
电子邮件: rhong@sioc.ac.cn
通信地址: 上海市徐汇区零陵路345号
邮政编码: 200032
研究领域
招生信息
招生专业
招生方向
不对称合成
生物酶催化
教育背景
2001-08--2002-06 休斯敦大学化学系(美国,德克萨斯州) 博士后
1996-09--2002-06 中国科学院上海有机化学研究所 理学博士
1992-09--1996-06 四川大学化学系 学士
学历
学位
出国学习工作
2001年8月—2002年6月博士后,UniversityofHouston(JayK.Kochi教授);
2002年7月—2007年3月博士后,BrandeisUniversity(LiDeng教授)
工作经历
工作简历
社会兼职
2020-01-01-今,Tetrahedron Letters, 副主编
2019-01-01-今,Asian Core Program, International coordinator (Mainland China)
2018-11-01-2022-10-31,中国化学会有机化学学科委员会, 秘书长
2017-07-31-今,有机化学 (Chinese Journal of Organic Chemistry), 编委成员
教授课程
专利与奖励
奖励信息
(2) Thieme Chemistry Journal Award, 其他, 2017
(3) ACP Lectureship (Japan), 其他, 2017
(4) ACP Lectureship (Japan), 其他, 2016
(5) ACP Lectureship (Malaysia), 其他, 2016
(6) ACP Lectrueship (Taiwan), 其他, 2015
出版信息
39. Guoli He, Yan Wang, Calvine Lai, Wenhua Li, and Ran Hong*, "Stereoselective construction of skipped polyol in polyketides enabled by oxonia-Cope rearrangement and iodolactonization: Enantioselective synthesis of (+)-yashabushitriol” Sci. China Chem. 2016, 59, 1197-1204.
http://link.springer.com/article/10.1007/s11426-016-0073-3
38. Lin Yang, Zuming Lin, Sha-Hua Huang*, and Ran Hong*, "Stereodivergent Synthesis of Functionalized Tetrahydropyrans Accelerated by Mechanism-Based Allylboration and Bioinspired oxa-Michael Cyclization" Angew. Chem. Int. Ed. 2016, 55, 6280-6284.
http://onlinelibrary.wiley.com/doi/10.1002/anie.201600558/full
37. Lumin Zhang, Lili Zhu, Jun Yang*, Jisheng Luo, and Ran Hong*, "Stereoselective alpha-Hydroxylation of Amides with Oppolzer's Sultam as Chiral Auxiliary" J. Org. Chem. 2016, 81, 3890-3900.
http://pubs.acs.org/doi/abs/10.1021/acs.joc.6b00068
36. Wenhua Li, Zuming Lin, Long Chen, Xuechao Tian, Sha-Hua Huang*, and Ran Hong*, "Highly Stereoselective Kinetic Resolution of alpha-Allenic Alcohols: An Enzymatic Approach" "Tetrahedron Lett. 2016, 57, 603-606.http://www.sciencedirect.com/science/article/pii/S004040391530513X
Highlighted as "Hot off the press" (Nat. Prod. Rep. 2016, doi:10.1039/c6np90012g)
35. Sha-Hua Huang*, Xuechao Tian, Xianwei Mi, Yan Wang*, Ran Hong, "Nitroso-ene Cyclization Enabled Access To 1-Azaspiro[4.4]nonane and Its Application In a Modular Synthesis Toward (±)-Cephalotaxine" Tetrahedron Lett. 2015, 56, 6656-6658. DOI:10.1016/j.tetlet.2015.10.002
http://www.sciencedirect.com/science/article/pii/S0040403915301994
34. Hao Liu#, Jing Yu#, Xinyu Li, Rui Yan, Ji-Chang Xiao, and Ran Hong*, "Stereoselectivity in N-Iminium Ion Cyclization: Development of an Efficient Synthesis of (+/-)-Cephalotaxine" Org. Lett. 2015, 17, 4444-4447. DOI: 10.1021/acs.orglett.5b02106. (# These authors contributed equally to the work.)
