植物天然产物在生物防御、信号转导和环境适应过程中发挥着核心作用，同时也是药物开发、作物改良和可持续农业的重要资源。由于其结构多样、功能丰富，系统解析天然产物的生物合成网络与调控机制不仅具有重要的基础科学意义，也蕴含广阔的应用前景。

本课题组聚焦于植物小分子天然产物的合成机制、酶催化特性及其进化规律，重点研究关键萜类和苯丙烷类化合物的生物合成途径，揭示其在植物发育与逆境响应中的功能，并据此培育出多种具有重要农业价值的优良种质材料。在合成生物学、生物信息学等交叉技术的支撑下，我们正在构建可调控的天然产物合成模块，探索天然产物的理性设计与精准利用，为高效利用植物化学资源提供新路径。

博士后招聘

实验室长期招聘具有有机化学、分子生物学、生物信息学或代谢组学背景的博士后。提供具有竞争力的薪酬待遇和良好的职业发展空间。

研究生招生

欢迎对植物天然产物与合成生物学感兴趣的推免生或考研学生报考。请提前将个人简历发送至黄金泉老师邮箱huangjinquan@cemps.ac.cn。

2023-12--中国科学院分子植物科学卓越创新中心   研究员
2021-11--2023-11   中国科学院分子植物科学卓越创新中心   副研究员
2021-10--2021-10   中国科学院分子植物科学卓越创新中心   助理研究员
2019-01--2021-09   中国科学院分子植物科学卓越创新中心   博士后
2013-09--2018-12   中国科学院大学   博士
2009-09--2013-06   山东师范大学   学士

1. Lin, Jia-Ling; Wu, Wen-Kai; Nie, Gui-Bin; Li, Jian-Xu; Fang, Xin; Sheng, Yin-Guo; Wang, Meng-Meng; Zheng, Qi-Yue; Guo, Xiao-Xiang; Huang, Jia-Fa; Ma, Li-Ying; Wang, Ling-Jian; Liu, Jia-Xin; Wang, Shan-Shan; Xu, Bao-Fu; Gao, Yi-Qun; Li, Yan; Wang, Dong; Martin, Cathie; Chen, Xiao-Ya; Huang, Jin-Quan*. (2025). A dirigent protein redirects extracellular terpenoid metabolism for defense against biotic challenges. Nature Communications.20;16(1):9270. doi: 10.1038/s41467-025-64323-z.
2. Hui-Xian Zhu; Jia-Fa Huang; Jun-Feng Cao; Ling-Jian Wang; Jin-Quan Huang*. (2025). SPL1 positively regulates cuticular ridge wax biosynthesis in Arabidopsis. Plant Stress. 6:100872. doi.org/10.1016/j.stress.2025.100872
3. Wu WK#, Nie GB#, Lin JL#, Huang JF#, Guo XX, Chen M, Fang X, Mao YB, Li Y, Wang LJ, Tao XY, Gao Y, Yang ZR, Huang JQ*. Regulation of glandular size and phytoalexin biosynthesis by a negative feedback loop in cotton. Adv Sci. 2024 Aug;11(30):e2403059.2.
4. Gao YQ#, Huang JQ#, Reyt G, Song T, Love A, Tiemessen D, Xue PY, Wu WK, George MW, Chen XY, Chao DY*, Castrillo G*, Salt DE*. A dirigent protein complex directs lignin polymerization and assembly of the root diffusion barrier. Science. 2023 Oct 27;382(6669):464-471.
5. Lin JL, Fang X, Li JX, Chen ZW, Wu WK, Guo XX, Liu NJ, Huang JF, Chen FY, Wang LJ, Xu B, Martin C, Chen XY*, Huang JQ*. Dirigent gene editing of gossypol enantiomers for toxicity-depleted cotton seeds. Nat Plants. 2023 Apr;9(4):605-615.
6. Lin JL#, Chen L#, Wu WK, Guo XX, Yu CH, Xu M, Nie GB, Dun JL, Li Y, Xu B, Wang LJ, Chen XY, Gao W*, Huang JQ*. Single-cell RNA sequencing reveals a hierarchical transcriptional regulatory network of terpenoid biosynthesis in cotton secretory glandular cells. Mol Plant. 2023 Dec 4;16(12):1990-2003.
7. Huang JQ and Chen XY. Removing the toxic enantiomer from crop products with selective gene editing. Nat Plants. 2023 Apr;9(4):513-514.
8. Huang JQ#, Li DM#, Tian X, Lin JL, Yang L, Xu JJ, Fang X. Side products of recombinant Amorpha-4,11-diene synthase and their effect on microbial Artemisinin production. J Agric Food Chem. 2021 Feb 24;69(7):2168-2178.
9. Huang JQ, Li DM, Li JX, Lin JL, Tian X, Wang LJ, Chen XY, Fang X. 1,10/1,11-Cyclization catalyzed by diverged plant sesquiterpene synthases is dependent on a single residue. Org Biomol Chem. 2021 Aug 5;19(30):6650-6656.
10. Huang JQ#, Fang X#, Tian X, Chen P, Lin JL, Guo XX, Li JX, Fan Z, Song WM, Chen FY, Ahati R, Wang LJ, Zhao Q, Martin C, Chen XY*. Aromatization of natural products by a specialized detoxification enzyme. Nat Chem Biol. 2020 Mar;16(3):250-256.
11. Huang JQ, Lin JL, Guo XX, Tian X, Tian Y, Shangguan XX, Wang LJ, Fang X, Chen XY. RES transformation for biosynthesis and detoxification. Sci China Life Sci. 2020 Sep;63(9):1297-1302.
12. Huang G, Huang JQ, Chen XY, Zhu YX. Recent advances and future perspectives in cotton research. Annu Rev Plant Biol. 2021 Jun 17;72:437-462.
13. Cao JF, Huang JQ, Liu X, Huang CC, Zheng ZS, Zhang XF, Shangguan XX, Wang LJ, Zhang YG, Wendel JF, Grover CE, Chen ZW. Genome-wide characterization of the GRF family and their roles in response to salt stress in Gossypium. BMC Genomics. 2020 Aug 24;21(1):575.
14. Tian X, Fang X, Huang JQ, Wang LJ, Mao YB, Chen XY. A gossypol biosynthetic intermediate disturbs plant defence response. Philos Trans R Soc Lond B Biol Sci. 2019 Mar 4;374(1767):20180319.
15. Tian X#, Ruan JX#, Huang JQ#, Yang CQ#, Fang X, Chen ZW, Hong H, Wang LJ, Mao YB, Lu S, Zhang TZ, Chen XY. Characterization of gossypol biosynthetic pathway. Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):E5410-E5418.
16. Fang X, Li JX, Huang JQ, Xiao YL, Zhang P, Chen XY. Systematic identification of functional residues of Artemisia annua amorpha-4,11-diene synthase. Biochem J. 2017 Jun 16;474(13):2191-2202.
17. Tian X, Ruan JX, Huang JQ, Fang X, Mao YB, Wang LJ, Chen XY, Yang CQ. Gossypol: phytoalexin of cotton. Sci China Life Sci. 2016 Feb;59(2):122-9.