Synthetic Biology; Biomedical Engineering; Gene and Cell Therapy; Electrogenetics; Precision Medicine; Cancer Therapy; Metabolic Disease Therapy

2019-09--2024-06 ETH Zurich, Switzerland PhD

2016-09--2019-06 Huazhong Agricultural University Master

2012-09--2016-06 Huazhong Agricultural University Bachelor

2025-12~Present, Hangzhou Institute of Medicine, Chinese Academy of Sciences, Principal Investigator

2024-07~2025-08, ETH Zurich, Switzerland, Postdoctoral Researcher

1.    Huang, J., Xue, S., Buchmann, P., Teixeira, A.P. and Fussenegger, M.*, An electrogenetic interface to program mammalian gene expression by direct current. Nature Metabolism, 2023, 5(8):1395-1407.

2.    Huang, J., Xue, S., Teixeira, A.P. and Fussenegger, M.*, A Gene-Switch Platform Interfacing with Reactive Oxygen Species Enables Transcription Fine-Tuning by Soluble and Volatile Pharmacologics and Food Additives. Advanced Science, 2024a, 11(20):e2306333.

3.    Huang, J., Xue, S., Xie, Y.-Q., Teixeira, A.P. and Fussenegger, M.*, Ultrashort-peptide-responsive gene switches for regulation of therapeutic protein expression in mammalian cells. Advanced Science, 2024b, 11(28):e2309411.

4.    Huang, J. and Fussenegger, M.*, Programming mammalian gene expression via physical cues. Trends in Biotechnology 2025, 43(1):16-42.

5.    Huang, J., Teixeira, A.P., Gao, T., Xue, S., Xie, M. and Fussenegger, M.*, Aspirin-responsive gene switch regulating therapeutic protein expression. Nature Communications, 2025, 16(1):2028.

6.    Huang, J., Xue, S., Teixeira, A.P. and Fussenegger, M.*, A mediator-free sonogenetic switch for therapeutic protein expression in mammalian cells. Nucleic Acids Research, 2025, 53(6):gkaf191.

7.    Lin, Z., Ray, P.G., Huang, J., Buchmann, P., Fussenegger, M.^*, Electromagnetic wireless remote control of mammalian transgene expression. Nature Nanotechnology, 2025, 20(8):1071–1078.

8.    Maity, D., Huang, J., and Fussenegger, M.*, Wearable thermoelectric generators for in vivo modulation of insulin release. Advanced Energy Materials, 2025, doi.org/10.1002/aenm.202505245.

9.    Hu, G., Huang, J. and Fussenegger, M.*, Toward photosynthetic mammalian cells through artificial endosymbiosis. Small, 2024, 20(31):e2310310.

10.  Teixeira, A.P.#, Xue, S.#, Huang, J. and Fussenegger, M.*, Evolution of molecular switches for regulation of transgene expression by clinically licensed gluconate. Nucleic Acids Research, 2023, 51(15):e85.

11.  Guha Ray, P., Maity, D., Huang, J., Zulewski, H. and Fussenegger, M.*, A versatile bioelectronic interface programmed for hormone sensing. Nature Communications, 2023, 14(1):3151.

Prior to 2019:

12.  Huang, J.#, Dong, X.#, Gong, Z.#, Qin, L.Y., Yang, S., Zhu, Y.L., Wang, X., Zhang, D., Zou, T., Yin, P.* and Tang, C.*, Solution structure of the RNA recognition domain of METTL3-METTL14 N6-methyladenosine methyltransferase. Protein & Cell, 2019, 10(4):272-284.

13.  Huang, J. and Yin, P.*, Structural insights into N6-methyladenosine (m6A) modification in the transcriptome. Genomics, Proteomics & Bioinformatics, 2018, 16(2):85-98.

14.  Huang, J., Guan, Z., Wan, L., Zou, T. and Sun, M.*, Crystal structure of Cry6Aa: A novel nematicidal ClyA-type α-pore-forming toxin from Bacillus thuringiensis. Biochemical and Biophysical Research Communications, 2016, 478:307-313.

15.  Wang, X., Huang, J., Zou, T. and Yin, P.*, Human m6A writers: Two subunits, 2 roles. RNA Biology, 2017, 14(3):300-304.

16.  Wang, X.#, Feng, J.#, Xue, Y.#, Guan, Z., Zhang, D., Liu, Z., Gong, Z., Wang, Q., Huang, J., Tang, C., Zou, T. and Yin P.*, Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex. Nature, 2016, 534(7608):575-578.