黄胜雄 男 博导 中国科学院昆明植物研究所
办公电话: 0871-65215112
电子邮件: sxhuang@mail.kib.ac.cn
通信地址: 昆明市蓝黑路132号
办公电话: 0871-65215112
电子邮件: sxhuang@mail.kib.ac.cn
通信地址: 昆明市蓝黑路132号
邮政编码: 650201
招生信息
招生专业
100701-药物化学100705-微生物与生化药学070303-有机化学
招生方向
天然药物化学生物合成,微生物化学生物合成,合成生物学
教育背景
2004-09--2007-07 中国科学院昆明植物研究所 博士2001-09--2004-07 中国科学院成都生物研究所 硕士1997-09--2001-07 陕西师范大学 学士
工作经历
工作简历
2013-05~现在, 中国科学院昆明植物研究所, 研究员2011-01~2013-02,美国斯克利普斯研究所, 研究助理2008-03~2010-12,威斯康辛大学麦迪逊分校, 研究助理2007-09~2008-03,香港赛马会中药研究院, 研究员
专利与奖励
奖励信息
(1) 青年科技创新领军人才, 国家级, 2017(2) 五味子化学研究, 特等奖, 省级, 2014(3) 香茶菜属植物二萜及其抗癌活性研究, 一等奖, 省级, 2013
专利成果
[1] 黄胜雄, 刘阳, 王莉, 周知, 李洁, 罗剑英. 一种吡咯倍半萜类化合物及其制备方法和用途. CN: CN110357864A, 2019-10-22.[2] 黄胜雄, 纪旭, 颜一军, 杨静, 罗剑英. 一种罗博卢酮的生物合成基因簇及其应用. CN: CN106636141B, 2019-08-13.[3] 黄胜雄, 纪旭, 颜一军, 杨静, 罗剑英. 一种托酚酮类化合物及其药物组合物和其制备方法与应用. 中国: CN105585573B, 2018-04-17.[4] 黄胜雄, 汪香婷, 杨静, 杨瑞敏, 张秀磊, 颜一军. α‑吡喃酮类化合物及其药物组合物和其在制药中的应用. 中国: CN107266406A, 2017.10.20.[5] 普建新, 孙汉董, 肖伟烈, 李蓉涛, 黄胜雄. 抗肿瘤活性的化合物,其制备方法和其应用. 中国: CN101195616, 2008.06.11.[6] 普建新, 孙汉董, 肖伟烈, 李蓉涛, 黄胜雄. 具有抗肿瘤活性的化合物,其制备方法和其应用. 中国: CN100363367, 2008-01-23.
出版信息
发表论文
[1] 邓陈洁, 郭晓为, 黄胜雄, 刘兴勇. 链霉菌Kib015次级代谢产物及其抗菌活性研究. 生物化工. 2023, 第 3 作者9(2): 22-27, http://lib.cqvip.com/Qikan/Article/Detail?id=7109760124.[2] Zhiyin Yu, Jian-Ping Huang, Jing Yang, Chongxi Liu, Yijun Yan, Li Wang, Junwei Zhao, Yin Chen, Wensheng Xiang, Sheng-Xiong Huang. Discovery and biosynthesis of karnamicins as angiotensin converting enzyme inhibitors. NATURE COMMUNICATIONS[J]. 2023, 第 10 作者 通讯作者 14(1): 1-11, http://dx.doi.org/10.1038/s41467-023-35829-1.[3] Wang, Li, Zhou, Zhi, Huang, JianPing, Zhang, Liang, Tuo, Xiaotao, Yu, Zhiyin, Huang, ShengXiong, Liu, Yang, Yang, Jing. Strepyrrolins A-E, five pyrrole-sesquiterpene hybrids from Streptomyces sp. KIB 015, revealing a new formation logic of pyrroles by isotope labeling. ORGANIC CHEMISTRY FRONTIERS[J]. 2023, 第 7 作者10(4): 880-889, http://dx.doi.org/10.1039/d2qo01767a.[4] Chen, Yin, Ren, Jinqiu, Yang, Ruimin, Li, Jie, Huang, ShengXiong, Yan, Yijun. Isolation and biosynthesis of daturamycins from Streptomyces sp. KIB-H1544. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY[J]. 2022, 第 5 作者 通讯作者 18(1): 1009-1016, http://dx.doi.org/10.3762/bjoc.18.101.[5] Wang, Zhiyan, Yang, FengXian, Liu, Chongxi, Wang, Li, Qi, Yuxin, Cao, Minghang, Guo, Xiaowei, Li, Jie, Huang, Xueshuang, Yang, Jing, Huang, ShengXiong. Isolation and Biosynthesis of Phenazine-Polyketide Hybrids from Streptomyces sp. KIB-H483. JOURNAL OF NATURAL PRODUCTS[J]. 2022, 第 11 作者 通讯作者 85(5): 1324-1331, http://dx.doi.org/10.1021/acs.jnatprod.2c00067.[6] Wang, YongJiang, Huang, JianPing, Tian, Tian, Yan, Yijun, Chen, Yin, Yang, Jing, Chen, Jianghua, Gu, YuCheng, Huang, ShengXiong. Discovery and Engineering of the Cocaine Biosynthetic Pathway. