sujun Jiang, Xuzhen Qin, Zucheng Ye, Zhiyuan Hu, Zihua Wang. Glioblastoma cell-derived exosomes functionalized with peptides as efficient nanocarriers for synergistic chemotherapy of glioblastoma with improved biosafety. NANO RESEARCH[J]. 2023, 第 11 作者 通讯作者 16(12): 13283-13293, http://lib.cqvip.com/Qikan/Article/Detail?id=7111405103.[10] Zhou, Ying, Guo, Yuxin, Chen, Lufei, Zhang, Xiaoli, Wu, Wei, Yang, Zhimin, Li, Xuejie, Wang, Yuanzhuo, 胡志远, Wang, Zihua. Co-delivery of phagocytosis checkpoint and STING agonist by a Trojan horse nanocapsule for orthotopic glioma immunotherapy. THERANOSTICS[J]. 2022, 第 9 作者 通讯作者 12(12): 5488-5503, http://dx.doi.org/10.7150/thno.73104.[11] Yuxin Guo, Zhiyuan Hu, Zihua Wang. Corrigendum: Recent Advances in the Application Peptide and Peptoid in Diagnosis Biomarkers of Alzheimer's Disease in Blood. FRONTIERS IN MOLECULAR NEUROSCIENCE[J]. 2022, 第 2 作者 通讯作者 15: https://doaj.org/article/90157f1315664f6da73d6d63c33e724a.[12] Zhou, Ying, Zhou, Jinmei, Xiao, Jinyi, Wang, Yuehua, Wang, Hao, Shi, Haoyuan, Yue, Chunyan, Jia, Fei, Li, Ping, Hu, Zhiyuan, Yang, Yanlian, Jiang, Zefei, Wang, Tao. Prognostic Relevance of Estrogen Receptor Status in Circulating Tumor Cells in Breast Cancer Patients Treated With Endocrine Therapy. FRONTIERS IN ONCOLOGY[J]. 2022, 第 10 作者 通讯作者 12: http://dx.doi.org/10.3389/fonc.2022.866293.[13] Jinmei Zhou, Jiangling Wu, Xiaopeng Hao, Ping Li, Huiqiang Zhang, Xuexue Wu, Jiaxin Chen, Jiawei Liu, Jinyi Xiao, Shaohua Zhang, Zefei Jiang, Yanlian Yang, Zhiyuan Hu, Tao Wang. An exploratory study on the checkout rate of circulating tumor cells and the prediction of efficacy of neoadjuvant therapy and prognosis in patients with HER-2-positive early breast cancer. FRONTIERS IN ONCOLOGY[J]. 2022, 第 13 作者 通讯作者 12: https://doaj.org/article/e96e8f7c72514b339da33c8daa3f75d9.[14] Fu, Linping, Zhang, Jianhu, Wu, Chenchen, Wang, Weizhi, Wang, Dong, Hu, Zhiyuan, Wang, Zihua. A novel PD-L1 targeting peptide self-assembled nanofibers for sensitive tumor imaging and photothermal immunotherapy in vivo. NANO RESEARCH[J]. 2022, 第 6 作者 通讯作者 15(8): 7286-7294, http://lib.cqvip.com/Qikan/Article/Detail?id=7108115790.[15] Nan, Xiaohui, Teng, Yan, Tian, Jiesheng, Hu, Zhiyuan, Fang, Qiaojun. A comprehensive assessment of the biocompatibility of Magnetospirillum gryphiswaldense MSR-1 bacterial magnetosomes in vitro and in vivo. TOXICOLOGY[J]. 2021, 第 4 作者 通讯作者 462: http://dx.doi.org/10.1016/j.tox.2021.152949.[16] Shi, Fanghao, Jia, Fei, Wei, Zewen, Ma, Yan, Fang, Zhiguo, Zhang, Weikai, Hu, Zhiyuan. A Microfluidic Chip for Efficient Circulating Tumor Cells Enrichment, Screening, and Single-Cell RNA Sequencing. PROTEOMICS[J]. 2021, 第 7 作者 通讯作者 21(3-4): https://www.webofscience.com/wos/woscc/full-record/WOS:000606935400001.[17] Huang Q, Zhang X, Hu Z. Application of Artificial Intelligence Modeling Technology Based on Multi-Omics in Noninvasive Diagnosis of Inflammatory Bowel Disease. JOURNAL OF INFLAMMATION RESEARCH[J]. 2021, 14: 1933-1943, https://doaj.org/article/fee1a9378efe4e389a78dda542c97428.