应用液体核磁共振研究蛋白质动态结构、相互作用和功能机制。

主要研究方向：

1. G蛋白偶联受体（GPCR）信号通路蛋白质的动态结构、相互作用和功能机制；

2. 蛋白质无序结构的动态研究和功能分析

   

070302-分析化学

生物大分子核磁共振

2005-09--2010-07   北京大学   博士
2001-09--2005-07   北京大学   学士

   

2019-06~现在, 中国科学院武汉精密测量科学与技术创新研究院, 研究员
2018-06~2019-06,苏州大学, 教授
2012-07~2018-06,北京大学, 副研究员
2010-07~2012-07,北京大学, 博士后

   

（1） Visualizing agonist-induced M2 receptor activation regulated by aromatic ring dynamics, Proc Natl Acad Sci U S A, 2025, 第 5 作者  通讯作者
（2） An improved cysteine-based labeling strategy for GPCR structural dynamics studies., Chem. Eur. J. , 2025, 第 5 作者  通讯作者
（3） 1H, 13C and 15N resonance assignments of the third intracellular loop of the muscarinic acetylcholine receptor M1, Biomol NMR Assign, 2025, 第 4 作者  通讯作者
（4） Structural basis for the regulation of plant transcription factor WRKY33 by the VQ protein SIB1, COMMUNICATIONS BIOLOGY, 2024, 第 11 作者  通讯作者
（5） Function and dynamics of the intrinsically disordered carboxyl terminus of beta 2 adrenergic receptor, NATURE COMMUNICATIONS, 2023, 第 2 作者
（6） Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor, NATURE COMMUNICATIONS, 2023, 第 4 作者
（7） Solution structure of the DNA binding domain of Arabidopsis transcription factor WRKY11, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2023, 第 6 作者  通讯作者
（8） Distinct activation mechanisms of β-arrestin-1 revealed by 19 F NMR spectroscopy, NATURE COMMUNICATIONS, 2023, 第 7 作者  通讯作者
（9） NMR-Based Methods for Protein Analysis, ANALYTICAL CHEMISTRY, 2021, 第 1 作者
（10） NMR assignments and characterization of the DNA-binding domain of Arabidopsis transcription factor WRKY11: Dedicated to Professor Xiuwen Han on the occasion of her 80th birthday, MAGNETIC RESONANCE LETTERS, 2021, 第 6 作者  通讯作者
（11） Analysis of β 2 AR-G s and β 2 AR-G i complex formation by NMR spectroscopy, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 第 2 作者
（12） Conformational Dynamics of the Periplasmic Chaperone SurA, BIOCHEMISTRY, 2020, 第 9 作者  通讯作者
（13） Backbone 1H, 13C and 15N resonance assignments of the proteasome lid subunit Rpn12 from Saccharomyces cerevisiae, Biomol. NMR Assign., 2020, 第 3 作者
（14） Mechanisms of Chaperones as Active Assistant/Protector for Proteins:Insights from NMR Studies, Mechanisms of Chaperones as Active Assistant/Protector for Proteins: Insights from NMR Studies, CHINESE JOURNAL OF CHEMISTRY, 2020, 第 1 作者  通讯作者
（15） Conformational Complexity and Dynamics in a Muscarinic Receptor Revealed by NMR Spectroscopy, MOLECULAR CELL, 2019, 第 2 作者
（16） Structural basis and mechanism of the unfolding-induced activation of HdeA, a bacterial acid response chaperone, JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 第 2 作者  通讯作者
（17） NMR 1H, 13C, 15N Backbone and side chain resonance assignment of the N-terminal domain of yeast proteasome lid subunit Rpn5, Biomol. NMR Assign., 2019, 第 3 作者
（18） 1H, 13C and 15N resonance assignments of the second peptidyl-prolyl isomerase domain of chaperone SurA from Escherichia coli, Biomol. NMR Assign., 2019, 第 2 作者  通讯作者
（19） Solution structure of the N-terminal domain of proteasome lid subunit Rpn5, BIOCHEMICALANDBIOPHYSICALRESEARCHCOMMUNICATIONS, 2018, 第 3 作者  通讯作者
（20） Intra- and inter-protein couplings of backbone motions underlie protein thiol-disulfide exchange cascade, SCIENTIFIC REPORTS, 2018, 第 4 作者  通讯作者
（21） Residue selective N-15 CEST and CPMG experiments for studies of millisecond timescale protein dynamics, JOURNAL OF MAGNETIC RESONANCE, 2018, 第 5 作者
（22） Characterizations of the Interactions between Escherichia coil Periplasmic Chaperone HdeA and Its Native Substrates during Acid Stress, BIOCHEMISTRY, 2017, 第 5 作者  通讯作者
