Development of in vivo multimodality molecular imaging system for biomedical applications

Magnetic particle imaging, Cardiovascular imaging

ORCID: https://orcid.org/0000-0002-6732-4232

Magnetic Particle Imaging (MPI) R&D project: http://mpilab.net/en/

PhD 2008 - 2013

FEMTO-ST, Time Frequency Department, University of Franche-Comté (UFC), Besançon, France and School of Mechatronic Northwestern Polytechnical University (NWPU), Xi'an Shaanxi, China

Co-supervision PhD. Mechanical Engineering, September 2008 to 2013

Master 2003 - 2006

School of Construction Machinery, Chang'an University, Xi’an, Shaanxi, China

Bachelor 1999 – 2003

School of Construction Machinery, Chang'an University, Xi’an, Shaanxi, China

​Professor 2022 to Present

Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, China

Associate Professor 2016 to 2022

Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, China

Assistant Professor 2013 to 2016

Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, China

2024

• Z. Wei, Y. Liu, T. Zhu, X. Yang, J. Tian and H. Hui, "BSS-TFNet: Attention-Enhanced Background Signal Suppression Network for Time-Frequency Spectrum in Magnetic Particle Imaging," in IEEE Transactions on Emerging Topics in Computational Intelligence, vol. 8, no. 2, pp. 1322-1336, April 2024, doi: 10.1109/TETCI.2023.3337342. [PDF]
• Yaxin Shang; Jie Liu; Yanjun Liu; Yueqi Wang; Yusong Shen; Xiangjun Wu; Liwen Zhang; Hui Hui; Jie Tian, Spatial-Frequency Multi-Scale Transformer for Deblurring and Shape-Preserving Reconstruction in Magnetic Particle Imaging, in IEEE Transactions on Computational Imaging, vol. 10, pp. 196-207, 2024, doi: 10.1109/TCI.2024.3356859. [PDF]
• Pengli Gao, Yu Liu, Xiaoli Wang, Xin Feng, Heng Liu, Songlu Liu, Xiazi Huang, Xiangjun Wu, Fei Xiong, Xiaohua Jia, Hui Hui, Jingying Jiang & Jie Tian，Adhesion molecule–targeted magnetic particle imaging nanoprobe for visualization of inflammation in acute lung injury. Eur J Nucl Med Mol Imaging, 51(5), 1233-1245, 2024. https://doi.org/10.1007/s00259-023-06550-4. [PDF]

