基本信息

贺焯皓 男 博导 中国科学院上海有机化学研究所
电子邮件: hezh@sioc.ac.cn
通信地址: 上海市浦东新区海科路100号13号楼240室
邮政编码:
电子邮件: hezh@sioc.ac.cn
通信地址: 上海市浦东新区海科路100号13号楼240室
邮政编码:
研究领域
神经退行性疾病病理发生机理及模型构建
招生信息
常年招收博士及博士后
招生专业
071009-细胞生物学071010-生物化学与分子生物学
招生方向
神经退行性疾病神经病理阿兹海默症
教育背景
2005-09--2012-01 中国科学院神经科学研究所 研究生,理学博士2001-09--2005-07 武汉大学 本科,理学学士
学历
研究生
学位
理学博士
工作经历
工作简历
2019-09~现在, 中国科学院上海有机化学研究所, 研究员2018-03~2019-08,美国宾夕法尼亚大学, 副研究员2013-03~2018-02,美国宾夕法尼亚大学, 博士后2012-01~2012-11,中国科学院神经科学研究所, 助理研究员
教授课程
神经系统疾病模式物种生物学及实验专业文献精读
专利与奖励
奖励信息
(1) 中国神经科学学会第五届神经退行性疾病分会年会青年神经科学家论文报告奖, 二等奖, 专项, 2021(2) AAIC2019, 其他, 2019(3) Cold Spring Harbor Asia, 一等奖, 其他, 2012
出版信息
发表论文
[1] Hong Xu, Qi Qiu, 贺焯皓, Virginia Lee. MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons. Acta Neuropathologica[J]. 2024, 第 3 作者147(55): https://link.springer.com/article/10.1007/s00401-024-02703-3#citeas.[2] Xinyi Zhao, Wen Zeng, Hong Xu, Zihan Sun, Yingxin Hu, Beibei Peng, Jennifer D McBride, Jiangtao Duan, Juan Deng, Bin Zhang, SooJung Kim, Bryan Zoll, Takashi Saito, Hiroki Sasaguri, Takaomi C Saido, Carlo Ballatore, Haishan Yao, Zhaoyin Wang, John Q Trojanowski, Kurt R Brunden, Virginia MY Lee, Zhuohao He. A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury. SCIENCE TRANSLATIONAL MEDICINE[J]. 2023, 第 22 作者 通讯作者 15(713): eabo6889-eabo6889, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10787216/.[3] Zhang, Tongtong, Cong, Lin, Chen, Ben, He, Zhuohao, Li, Guozhong, Qin, Qi. Editorial: Multimodal interventions in Alzheimer's disease: from basic research to clinical practice. FRONTIERS IN NEUROLOGY[J]. 2023, 第 4 作者 通讯作者 14: http://dx.doi.org/10.3389/fneur.2023.1303733.[4] Han, Yuliang, He, Zhuohao. Concomitant protein pathogenesis in Parkinson's disease and perspective mechanisms. FRONTIERS IN AGING NEUROSCIENCE. 2023, 第 2 作者 通讯作者 15: http://dx.doi.org/10.3389/fnagi.2023.1189809.[5] Zhang, Shengnan, Zhu, Yi, Lu, Jinxia, Liu, Zhenying, Lobato, Amanda G, Zeng, Wen, Liu, Jiaqi, Qiang, Jiali, Zeng, Shuyi, Zhang, Yaoyang, Liu, Cong, Liu, Jun, He, Zhuohao, Zhai, R Grace, Li, Dan. Specific binding of Hsp27 and phosphorylated Tau mitigates abnormal Tau aggregation- induced pathology. ELIFE[J]. 2022, 第 13 作者11: http://dx.doi.org/10.7554/eLife.79898.[6] Xu, Gang, Li, Ying, Zhang, Shengyuan, Peng, Haoran, Wang, Yunyun, Li, Dekang, Jin, Taijie, He, Zhuohao, Tong, Yilun, Qi, Chunting, Wu, Guowei, Dong, Kangyun, Gou, Jizhou, Liu, Yang, Xiao, Tongyang, Qu, Jing, Li, Liang, Liu, Liang, Zhao, Ping, Zhang, Zheng, Yuan, Junying. SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation. CELL RESEARCH[J]. 2021, 第 8 作者31(12): 1230-1243, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7107624&detailType=1.[7] Weitzman, Sarah A, Narasimhan, Sneha, He, Zhuohao, Changolkar, Lakshmi, McBride, Jennifer D, Zhang, Bin, Schellenberg, Gerard D, Trojanowski, John Q, Lee, Virginia M Y. Insoluble Tau From Human FTDP-17 Cases Exhibit Unique Transmission Properties In Vivo. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY[J]. 