[18] Liu, Tianzi, Momin, Mohetaboer, Zhou, Huiyue, Zheng, Qiwen, Fan, Fangfang, Jia, Jia, Liu, Mengyuan, Bao, Minghui, Li, Jianping, Huo, Yong, Liu, Jialin, Zhang, Yaning, Mao, Xuemei, Han, Xiao, Hu, Zhiyuan, Zeng, Changqing, Liu, Fan, Zhang, Yan. Exome-Wide Association Study Identifies East Asian-Specific Missense Variant MTHFR C136T Influencing Homocysteine Levels in Chinese Populations RH: ExWAS of tHCY in a Chinese Population. FRONTIERS IN GENETICS[J]. 2021, 第 15 作者12: http://dx.doi.org/10.3389/fgene.2021.717621.[19] Nan, Xiaohui, Lai, Wenjia, Li, Dan, Tian, Jiesheng, Hu, Zhiyuan, Fang, Qiaojun. Biocompatibility of Bacterial Magnetosomes as MRI Contrast Agent: A Long-Term In Vivo Follow-Up Study. NANOMATERIALS[J]. 2021, 第 5 作者 通讯作者 11(5): https://doaj.org/article/3db34cc631b34b26a27bbfef8a214b6f.[20] Fan, Linyang, Chong, Xiaoyi, Zhao, Minzhi, Jia, Fei, Wang, Zihua, Zhou, Ying, Lu, Xiao, Huang, Qiongrong, Li, Ping, Yang, Yanlian, Hu, Zhiyuan, Li, Qin, Zhang, Xiaotian, Shen, Lin. Ultrasensitive Gastric Cancer Circulating Tumor Cellular CLDN18.2 RNA Detection Based on a Molecular Beacon. ANALYTICAL CHEMISTRY[J]. 2021, 第 11 作者 通讯作者 93(2): 665-670, http://dx.doi.org/10.1021/acs.analchem.0c04055.[21] Jia, Fei, Wang, Yuehua, Fang, Zhiguo, Dong, Jierong, Shi, Fanghao, Zhang, Weikai, Wang, Zihua, Hu, Zhiyuan. Novel Peptide-Based Magnetic Nanoparticle for Mesenchymal Circulating Tumor Cells Detection. ANALYTICAL CHEMISTRY[J]. 2021, 第 8 作者 通讯作者 93(14): 5670-5675, http://dx.doi.org/10.1021/acs.analchem.1c00577.[22] Wang, Zihua, Sun, Mengqi, Li, Wang, Fan, Linyang, Zhou, Ying, Hu, Zhiyuan. A Novel CD133-and EpCAM-Targeted Liposome With Redox-Responsive Properties Capable of Synergistically Eliminating Liver Cancer Stem Cells. FRONTIERS IN CHEMISTRY[J]. 2020, 第 6 作者 通讯作者 8: https://doaj.org/article/fc6449c4e3fb407a8d23504c5e77e949.[23] Xiang, Zhichu, Jiang, Gexuan, Fan, Di, Tian, Jiesheng, Hu, Zhiyuan, Fang, Qiaojun. Drug-internalized bacterial swimmers for magnetically manipulable tumor-targeted drug delivery. 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ANALYTICAL CHEMISTRY[J]. 2019, 第 9 作者91(11): 7245-7253, https://www.webofscience.com/wos/woscc/full-record/WOS:000470793800041.[29] Wang, Yuehua, Wang, Zihua, Qian, Yixia, Fan, Linyang, Yue, Chunyan, Jia, Fei, Sun, Jian, Hu, Zhiyuan, Wang, Weizhi. Synergetic estrogen receptor-targeting liposome nanocarriers with anti-phagocytic properties for enhanced tumor theranostics. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2019, 第 8 作者 通讯作者 7(7): 1056-1063, https://www.webofscience.com/wos/woscc/full-record/WOS:000458659200003.[30] Xu, Jianming, Zhang, Yun, Jia, Ru, Yue, Chunyan, Chang, Lianpeng, Liu, Rongrui, Zhang, Gairong, Zhao, Chuanhua, Zhang, Yaoyue, Chen, Chunxia, Wang, Yan, Yi, Xin, Hu, Zhiyuan, Zou, Jianjun, Wang, Quanren. Anti-PD-1 Antibody SHR-1210 Combined with Apatinib for Advanced Hepatocellular Carcinoma, Gastric, or Esophagogastric Junction Cancer: An Open-label, Dose Escalation and Expansion Study. 