2023

1. Gen Shi; Lin Yin; Yu An; Guanghui Li; Liwen Zhang; Zhongwei Bian; Ziwei Chen; Haoran Zhang; Hui Hui; Jie Tian, Progressive Pretraining Network for 3D System Matrix Calibration in Magnetic Particle Imaging, IEEE Transactions on Medical Imaging, vol. 42, no. 12, pp. 3639-3650, Dec., 2023, doi: 10.1109/TMI.2023.3297173. [PDF]
2. Yusong Shen, Liwen Zhang, Yaxin Shang, Guang Jia, Lin Yin, Hui Zhang, Jie Tian, Guanyu Yang and Hui Hui, An Adaptive Multi-Frame Parallel Iterative Method for Accelerating Real-time Magnetic Particle Imaging Reconstruction, Physics in Medicine & Biology, 68, 245016, 2023, DOI: 10.1088/1361-6560/ad078d. [PDF]
3. Jiaxin Zhang, Zechen Wei, Xiangjun Wu, Yaxin Shang, Jie Tian, Hui Hui, Magnetic particle imaging deblurring with dual contrastive learning and adversarial framework, Computers in Biology and Medicine, Volume 165, 2023, 107461. [PDF]
4. Lin Yin, Wei Li, Zhongwei Bian, Ziwei Chen, Yanjun Liu, Jing Zhong, Shuixing Zhang, Yang Du, Hui Hui, Jie Tian, A Streamlined 3D Magnetic Particle Imaging System with A Two-stage Excitation Feed-through Compensation Strategy, IEEE Transactions on Instrumentation and Measurement, vol. 72, pp. 1-10, 2023, Art no. 4508510, doi: 10.1109/TIM.2023.3328682. [PDF]
5. Haoran Zhang; Bo Zhang; Xin Feng; Yingqian Zhang; Yundai Chen; Hui Hui; Jie Tian, Rapid Viscosity Measurement using Arbitrary Frequency Magnetic Particle Spectrometer,  IEEE Transactions on Instrumentation and Measurement, vol. 72, pp. 1-10, 2023, Art no. 6008010, doi: 10.1109/TIM.2023.3298428. [PDF]
6. Huang, X., Hui, H., Shang, W., Gao, P., Zhou, Y., Pang, W., Woo, C. M., Tian, J., Lai, P., Deep Penetrating and Sensitive Targeted Magnetic Particle Imaging and Photothermal Therapy of Early-Stage Glioblastoma Based on a Biomimetic Nanoplatform. Adv. Sci. 2023, 10, 2300854. [PDF]
7. Hui Hui, Jiaojiao Liu, Hui Zhang, Jing Zhong, Jie He, Bo Zhang, Haoran Zhang, Qin Li,Hongjun Li, and Jie Tian, In vivo measurement of cerebral SPIO concentration in nonhuman primate using magnetic particle imaging detector, IEEE Magnetics Letters, vol. 14, pp. 1-5, 2023, Art no. 8100105, doi: 10.1109/LMAG.2023.3281933. [PDF]
8. Yanjun Liu, Xin Feng, Haoran Zhang, Sijia Liu, Guanghui Li, Yu An, Hui Hui, and Jie Tian, Field-Swept Magnetic Particle Spectroscopy: A Single-Harmonic Method for Simultaneous Determination of Magnetic Nanoparticle Types and Quantities, IEEE Transactions on Magnetics, vol. 59, no. 7, pp. 1-9, July 2023, Art no. 5300109, doi: 10.1109/TMAG.2023.3279930. [PDF]
9. Xiangjun Wu , Pengli Gao, Peng Zhang, Yaxin Shang, Bingxi He, Liwen Zhang, Jingying Jiang, Hui Hui, Jie Tian. Cross-domain knowledge transfer based parallel-cascaded multi-scale attention network for limited view reconstruction in projection magnetic particle imaging. Computers in biology and medicine, 158, 106809, 2023. https://doi.org/10.1016/j.compbiomed.2023.106809. [PDF]
10. Wei Tong, Yingqian Zhang, Hui Hui, Xin Feng, Bin Ning, Tengfei Yu, Wei Wang, Yaxin Shang, Guanghao Zhang, Suhui Zhang, Feng Tian, Wen He, Yundai Chen, Jie Tian, Sensitive magnetic particle imaging of haemoglobin degradation for the detection and monitoring of intraplaque haemorrhage in atherosclerosis, eBioMedicine, Volume 90, 2023,104509, DOI: 10.1016/j.ebiom.2023.104509. [PDF]
11. Zhang, Peng and Liu, Jie and Li, Yimeng and Yin, Lin and An, Yu and Zhong, Jing and Hui, Hui and Tian, Jie, Dual-Feature Frequency Component Compression Method for Accelerating Reconstruction in Magnetic Particle Imaging, IEEE Transactions on Computational Imaging, 2023, 9, 289-297,DOI: 10.1109/TCI.2023.3255787 [PDF]
12. Huiling Peng, Zechen Wei, Yimeng Li, Tao Zhu, Tan Wang, Zhan Fan, Xin Yang, Jie Tian, Hui Hui, Multi-scale dual domain network for nonlinear magnetization signal filtering in magnetic particle imaging, Biomedical Signal Processing and Control, Volume 85, 2023,104863, DOI: 10.1016/j.bspc.2023.104863. [PDF]
13. Yaxin Shang, Jie Liu*, Yanjun Liu, Bo Zhang, Xiangjun Wu, Liwen Zhang*, Wei Tong, Hui Hui and Jie Tian*，Anisotropic edge-preserving network for resolution enhancement in unidirectional Cartesian magnetic particle imaging，Physics in Medicine & Biology, 2023, 68, Number 4. doi: 10.1088/1361-6560/acb584  [PDF]
14. Yimeng Li; Hui Hui; Peng Zhang; Jing Zhong; Lin Yin; Haoran Zhang; Bo Zhang; Yu An; Jie Tian "Modified Jiles–Atherton Model for Dynamic Magnetization in X-Space Magnetic Particle Imaging," in IEEE Transactions on Biomedical Engineering, vol. 70, no. 7, pp. 2035-2045, 2023, doi: 10.1109/TBME.2023.3234256. [PDF]
15. Jiaming Zhuo#, Yueqi Wang#, Hui Hui#, Changjian Li, Junying Yang, Peng Zhang, Chihua Fang*, Jie Tian*, Enhanced glypican-3-targeted identification of hepatocellular carcinoma with liver fibrosis by pre-degrading excess fibrotic collagen, Acta Biomaterialia, 158, 435–448, 2023, https://doi.org/10.1016/j.actbio.2022.12.062. [PDF]