http://pubs.acs.org/doi/abs/10.1021/acs.orglett.5b02106?src=recsys
33. Jie Ouyang#, Rui Yan#, Xianwei Mi, and Ran Hong*, "Enantioselective Total Synthesis of (−)-Hosieine A" Angew. Chem. Int. Ed. 2015, 54, 10940-10943. DOI: 10.1002/anie.201505251. (#These authors contributed equally to the work.)
http://onlinelibrary.wiley.com/doi/10.1002/anie.201505251/abstract
32. Kuan Zheng, Changmin Xie, and Ran Hong*, "Bioinspired Iterative Synthesis of Polyketides", Front. Chem. 2015, 3, e32.http://journal.frontiersin.org/article/10.3389/fchem.2015.00032/abstract
31. Lili Zhu*, Sha-Hua Huang, Jing Yu, and Ran Hong*, "Constructive Innovation of Approaching Bicyclo[3.2.1]octane in ent-Kauranoids" (Digest paper) Tetrahedron Lett. 2015, 56, 23-31. doi:10.1016/j.tetlet.2014.11.035
http://www.sciencedirect.com/science/article/pii/S0040403914019170
30. Sha-Hua Huang*, Wenhua Li, Long Chen, Jian-He Xu, and Ran Hong*, "Chemoenzymatic Construction of Chiral Alkenyl Acetylenic Alcohol: A Key Building Block to Access Diastereoisomers of Polyacetylenes: " Bioresources and Bioprocessing 2015, 2, e10.
http://www.bioresourcesbioprocessing.com/content/2/1/10
29. Sha-Hua Huang*, Meng-Yuan Huang, Xueshun Jia, and Ran Hong, "Chemistry and Biology of Bakuchiol" Chin. J. Org. Chem. 2014, 34, 2412-2423.
http://sioc-journal.cn/Jwk_yjhx/CN/abstract/abstract344619.shtml
28. Lin Yang,# Guoli He,# Ruifeng Yin,# Lili Zhu, Xiaoxia Wang, and Ran Hong*, "Synthesis of Polyketide Stereoarrays Enabled by A Traceless Oxonia–Cope Rearrangement" Angew. Chem. Int. Ed. 2014, 53, 11600-116004. (#These authors contributed equally to the work.) DOI: 10.1002/anie.201407231.
http://onlinelibrary.wiley.com/doi/10.1002/anie.201407231/abstract
27. Meng-Yuan Huang, Long Chen, Ruoxi Li, Xueshun Jia*, and Ran Hong*, "Synthesis of rac-Bakuchiol via a Pot-Economy Approach" Chin. J. Chem. 2014, 32, 715-720. (Dedicated to Professors Lixin Dai and Chengye Yuan on the Occasion of Their 90th Birthdays.)
http://onlinelibrary.wiley.com/doi/10.1002/cjoc.201400160/pdf
26. Hua-Xing Huo, Jeremy R. Duvall, Meng-Yuan Huang, and Ran Hong*, "Catalytic Asymmetric Allylation of Carbonyl Compounds and Imines with Allyl Boronates" Org. Chem. Front. 2014, 1, 303-320. doi:10.1039/C3QO00081H.
http://pubs.rsc.org/en/content/articlelanding/2014/qo/c3qo00081h#!divAbstract
25. Lili Zhu,# Chisheng Loh,# and Ran Hong*, "Total Synthesis of (±)-Cafestol: A Late-Stage Construction of the Furan Ring Inspired by A Biosynthesis Strategy" Org. Lett. 2014, 16, 2162-2165. (#These authors contributed equally to the work.) (ACS Editor's Choice)
Open Acess: http://pubs.acs.org/doi/full/10.1021/ol500623w
24. Changmin Xie,# Donghu Bai,# Sha-Hua Huang, Xueshun Jia*, and Ran Hong*, "Kinetic Resolution of Diols via Etherification Catalyzed by a Chiral Phosphoric Acid: Concise Synthesis of (+)-Sacidumlignan D" Asian J. Org. Chem. 2014, 3, 277-280. doi:10.1002/ajoc.201300250. (#These authors contributed equally to the work.) (Editor's Choice)
http://onlinelibrary.wiley.com/doi/10.1002/ajoc.201300250/pdf
23. Huili Liu, Kuan Zheng, Xiang Lu, Xiaoxia Wang*, and Ran Hong*, "Study on Total Synthesis of Velbanamine: Chemoselective Dioxygenation of Alkenes with PIFA via a Stop-and-Flow Strategy" Beilstein J. Org. Chem. 2013, 9, 983-990 (Invited for the Thematic Issue on Natural Product Synthesis).