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LAB ON A CHIP[J]. 2019, 第 7 作者 通讯作者 19(19): 3168-3178, [34] Yang, Xiaoliang, Zhang, Yan, Lai, Wenjia, Xiang, Zhichu, Tu, Bin, Li, Dan, Nan, Xiaohui, Chen, Chunying, Hu, Zhiyuan, Fang, Qiaojun. Proteomic profiling of RAW264.7 macrophage cells exposed to graphene oxide: insights into acute cellular responses. NANOTOXICOLOGY[J]. 2019, 第 9 作者 通讯作者 13(1): 35-49, https://www.webofscience.com/wos/woscc/full-record/WOS:000467971900003.[35] Ma, Yan, Lai, Wenjia, Zhao, Minzhi, Yue, Chunyan, Shi, Fanghao, Li, Ren, Hu, Zhiyuan. Plastin 3 down-regulation augments the sensitivity of MDA-MB-231 cells to paclitaxel via the p38 MAPK signalling pathway. ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY[J]. 2019, 第 7 作者 通讯作者 47(1): 685-695, https://www.webofscience.com/wos/woscc/full-record/WOS:000460101400001.[36] Gao, Houqian, Zhao, Zijian, He, Zhaohui, Wang, Huayi, Liu, Mingzhu, Hu, Zhiyuan, Cheng, Oumei, Yang, Yanlian, Zhu, Ling. 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Identifying EGFR-Expressed Cells and Detecting EGFR Multi-Mutations at Single-Cell Level by Microfluidic Chip. 纳微快报:英文版[J]. 2018, 第 10 作者148-157, http://lib.cqvip.com/Qikan/Article/Detail?id=78657879504849564849484954.[47] Qian, Yixia, Wang, Weizhi, Wang, Zihua, Jia, Xiangqian, Han, Qiuju, Rostami, Iman, Wang, Yuehua, Hu, Zhiyuan. pH-Triggered Peptide Self-Assembly for Targeting Imaging and Therapy toward Angiogenesis with Enhanced Signals. ACS APPLIED MATERIALS & INTERFACES[J]. 2018, 第 8 作者 通讯作者 10(9): 7871-7881, http://www.corc.org.cn/handle/1471x/2178098.[48] Li, Ren, Zhou, Mingxing, Yue, Chunyan, Zhang, Weikai, Ma, Yan, Peng, Hailin, Hu, Zhiyuan, Wei, Zewen. Multiple single cell screening and DNA MDA amplification chip for oncogenic mutation profiling. 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Methods Mol Biol. 2016, 第 1 作者 通讯作者 [69] Qian, Yixia, Wang, Weizhi, Wang, Zihua, Han, Qiuju, Jia, Xiangqian, Yang, Shu, Hu, Zhiyuan. Switchable probes: pH-triggered and VEGFR2 targeted peptides screening through imprinting microarray. CHEMICAL COMMUNICATIONS[J]. 2016, 第 7 作者 通讯作者 52(33): 5690-5693, http://dx.doi.org/10.1039/c6cc01302c.[70] Jia, Xiangqian, Wang, Weizhi, Han, Qiuju, Wang, Zihua, Jia, Yunhong, Hu, Zhiyuan. Micromixer Based Preparation of Functionalized Liposomes and Targeting Drug Delivery. ACS MEDICINAL CHEMISTRY LETTERS[J]. 2016, 第 6 作者 通讯作者 7(4): 429-434, http://www.corc.org.cn/handle/1471x/2176524.[71] Zhao, Minzhi, Li, Haiyun, Liu, Xiaochen, Wei, Jie, Ji, Jianguo, Yang, Shu, Hu, Zhiyuan, Wei, Shicheng. Response of Human Osteoblast to n-HA/PEEK-Quantitative Proteomic Study of Bio-effects of Nano-Hydroxyapatite Composite. SCIENTIFIC REPORTS. 2016, 第 7 作者 通讯作者 6: http://www.corc.org.cn/handle/1471x/2176545.[72] Li, LiLi, Ma, HuaiLei, Qi, GuoBin, Zhang, Di, Yu, Faquan, Hu, Zhiyuan, Wang, Hao. Pathological-Condition-Driven Construction of Supramolecular Nanoassemblies for Bacterial Infection Detection. ADVANCED MATERIALS[J]. 2016, 第 6 作者 通讯作者 28(2): 254-262, https://www.webofscience.com/wos/woscc/full-record/WOS:000367842400005.