2022

1. Wu X, He B, Gao P, Zhang P, Shang Y, Zhang L, Zhong J, Jiang J*, Hui H*, Tian J*. PGNet: Projection generative network for sparse-view reconstruction of projection-based magnetic particle imaging. Med Phys. 2022 Oct 14. doi: 10.1002/mp.16048. [PDF]
2. Yin L#, Li W#, Du Y, Wang K, Liu Z, Hui H*, Tian J*. Recent developments of the reconstruction in magnetic particle imaging. Vis Comput Ind Biomed Art. 2022 Oct 1;5(1):24. doi: 10.1186/s42492-022-00120-5. [PDF]
   
3. Peng Zhang, Jie Liu*, Lin Yin, Yu An, Suhui Zhang, Wei Tong, Hui Hui* and Jie Tian*. Adaptive permissible region based random Kaczmarz reconstruction method for localization of carotid atherosclerotic plaques in fluorescence molecular tomography. Physics in Medicine & Biology, Volume 67, Number 17, 175008, 2022. [PDF]
   
4. Jia G*, Huang L, Wang Z, Liang X, Zhang Y, Zhang Y, Miao Q, Hu K, Li T*, Wang Y, Xi L, Feng X, Hui H, Tian J*. Gradient-Based Pulsed Excitation and Relaxation Encoding in Magnetic Particle Imaging. IEEE Trans Med Imaging.vol. 41, no. 12, pp. 3725-3733, Dec. 2022, doi: 10.1109/TMI.2022.3193219. [PDF]
   
5. Wangting Zhou, Jiangshan He, Yu Li, Zhiyuan Sun, Jiangbo Chen, Lidai Wang, Hui Hui, and Xueli Chen*, "Multi-focus image fusion with enhancement filtering for robust vascular quantification using photoacoustic microscopy," Opt. Lett. 47, 3732-3735 (2022). [PDF]
6. Shang Y, Liu J*, Zhang L, Wu X, Zhang P, Yin L, Hui H*, Tian J*. Deep learning for improving the spatial resolution of magnetic particle imaging. Phys Med Biol. 2022, 67, 125012. doi: 10.1088/1361-6560/ac6e24. [PDF]
7. Zechen Wei, Xiangjun Wu, Wei Tong, Suhui Zhang, Xin Yang, Jie Tian*, and Hui Hui*. Elimination of stripe artifacts in light sheet fluorescence microscopy using an attention-based residual neural network. Biomedical Optics Express 2022, 13(3): 1292-1311. [PDF]
8. Xiangjun Wu#, Yingqian Zhang#, Peng Zhang#, Hui Hui#, Jing Jing, Feng Tian, Jingying Jiang, Xin Yang, Yundai Chen*, Jie Tian*. Structure attention co-training neural network for neovascularization segmentation in intravascular optical coherence tomography. Medical Physics 2022; 49(3): 1723-1738. [PDF]
9. Yusong Shen#, Chaoen Hu#, Peng Zhang, Jie Tian*, Hui Hui*. A novel software framework for magnetic particle imaging reconstruction.  International Journal of Imaging Systems and Technology 2022; 32( 4): 1119- 1132. DOI: 10.1002/ima.22707. [PDF]
10. Guanghao Zhang#, Bin Ning#, Hui Hui#, Tengfei Yu, Xin Yang, Hongxia Zhang, Jie Tian*, Wen He*. Image-to-Images Translation for Multiple Virtual Histological Staining of Unlabeled Human Carotid Atherosclerotic Tissue. Molecular Imaging and Biology volume 24, pages 31–41 (2022). [PDF]

2021

1. Tong W#, Hui H#*, Shang W#, Zhang Y#, Tian F, Ma Q, Yang X, Tian J*, Chen Y*. Highly sensitive magnetic particle imaging of vulnerable atherosclerotic plaque with active myeloperoxidase-targeted nanoparticles. Theranostics 2021; 11(2):506-521. (Back Cover) [PDF]
2. Wei Wang#, Yingqian Zhang#, Hui Hui#, Wei Tong, Zechen Wei, Zhongxuan Li, Suhui Zhang, Xin Yang, Jie Tian*, Yundai Chen*. The effect of endothelial progenitor cell transplantation on neointimal hyperplasia and reendothelialisation after balloon catheter injury in rat carotid arteries, Stem Cell Res Ther 12, 99 (2021). https://doi.org/10.1186/s13287-021-02135-w. [PDF]
3. Huanhao Li#, Chi Man Woo#, Tianting Zhong, Zhipeng Yu, Yunqi Luo, Yuanjin Zheng, Xin Yang, Hui Hui*, and Puxiang Lai*, Adaptive optical focusing through perturbed scattering media with a dynamic mutation algorithm. Photonics Research, 2021, 9(2), 202-212. [PDF]
4. Dong D#, Tang Z#, Wang S#, Hui H#, Gong L#, Lu Y#, Xue Z, Liao H, Chen F, Yang F, Jin R, Wang K, Liu Z, Wei J, Mu W, Zhang H, Jiang J, Tian J*, Li H*. The Role of Imaging in the Detection and Management of COVID-19: A Review. IEEE Rev Biomed Eng. 2021;14:16-29. doi: 10.1109/RBME.2020.2990959. (ESI Highly Cited Paper) [PDF]

