基本信息
胡徐智  男    中国科学院兰州化学物理研究所
电子邮件: xuzhihu@licp.cas.cn
通信地址: 甘肃省兰州市天水中路19号
邮政编码:

研究方向

胶体与界面化学

招生信息

   
招生专业
070304-物理化学
招生方向
胶体与界面化学

教育背景

2016-09--2020-11   曼彻斯特大学   博士
2015-09--2016-06   曼彻斯特大学   硕士
2011-09--2015-06   山东大学   学士

工作经历

   
工作简历
2024-01~现在, 中国科学院兰州化学物理研究所, 副研究员
2020-11~2024-01,曼彻斯特大学, 博士后
社会兼职
2022-12-01-今,国际阿斯利康抗体吸附会议, 会议秘书
2021-07-01-今,国际短肽自组装会议, 会议秘书

专利与奖励

   
奖励信息
(1) 英国卢瑟福实验室年度亮点工作, 一等奖, 研究所(学校), 2023
(2) 英国卢瑟福实验室年度亮点工作, 一等奖, 研究所(学校), 2020

出版信息

   
发表论文
[1] Gong Haoning, Wang Xiaonan, Hu Xuzhi, Liao Mingrui, Yuan, Chengqian, Lu Jianren, Gao, Lizeng, Yan Xuehai. Effective Treatment of Helicobacter pylori Infection Using Supramolecular Antimicrobial Peptide Hydrogels. Biomacromolecules[J]. 2024, 第 3 作者25(3): 1602-1611, 
[2] Mingrui Liao, Haoning Gong, Huayang Liu, Kangcheng Shen, Tianhao Ge, Stephen King, Ralf Schweins, Andrew J McBain, Xuzhi Hu, Jian R Lu. Combination of a pH-responsive peptide amphiphile and a conventional antibiotic in treating Gram-negative bacteria. JOURNAL OF COLLOID AND INTERFACE SCIENCE. 2024, 第 9 作者  通讯作者  659: 397-412, http://dx.doi.org/10.1016/j.jcis.2023.12.146.
[3] Gong, Haoning, Hu, Xuzhi, Zhang, Lin, Fa, Ke, Liao, Mingrui, Liu, Huayang, Fragneto, Giovanna, Campana, Mario, Lu, Jian Ren. How do antimicrobial peptides disrupt the lipopolysaccharide membrane leaflet of Gram-negative bacteria?. JOURNAL OF COLLOID AND INTERFACE SCIENCE[J]. 2023, 第 2 作者637: 182-192, http://dx.doi.org/10.1016/j.jcis.2023.01.051.
[4] Hu, Xuzhi, Liao, Mingrui, Ding, Ke, Wang, Jiqian, Xu, Hai, Tao, Kai, Zhou, Feng, Lu, Jian R. Neutron reflection and scattering in characterising peptide assemblies. ADVANCES IN COLLOID AND INTERFACE SCIENCE[J]. 2023, 第 1 作者322: http://dx.doi.org/10.1016/j.cis.2023.103033.
[5] Shen, Kangcheng, Hu, Xuzhi, Li, Zongyi, Liao, Mingrui, Zhuang, Zeyuan, Ruane, Sean, Wang, Ziwei, Li, Peixun, Micciulla, Samantha, Kasinathan, Narayanan, Kalonia, Cavan, Lu, Jian Ren. Competitive Adsorption of a Monoclonal Antibody and Nonionic Surfactant at the PDMS/Water Interface. MOLECULAR PHARMACEUTICS[J]. 2023, 第 2 作者20(5): 2502-2512, http://dx.doi.org/10.1021/acs.molpharmaceut.2c01099.
[6] Liao, Mingrui, Gong, Haoning, Quan, Xuebo, Wang, Ziwei, Hu, Xuzhi, Chen, Zheng, Li, Zongyi, Liu, Huayang, Zhang, Lin, McBain, Andrew J J, Waigh, Thomas A A, Zhou, Jian, Lu, Jian Ren. Intramembrane Nanoaggregates of Antimicrobial Peptides Play a Vital Role in Bacterial Killing. SMALL[J]. 2023, 第 5 作者19(3): 
[7] Xuzhi Hu, Mingrui Liao, Kangcheng Shen, Ke Ding, Mario Campana, Sophie van der Kamp, Elizabeth F McInnes, Faheem Padia, Jian R Lu. Unraveling How MembraneNanostructure Changes Impactthe Eye Irritation of Nonionic Alkyl Ethoxylate Surfactants. ACS APPLIED MATERIALS & INTERFACES. 2023, 第 1 作者15(50): 59087-59098, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10739585/.