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2022, 第 9 作者 通讯作者 144(48): 22000-22007, http://dx.doi.org/10.1021/jacs.2c09091.[7] Lv Yulian, Tian Tian, Wang Yongjiang, Huang Jianping, Huang Shengxiong. Advances in chemistry and bioactivity of the genus Erythroxylum. NATURAL PRODUCTS AND BIOPROSPECTING[J]. 2022, 第 5 作者 通讯作者 12(3): 1-20, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7284146&detailType=1.[8] Tian, Tian, Wang, YongJiang, Huang, JianPing, Li, Jie, Xu, Bingyan, Chen, Yin, Wang, Li, Yang, Jing, Yan, Yijun, Huang, ShengXiong. Catalytic innovation underlies independent recruitment of polyketide synthases in cocaine and hyoscyamine biosynthesis. NATURE COMMUNICATIONS[J]. 2022, 第 10 作者 通讯作者 13(1): http://dx.doi.org/10.1038/s41467-022-32776-1.[9] Yan, Yijun, Yu, Zhiyin, Zhong, Wei, Hou, Xiaodong, Tao, Qiaoqiao, Cao, Minhang, Wang, Li, Cai, Xiaofeng, Rao, Yijian, Huang, ShengXiong. Characterization of Multifunctional and Non-stereoselective Oxidoreductase RubE7/IstO, Expanding the Functional Diversity of the Flavoenzyme Superfamily. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2022, 第 10 作者 通讯作者 [10] Qiu, Fei, Yan, Yijun, Zeng, Junlan, Huang, JianPing, Zeng, Lingjiang, Zhong, Wei, Lan, Xiaozhong, Chen, Min, Huang, ShengXiong, Liao, Zhihua. Biochemical and Metabolic Insights into Hyoscyamine Dehydrogenase. ACS CATALYSIS[J]. 2021, 第 9 作者 通讯作者 11(5): 2912-2924, http://dx.doi.org/10.1021/acscatal.0c04667.[11] Li, Shanni, Zhong, Wei, Pan, Ying, Lin, Lisha, Cai, Ying, Mao, Hui, Zhang, Taocui, Li, Sujuan, Chen, Ru, Zhou, Lutan, Wang, Weili, Cui, Qinghua, Yin, Ronghua, Huang, Shengxiong, Zhao, Jinhua. Structural characterization and anticoagulant analysis of the novel branched fucosylated glycosaminoglycan from sea cucumber Holothuria nobilis. CARBOHYDRATE POLYMERS[J]. 2021, 第 14 作者 通讯作者 269: http://dx.doi.org/10.1016/j.carbpol.2021.118290.[12] Wang, Li, Yu, Zhiyin, Guo, Xiaowei, Huang, JianPing, Yan, Yijun, Huang, ShengXiong, Yang, Jing. Bisaspochalasins D and E: Two Heterocycle-Fused Cytochalasan Homodimers from an Endophytic Aspergillus flavipes. JOURNAL OF ORGANIC CHEMISTRY[J]. 2021, 第 6 作者 通讯作者 86(16): 11198-11205, http://dx.doi.org/10.1021/acs.joc.1c00425.[13] 余志银, 颜一军, 刘重喜, 黄建萍, 向文胜, 黄胜雄. 稀有放线菌Lechevalieria rhizosphaerae NEAU-A2的次级代谢产物研究及遗传操作系统的建立. 微生物学通报[J]. 2021, 第 6 作者48(7): 2318-2328, https://wswxtb.ijournals.cn/wswxtbcn/article/abstract/tb21072318?st=article_issue.[14] Yin, Ronghua, Zhou, Lutan, Gao, Na, Lin, Lisha, Sun, Huifang, Chen, Dingyuan, Cai, Ying, Zuo, Zhili, Hu, Kaifeng, Huang, Shengxiong, Liu, Jikai, Zhao, Jinhua. Unveiling the Disaccharide-Branched Glycosaminoglycan and Anticoagulant Potential of Its Derivatives. BIOMACROMOLECULES[J]. 