http://www.beilstein-journals.org/bjoc/content/pdf/1860-5397-9-113.pdf
22. Donghu Bai, Sha-Hua Huang*, Zuming Lin, Lin Yang, Junzeng Dai, Meng-Yuan Huang, Xueshun Jia*, and Ran Hong*, "Aza-Belluš-Claisen Rearrangement-Enabled Synthesis of Racemic Tapentadol and Its Stereoisomers" Chin. J. Chem. 2013, 31, 317-320 (selected as the Cover Paper) (Dedicated to Professor Guo-Qiang Lin on the occasion of his 70th Birthday).
21. Lili Zhu and Ran Hong*, "Biomimetic Cationic Cyclization toward ent–Kaurene-type Diterpenoids" Chin. J. Chem. 2013, 31, 111-118 (Special Issue, Dedicated to the Memory of Professor Wei-Shan Zhou).
20. Ran Hong, "Biomimetic Organic Synthesis" in Advances in Chemistry (China, 1982-2012), Sciences Press: Beijing; 2012, pp. 153-155.
19. Yan Wang, Rob Hoen, and Ran Hong*, "Development of a Non-enzymatic Kinetic Resolution of α-Allenic Alcohols" Synlett 2012, 23, 2729-2734 (doi:10.1055/s-0032-1317566) (Synpacts).
https://www.thieme-connect.com/ejournals/pdf/10.1055/s-0032-1317566.pdf
18. Xianwei Mi, Yan Wang, Lili Zhu, Ren-Xiao Wang, and Ran Hong*, "Enantioselective Synthesis of (-)-Stemoamide" Synthesis 2012, 44, 3432-3440 (doi:10.1055/s-0032-1317499) (Feature article).
https://www.thieme-connect.com/ejournals/pdf/10.1055/s-0032-1317499.pdf
17. Sha-Hua Huang*, Huaxin Huo, Wenhua Li, and Ran Hong*, "Research Progress on Nitroso-ene Reaction" Chin. J. Org. Chem. 2012, 32, 1776-1791.
16. Yan Wang, Kuan Zheng, and Ran Hong*, "Chiral Silver Phosphate-catalyzed Cycloisomeric Kinetic Resolution of alpha-Allenic Alcohols" J. Am. Chem. Soc. 2012, 134, 4096-4099.
(https://www.thieme-connect.com/ejournals/pdf/synfacts/doi/10.1055/s-0031-1291094.pdf)
15. He Zhang, Chang-Bing Zhou, Qing-Yun Chen, Ji-Chang Xiao*, and Ran Hong*, "Monofluorovinyl Tosylate: A Useful Building Block for the Synthesis of Terminal Vinyl Monofluorides via Suzuki-Miyaura Coupling" Org. Lett. 2011, 13, 560-563.
(https://www.thieme-connect.com/ejournals/pdf/synfacts/doi/10.1055/s-0030-1259822.pdf and http://www.organic-chemistry.org/abstracts/lit3/158.shtm
14. Yan Wang, Lili Zhu, Yuying Zhang, and Ran Hong*, "Bioinspired and Concise Synthesis of (+/-)-Stemoamide" Angew. Chem. 2011, 123, 2839-2842; Angew. Chem., Int. Ed. 2011, 50, 2787-2790.
(https://www.thieme-connect.com/ejournals/pdf/synfacts/doi/10.1055/s-0030-1260373.pdf)
13. Zhiyun Zhong, Ran Hong, and Xiaoxia Wang* "Construction of 3-Aryl-1,2,4-benzotriazines via Unprecedented Rearrangement of Bis(benzotrizaol-1-yl)methylarenes" Tetrahedron Lett. 2010, 51, 6763-6766.