[8] Qi, Hao, Qi, Kai, Li, Jie, He, Chunyong, Liao, Mingrui, Hu, Xuzhi, Zhao, Yurong, Ke, Yubin, Zhang, Chunqiu, Zhang, Jun, Wang, Jiqian, Lu, Jian R, Xu, Hai. The role of aromatic residues in controlling the supramolecular chirality of short amphiphilic peptides. NANO RESEARCH[J]. 2023, 第 6 作者16(10): 12230-12237, http://dx.doi.org/10.1007/s12274-023-5783-y.
[9] Zhao, Yurong, Qi, Hao, Zhang, Limin, He, Chunyong, Wei, Feng, Wang, Dong, Li, Jie, Qi, Kai, Hu, Xuzhi, Wang, Jiqian, Ke, Yubin, Zhang, Chunqiu, Lu, Jian R, Xu, Hai. Exploiting terminal charged residue shift for wide bilayer nanotube assembly. JOURNAL OF COLLOID AND INTERFACE SCIENCE[J]. 2023, 第 9 作者629: 1-10, http://dx.doi.org/10.1016/j.jcis.2022.08.104.
[10] Ge, Tianhao, Hu, Xuzhi, Liao, Mingrui, Zhou, Feng, Lu, Jian Ren. Recent advances in the development and application of peptide self-assemblies in infection control. CURRENT OPINION IN COLLOID & INTERFACE SCIENCE. 2023, 第 2 作者68: http://dx.doi.org/10.1016/j.cocis.2023.101745.
[11] Zhou, Peng, Hu, Xuzhi, Li, Jie, Wang, Yan, Yu, Henghao, Chen, Zhaoyu, Wang, Dong, Zhao, Yurong, King, Stephen M, Rogers, Sarah E, Wang, Jiqian, Lu, Jian Ren, Xu, Hai. Peptide Self-Assemblies from Unusual alpha-Sheet Conformations Based on Alternation of D/L Amino Acids. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2022, 第 2 作者144(47): 21544-21554, 
[12] Liu, Huayang, Fa, Ke, Hu, Xuzhi, Li, Zongyi, Zhang, Lin, Ma, Kun, Fragneto, Giovanna, Li, Peixun, Webster, John R P, Petkov, Jordan T, Thomas, Robert K, Lu, Jian Ren. Structural features of interfacially adsorbed acyl-L-carnitines. JOURNAL OF COLLOID AND INTERFACE SCIENCE[J]. 2022, 第 3 作者623: 368-377, http://dx.doi.org/10.1016/j.jcis.2022.05.024.
[13] Fa, Ke, Liu, Huayang, Gong, Haoning, Zhang, Lin, Liao, Mingrui, Hu, Xuzhi, Ciumac, Daniela, Li, Peixun, Webster, John, Petkov, Jordan, Thomas, Robert K, Lu, Jian Ren. In-Membrane Nanostructuring of Cationic Amphiphiles Affects Their Antimicrobial Efficacy and Cytotoxicity: A Comparison Study between a De Novo Antimicrobial Lipopeptide and Traditional Biocides. LANGMUIR. 2022, 第 6 作者38(21): 6623-6637, http://dx.doi.org/10.1021/acs.langmuir.2c00506.
[14] Hu, Xuzhi, Gong, Haoning, Liu, Huayang, Wang, Xi, Wang, Weimiao, Liao, Mingrui, Li, Zongyi, Ma, Kun, Li, Peixun, Rogers, Sarah, Schweins, Ralf, Liu, Xuqing, Padia, Faheem, Bell, Gordon, Lu, Jian R. Contrasting impacts of mixed nonionic surfactant micelles on plant growth in the delivery of fungicide and herbicide. JOURNAL OF COLLOID AND INTERFACE SCIENCE[J]. 2022, 第 1 作者618: 78-87, http://dx.doi.org/10.1016/j.jcis.2022.03.002.
[15] Liu, Huayang, Fa, Ke, Hu, Xuzhi, Li, Zongyi, Ma, Kun, Liao, Mingrui, Zhang, Lin, Schweins, Ralf, Maestro, Armando, Li, Peixun, Webster, John R P, Petkov, Jordan, Thomas, Robert K, Lu, Jian Ren. How do chain lengths of acyl-L-carnitines affect their surface adsorption and solution aggregation?. JOURNAL OF COLLOID AND INTERFACE SCIENCE[J]. 2022, 第 3 作者609: 491-502, http://dx.doi.org/10.1016/j.jcis.2021.11.056.