2021, 第 10 作者 通讯作者 22(3): 1244-1255, http://dx.doi.org/10.1021/acs.biomac.0c01739.[15] Huang, JianPing, Wang, YongJiang, Tian, Tian, Wang, Li, Yan, Yijun, Huang, ShengXiong. Tropane alkaloid biosynthesis: a centennial review. NATURAL PRODUCT REPORTS[J]. 2021, 第 6 作者 通讯作者 38(9): 1634-1658, http://dx.doi.org/10.1039/d0np00076k.[16] Yu, Mingming, Luo, Jianying, Luo, Dan, He, Qiang, Yan, Yijun, Ji, Xu, Huang, ShengXiong. Discovery and heterologous production of sarubicins and quinazolinone C-glycosides with protecting activity for cardiomyocytes. ORGANIC CHEMISTRY FRONTIERS[J]. 2021, 第 7 作者 通讯作者 8(14): 3829-3837, http://dx.doi.org/10.1039/d1qo00470k.[17] Han, Chuanyu, Yu, Zhiyin, Zhang, Yuting, Wang, Zhiyan, Zhao, Junwei, Huang, ShengXiong, Ma, Zhonghua, Wen, Ziyue, Liu, Chongxi, Xiang, Wensheng. Discovery of Frenolicin B as Potential Agrochemical Fungicide for Controlling Fusarium Head Blight on Wheat. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2021, 第 6 作者69(7): 2108-2117, http://dx.doi.org/10.1021/acs.jafc.0c04277.[18] Qiu, Fei, Zeng, Junlan, Wang, Jing, Huang, JianPing, Zhou, Wei, Yang, Chunxian, Lan, Xiaozhong, Chen, Min, Huang, ShengXiong, Kai, Guoyin, Liao, Zhihua. Functional genomics analysis reveals two novel genes required for littorine biosynthesis. NEW PHYTOLOGIST[J]. 2020, 第 9 作者 通讯作者 225(5): 1906-1914, http://dx.doi.org/10.1111/nph.16317.[19] Wang, Li, Yang, Jing, Huang, JianPing, Li, Jie, Luo, Jianying, Yan, Yijun, Huang, ShengXiong. Bisaspochalasins A-C: Three Cytochalasan Homodimers with Highly Fused Ring System from an Endophytic Aspergillus flavipes. ORGANIC LETTERS[J]. 2020, 第 7 作者 通讯作者 22(20): 7930-7935, http://dx.doi.org/10.1021/acs.orglett.0c02860.[20] Yu, Zhiyin, Jiang, Hao, Wang, Li, Yang, FengXian, Huang, JianPing, Liu, Chongxi, Guo, Xiaowei, Xiang, Wensheng, Huang, ShengXiong. Dimeric Pimprinine Alkaloids From Soil-Derived Streptomyces sp. NEAU-C99. FRONTIERS IN CHEMISTRY[J]. 2020, 第 9 作者 通讯作者 8: https://doaj.org/article/d206e47582f541f68f4b4ade2e61060e.[21] Yuan, Jie, Wang, Li, Ren, Jinqiu, Huang, JianPing, Yu, Mingming, Tang, Jun, Yan, Yijun, Yang, Jing, Huang, ShengXiong. Antibacterial Pentacyclic Polyketides from a Soil-Derived Streptomyces. JOURNAL OF NATURAL PRODUCTS[J]. 2020, 第 9 作者 通讯作者 83(6): 1919-1924, https://www.webofscience.com/wos/woscc/full-record/WOS:000545691700019.[22] Wu, Ya, Li, Hao, Yan, Jiao, Cai, Qing, Huang, Shengxiong, Tang, Ying, Ji, Yue, Hao, Xiaojiang, Chen, Gang. Catalyzed Synthesis of 3-hydroxy-indol-2-one Derivatives as a Novel Phosphodiesterases 10 Inhibitor. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY[J]. 