12. Xinyu Li, Cheng Li, Wenjing Zhang, Shiqing Han, Xiang Lu, and Ran Hong* "Highly Stereoselective 7-Endo-Trig/Ring Contraction Cascade To Construct Pyrrolo[1,2-a]quinoline Derivatives" Org. Lett. 2010, 12, 1696-1699.
11. Cheng Li, Xinyu Li, and Ran Hong* “Synthetic Study on Tetrapetalones: Stereoselective Cyclization of N-acyliminium Ion To Construct Substituted 1-Benzazepines” Org. Lett. 2009, 11, 4036-4039.
Representative publications (PhD and postdoc period):10. Bingfeng Sun, Ran Hong, Yanbiao Kang, and Li Deng* “Asymmetric Total Synthesis of (-)-Plicatic Acid via a Highly Enantioselective and Diastereoselective Nucleophilic Epoxidation of Acyclic Trisubstitued Olefins” J. Am. Chem. Soc. 2009, 131, 10384-10385.
9. Yongqiang Wang, Jun Song, Ran Hong, Hongmin Li, and Li Deng* “Asymmetric Friedel-Crafts Reaction of Indoles with Imines by an Organic Catalyst” J. Am. Chem. Soc. 2006, 128, 8156-8157.
8. Fanghui Wu, Ran Hong, Jihan Khan, Xiaofeng Liu, and Li Deng* “Asymmetric Synthesis of Chiral Aldehydes by Conjugate Additions with Bifunctional Organocatalysis by Cinchona Alkaloids” Angew. Chem., Int. Ed. 2006, 45, 4301-4305.
7. Fanghui Wu, Hongmin Li, Ran Hong, and Li Deng* “Construction of Quaternary Stereocenters by Efficient and Practical Conjugate Additions to α,β-Unsaturated Ketones with a Chiral Organic Catalyst” Angew. Chem., Int. Ed. 2006, 45, 947-950.
6. Ran Hong, Yonggang Chen, and Li Deng* “Catalytic Enantioselective Total Syntheses of Bisorbicillinolide, Bisorbicillinol and Bisorbibutenolide” Angew. Chem., Int. Ed. 2005, 44, 3478-3481.
5. Shi-Kai Tian, Ran Hong, and Li Deng* “Catalytic Asymmetric Cyanosilylation of Ketones with Chiral Lewis Base” J. Am. Chem. Soc. 2003, 125, 9900-9901.
4. Jian-Guang Lei, Ran Hong, Shen-Gang Yuan, and Guo-Qiang Lin* “Nickel-catalyzed Tandem Reaction To Asymmetric Synthesis of Chiral Phthalides” Synlett 2002, 927-930.
3. Ran Hong, Rob Hoen, Jing Zhang, and Guo-Qiang Lin* “Nickel-catalyzed Ullmann-type Coupling Reaction to Prepare tetra-ortho-substituted Biaryls” Synlett 2001, 1527-1530.
2. Ran Hong, Jun Feng, Rob Hoen, and Guo-Qiang Lin* “Synthesis of (±)-3,3'-Bis(4-hydroxy-2H-benzopyran): A Literature Correction” Tetrahedron 2001, 57, 8685-8689.
1. Guo-Qiang Lin* and Ran Hong “A New Reagent System for Modified Ullmann-Type Coupling Reactions: NiCl2(PPh3)2/PPh3/Zn/NaH/Toluene” J. Org. Chem. 2001, 66, 2877-2880.