[16] Liu, Huayang, Hu, Xuzhi, Li, Zongyi, Fa, Ke, Gong, Haoning, Ma, Kun, Liao, Mingrui, Li, Peixun, Webster, John R P, Petkov, Jordan T, Thomas, Robert K, Lu, Jian Ren. Surface adsorption and solution aggregation of a novel lauroyl-L-carnitine surfactant. JOURNAL OF COLLOID AND INTERFACE SCIENCE[J]. 2021, 第 2 作者591: 106-114, http://dx.doi.org/10.1016/j.jcis.2021.01.106.
[17] Gong, Haoning, Hu, Xuzhi, Liao, Mingrui, Fa, Ke, Ciumac, Daniela, Clifton, Luke A, Sani, MarcAntoine, King, Stephen M, Maestro, Armando, Separovic, Frances, Waigh, Thomas A, Xu, Hai, McBain, Andrew J, Lu, Jian Ren. Structural Disruptions of the Outer Membranes of Gram-Negative Bacteria by Rationally Designed Amphiphilic Antimicrobial Peptides. ACS APPLIED MATERIALS & INTERFACES[J]. 2021, 第 2 作者13(14): 16062-16074, http://dx.doi.org/10.1021/acsami.1c01643.
[18] Liao, Mingrui, Liu, Huayang, Wang, Xi, Hu, Xuzhi, Huang, Yuhao, Liu, Xuqing, Brenan, Keith, Mecha, Jared, Nirmalan, Mahesan, Lu, Jian Ren. A technical review of face mask wearing in preventing respiratory COVID-19 transmission. CURRENT OPINION IN COLLOID & INTERFACE SCIENCE. 2021, 第 4 作者52: 101417-101417, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902177/.
[19] Zhao, Yurong, Hu, Xuzhi, Zhang, Limin, Wang, Dong, King, Stephen M, Rogers, Sarah E, Wang, Jiqian, Lu, Jian R, Xu, Hai. Monolayer wall nanotubes self-assembled from short peptide bolaamphiphiles. JOURNAL OF COLLOID AND INTERFACE SCIENCE[J]. 2021, 第 2 作者583: 553-562, http://dx.doi.org/10.1016/j.jcis.2020.09.023.
[20] Hu, Xuzhi, Gong, Haoning, Hollowell, Peter, Liao, Mingrui, Li, Zongyi, Ruane, Sean, Liu, Huayang, Pambou, Elias, Mahmoudi, Najet, Dalgliesh, Robert M, Padia, Faheem, Bell, Gordon, Lu, Jian R. What happens when pesticides are solubilised in binary ionic/zwitterionic-nonionic mixed micelles?. JOURNAL OF COLLOID AND INTERFACE SCIENCE[J]. 2021, 第 1 作者586: 190-199, http://dx.doi.org/10.1016/j.jcis.2020.10.083.
[21] Hollowell, Peter, Li, Zongyi, Hu, Xuzhi, Ruane, Sean, Kalonia, Cavan, van der Walle, Christopher F, Lu, Jian R. Recent Advances in Studying Interfacial Adsorption of Bioengineered Monoclonal Antibodies. MOLECULES. 2020, 第 3 作者25(9): https://doaj.org/article/44d1b41bc4d24bfea42125a37085f16b.
[22] Hu, Xuzhi, Liao, Mingrui, Gong, Haoning, Zhang, Lin, Cox, Henry, Waigh, Thomas A, Lu, Jian R. Recent advances in short peptide self-assembly: from rational design to novel applications. CURRENT OPINION IN COLLOID & INTERFACE SCIENCE. 2020, 第 1 作者45: 1-13, http://dx.doi.org/10.1016/j.cocis.2019.08.003.
[23] Li, Jie, Zhao, Yurong, Zhou, Peng, Hu, Xuzhi, Wang, Dong, King, Stephen M, Rogers, Sarah E, Wang, Jiqian, Lu, Jian R, Xu, Hai. Ordered Nanofibers Fabricated from Hierarchical Self-Assembling Processes of Designed alpha-Helical Peptides. SMALL[J]. 2020, 第 4 作者16(45): http://dx.doi.org/10.1002/smll.202003945.
