神经退行性变，干细胞定向分化

   

1001J6-再生医学
071008-发育生物学
071006-神经生物学

干细胞与再生医学
神经干细胞与神经修复
干细胞生物学

1999-07--2004-07 复旦大学 博士
1990-07--1995-07 济宁医学院 学士

   

2011-02--今 中国科学院动物研究所 研究员
2009-04--2010-09 University of Wisconsin-Madison Assistant Scientist
2005-10--2009-03 University of Wisconsin-Madison Research Associate
2004-07--2005-10 济宁医学院 教师
1995-07--1999-07 济宁医学院 教师

2014-06--2016-05 中国细胞生物学会干细胞分会，理事

干细胞研究进展系列讲座

   

   

[1] Wang, YuKai, Feng, Lin, Ma, AiJin, Hao, Jie, Zhang, Ying, Chen, YueJun, Chen, ZhiGuo, Yu, JunYing, Liu, Yan, Liu, ChangMei, Zhang, Yu, Wang, ChangLin, Teng, ZhaoQian, Zhou, JiaXi, Li, TianQing, Wang, Liu, Fu, BoQiang, Fu, Yu Vincent, Zhu, LiJun, Liang, LingMin, Cao, JiaNi, Wang, Lei, Zhou, Qi, Xiang, Andy Peng, Hu, BaoYang, Zhao, TongBiao. Human midbrain dopaminergic progenitors. CELL PROLIFERATION[J]. 2024, 第 25 作者  通讯作者  57(4): http://dx.doi.org/10.1111/cpr.13563.
[2] Wang, YuKai, Yu, Juan, Zhang, TingTing, Ma, AiJin, Hao, Jie, Chen, YueJun, Liu, ChangMei, Liu, Yan, Wang, ChangLin, Zhai, PeiJun, Xiang, Andy Peng, Li, TianQing, Tang, TieShan, Chen, Hong, Bao, XinJie, Wang, YanLin, He, WenYan, Fan, Jing, Teng, ZhaoQian, Wang, Liu, Zhou, JiaXi, Fu, BoQiang, Fu, Yu Vincent, Feng, Lin, Cao, JiaNi, Liang, LingMin, Wang, Lei, Zhou, Qi, Zhang, Yu, Hu, BaoYang, Zhao, TongBiao. Human neural stem cells. CELL PROLIFERATION. 2024, 第 30 作者  通讯作者  57(4): http://dx.doi.org/10.1111/cpr.13564.
[3] Lin Feng, Da Li, Yao Tian, Chengshun Zhao, Yun Sun, Xiaolong Kou, Jun Wu, Liu Wang, Qi Gu, Wei Li, Jie Hao, Baoyang Hu, Yukai Wang. One-step cell biomanufacturing platform:porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation in vitro and survival after transplantation in vivo. 中国神经再生研究:英文版[J]. 2024, 第 12 作者19(2): 458-464, http://lib.cqvip.com/Qikan/Article/Detail?id=7110261206.
[4] Yaojin Peng, Aijin Ma, Zhenyu Xiao, Jie Hao, Ruohan Feng, Changlin Wang, Baoyang Hu, Peijun Zhai, Ka Li, Lei Wang, Jiani Cao, Peng Xiang, Yu Zhang, Jun Wei, Xiaolong Wang, Boqiang Fu, Qubo Chen, Qiang Wei, Hengjun Gao, Jianwei Lv, Xing Liu, Yonghui Ma, Tao Cheng, Xiaoru Huang, Yeyang Su, Haihong Zhang, Qi Zhou, Tongbiao Zhao. Technical specifications for ethics review of human stem cell research. Cell Proliferation[J]. 2024, 第 7 作者57(3): e13556, 
[5] Chunfu Xiao, Fan Mo, Yingfei Lu, Qi Xiao, Chao Yao, Ting Li, 戚见欢, xiaoge liu, Jia-Yu Chen, Li Zhang, Tiannan Guo, 胡宝洋, Ni A. An, 李川昀. Reply to: Identification of old coding regions disproves the hominoid de novo status of genes. Nature Ecology & Evolution[J]. 2024, 第 12 作者  通讯作者  null(null): 
[6] An, Ni A A, Zhang, Jie, Mo, Fan, Luan, Xuke, Tian, Lu, Shen, Qing Sunny, Li, Xiangshang, Li, Chunqiong, Zhou, Fanqi, Zhang, Boya, Ji, Mingjun, Qi, Jianhuan, Zhou, WeiZhen, Ding, Wanqiu, Chen, JiaYu, Yu, Jia, Zhang, Li, Shu, Shaokun, Hu, Baoyang, Li, ChuanYun. De novo genes with an lncRNA origin encode unique human brain developmental functionality. NATURE ECOLOGY & EVOLUTION[J]. 2023, 第 19 作者  通讯作者  7(2): 264-+, http://dx.doi.org/10.1038/s41559-022-01925-6.