发表论文
(2) Structure-guided Tuning of a Hydroxynitrile Lyase to Accept Rigid Pharmaco Aldehydes, ACS Catalysis, 2020, 通讯作者
(3) A Modular Synthesis of Antitumor Macrolide Lasonolide A, Chin J Chem, 2020, 通讯作者
(4) Stereoselective Access to Polypropionates Expediated by the Double Hydroboration of Allenes: Total Synthesis of Antitumor (-)-Pironetin, CCS Chemistry, 2020, 通讯作者
(5) Recent Advances in Asymmetric Synthesis of Nucleoside Phosphoramidates (ProTides): Construction of the P-Stereogenic Centers, Chin J Org Chem, 2020, 通讯作者
(6) Stereoselectivity in a Nitroso-Ene Cyclization: Formal Synthesis of rac-Manzacidins A and C, Tetrahedron, 2019, 通讯作者
(7) Preface: Special Memorial issue for Professor Wei-Shan Zhou, Tetrahedron, 2019, 通讯作者
(8) Methods and Strategies for the Synthesis of Peduncularine, Youji Huaxue, 2019, 通讯作者
(9) FR901483: Synthetic Efficiency Remains a Challenge, Synthesis, 2019, 通讯作者
(10) Stereoconfining Macrocyclizations in the Total Synthesis of Natural Products, Natural Product Reports, 2019, 通讯作者
(11) An Enantioconvergent and Concise Synthesis of Lasonolide A, Angew Chem Int Ed, 2018, 通讯作者
(12) Total Syntheses of Melinonine-E and Strychnoxanthine: Evolution of the Synthetic Strategy Enabled by Novel Method Development, Tetrahedron, 2018, 通讯作者
(13) Total Synthesis of Strictamine: A Tutorial for Novel and Efficient Synthesis, Org. Chem. Front., 2018, 通讯作者
(14) Pursuing Effective Gram-negative Antibiotics: The Chemical Synthesis of Negamycin, Tetrahedron Letters, 2018, 通讯作者
(15) Pinacol Coupling Going in a Photocatalytic Asymmetric Manner: Construction of Chiral Vicinal Amino Alcohols, Science China Chem., 2018, 通讯作者
(16) Catalytic Aza-Wacker Annulation: Tuning Mechanism by the Activation Mode of Amide and Enantioselective Syntheses of Melinonine-E and Strychnoxanthine, Organic Letters, 2018, 通讯作者
(17) Crossing the Ring: A Journey of the Nitroso-ene Reaction, Synlett, 2017, 通讯作者
(18) Hydroxynitrile lyase isozymes from Prunus communis: identification, characterization and synthetic application, Adv. Synth. Catal., 2017, 通讯作者
(19) A Chiral Pentenolide-Based Unified Synthesis of Dihydrocorynantheal, Dihydrocorynantheol, Protoemetine, Protoemetinol, and Yohimbane, Organic Letters, 2017, 通讯作者
(20) Construction of Morphan Derivatives by Nitroso-Ene Cyclization: Mechanistic Insight and Total Synthesis of rac-Kopsone, Angew Chem Int Ed, 2017, 通讯作者
(21) Biomimetic Synthesis of Lankacidin Antibiotics, J Am Chem Soc, 2017, 通讯作者
(22) Concise Synthesis and Revision to the Proposed Biogenesis of Helicascolides, Tetrahedron Letters, 2017, 通讯作者
(23) Highly Stereoselective Kinetic Resolution of alpha-Allenic Alcohols: An Enzymatic Approach, Tetrahedron Lett., 2016, 通讯作者
(24) Stereoselective alpha-Hydroxylation of Amides with Oppolzer's Sultam as Chiral Auxiliary, J. Org. Chem., 2016, 通讯作者
(25) Stereodivergent Synthesis of Functionalized Tetrahydropyrans Accelerated by Mechanism-Based Allylboration and Bioinspired oxa-Michael Cyclization, Angew. Chem. Int. Ed., 2016, 通讯作者