[73] Wang, Weizhi, Wang, Zihua, Bu, Xiangli, Li, Ren, Zhou, Mingxing, Hu, Zhiyuan. Discovering of Tumor-targeting Peptides using Bi-functional Microarray. ADVANCED HEALTHCARE MATERIALS[J]. 2015, 第 6 作者4(18): 2802-2808, http://www.corc.org.cn/handle/1471x/2176578.[74] Zhao, Minzhi, Li, Haiyun, Bu, Xiang Li, Lei, Chunni, Fang, Qiaojun, Hu, Zhiyuan. Quantitative Proteomic Analysis of Cellular Resistance to the Nanoparticle Abraxane. ACS NANO[J]. 2015, 第 6 作者 通讯作者 9(10): 10099-10112, http://www.corc.org.cn/handle/1471x/2176456.[75] Zhao, Minzhi, Lei, Chunni, Yang, Yadong, Bu, Xiangli, Ma, Huailei, Gong, He, Liu, Juan, Fang, Xiangdong, Hu, Zhiyuan, Fang, Qiaojun. Abraxane, the Nanoparticle Formulation of Paclitaxel Can Induce Drug Resistance by Up-Regulation of P-gp. PLOS ONE[J]. 2015, 第 9 作者10(7): http://www.corc.org.cn/handle/1471x/2176414.[76] Zhao, Zijian, Zhu, Ling, Bu, Xiangli, Ma, Huailei, Yang, Shu, Yang, Yanlian, Hu, Zhiyuan. Label-free detection of Alzheimer's disease through the ADP3 peptoid recognizing the serum amyloid-beta42 peptide. CHEMICAL COMMUNICATIONS[J]. 2015, 第 7 作者51(4): 718-721, https://www.webofscience.com/wos/woscc/full-record/WOS:000346166600025.[77] Wang, Zihua, Wang, Weizhi, Bu, Xiangli, Wei, Zewen, Geng, Lingling, Wu, Yue, Dong, Chengyan, Li, Liqiang, Zhang, Di, Yang, Shu, Wang, Fan, Lausted, Christopher, Hood, Leroy, Hu, Zhiyuan. Microarray Based Screening of Peptide Nano Probes for HER2 Positive Tumor. ANALYTICAL CHEMISTRY[J]. 2015, 第 14 作者87(16): 8367-8372, http://www.corc.org.cn/handle/1471x/2176409.[78] Geng, Lingling, Wang, Zihua, Yang, Xiaoliang, Li, Dan, Lian, Wenxi, Xiang, Zhichu, Wang, Weizhi, Bu, Xiangli, Lai, Wenjia, Hu, Zhiyuan, Fang, Qiaojun. Structure-based Design of Peptides with High Affinity and Specificity to HER2 Positive Tumors. THERANOSTICS[J]. 2015, 第 10 作者5(10): 1154-1165, https://www.webofscience.com/wos/woscc/full-record/WOS:000359472700009.[79] Zhong, Yeteng, Rostami, Iman, Wang, Zihua, Dai, Hongjie, Hu, Zhiyuan. Energy Migration Engineering of Bright Rare-Earth Upconversion Nanoparticles for Excitation by Light-Emitting Diodes. ADVANCED MATERIALS[J]. 2015, 第 5 作者27(41): 6418-+, https://www.doi.org/10.1002/adma.201502272.[80] Wang, Zihua, Wang, Weizhi, Geng, Lingling, Hu, Zhiyuan. Distinguishing of tumor cell-targeting peptide ligands through a color-encoding microarray. LAB ON A CHIP[J]. 2015, 第 4 作者15(24): 4512-4516, http://www.corc.org.cn/handle/1471x/2176431.[81] Wei, Zewen, Huang, Yuanyu, Zhao, Deyao, Hu, Zhiyuan, Li, Zhihong, Liang, Zicai. A Pliable Electroporation Patch (ep-Patch) for Efficient Delivery of Nucleic Acid Molecules into Animal Tissues with Irregular Surface Shapes. SCIENTIFIC REPORTS[J]. 2015, 第 4 作者 通讯作者 5: https://www.webofscience.com/wos/woscc/full-record/WOS:000347794900005.[82] Wang, Weizhi, Zhang, Di, Wei, Zewen, Wang, Zihua, Bu, Xiangli, Yang, Shu, Fang, Qiaojun, Hu, Zhiyuan. Label-free detection microarray for novel peptide ligands screening base on MS-SPRi combination. TALANTA[J]. 