[7] Qi, Jianhuan, Mo, Fan, An, Ni A, Mi, Tingwei, Wang, Jiaxin, Qi, JunTian, Li, Xiangshang, Zhang, Boya, Xia, Longkuo, Lu, Yingfei, Sun, Gaoying, Wang, Xinyue, Li, ChuanYun, Hu, Baoyang. A Human-Specific De Novo Gene Promotes Cortical Expansion and Folding. ADVANCED SCIENCE[J]. 2023, 第 14 作者  通讯作者  10(7): https://www.doi.org/10.1002/advs.202204140.
[8] Sun, Gaoying, Tang, Mingming, Wang, Xinyue, Li, Da, Liu, Wenwen, Qi, Jianhuan, Wang, Haibo, Hu, Baoyang. Generation of human otic neuronal organoids using pluripotent stem cells. CELL PROLIFERATION[J]. 2023, 第 8 作者  通讯作者  56(5): https://www.doi.org/10.1111/cpr.13434.
[9] Xia, Longkuo, Qi, Jianhuan, Tang, Mingming, Liu, Jing, Zhang, Da, Zhu, Yanbing, Hu, Baoyang. Continual Deletion of Spinal Microglia Reforms Astrocyte Scar Favoring Axonal Regeneration. FRONTIERS IN PHARMACOLOGY[J]. 2022, 第 7 作者  通讯作者  13: http://dx.doi.org/10.3389/fphar.2022.881195.
[10] Sun, Yun, Feng, Lin, Liang, Lingmin, Stacey, Glyn N, Wang, Chaoqun, Wang, Yukai, Hu, Baoyang. Neuronal cell-based medicines from pluripotent stem cells: Development, production, and preclinical assessment. STEM CELLS TRANSLATIONAL MEDICINE. 2021, 第 7 作者  通讯作者  10(Suppl 2): S31-S40, http://dx.doi.org/10.1002/sctm.20-0522.
[11] Liu, Jing, Hou, Zongren, Wu, Jun, Liu, Kailun, Li, Da, Gao, Tingting, Liu, Wenjing, An, Bin, Sun, Yun, Mo, Fan, Wang, Liu, Wang, Yukai, Hao, Jie, Hu, Baoyang. Infusion of hESC derived Immunity-and-matrix regulatory cells improves cognitive ability in early-stage AD mice. CELL PROLIFERATION[J]. 2021, 第 14 作者  通讯作者  54(8): http://dx.doi.org/10.1111/cpr.13085.
[12] Sun, Han, Liu, Jing, Lv, Fengting, Liu, Libing, Gu, Qi, Hu, Baoyang, Wang, Shu. Selective reaction of conjugated polymers with basic proteins for broad-spectrum antivirulence therapy. NPG ASIA MATERIALS[J]. 2021, 第 6 作者  通讯作者  13(1): http://dx.doi.org/10.1038/s41427-020-00252-1.
[13] Wu, Jun, Hu, Zhongjie, Wang, Liu, Tan, Yuanqing, Hou, Wei, Li, Zhongwen, Gao, Tingting, Fan, Jiaqi, Guo, Baojie, Dai, Huaping, Li, Wei, Hao, Jie, Jin, Ronghua, Hu, Baoyang. First case of COVID-19 infused with hESC derived immunity- and matrix-regulatory cells. CELL PROLIFERATION[J]. 2020, 第 14 作者  通讯作者  53(12): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645847/.
[14] Wu, Jun, Song, Dingyun, Li, Zhongwen, Guo, Baojie, Xiao, Yani, Liu, Wenjing, Liang, Lingmin, Feng, Chunjing, Gao, Tingting, Chen, Yanxia, Li, Ying, Wang, Zai, Wen, Jianyan, Yang, Shengnan, Liu, Peipei, Wang, Lei, Wang, Yukai, Peng, Liang, Stacey, Glyn Nigel, Hu, Zheng, Feng, Guihai, Li, Wei, Huo, Yan, Jin, Ronghua, ShyhChang, Ng, Zhou, Qi, Wang, Liu, Hu, Baoyang, Dai, Huaping, Hao, Jie. Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis. CELL RESEARCH[J]. 2020, 第 28 作者  通讯作者  30(9): 794-809, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6805741&detailType=1.
[15] Zhongwen Li, Jun Wu, Lei Wang, Weifang Han, Juan Yu, Xin Liu, Yukai Wang, Ying Zhang, Guihai Feng, Wei Li, Glyn Nigel Stacey, Qi Gu, Baoyang Hu, Liu Wang, Qi Zhou, Jie Hao. Correction: Generation of qualified clinical-grade functional hepatocytes from human embryonic stem cells in chemically defined conditions. CELL DEATH & DISEASE. 2020, 第 13 作者11(1): 