2020, 第 5 作者126: 33-34, https://www.webofscience.com/wos/woscc/full-record/WOS:000509492400043.[23] Ma, Xiaoyan, Zhang, Zhouxin, Wang, Li, Hu, Xinjun, Liu, Xingyong, Huang, ShengXiong. Two New 2(1H)-Pyrazinone Derivatives from the Plant Endophyte Streptomyces sp. KIB-H1992. RECORDS OF NATURAL PRODUCTS[J]. 2020, 第 6 作者 通讯作者 14(3): 196-200, http://dx.doi.org/10.25135/rnp.154.1907.1355.[24] Yu, Zhiyin, Han, Chuanyu, Yu, Bing, Zhao, Junwei, Yan, Yijun, Huang, Shengxiong, Liu, Chongxi, Xiang, Wensheng. Taxonomic Characterization, and Secondary Metabolite Analysis of Streptomyces triticiradicis sp. nov.: A Novel Actinomycete with Antifungal Activity. MICROORGANISMS[J]. 2020, 第 6 作者8(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000514650700082.[25] Zhuang, Xiaoxin, Wang, Zhiyan, Peng, Chenghui, Su, Can, Gao, Congting, Wang, Yongjiang, Huang, Shengxiong, Liu, Chongxi. Characterization of Streptomyces piniterrae sp. nov. and Identification of the Putative Gene Cluster Encoding the Biosynthesis of Heliquinomycins. MICROORGANISMS[J]. 2020, 第 7 作者 通讯作者 8(4): https://www.webofscience.com/wos/woscc/full-record/WOS:000533510400061.[26] Zhang, Dingli, Hu, Yikao, Wang, Li, Huang, Shengxiong, Zhao, Yan, Li, Mengjia, Li, Feng, Zhao, Yong. Diterpenoids and Sesquiterpenoids from Syzygium fluviatile. RECORDS OF NATURAL PRODUCTS[J]. 2020, 第 4 作者14(3): 190-195, http://dx.doi.org/10.25135/rnp.158.19.08.1393.[27] Wang YongJiang, Wang Li, He Xin, Xu DongDong, Tang Jun, Ma YaTuan, Yan YiJun, Gu YuCheng, Yang Jing, Huang ShengXiong. Characterization of inthomycin biosynthetic gene cluster revealing new insights into carboxamide formation. CHINESE JOURNAL OF NATURAL MEDICINES[J]. 2020, 第 10 作者 通讯作者 18(9): 677-683, http://dx.doi.org/10.1016/S1875-5364(20)60006-1.[28] Yang, FengXian, Huang, JianPing, Liu, Zhixiang, Wang, Zhiyan, Yang, Jing, Tang, Jun, Yu, Zhiyin, Yan, Yijun, Kai, Guoyin, Huang, ShengXiong. Benwamycins A-G, Trialkyl-Substituted Benzene Derivatives from a Soil-Derived Streptomyces. JOURNAL OF NATURAL PRODUCTS[J]. 2020, 第 10 作者 通讯作者 83(1): 111-117, https://www.webofscience.com/wos/woscc/full-record/WOS:000510076700015.[29] Xu, Min, Zhang, Fei, Cheng, Zhuo, Bashiri, Ghader, Wang, Jing, Hong, Jiali, Wang, Yemin, Xu, Lijun, Chen, Xuefei, Huang, ShengXiong, Lin, Shuangjun, Deng, Zixin, Tao, Meifeng. Functional Genome Mining Reveals a Class V Lanthipeptide Containing ad-Amino Acid Introduced by an F420H2-Dependent Reductase. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2020, 第 10 作者59(41): 18029-18035, https://www.webofscience.com/wos/woscc/full-record/WOS:000561818000001.