2015, 第 8 作者134: 705-711, http://dx.doi.org/10.1016/j.talanta.2014.12.012.[83] Wang, Weizhi, Wei, Zewen, Zhang, Di, Ma, Huailei, Wang, Zihua, Bu, Xiangli, Li, Menglin, Geng, Lingling, Lausted, Christopher, Hood, Leroy, Fang, Qiaojun, Wang, Hao, Hu, Zhiyuan. Rapid Screening of Peptide Probes through In Situ Single-Bead Sequencing Microarray. ANALYTICAL CHEMISTRY[J]. 2014, 第 13 作者86(23): 11854-11859, https://www.webofscience.com/wos/woscc/full-record/WOS:000345803300056.[84] Wei, Zewen, Zheng, Shuquan, Wang, Renxin, Bu, Xiangli, Ma, Huailei, Wu, Yidi, Zhu, Ling, Hu, Zhiyuan, Liang, Zicai, Li, Zhihong. A flexible microneedle array as low-voltage electroporation electrodes for in vivo DNA and siRNA delivery. LAB ON A CHIP[J]. 2014, 第 8 作者 通讯作者 14(20): 4093-4102, https://www.webofscience.com/wos/woscc/full-record/WOS:000342866400023.[85] Ma, Huailei, Ning, Jing, Jin, Xin, Mao, Chunming, Bu, Xiangli, Wang, Miao, Liu, Huan, Wang, Kun, Lausted, Christopher, Hood, Leroy, Chen, Jiankui, Hu, Zhiyuan. Betaine homocysteine methyltransferase (BHMT) as a specific and sensitive blood marker for acute liver injury. BIOMARKERS[J]. 2014, 第 12 作者 通讯作者 19(7): 578-584, http://dx.doi.org/10.3109/1354750X.2014.951880.[86] Hu, Zhiyuan, Lausted, Christopher, Yoo, Hyuntae, Yan, Xiaowei, Brightman, Amy, Chen, Jiankui, Wang, Weizhi, Bu, Xiangli, Hood, Leroy. Quantitative Liver-Specific Protein Fingerprint in Blood: A Signature for Hepatotoxicity. THERANOSTICS[J]. 2014, 第 1 作者 通讯作者 4(2): 215-228, https://www.webofscience.com/wos/woscc/full-record/WOS:000334663600008.[87] Zhiyuan Hu. Bimodal Imprint Chips for Peptide Screening: Integration of high-throughput sequencing by MS and affinity analyses by SPRi. Anal. Chem.. 2014, 第 1 作者 通讯作者 [88] Zhu, Ling, Wang, Kun, Cui, Jian, Liu, Huan, Bu, Xiangli, Ma, Huailei, Wang, Weizhi, Gong, He, Lausted, Christopher, Hood, Leroy, Yang, Guang, Hu, Zhiyuan. Label-Free Quantitative Detection of Tumor-Derived Exosomes through Surface Plasmon Resonance Imaging. ANALYTICAL CHEMISTRY[J]. 2014, 第 12 作者86(17): 8857-8864, https://www.webofscience.com/wos/woscc/full-record/WOS:000341229200050.[89] Wei, Zewen, Li, Xueming, Zhao, Deyao, Yan, Hao, Hu, Zhiyuan, Liang, Zicai, Li, Zhihong. Flow-Through Cell Electroporation Microchip Integrating Dielectrophoretic Viable Cell Sorting. ANALYTICAL CHEMISTRY[J]. 2014, 第 5 作者 通讯作者 86(20): 10215-10222, https://www.webofscience.com/wos/woscc/full-record/WOS:000343639800032.[90] Zefei Jiang, Bing Liu, Shikai Wu, Zhiyuan Hu, Sha Li, Haixu Hu, Shaohua Zhang, Li Bian, Tao Wang, Qian Liu, Yi Liu. Circulating tumor cells in HER2-positive metastatic breast cancer patients: a valuable prognostic and predictive biomarker. 2013, 第 4 作者http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201706291172673ZK.[91] Sun, Bingyun, Utleg, Angelita G, Hu, Zhiyuan, Qin, Shizhen, Keller, Andrew, Lorang, Cynthia, Gray, Li, Brightman, Amy, Lee, Denis, Alexander, Vinita M, Ranish, Jeffrey A, Moritz, Robert L, Hood, Leroy. Glycocapture-Assisted Global Quantitative Proteomics (gagQP) Reveals Multiorgan Responses in Serum Toxicoproteome. JOURNAL OF PROTEOME RESEARCH[J]. 