[24] Hu, Xuzhi, Pambou, Elias, Gong, Haoning, Liao, Mingrui, Hollowell, Peter, Liu, Huayang, Wang, Weimiao, Bawn, Carlo, Cooper, Jos, Campana, Mario, Ma, Kun, Li, Peixun, Webster, John R P, Padia, Faheem, Bell, Gordon, Lu, Jian R. How does substrate hydrophobicity affect the morphological features of reconstituted wax films and their interactions with nonionic surfactant and pesticide?. JOURNAL OF COLLOID AND INTERFACE SCIENCE[J]. 2020, 第 1 作者575: 245-253, http://dx.doi.org/10.1016/j.jcis.2020.04.043.
[25] Gong, Haoning, Sani, MarcAntoine, Hu, Xuzhi, Fa, Ke, Hart, Jack William, Liao, Mingrui, Hollowell, Peter, Carter, Jessica, Clifton, Luke A, Campana, Mario, Li, Peixun, King, Stephen M, Webster, John R P, Maestro, Armando, Zhu, Shiying, Separovic, Frances, Waigh, Thomas A, Xu, Hai, McBain, Andrew J, Lu, Jian Ren. How do Self-Assembling Antimicrobial Lipopeptides Kill Bacteria?. ACS APPLIED MATERIALS & INTERFACES[J]. 2020, 第 3 作者12(50): 55675-55687, http://dx.doi.org/10.1021/acsami.0c17222.
[26] Gong, Haoning, Liao, Mingrui, Hu, Xuzhi, Fa, Ke, Phanphak, Sorasak, Ciumac, Daniela, Hollowell, Peter, Shen, Kangcheng, Clifton, Luke A, Campana, Mario, Webster, John R P, Fragneto, Giovanna, Waigh, Thomas A, McBain, Andrew J, Lu, Jian Ren. Aggregated Amphiphilic Antimicrobial Peptides Embedded in Bacterial Membranes. ACS APPLIED MATERIALS & INTERFACES[J]. 2020, 第 3 作者12(40): 44420-44432, http://dx.doi.org/10.1021/acsami.0c09931.
[27] Hu, Xuzhi, Gong, Haoning, Li, Zongyi, Ruane, Sean, Liu, Huayang, Hollowell, Peter, Pambou, Elias, Bawn, Carlo, King, Stephen, Rogers, Sarah, Ma, Kun, Li, Peixun, Padia, Faheem, Bell, Gordon, Lu, Jian Ren. How does solubilisation of plant waxes into nonionic surfactant micelles affect pesticide release?. JOURNAL OF COLLOID AND INTERFACE SCIENCE[J]. 2019, 第 1 作者556: 650-657, http://dx.doi.org/10.1016/j.jcis.2019.08.098.
[28] Cao, Meiwen, Wang, Yu, Hu, Xuzhi, Gong, Haoning, Li, Ruiheng, Cox, Henry, Zhang, Jing, Waigh, Thomas A, Xu, Hai, Lu, Jian Ren. Reversible Thermoresponsive Peptide-PNIPAM Hydrogels for Controlled Drug Delivery. BIOMACROMOLECULES[J]. 2019, 第 3 作者20(9): 3601-3610, http://dx.doi.org/10.1021/acs.biomac.9b01009.
[29] Ciumac, Daniela, Gong, Haoning, Hu, Xuzhi, Lu, Jian Ren. Membrane targeting cationic antimicrobial peptides. JOURNAL OF COLLOID AND INTERFACE SCIENCE[J]. 2019, 第 3 作者537: 163-185, http://dx.doi.org/10.1016/j.jcis.2018.10.103.
[30] Gong, Haoning, Zhang, Jing, Hu, Xuzhi, Li, Zongyi, Fa, Ke, Liu, Huayang, Waigh, Thomas A, McBain, Andrew, Lu, Jian Ren. Hydrophobic Control of the Bioactivity and Cytotoxicity of de Novo-Designed Antimicrobial Peptides. ACS APPLIED MATERIALS & INTERFACES[J]. 2019, 第 3 作者11(38): 34609-34620, http://dx.doi.org/10.1021/acsami.9b10028.
[31] Jidong Jin, Lei Wang, Zhaoliang Zheng, Jiawei Zhang, Xuzhi Hu, Jian R Lu, David Etor, Chris Pearson, Aimin Song, David Wood, Andrew J Gallant, Claudio Balocco. Metal-insulator-metal diodes based on alkyltrichlorosilane self-assembled monolayers. AIP ADVANCES[J]. 2019, 第 5 作者9(6): https://doaj.org/article/9bb2028f3c3c40319ff1868bbd927997.