2020

1. Zihao Li#, Zhipeng Yu#, Hui Hui#, Huanhao Li, Tianting Zhong, Honglin Liu, Puxiang Lai*. Edge enhancement through scattering media enabled by optical wavefront shaping. Photonics Research, 2020, 8(6):954. [PDF]

2. Xiangjun Wu#, Hui Hui#, Meng Niu#*, Liang Li#, Li Wang, Bingxi He, Xin Yang, Li Li, Hongjun Li, Jie Tian*, Yunfei Zha*, Deep learning-based multi-view fusion model for screening 2019 novel coronavirus pneumonia: A multicentre study, European Journal of Radiology, Volume 128, 2020, 109041. (ESI Highly Cited Paper) [PDF]

3. Li D#, Hui H#, Zhang Y#, Tong W, Tian F, Yang X, Liu J*, Chen Y*, Tian J*. Deep Learning for Virtual Histological Staining of Bright-Field Microscopic Images of Unlabeled Carotid Artery Tissue. Mol Imaging Biol. 2020 Oct;22(5):1301-1309. [PDF]

4. Zhang P#, Liu J*, Hui H#, An Y#, Wang K, Yang X, Tian J. Linear scheme for the direct reconstruction of noncontact time-domain fluorescence molecular lifetime tomography. Appl Opt. 2020 Sep 10;59(26):7961-7967. [PDF]

5. Wenting Shang#, Li Peng#, Pengyu Guo, Hui Hui*, Xin Yang*, Jie Tian*, Metal Organic Frameworks as a Theranostic Nanoplatform for Combinatorial Chemo-Photothermal Therapy Adapted to Different Administration, ACS Biomaterials Science &. Engineering 2020, 6, 2, 1008-1016. [PDF]

2019

1. Li T#, Hui H#, Hu C, Ma H*, Yang X*, Tian J*. Multiscale imaging of colitis in mice using confocal laser endomicroscopy, light-sheet fluorescence microscopy, and magnetic resonance imaging. J Biomed Opt. 2019 Jan;24(1):1-8. [PDF]

2017

1. Chen J#, Luo Y#, Hui H, Cai T, Huang H, Yang F, Feng J, Zhang J*, Yan X*. CD146 coordinates brain endothelial cell-pericyte communication for blood-brain barrier development. Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):E7622-E7631. [PDF]

2016

1. Ma X#, Hui H#, Jin Y, Dong D, Liang X, Yang X, Tan K, Dai Z, Cheng Z*, Tian J*. Enhanced immunotherapy of SM5-1 in hepatocellular carcinoma by conjugating with gold nanoparticles and its in vivo bioluminescence tomographic evaluation. Biomaterials. 2016 May;87:46-56. [PDF]
2. Liang X#, Zang Y#, Dong D#, Zhang L, Fang M, Yang X, Arranz A, Ripoll J, Hui H*, Tian J*. Stripe artifact elimination based on nonsubsampled contourlet transform for light sheet fluorescence microscopy. J Biomed Opt. 2016 Oct 1;21(10):106005. [PDF]

2023

Method and System for Reconstructing Magnetic Particle Distribution Model Based on Time-frequency Spectrum Enhancement, Date of Patent: 2023-11-14, Patent No.: US 11,816,767 B1,Inventor(s): Jie Tian; Zechen Wei; Hui Hui; Xin Yang; Huiling Peng ;

Non-uniform Excitation Field-based Method and System for Performing Magnetic Nanoparticle Imaging, Date of Patent：2023-10-3, Patent No.: US 11, 771, 336 B2, Inventor(s): Jie Tian; Yanjun Liu; Hui Hui; Lin Yin; Xin Feng

2021​
FFL-based Magnetic Particle Imaging Three-dimensional Reconstruction Method, System and Device, Date of Patent: 2021-03-09, Patent No.：US 10,939,845 B2, Inventor(s): Jie Tian, Peng Zhang, Hui Hui, Kun Wang, Xin Yang

Development of in vivo multimodality molecular imaging system for biomedical applications

已指导学生

王才成  硕士研究生  085211-计算机技术  

潘浩楠  硕士研究生  085211-计算机技术  

王探  硕士研究生  085400-电子信息  

彭慧玲  硕士研究生  19256  

现指导学生

张家鑫  硕士研究生  19256  

王炳烨  硕士研究生  19256  

邵致明  硕士研究生  085410-人工智能