2013, 第 3 作者12(5): 2034-2044, https://www.webofscience.com/wos/woscc/full-record/WOS:000318589000003.[92] Zheng, Hui, Wang, Weizhi, Li, Xiaojun, Wang, Zihua, Hood, Leroy, Lausted, Christopher, Hu, Zhiyuan. An automated Teflon microfluidic peptide synthesizer. LAB ON A CHIP[J]. 2013, 第 7 作者 通讯作者 13(17): 3347-3350, https://www.webofscience.com/wos/woscc/full-record/WOS:000322515200004.[93] Hui Zheng, Weizhi Wang, Xiaojun Li, Zhiyuan Hu. Automated Teflon Microfluidic Peptide Synthesizer. 2013, 第 4 作者http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=2&recid=&FileName=NMZX2013090010CJ&DbName=IPFD9914&DbCode=IPFD&yx=&pr=&URLID=&bsm=.[94] Kun Wang, Yuhang Wan, Zheng Zheng, Fuchu He, Zhiyuan Hu, Jinsong Zhu. A novel refractive index detection method in voltage scanning surface plasmon resonance system. SENSORS & ACTUATORS: B. CHEMICAL. 2012, 第 5 作者169: 393-396, http://dx.doi.org/10.1016/j.snb.2011.12.030.[95] Raz, Sabina Rebe, Bremer, Maria G E G, Haasnoot, Willem, Norde, Willem. Label-Free and Multiplex Detection of Antibiotic Residues in Milk Using Imaging Surface Plasmon Resonance-Based Immunosensor. ANALYTICAL CHEMISTRY[J]. 2009, 81(18): 7743-7749, https://www.webofscience.com/wos/woscc/full-record/WOS:000269656700028.[96] Zhiyuan Hu. Circulating microRNAs, a new class of blood biomarker for drug- induced liver injury. Proc. Natl. Acad. Sci. U S A.. 2009, 第 1 作者 通讯作者 [97] Lausted, Christopher, Hu, Zhiyuan, Hood, Leroy. Quantitative Serum Proteomics from Surface Plasmon Resonance Imaging. MOLECULAR & CELLULAR PROTEOMICS[J]. 2008, 第 2 作者7(12): 2464-2474, http://dx.doi.org/10.1074/mcp.M800121-MCP200.[98] Hu, Zhiyuan, Hood, Leroy, Tan, Oiang. Quantitative proteomic approaches for biomarker discovery. PROTEOMICS CLINICAL APPLICATIONS. 2007, 第 1 作者1(9): 1036-1041, https://www.webofscience.com/wos/woscc/full-record/WOS:000249635500010.[99] Dowell, P, Hu, ZY, Lane, MD. Monitoring energy balance: Metabolites of fatty acid synthesis as hypothalamic sensors. ANNUAL REVIEW OF BIOCHEMISTRY. 2005, 74: 515-534, https://www.webofscience.com/wos/woscc/full-record/WOS:000231235100018.[100] Zhiyuan Hu. Effect of centrally-administered C75, a FAS inhibitor, on ghrelin secretion and its downstream effects. Proc. Natl. Acad. Sci. U S A.. 2005, 第 1 作者[101] Lane, MD, Hu, Z, Cha, SH, Dai, Y, Wolfgang, M, Sidhaye, A. Role of malonyl-CoA in the hypothalamic control of food intake and energy expenditure. BIOCHEMICAL SOCIETY TRANSACTIONS[J]. 2005, 33: 1063-1067, https://www.webofscience.com/wos/woscc/full-record/WOS:000233378200042.[102] Zhiyuan Hu. Centrally administered C75, a fatty acid synthase inhibitor, rapidly activates fatty acid oxidation in skeletal muscle. Proc. Natl. Acad. Sci. U S A.. 2005, 第 1 作者[103] Hu, ZY, Cha, SH, Chohnan, S, Lane, MD. Hypothalamic malonyl-CoA as a mediator of feeding behavior. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2003, 100(22): 12624-12629, https://www.webofscience.com/wos/woscc/full-record/WOS:000186301100023.