[30] Ma, XiaoYan, Huang, JianPing, Yang, Jing, Liu, Xingyong, Hu, Xinjun, Huang, ShengXiong. Concise and efficient syntheses of methyl 4-(1-methylpyrrolidin-2-yl)-3-oxobutanoate and hygrine. CANADIAN JOURNAL OF CHEMISTRY[J]. 2020, 第 6 作者 通讯作者 98(4): 191-193, http://dx.doi.org/10.1139/cjc-2019-0442.[31] Yan, Yijun, Yang, Jing, Wang, Li, Xu, Dongdong, Yu, Zhiyin, Guo, Xiaowei, Horsman, Geoff P, Lin, Shuangjun, Tao, Meifeng, Huang, ShengXiong. Biosynthetic access to the rare antiarose sugar via an unusual reductase-epimerase. CHEMICAL SCIENCE[J]. 2020, 第 10 作者 通讯作者 11(15): 3959-3964, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152690/.[32] Feng, KeNa, Yang, YanLong, Xu, YuXing, Zhang, Yue, Feng, Tao, Huang, ShengXiong, Liu, JiKai, Zeng, Ying. A Hydrolase-Catalyzed Cyclization Forms the Fused Bicyclic beta-Lactone in Vibralactone. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2020, 第 6 作者 通讯作者 59(18): 7209-7213, http://dx.doi.org/10.1002/anie.202000710.[33] Guo, Xiaowei, Wang, Jidong, Su, Can, Liu, Chongxi, Ma, XiaoYan, Yu, Zhiyin, Li, Jiansong, Wang, Xiangjing, Xiang, Wensheng, Huang, ShengXiong. A unique spiro-beta-triazinedione-gamma-hydantoin type alkaloid with antiviral activity against tobacco mosaic virus from Streptomyces gamaensis. ORGANIC CHEMISTRY FRONTIERS[J]. 2019, 第 10 作者 通讯作者 6(18): 3215-3219, https://www.webofscience.com/wos/woscc/full-record/WOS:000484960000003.[34] Wang Lei, Wang Li, Zhou Zhi, Wang YongJiang, Huang JianPing, Ma YaTuan, Liu Yang, Huang ShengXiong. Cangumycins A-F, six new angucyclinone analogues with immunosuppressive activity from Streptomyces. CHINESE JOURNAL OF NATURAL MEDICINES[J]. 2019, 第 8 作者 通讯作者 17(12): 982-987, http://lib.cqvip.com/Qikan/Article/Detail?id=7100772594.[35] Zhang, Zhouxin, Cao, Pei, Shang, NingNing, Yang, Jing, Wang, Li, Yan, Yijun, Huang, ShengXiong. Naphthomycin-derived macrolactams with two new carbon skeletons from endophytic Streptomyces. ORGANIC CHEMISTRY FRONTIERS[J]. 2019, 第 7 作者 通讯作者 6(2): 177-182, http://ir.kib.ac.cn/handle/151853/64226.[36] He, Xin, Wang, Yongjiang, Luo, RongHua, Yang, LiuMeng, Wang, Li, Guo, Dale, Yang, Jing, Deng, Yun, Zheng, YongTang, Huang, ShengXiong. Dimeric Pyranonaphthoquinone Glycosides with Anti-HIV and Cytotoxic Activities from a Soil-Derived Streptomyces. JOURNAL OF NATURAL PRODUCTS[J]. 2019, 第 10 作者 通讯作者 82(7): 1813-1819, [37] JianPing Huang, Chengli Fang, Xiaoyan Ma, Li Wang, Jing Yang, Jianying Luo, Yijun Yan, Yu Zhang, ShengXiong Huang. Tropane alkaloids biosynthesis involves an unusual type III polyketide synthase and non-enzymatic condensation. NATURE COMMUNICATIONS[J]. 2019, 第 9 作者 通讯作者 10(1): 1-8, http://dx.doi.org/10.1038/s41467-019-11987-z.