（23） 枯草芽孢杆菌双精氨酸转运系统TatAy蛋白的溶液结构, Solution Structure ofBacillus subtilis Twin-Arginine Translocation TatAy Protein, 波谱学杂志, 2015, 第 1 作者
（24） Solution Structure of Yeast Rpn9: INSIGHTS INTO PROTEASOME LID ASSEMBLY, JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 第 1 作者
（25） HdeB chaperone activity is coupled to its intrinsic dynamic properties, SCIENTIFIC REPORTS, 2015, 第 4 作者  通讯作者
（26） Long-chain flavodoxin FldB from Escherichia coli, JOURNAL OF BIOMOLECULAR NMR, 2014, 第 3 作者  通讯作者
（27） Solution structure of the TatB component of the twin-arginine translocation system, BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2014, 第 3 作者  通讯作者
（28） Conformational Dynamics of Escherichia coli Flavodoxins in Apo- and Holo-States by Solution NMR Spectroscopy, PLOS ONE, 2014, 第 2 作者  通讯作者
（29） H-1, C-13 and N-15 resonance assignments of Rpn9, a regulatory subunit of 26S proteasome from Saccharomyces cerevisiae, BIOMOLECULAR NMR ASSIGNMENTS, 2014, 第 2 作者  通讯作者
（30） Structural Basis for TatA Oligomerization: An NMR Study of Escherichia coli TatA Dimeric Structure, PLOS ONE, 2014, 第 2 作者  通讯作者
（31） H-1, C-13 and N-15 resonance assignments of the VWA domain of Saccharomyces cerevisiae Rpn10, a regulatory subunit of 26S proteasome, BIOMOLECULAR NMR ASSIGNMENTS, 2014, 第 2 作者  通讯作者
（32） H-1, C-13 and N-15 resonance assignments of the apo and holo states of flavodoxin YqcA from Escherichia coli, BIOMOLECULAR NMR ASSIGNMENTS, 2014, 第 2 作者  通讯作者
（33） Chitin-Induced Dimerization Activates a Plant Immune Receptor, SCIENCE, 2012, 第 4 作者
（34） Structures of Anabaena Calcium-binding Protein CcbP: INSIGHTS INTO CA2+ SIGNALING DURING HETEROCYST DIFFERENTIATION, JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 第 1 作者
（35） Solution structure of a Plasmodium falciparum AMA-1/MSP 1 chimeric protein vaccine candidate (PfCP-2.9) for malaria, MALARIA JOURNAL, 2010, 第 2 作者
（36） NMR Characterizations of the Ice Binding Surface of an Antifreeze Protein, PLOS ONE, 2010, 第 2 作者
（37） Solution NMR Structure of the TatA Component of the Twin-Arginine Protein Transport System from Gram-Positive Bacterium Bacillus subtilis, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010, 第 1 作者
（38） Solution structure of the Escherichia cali HybE reveals a novel fold, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2009, 第 3 作者
（39） 蛋白质溶液结构及动力学的核磁共振研究, NMR Studies of Protein Solution Structures and Dynamics, 波谱学杂志, 2009, 第 1 作者
（40） Solution structure of the bacterial chemotaxis adaptor protein CheW from Escherichia coli, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 第 2 作者
（41） Lipid interaction converts prion protein to a PrPSc-like proteinase K-Resistant conformation under physiological conditions, BIOCHEMISTRY, 2007, 第 3 作者
（42） Conformational Fluctuations Coupled to the Thiol-Disulfide Transfer between Thioredoxin and Arsenate Reductase in Bacillus subtilis*, JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 第 2 作者
（43） Solution structures and backbone dynamics of a flavodoxin MioC from Escherichia coli in both apo- and holo-forms - Implications for cofactor binding and electron transfer, JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 第 1 作者
（44） A Hybrid Mechanism for the Synechocystis Arsenate Reductase Revealed by Structural Snapshots during Arsenate Reduction *, THE JOURNAL OF BIOLOGICAL CHEMISTRY, 第 6 作者

（1） Structural Disorder in Chaperone Functions Probed by NMR, The Royal Society of Chemistry, 2023-11, 第 1 作者