1. Hippo信号通路与代谢相互作用在肿瘤发生发展中的功能与机制; 

2. 肿瘤微环境内的细胞间代谢通讯与肿瘤免疫; 

3. 多胺的代谢调控机制和病理生理功能。

每年招收1-2名硕士研究生

100701-药物化学
100706-药理学

肿瘤代谢与免疫调控，抗肿瘤药物靶点发现

2009-09--2014-07   中国科学院大学   博士
2004-09--2009-06   华中科技大学   医学学士

   

2023-09~现在, 中国科学院杭州医学研究所, 特聘研究员
2018-09~2023-06,德克萨斯大学西南医学中心, 研究科学家
2014-09~2018-08,印第安纳大学布鲁明顿分校, 博士后研究员

   

（ 1 ） 联合制剂及其在制备非小细胞肺癌药物中的应用, 发明专利, 2016, 第 2 作者, 专利号: ZL201310291126.4

   

（1） Lactylation in cancer: Current understanding and challenges, Cancer Cell, 2024, 第 1 作者
（2） Multiphase coalescence mediates Hippo pathway activation, Cell, 2022, 第 8 作者
（3） YAP-VGLL4 antagonism defines the major physiological function of the Hippo signaling effector YAP, Genes & Development, 2022, 第 3 作者
（4） YAP/TAZ drives cell proliferation and tumour growth via a polyamine-eIF5A hypusination-LSD1 axis, Nature Cell Biology, 2022, 第 1 作者
（5） FADS3 is a ��14Z sphingoid base desaturase that contributes to gender differences in the human plasma sphingolipidome, Journal of Biological Chemistry, 2020, 第 5 作者
（6） The oncometabolite L-2-hydroxyglutarate is a common product of dipteran larval development, Insect Biochemistry and Molecular Biology, 2020, 第 8 作者
（7） Lactate dehydrogenase and glycerol-3-phosphate dehydrogenase cooperatively regulate growth and carbohydrate metabolism during Drosophila melanogaster larval development, Development, 2019, 第 1 作者
（8） A Drosophila model of combined D-2- and L-2-hydroxyglutaric aciduria reveals a mechanism linking mitochondrial citrate export with oncometabolite accumulation, Disease Models & Mechanisms, 2018, 第 1 作者
（9） Preparation of Drosophila larval samples for gas chromatography-mass spectrometry (GC-MS)-based metabolomics, JoVE-Journal of Visualized Experiments, 2018, 第 1 作者
（10） Inflammation-induced DNA methylation of DNA Polymerase gamma alters the metabolic profile of colon tumors, Cancer & Metabolism, 2018, 第 2 作者
（11） Metabolomic analysis reveals that the Drosophila gene lysine influences diverse aspects of metabolism, Genetics, 2017, 第 2 作者
（12） Methods for studying the metabolic basis of Drosophila development, Wiley Interdisciplinary Reviews-Developmental Biology, 2017, 第 1 作者
（13） Glutaminolysis is essential for energy production and ion transport in human corneal endothelium, eBioMedicine, 2017, 第 2 作者
（14） Conditionally immortal Slc4a11���/��� mouse corneal endothelial cell line recapitulates disrupted glutaminolysis seen in Slc4a11���/��� mouse model, Investigative Ophthalmology & Visual Science, 2017, 第 5 作者
（15） Drosophila larvae synthesize the putative oncometabolite L-2-hydroxyglutarate during normal developmental growth, Proceedings of the National Academy of Sciences of USA, 2017, 第 1 作者
（16） Decreased glutathione biosynthesis contributes to EGFR T790M-driven erlotinib resistance in non-small cell lung cancer, Cell Discovery, 2016, 第 1 作者
（17） Dietary modulation of gut microbiota contributes to alleviation of both genetic and simple obesity in children, eBioMedicine, 2015, 第 3 作者
（18） The metabolic responses to hepatitis B virus infection shed new light on pathogenesis and targets for treatment, SCIENTIFIC REPORTS, 2015, 第 1 作者
（19） An optimized method for NMR-based plant seed metabolomic analysis with maximized polar metabolite extraction efficiency, signal-to-noise ratio, and chemical shift consistency, ANALYST, 2014, 第 3 作者
（20） Advances in Metabonomics on Infectious Diseases, CURRENT METABOLOMICS, 2013, 第 1 作者
（21） Enhanced Green Fluorescent Protein Transgenic Expression In Vivo Is Not Biologically Inert, JOURNAL OF PROTEOME RESEARCH, 2013, 第 1 作者