2020, 第 3 作者79(9): 941-949, http://dx.doi.org/10.1093/jnen/nlaa086.[8] Xu, Daichao, Zhao, Heng, Jin, Minzhi, Zhu, Hong, Shan, Bing, Geng, Jiefei, Dziedzic, Slawomir A, Amin, Palak, Mifflin, Lauren, Naito, Masanori Gomi, Najafov, Ayaz, Xing, Jing, Yan, Lingjie, Liu, Jianping, Qin, Ying, Hu, Xinqian, Wang, Huibing, Zhang, Mengmeng, Manuel, Vica Jean, Tan, Li, He, Zhuohao, Sun, Zhenyu J, Lee, Virginia M Y, Wagner, Gerhard, Yuan, Junying. Modulating TRADD to restore cellular homeostasis and inhibit apoptosis. NATURE[J]. 2020, 第 21 作者587(7832): 133-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000572352700003.[9] Darwich, Nabil F, Phan, Jessica M, Kim, Boram, Suh, EunRan, Papatriantafyllou, John D, Changolkar, Lakshmi, Nguyen, Aivi T, ORourke, Caroline M, He, Zhuohao, Porta, Silvia, Gibbons, Garrett S, Luk, Kelvin C, Papageorgiou, Sokratis G, Grossman, Murray, Massimo, Lauren, Irwin, David J, McMillan, Corey T, Nasrallah, Ilya M, Toro, Camilo, Aguirre, Geoffrey K, Van Deerlin, Vivianna M, Lee, Edward B. Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau. SCIENCE[J]. 2020, 第 9 作者370(6519): 932-+, http://dx.doi.org/10.1126/science.aay8826.[10] Zhuohao He, Jennifer D McBride, Hong Xu, Lakshmi Changolkar, Soojung Kim, Bin Zhang, Sneha Narasimhan, Garrett S Gibbons, Jing L Guo, Michael Kozak, Gerard D Schellenberg, John Q Trojanowski, Virginia M Y Lee. Transmission of tauopathy strains is independent of their isoform composition. NATURE COMMUNICATIONS[J]. 2020, 第 1 作者 通讯作者 11(1): 1-18, http://dx.doi.org/10.1038/s41467-019-13787-x.[11] He Zhuohao. Abeta Plaques Enhance Alzheimer Brain Tau Seeded Pathologies Via Facilitating Neuritic Plaque Tau Aggregation.. Nature Medicine. 2018, 第 1 作者[12] He, Zhuohao, Wang, Y. TRPC Channel Downstream Signaling Cascades. TRANSIENT RECEPTOR POTENTIAL CANONICAL CHANNELS AND BRAIN DISEASES[J]. 2017, 第 1 作者976: 25-33, https://www.webofscience.com/wos/woscc/full-record/WOS:000429061700003.[13] Guo, Jing L, Narasimhan, Sneha, Changolkar, Lakshmi, He, Zhuohao, Stieber, Anna, Zhang, Bin, Gathagan, Ronald J, Iba, Michiyo, McBride, Jennifer D, Trojanowski, John Q, Lee, Virginia M Y. Unique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic mice. JOURNAL OF EXPERIMENTAL MEDICINE[J]. 2016, 第 4 作者213(12): 2635-2654, https://www.webofscience.com/wos/woscc/full-record/WOS:000391122400009.[14] Feng, Shengjie, He, Zhuohao, Li, Hongyu, Wang, Yizheng. Ca2+ signaling initiated by canonical transient receptor potential channels in dendritic development. NEUROSCIENCE BULLETIN[J]. 2015, 第 2 作者31(3): 351-356, http://ir.sibs.ac.cn/handle/331001/3946.[15] Junfeng Wang, Rui Lu, Jian Yang, Hongyu Li, Zhuohao He, Naihe Jing,, Xiaoming Wang, Yizheng Wang. TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production.. NATURE COMMUNICATIONS. 2015, 第 5 作者6: http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201804160009449LZ.[16] Zhuohao He, Caixia Jia, Shengjie Feng, Kechun Zhou, Yilin Tai, Xue Bai, Yizheng Wang. TRPC5 Channel Is the Mediator of Neurotrophin-3 in Regulating Dendritic Growth via CaMKIIα in Rat Hippocampal Neurons. THE JOURNAL OF NEUROSCIENCE. 