Hibernation; Hibernation-inspired protective mechanisms & translational medicine; anti-aging; stem cells;

Ph.D.: School of Medicine, University of Aberdeen, the United Kingdom;

M.Sc.: School of Life Sciences, Sun Yat-sen University, China, P.R.;

B.Eng.: Dept. of Bioengineering, South China University of Technology, China, P.R.;

Aging-rewired metabolic cues promote autophagy and senescence via DRAM1 J Yang, H Sun, K Xu, X Zhang, et al., J Ou. 2025;

Autophagy, 1-23

Cross-species metabolomic profiling reveals phosphocholine-mediated liver protection from cold and ischemia/reperfusion L Zhang, L Chen, Y Jiang, G Jin, et al., J Ou, Y Yang. 2024;

American Journal of Transplantation 24 (11), 1979-1993

Cold-induced FOXO1 nuclear transport aids cold survival and tissue storage X Zhang, L Ge, G Jin, Y Liu, et al., J Ou. 2024; Nature Communications 15 (1), 2859

Synergy of 5-aminolevulinate supplement and CX3CR1 suppression promotes liver regeneration via elevated IGF-1 signaling L Chen, L Zhang, G Jin, Y Liu, et al., J Ou. 2023; Cell Reports 42 (8)

5-aminolevulinate and CHIL3/CHI3L1 treatment amid ischemia aids liver metabolism and reduces ischemia-reperfusion injury G Jin, N Guo, Y Liu, L Zhang, et al., J Ou. 2023; Theranostics 13 (14), 4802

5-Aminolevulinate improves metabolic recovery and cell survival of the liver following cold preservation X Zhang, L Chen, W Liu, J Shen, et al., J Ou. 2022; Theranostics 12 (6), 2908

Induced pluripotent stem cells as a tool for comparative physiology: lessons from the thirteen-lined ground squirrel J Ou, S Rosa, LE Berchowitz, W Li. 2019; Journal of Experimental Biology 222 (19), jeb196493

iPSCs from a hibernator provide a platform for studying cold adaptation and its potential medical applications J Ou, JM Ball, Y Luan, T Zhao, et al., W Li. 2018; Cell 173 (4), 851-863. e16

Integrated transcriptomic and metabolomic analysis reveals adaptive changes of hibernating retinas Y Luan, J Ou, VP Kunze, F Qiao, Y Wang, L Wei, W Li, Z Xie. 2018; Journal of Cellular Physiology 233 (2), 1434-1445

Synaptic pathology and therapeutic repair in adult retinoschisis mouse by AAV-RS1 transfer J Ou, C Vijayasarathy, L Ziccardi, S Chen, et al., PA Sieving. 2015; The Journal of clinical investigation 125 (7), 2891-2903