[16] Xu, YanPeng, Qiu, Yang, Zhang, Boya, Chen, Guilai, Chen, Qi, Wang, Miao, Mo, Fan, Xu, Jiuyue, Wu, Jin, Zhang, RongRong, Cheng, Meng Li, Zhang, NaNa, Lyu, Bao, Zhu, WenLiang, Wu, MengHua, Ye, Qin, Zhang, Da, Man, JiangHong, Li, XiaoFeng, Cui, Jie, Xu, Zhiheng, Hu, Baoyang, Zhou, Xi, Qin, ChengFeng. Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids. CELL RESEARCH[J]. 2019, 第 22 作者  通讯作者  29(4): 265-273, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6474850&detailType=1.
[17] Wenliang Zhu, Boya Zhang, Mengqi Li, Fan Mo, Tingwei Mi, Yihui Wu, Zhaoqian Teng, Qi Zhou, Wei Li, Baoyang Hu. Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome. NATURE COMMUNICATIONS[J]. 2019, 第 10 作者  通讯作者  10(1): 1-18, https://doaj.org/article/fe289d2c0c864031a37e09fb8593c020.
[18] Wang, Lei, Wu, Wei, Gu, Qi, Liu, Zengping, Li, Qiyou, Li, Zhongwen, Fang, Jinhui, Liu, Wenjing, Wu, Jun, Zhang, Ying, Wang, Liu, Xu, Haiwei, Li, Wei, Hu, Baoyang, Zhou, Qi, Yin, Zhengqin, Hao, Jie. The effect of clinical-grade retinal pigment epithelium derived from human embryonic stem cells using different transplantation strategies. PROTEIN & CELL[J]. 2019, 第 14 作者10(6): 455-460, http://lib.cqvip.com/Qikan/Article/Detail?id=7002265647.
[19] Jiang, Yuan, Yan, Long, Xia, Longkuo, Lu, Xiaoyin, Zhu, Wenliang, Ding, Dewen, Du, Mingxia, Zhang, Da, Wang, Hongmei, Hu, Baoyang. Zinc finger E-box-binding homeobox 1 (ZEB1) is required for neural differentiation of human embryonic stem cells. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2018, 第 10 作者  通讯作者  293(50): 19317-19329, http://dx.doi.org/10.1074/jbc.RA118.005498.
[20] Zhang, Weiqi, Wan, Haifeng, Feng, Guihai, Qu, Jing, Wang, Jiaqiang, Jing, Yaobin, Ren, Ruotong, Liu, Zunpeng, Zhang, Linlin, Chen, Zhiguo, Wang, Shuyan, Zhao, Yong, Wang, Zhaoxia, Yuan, Yun, Zhou, Qi, Li, Wei, Liu, GuangHui, Hu, Baoyang. SIRT6 deficiency results in developmental retardation cynomolgus monkeys. NATURE[J]. 2018, 第 18 作者  通讯作者  560(7720): 661-665, https://www.webofscience.com/wos/woscc/full-record/WOS:000443218600053.
[21] Wu, Menghua, Zhang, Da, Bi, Chunying, Mi, Tingwei, Zhu, Wenliang, Xia, Longkuo, Teng, Zhaoqian, Hu, Baoyang, Wu, Yihui. A Chemical Recipe for Generation of Clinical-Grade Striatal Neurons from hESCs. STEM CELL REPORTS[J]. 2018, 第 8 作者  通讯作者  11(3): 635-650, https://doaj.org/article/ecad29fbf87f47ecaee6b19923d1b0d4.
[22] Xia Li, Ruoyu Ma, Qi Gu, Lingmin Liang, Lei Wang, Ying Zhang, Xianning Wang, Xin Liu, Zhongwen Li, Jinhui Fang, Jun Wu, Yukai Wang, Wei Li, Baoyang Hu, Liu Wang, Qi Zhou, Jie Hao. A fully defined static suspension culture system for large-scale human embryonic stem cell production. CELL DEATH AND DISEASE[J]. 2018, 第 14 作者9(9): 1-9, https://doaj.org/article/517fbb632f3142c385073e2f1824afd8.
[23] Chen, Guilai, Zhang, Da, Zhang, Linlin, Feng, Guihai, Zhang, Boya, Wu, Yihui, Li, Wei, Zhang, Ying, Hu, Baoyang. RBM14 is indispensable for pluripotency maintenance and mesoderm development of mouse embryonic stem cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2018, 第 9 作者  通讯作者  501(1): 259-265, http://dx.doi.org/10.1016/j.bbrc.2018.04.231.