2012, 第 1 作者32(27): 9383-9395, [17] Ding, Xia, He, Zhuohao, Zhou, Kechun, Cheng, Ju, Yao, Hailan, Lu, Dongliang, Cai, Rong, Jin, Yening, Dong, Bin, Xu, Yinghui, Wang, Yizheng. Essential Role of TRPC6 Channels in G2/M Phase Transition and Development of Human Glioma. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE[J]. 2010, 第 2 作者102(14): 1052-1068, http://dx.doi.org/10.1093/jnci/djq217.[18] He Zhuohao. Targeting TRPC6 channels in oesophageal carcinoma growth. Expert opinion on therapeutic targets. Expert opinion on therapeutic targets. 2010, 第 1 作者[19] Shi, Y, Ding, X, He, ZH, Zhou, KC, Wang, Q, Wang, YZ. Critical role of TRPC6 channels in G2 phase transition and the development of human oesophageal cancer. GUT[J]. 2009, 58(11): 1443-1450, http://www.irgrid.ac.cn/handle/1471x/502351.[20] Tai, Yilin, Feng, Shengjie, Ge, Ruiliang, Du, Wanlu, Zhang, Xiaoxing, He, Zhuohao, Wang, Yizheng. TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway. JOURNAL OF CELL SCIENCE[J]. 2008, 第 6 作者121(14): 2301-2307, http://www.irgrid.ac.cn/handle/1471x/502221.[21] Narasimhan Sneha, Guo Jing L., Changolkar Lakshmi, Stieber Anna, McBride Jennifer D., Silva Luisa V., He Zhuohao, Zhang Bin, Gathagan Ronald J., Trojanowski John Q., Lee Virginia M.Y.. Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain. THE JOURNAL OF NEUROSCIENCE. 第 7 作者37(47): 11406-11423, https://www.webofscience.com/wos/woscc/full-record/WOS:000416595200011.
科研活动
科研项目
( 1 ) Studying an Alzheimer's disease specific tau strain, 负责人, 其他国际合作项目, 2018-07--2021-06( 2 ) 脑撞击引起的慢性脑损伤在阿兹海默症相关的tau蛋白病理发生中的作用与机理研究, 负责人, 国家任务, 2022-01--2025-12( 3 ) 阿兹海默症中tau蛋白病理变性传播的机制研究, 负责人, 地方任务, 2021-07--2024-06( 4 ) 神经退行性疾病的病理发生机制研究, 负责人, 中国科学院计划, 2022-01--2024-12( 5 ) 神经退行性疾病的病理机制研究, 负责人, 国家任务, 2021-01--2023-12
参与会议
(1)Axonal microtubule disruption is involved in Alzheimer's disease-related tau pathogenesis 冷泉港亚洲会议 2024-04-08(2)Tau pathogenesis: insights from novel sporadic tauopathy mouse models 新基石研讨会 2024-04-05(3)Polymorphism proportion change contributes to a-synuclein transmission activity decline after repeated passages 2024-03-05(4)rTBI induce AD-like protein pathogenesis and neurodegeneration via microtubule disruption 中国细胞生物学学会第十八次会员代表大会 暨2023 年全国学术大会 贺焯皓 2023-04-10(5)rTBI induce protein pathogenesis and neurodegeneration via microtubule disruption 2023-03-28(6)阿尔茨海默病研究重大科学问题圆桌论坛 2022年全国认知、衰老及其相关疾病学术会议 2022-12-01(7)Generating new mouse models for studying Alzheimer’s disease and related dementia 中国神经科学学会第15届代表大会 2022-11-26(8)Traumatic Brain Injury Induced Alzheimer’s Disease-Related Pathogenesis and Neurodegeneration Through Disrupting Axonal Microtubules 第五届中国神经科学学会神经退行性疾病分会年会 暨杭州国际神经退行性疾病前沿研讨会 2021-11-05(9)慢性脑损伤与阿尔兹海默症的病理发生 第二节神经退行性疾病研究前沿论坛会议 2021-05-13(10)Understanding tau pathology transmission in AD and FTLD using new mouse models. 2019-07-14(11)Understanding tau pathology transmission in AD and FTLD using new mouse models. 2019-06-18