[38] Su, Can, Yan, Yijun, Guo, Xiaowei, Luo, Jianying, Liu, Chongxi, Zhang, Zhouxin, Xiang, WenSheng, Huang, ShengXiong. Characterization of the N-methyltransferases involved in the biosynthesis of toxoflavin, fervenulin and reumycin from Streptomyces hiroshimensis ATCC53615. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2019, 第 8 作者 通讯作者 17(3): 477-481, https://www.webofscience.com/wos/woscc/full-record/WOS:000458578900007.[39] Pan, HaiXue, Chen, Zhang, Zeng, Tianfang, Jin, WenBing, Geng, Yujie, Lin, GengMin, Zhao, Juan, Li, WeiTao, Xiong, Zijun, Huang, ShengXiong, Zhai, Xin, Liu, Hungwen, Tang, GongLi. Elucidation of the Herbicidin Tailoring Pathway Offers Insights into Its Structural Diversity. ORGANIC LETTERS[J]. 2019, 第 10 作者21(5): 1374-1378, https://www.webofscience.com/wos/woscc/full-record/WOS:000460491700028.[40] 黄胜雄. Naphthomycins-Derived Macrolactams with Two New Carbon Skeletons from an Endophytic Streptomyces. Org. Chem. Front.. 2019, 第 1 作者 通讯作者 [41] 黄胜雄. A unique spiro-β-triazinedione-γ-hydantoin type alkaloid with antiviral activity against tobacco mosaic virus from Streptomyces gamaensis.. Organic Chemistry Frontiers. 2019, 第 1 作者 通讯作者 [42] Dong, Miao, Cao, Pei, Ma, YaTuan, Luo, Jianying, Yan, Yijun, Li, RongTao, Huang, ShengXiong. A new actinomycin Z analogue with an additional oxygen bridge between chromophore and beta-depsipentapeptide from Streptomyces sp. KIB-H714. NATURAL PRODUCT RESEARCH[J]. 2019, 第 7 作者 通讯作者 33(2): 219-225, [43] Liu, Chongxi, Zhuang, Xiaoxin, Yu, Zhiyin, Wang, Zhiyan, Wang, Yongjiang, Guo, Xiaowei, Xiang, Wensheng, Huang, Shengxiong. Community Structures and Antifungal Activity of Root-Associated Endophytic Actinobacteria of Healthy and Diseased Soybean. MICROORGANISMS[J]. 2019, 第 8 作者 通讯作者 7(8): https://doaj.org/article/b38629be2fd341349142438f9de921a7.[44] Su, Can, Liu, Chongxi, Wang, Yongjiang, Xiang, WenSheng, Zou, Chenggang, Huang, ShengXiong. A New Heliquinomycin Analogue with Immunosuppressive Activity from Streptomyces sp. jys28. RECORDS OF NATURAL PRODUCTS[J]. 2019, 第 6 作者 通讯作者 13(6): 456-461, [45] Wang, Li, Yan, Yijun, Huang, Jianping, Xiong, Zi-Jun, Yang, Jing, Li, Jie, Huang, Sheng-Xiong, Wang, Zhiyan, Luo, Jianying. Isolation and biosynthesis of labdanmycins: four new labdane diterpenes from endophytic Streptomyces. JOURNAL OF ORGANIC CHEMISTRY[J]. 2018, 第 7 作者83(8): 4867-4870, http://ir.kib.ac.cn/handle/151853/63378.[46] Yang, FengXian, Hou, GuanXiong, Luo, Jianying, Yang, Jing, Yan, Yijun, Huang, ShengXiong. New phenoxazinone-related alkaloids from strain Streptomyces sp KIB-H1318. JOURNAL OF ANTIBIOTICS[J]. 2018, 第 6 作者 通讯作者 71(12): 1040-1043, http://ir.kib.ac.cn/handle/151853/64674.