[32] Hu, Xuzhi, Gong, Haoning, Li, Zongyi, Ruane, Sean, Liu, Huayang, Pambou, Elias, Bawn, Carlo, King, Stephen, Ma, Kun, Li, Peixun, Padia, Faheem, Bell, Gordon, Lu, Jian R. What happens when pesticides are solubilized in nonionic surfactant micelles. JOURNAL OF COLLOID AND INTERFACE SCIENCE[J]. 2019, 第 1 作者541: 175-182, http://dx.doi.org/10.1016/j.jcis.2019.01.056.
[33] Ruane, Sean, Li, Zongyi, Campana, Mario, Hu, Xuzhi, Gong, Haoning, Webster, John R P, Uddin, Faisal, Kalonia, Cavan, Bishop, Steven M, van Der Walle, Christopher F, Lu, Jian R. Interfacial Adsorption of a Monoclonal Antibody and Its Fab and Fc Fragments at the Oil/Water Interface. LANGMUIR[J]. 2019, 第 4 作者35(42): 13543-13552, http://dx.doi.org/10.1021/acs.langmuir.9b02317.
[34] Wang, Meng, Wang, Jiqian, Zhou, Peng, Deng, Jing, Zhao, Yurong, Sun, Yawei, Yang, Wei, Wang, Dong, Li, Zongyi, Hu, Xuzhi, King, Stephen M, Rogers, Sarah E, Cox, Henry, Waigh, Thomas A, Yang, Jun, Lu, Jian Ren, Xu, Hai. Nanoribbons self-assembled from short peptides demonstrate the formation of polar zippers between beta-sheets. NATURE COMMUNICATIONS[J]. 2018, 第 10 作者9: http://ir.wipm.ac.cn/handle/112942/13545.
[35] Pambou, Elias, Hu, Xuzhi, Li, Zongyi, Campana, Mario, Hughes, Arwel, Li, Peixun, Webster, John R P, Bell, Gordon, Lu, Jian R. Structural Features of Reconstituted Cuticular Wax Films upon Interaction with Nonionic Surfactant C12E6. LANGMUIR[J]. 2018, 第 2 作者34(11): 3395-3404, http://dx.doi.org/10.1021/acs.langmuir.8b00143.
[36] Meng Wang, Jiqian Wang, Peng Zhou, Jing Deng, Yurong Zhao, Yawei Sun, Wei Yang, Dong Wang, Zongyi Li, Xuzhi Hu, Stephen M King, Sarah E Rogers, Henry Cox, Thomas A Waigh, Jun Yang, Jian Ren Lu, Hai Xu. Nanoribbons self-assembled from short peptides demonstrate the formation of polar zippers between β-sheets. NATURE COMMUNICATIONS[J]. 2018, 第 10 作者9(1): 1-11, https://doaj.org/article/ab751f3bb7214319b08456ee2c3baa73.
[37] Zhao, Yurong, Yang, Wei, Wang, Dong, Wang, Jiqian, Li, Zongyi, Hu, Xuzhi, King, Stephen, Rogers, Sarah, Lu, Jian R, Xu, Hai. Controlling the Diameters of Nanotubes Self-Assembled from Designed Peptide Bolaphiles. SMALL[J]. 2018, 第 6 作者14(12): http://dx.doi.org/10.1002/smll.201703216.
[38] Li, Zongyi, Pan, Fang, Li, Ruiheng, Pambou, Elias, Hu, Xuzhi, Ruane, Sean, Ciumac, Daniela, Li, Peixun, Welbourn, Rebecca J L, Webster, John R P, Bishop, Steven M, Narwal, Rojaramani, van der Walle, Christopher F, Lu, Jian Ren. Coadsorption of a Monoclonal Antibody and Nonionic Surfactant at the SiO2/Water Interface. ACS APPLIED MATERIALS & INTERFACES[J]. 2018, 第 5 作者10(51): 44257-44266, http://dx.doi.org/10.1021/acsami.8b16832.
发表著作
(1) Peptide Self‐Assembly and Engineering: Fundamentals, Structures, and Applications, Wiley, 2024-04, 第 1 作者

科研活动

   
科研项目
( 1 ) 国家重点实验室专项(LICP), 负责人, 国家任务, 2024-04--2027-12
( 2 ) 绿色表面活性剂创制及其摩擦界面作用机理, 负责人, 研究所自主部署, 2024-01--2028-12
参与会议
(1)中子散射在纳米农药领域中的应用   第一届全国纳米农药研讨会   胡徐智   2024-03-29
(2)How do nonionic surfactants interact with plant wax film   11届国际胶体与界面化学会   胡徐智   2022-06-12
(3)Probing the Interactions of Surfactant Micelles with AIs and Plant Waxes   Xuzhi Hu   2022-04-24