[24] Li, ZhiKun, Wang, LeYun, Wang, LiBin, Feng, GuiHai, Yuan, XueWei, Liu, Chao, Xu, Kai, Li, YuHuan, Wan, HaiFeng, Zhang, Ying, Li, YuFei, Li, Xin, Li, Wei, Zhou, Qi, Hu, BaoYang. Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions. CELL STEM CELL[J]. 2018, 第 15 作者  通讯作者  23(5): 665-+, http://dx.doi.org/10.1016/j.stem.2018.09.004.
[25] Boya Zhang, Yangzhige He, Yanpeng Xu, Fan Mo, Tingwei Mi, Qing Sunny Shen, Chunfeng Li, Yali Li, Jing Liu, Yihui Wu, Guilai Chen, Wenliang Zhu, Chengfeng Qin, Baoyang Hu, Guomin Zhou. Differential antiviral immunity to Japanese encephalitis virus in developing cortical organoids. CELL DEATH AND DISEASE[J]. 2018, 第 14 作者  通讯作者  9(7): 1-10, https://doaj.org/article/52a061027b714c9184fec9199e231068.
[26] Wang, Xuepeng, Li, Tianda, Cui, Tongtong, Yu, Dawei, Liu, Chao, Jiang, Liyuan, Feng, Guihai, Wang, Lei, Fu, Rui, Zhang, Xinxin, Hao, Jie, Wang, Yukai, Wang, Liu, Zhou, Qi, Li, Wei, Hu, Baoyang. Human embryonic stem cells contribute to embryonic and extraembryonic lineages in mouse embryos upon inhibition of apoptosis. CELL RESEARCH[J]. 2018, 第 16 作者  通讯作者  28(1): 126-129, https://www.webofscience.com/wos/woscc/full-record/WOS:000423834700012.
[27] Wang, YuKai, Zhu, WanWan, Wu, MengHua, Wu, YiHui, Liu, ZhengXin, Liang, LingMin, Sheng, Chao, Hao, Jie, Wang, Liu, Li, Wei, Zhou, Qi, Hu, BaoYang. Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson's Disease. STEM CELL REPORTS[J]. 2018, 第 12 作者  通讯作者  11(1): 171-182, http://dx.doi.org/10.1016/j.stemcr.2018.05.010.
[28] Gu, Qi, Wang, Juan, Wang, Lei, Liu, ZhengXin, Zhu, WanWan, Tan, YuanQing, Han, WeiFang, Wu, Jun, Feng, ChunJing, Fang, JinHui, Liu, Lei, Wang, Liu, Li, Wei, Zhao, XiaoYang, Hu, BaoYang, Hao, Jie, Zhou, Qi. Accreditation of Biosafe Clinical-Grade Human Embryonic Stem Cells According to Chinese Regulations. STEM CELL REPORTS[J]. 2017, 第 15 作者9(1): 366-380, http://dx.doi.org/10.1016/j.stemcr.2017.04.017.
[29] Qian, Kun, Huang, Hailong, Peterson, Andrew, Hu, Baoyang, Maragakis, Nicholas J, Ming, Guoli, Chen, Hong, Zhang, SuChun. Sporadic ALS Astrocytes Induce Neuronal Degeneration In Vivo. STEM CELL REPORTS[J]. 2017, 第 4 作者8(4): 843-855, https://doaj.org/article/de68224948ca49d5aafb12c598559e62.
[30] Li Tianda, Feng Guihai, Li Yufei, Wang Mei, Mao Junjie, Wang Jiaqiang, Li Xin, Wang Xuepeng, Qu Bin, Wang Leyun, XinXin Zhang, Wan Haifeng, Cui Tongtong, Wan Cong, Liu Lei, Zhao Xiaoyang, Hu Baoyang, Li Wei, Zhou Qi. Rat Embryonic Stem Cells Produce Fertile Offspring Through Tetraploid Complementation. PNAS[J]. 2017, 第 17 作者114(45): 11974-11979, http://ir.ioz.ac.cn/handle/000000/12809.
[31] Yuan, Ling, Huang, XingYao, Liu, ZhongYu, Zhang, Feng, Zhu, XingLiang, Yu, JiuYang, Ji, Xue, Xu, YanPeng, Li, Guanghui, Li, Cui, Wang, HongJiang, Deng, YongQiang, Wu, Menghua, Cheng, MengLi, Ye, Qing, Xie, DongYang, Li, XiaoFeng, Wang, Xiangxi, Shi, Weifeng, Hu, Baoyang, Shi, PeiYong, Xu, Zhiheng, Qin, ChengFeng. A single mutation in the prM protein of Zika virus contributes to fetal microcephaly. SCIENCE[J]. 2017, 第 20 作者358(6365): 933-+, http://dx.doi.org/10.1126/science.aam7120.
[32] Zhang JbrChen SQbrZhang DMbrShi ZXbrLi HbrZhao TBbrHu BYbrZhou QbrJiao JW. Tet3-Mediated DNA Demethylation Contributes to the Direct Conversion of Fibroblast to Functional Neuron. CELL REPORTS. 