科研活动
科研项目
( 1 ) 中科院“****”, 主持, 部委级, 2011-01--2013-12( 2 ) 蛋白质组国家重点实验室项目, 主持, 国家级, 2009-12--2012-12( 3 ) 科技部国际合作项目, 参与, 国家级, 2011-03--2014-02( 4 ) 973, 参与, 国家级, 2011-01--2015-12( 5 ) 单细胞精确操控与基因组测序新方法在肿瘤防治中的应用研究, 参与, 国家级, 2015-01--2017-12( 6 ) 纳米肽材料高通量合成中试技术开发, 主持, 省级, 2014-01--2015-12( 7 ) 识别循环肿瘤细胞的类肽纳米片层研究, 主持, 国家级, 2015-01--2016-12( 8 ) 利用高通量SPR微阵列芯片对类肽-蛋白亲和作用的研究, 主持, 国家级, 2013-01--2016-12( 9 ) 基于微流控结构的高通量多肽合成技术平台, 主持, 部委级, 2013-01--2014-12( 10 ) 多肽-纳米磁珠材料中试工艺研究, 主持, 省级, 2017-01--2018-12( 11 ) 基于微纳技术的循环肿瘤细胞分子诊断技术、设备及应用, 主持, 部委级, 2017-05--2019-05
参与会议
(1)微流控芯片高通量多肽筛选和鉴定 第八届中国蛋白质组学大会蛋白质组学支撑技术分会 2013-09-08(2)SPRi芯片定量检测纳米外囊体 2013中国国际纳米科学技术会议 2013-09-05(3)Protein Microarray for Biomarker Discovery 中国蛋白质组学大会 Hu Zhiyuan 2011-04-15(4)Quantitative Liver-specific Blood Protein Fingerprint A Signature for Hepatotoxicity 世界药学联合会年会 Hu Zhiyuan 2010-06-15(5)Novel Protein Markers and Platforms 美国肝病学会年会 Hu Zhiyuan 2010-03-24(6)Surface Plasmon Resonance Imaging (SPRI) Protein Microarray 中国蛋白质组学大会 Hu Zhiyuan 2009-07-28(7)Surface Plasmon Resonance Imaging (SPRI) Antibody Array in Biomarker Discovery 国际抗体大会 Hu Zhiyuan 2009-05-22(8)A Protein Chip for Hepatotoxicity 世界药学联合会年会 Hu Zhiyuan 2008-05-14(9)A panel of liver specific blood biomarkers 临床前安全评价联盟会议 Hu Zhiyuan 2008-03-01(10)Quantitative Proteomics by Surface Plasmon Resonance Based Antibody Microarrays 第一届国际毒理基因组学研讨会 Hu Zhiyuan 2007-10-25(11)Selected Serum Proteome Analyses of Drug Induced Liver Injury by Surface Plasmon Resonance Antibody Microarray 美国蛋白质组大会 Hu Zhiyuan 2007-03-05
合作情况
项目协作单位
美国系统生物学研究所
北京蛋白质组学研究中心
指导学生
已指导学生
马怀雷 博士研究生 070304-物理化学
雷春妮 硕士研究生 071011-生物物理学
郑晖 博士研究生 070304-物理化学
王子华 博士研究生 070304-物理化学
赵子健 博士研究生 070304-物理化学
现指导学生
李仁 博士研究生 070304-物理化学
丛勇 硕士研究生 071011-生物物理学
岳春燕 博士研究生 0703J1-纳米科学与技术
史方浩 硕士研究生 0710J1-纳米科学与技术
贾斐 博士研究生 0703J1-纳米科学与技术
钱怡霞 博士研究生 0703J1-纳米科学与技术
方治国 硕士研究生 085238-生物工程
胡志远课题组网页链接
http://www.nanoctr.cn/huzhiyuan/ktzjj/