[47] Shang, NingNing, Zhang, Zhouxin, Huang, JianPing, Wang, Li, Luo, Jianying, Yang, Jing, Peng, Teng, Yan, Yijun, Ma, YaTuan, Huang, ShengXiong. Glycosylated piericidins from an endophytic streptomyces with cytotoxicity and antimicrobial activity. JOURNAL OF ANTIBIOTICS[J]. 2018, 第 10 作者 通讯作者 71(7): 672-676, http://ir.kib.ac.cn/handle/151853/64722.[48] Huang, Sheng-Xiong, Yang, Feng-Xian, Luo, Jianying, Hou, Guan-Xiong, Yang, Jing, Yan, Yijun. New phenoxazinone-related alkaloids from strain Streptomyces sp KIB-H1318. CANCERS[J]. 2018, 第 1 作者10(11): 449, http://www.irgrid.ac.cn/handle/1471x/1781670.[49] Yang, Jing, Peng, Teng, Yan, Yijun, Huang, Sheng-Xiong, Ma, Ya-Tuan, Shang, Ning-Ning, Zhang, Zhouxin, Huang, Jian-Ping, Wang, Li, Luo, Jianying. Glycosylated piericidins from an endophytic streptomyces with cytotoxicity and antimicrobial activity. NATURAL PRODUCT COMMUNICATIONS[J]. 2018, 第 4 作者13(7): 795-798, http://ir.kib.ac.cn/handle/151853/63350.[50] Xiong, ZiJun, Huang, Jianping, Yan, Yijun, Wang, Li, Wang, Zhiyan, Yang, Jing, Luo, Jianying, Li, Jie, Huang, ShengXiong. Isolation and biosynthesis of labdanmycins: four new labdane diterpenes from endophytic Streptomyces. 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HELVETICA CHIMICA ACTA[J]. 2008, 第 3 作者91(11): 2139-2147, http://www.corc.org.cn/handle/1471x/2388898.[123] Zhou, Yan, Huang, ShengXiong, Li, LiMei, Yang, Jing, Liu, Xin, Peng, ShuLin, Ding, LiSheng, Sun, HanDong. Negative electrospray ionization tandem mass spectrometric investigation of ent-kaurane diterpenoids from the genus Isodon. JOURNAL OF MASS SPECTROMETRY[J]. 2008, 第 2 作者43(1): 63-73, http://www.irgrid.ac.cn/handle/1471x/256487.[124] Zhao, Yong, Bin Yang, Li, Huang, Sheng Xiong, Xiao, Wei Lie, Pu, Jian Xin, Li, Mei Li, Bin Han, Quan, Sun, Han Dong. Two new ent-kaurane diterpenoids from Isodon henryi. CHINESE CHEMICAL LETTERS[J]. 2008, 第 3 作者19(9): 1096-1098, http://lib.cqvip.com/Qikan/Article/Detail?id=28210168.[125] Lei, Chun, Huang, ShengXiong, Chen, JiJun, Pu, JianXin, Li, LiMei, Xiao, WeiLie, Liu, JinPing, Yang, LiBin, Sun, HanDong. Four new schisanartane-type nortriterpenoids from Schisandra propinqua var. propinqua. 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发表著作
(1) 二萜化学, 二萜化学, 化学工业出版社, 2012-04, 第 3 作者
科研活动
科研项目
( 1 ) 托酚酮类天然产物rubrolone 的生物合成研究, 主持, 国家级, 2014-01--2017-12( 2 ) 青年****基金, 主持, 国家级, 2015-11--2018-10( 3 ) 云南省高端科技人才计划, 主持, 省级, 2014-01--2018-12( 4 ) 天然药物化学, 主持, 国家级, 2016-01--2018-12( 5 ) 云南特色内生菌资源中生物碱类先导化 合物的发现与生物合成, 主持, 国家级, 2018-01--2021-12
指导学生
已指导学生
杨瑞敏 硕士研究生 078001-药物化学
熊子君 博士研究生 071010-生物化学与分子生物学
现指导学生
王莉 博士研究生 100701-药物化学
苏灿 博士研究生 071010-生物化学与分子生物学
喻明明 博士研究生 100701-药物化学
任金秋 硕士研究生 078001-药物化学
徐冬冬 博士研究生 100701-药物化学
杨凤仙 博士研究生 100701-药物化学
徐冰艳 硕士研究生 078001-药物化学
唐俊 博士研究生 100701-药物化学
王志岩 博士研究生 100701-药物化学