（1） 新生物学年鉴2013，Advances in Biology 2013，科学出版社，2014-01，第1作者
（2） 分子生物学方法-编程与重编程章节：神经特定细胞类型定向分化，Directed differentiation of neural and subtype specific neuronal cells from hESCs. in Reprogramming and Programming of Cell Fate, Methods in Molecular Biology，Humana Press.，2009-07，第1作者
（3） 人胚干细胞实用手册章节：人胚干细胞和运动神经元定向分化，Differentiation of human embryonic stem cells into spinal motor neurons, in Human Embryonic Stem Cells: The Practical Handbook，Wiley Publishing，2007-07，第1作者
（4） 医学发育生物学章节：中枢神经系统发育，Development of Central Nervous System, in Developmental Neurobiology，科学出版社，2004-07，第1作者

   

（1） 人特异性miRNA-F1对人脑发育调控研究，主持，国家级，2015-01--2019-12
（2） 体外定向分化神经干细胞移植及功能整合，参与，国家级，2014-01--2018-12
（3） 神经外胚层细胞R-C化和D-V化的调控网络，主持，国家级，2012-12--2016-12
（4） 人多能干细胞分化神经细胞移植的免疫耐受诱导，主持，院级级，2012-08--2015-12
（5） 干细胞与神经再生，主持，院级级，2012-07--2015-06
（6） 人多能干细胞来源OLIG2+前体细胞向运动神经元的分化调控，主持，国家级，2012-01--2015-12
（7） 灵长类ES和iPS细胞分化为多巴胺神经细胞，参与，国家级，2012-01--2016-12
（8） 干细胞医学转化研究，主持，院级级，2011-02--2013-02

已指导学生

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蒋远  博士研究生  071008-发育生物学  

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