(26) Stereoselective construction of skipped polyol in polyketides enabled by oxonia-Cope rearrangement and iodolactonization: Enantioselective synthesis of (+)-yashabushitriol, Science China: Chemistry, 2016, 通讯作者
(27) Bioinspired Iterative Synthesis of Polyketides, Front. Chem., 2015, 通讯作者
(28) Enantioselective Total Synthesis of (−)-Hosieine A, Angew. Chem. Int. Ed., 2015, 通讯作者
(29) "Stereoselectivity in N-Iminium Ion Cyclization: Development of an Efficient Synthesis of (+/-)-Cephalotaxine, Org. Lett., 2015, 通讯作者
(30) Nitroso-ene Cyclization Enabled Access To 1-Azaspiro[4.4]nonane and Its Application In a Modular Synthesis Toward (±)-Cephalotaxine, Tetrahedron Lett., 2015, 第 4 作者
(31) Constructive Innovation of Approaching Bicyclo[3.2.1]octane in ent-Kauranoids, Tetrahedron Letters, 2015, 通讯作者
(32) Total Synthesis of (±)-Cafestol: A Late-Stage Construction of the Furan Ring Inspired by A Biosynthesis Strategy, Org. Lett., 2014, 通讯作者
(33) Catalytic Asymmetric Allylation of Carbonyl Compounds and Imines with Allyl Boronates, Org. Chem. Front., 2014, 通讯作者
(34) Kinetic Resolution of Diols via Etherification Catalyzed by a Chiral Phosphoric Acid: Concise Synthesis of (+)-Sacidumlignan D, Asian J. Org. Chem., 2014, 通讯作者
(35) Synthesis of rac-Bakuchiol via a Pot-Economy Approach, Chin. J. Chem., 2014, 通讯作者
(36) Synthesis of Polyketide Stereoarrays Enabled by A Traceless Oxonia–Cope Rearrangement, Angew Chem Int Ed, 2014, 通讯作者
(37) Study on Total Synthesis of Velbanamine: Chemoselective Dioxygenation of Alkenes with PIFA via a Stop-and-Flow Strategy, Beilstein J. Org. Chem., 2013, 通讯作者
(38) Biomimetic Cationic Cyclization toward ent–Kaurene-type Diterpenoids, Chin. J. Chem., 2013, 通讯作者
(39) Aza-Bellu?-Claisen Rearrangement-Enabled Synthesis of Racemic Tapentadol and Its Stereoisomers, Chin. J. Chem., 2013, 通讯作者
(40) Synthesis, 2012, 通讯作者
(41) Synlett, 2012, 通讯作者
(42) Chiral Silver Phosphate-catalyzed Cycloisomeric Kinetic Resolution of alpha-Allenic Alcohols, J. Am. Chem. Soc., 2012, 通讯作者
(43) Angew. Chem., Int. Ed., 2011, 通讯作者
(44) Org. Lett., 2011, 通讯作者
(45) Org. Lett., 2010, 通讯作者
(46) Tetrahedron Lett., 2010, 第 2 作者
(47) Org. Lett., 2009, 通讯作者
(48) J. Am. Chem. Soc., 2009, 第 2 作者
发表著作
(2) 天然产物全合成荟萃-抗生素及其他, Highlights of Total Synthesis of Natural Products III-Antibiotics and more, 科学出版社, 2012-07, 第 2 作者
(3) 手性合成:基础研究与进展, 科学出版社, 2018-01, 第 3 作者
科研活动
科研项目
( 2 ) 结构与功能导向的新物质创制专项, 参与, 中国科学院计划, 2016-07--2020-12
( 3 ) 亚硝基-烯反应的合成方法学及其在生物碱合成中的应用, 负责人, 国家任务, 2017-01--2020-12
参与会议
指导学生
已指导学生
张玉莹 硕士研究生 070303-有机化学
李程 博士研究生 070303-有机化学
朱莉莉 博士研究生 070303-有机化学
鲁翔 硕士研究生 070303-有机化学
王燕 博士研究生 070303-有机化学
霍华兴 博士研究生 070303-有机化学
罗济生 博士研究生 070303-有机化学
刘浩 博士研究生 070303-有机化学
和国力 硕士研究生 085216-化学工程
欧阳杰 博士研究生 070303-有机化学
郑宽 博士研究生 070303-有机化学
谢昌敏 博士研究生 070303-有机化学
米贤伟 博士研究生 070303-有机化学
严睿 博士研究生 070303-有机化学
杨林 博士研究生 070303-有机化学
王超 博士研究生 070303-有机化学
沈德风 博士研究生 070303-有机化学
翟丽 博士研究生 070303-有机化学
张岩 博士研究生 070303-有机化学
唐也 博士研究生 070303-有机化学
邵顺杰 博士研究生 070303-有机化学
现指导学生
张冰冰 博士研究生 070303-有机化学
阮朱伟 博士研究生 070303-有机化学
孔露瑶 博士研究生 070303-有机化学
杨晨 硕士研究生 070303-有机化学
刘祎辰 博士研究生 070303-有机化学
王凌永 博士研究生 070303-有机化学