基本信息
贺鹏博  男  硕导  中国科学院近代物理研究所
电子邮件: hepengbo@impcas.ac.cn
通信地址: 兰州市南昌路509号
邮政编码:

研究领域

肿瘤重离子放射治疗(Heavy-ion radiotherapy)

图像引导放射治疗 (Image guided radiotherapy, IGRT)

靶区运动管理 (Motion management)

四维放射治疗计划系统 (4D treatment planninng system)

实时自适应放射治疗(Real-time adaptive radiation therapy)

人工智能(AI)

招生信息

肿瘤放射治疗已进入粒子放射治疗时代,重离子由于在物理学和生物学上展现的优势被誉为二十一世纪最理想的放射治疗用射线,粒子放射治疗是一个高速发展的学科,技术与设备处于不断更新换代中,其中尤为突出的技术热点及难点问题是动态靶区定位及四维粒子放射治疗技术,我们在粒子放射治疗系统设计开发、四维粒子放射治疗技术研究、图像引导放疗、人工智能等方面有着丰富的经验积累,热忱欢迎各位学子加盟本课题组,为实现精准、高效、智能的下一代粒子束放疗技术、为攻克粒子放射治疗世界难题出谋划策,也为我国实现先进粒子放射治疗贡献力量!

招生专业
082704-辐射防护及环境保护
086000-生物与医药
招生方向
放射治疗技术及防护
生物与医药

教育背景

2010-09--2015-07   中国科学院大学   博士研究生
2006-09--2010-07   西北大学   理学学士
学历

博士研究生

学位

理学博士

工作经历

工作简历
2019-11~现在, 中国科学院近代物理研究所, 青年研究员
2019-04~2020-03,日本国立放射线医学综合研究所(NIRS), 访问学者
2017-11~现在, 中国科学院近代物理研究所, 副研究员
2015-07~2017-11,中国科学院近代物理研究所, 助理研究员

教授课程

粒子放射治疗中的医学物理学
粒子治疗中的医学物理学
重离子治癌技术

专利与奖励

(1) REPIRATORY GUIDANCE AND METHOD APPLIED IN RESPIRATORY-GATED ION BEAM IRRADIATION. 美国发明专利,第1作者,Patent No.: US10300301B2

 (2)  ESPIRATORY GUIDING DEVICE AND METHOD IN RESPIRATORY GATING ION BEAM IRRADIATION. 欧洲发明专利,第1作者,Patent No.: 3184147

奖励信息
(1) 医用重离子加速器研发转化, 院级, 2020
专利成果
[1] 张新阳, 李强, 贺鹏博, 刘新国, 戴中颖, 马圆圆, 申国盛, 张晖. 一种智能型的离子束自适应放疗系统、存储介质及设备. CN: CN113744320A, 2021-12-03.

[2] 贺鹏博, 李强, 陈卫强, 唐凯, 车宇航, 康宇杰. 一种离子束三维剂量分布探测装置及方法. CN113406686A, 2021-09-17.

[3] 贺鹏博, 李强. 一种四维剂量计算方法、系统及存储介质. CN: CN113096724A, 2021-07-09.

[4] 贺鹏博, 李强. 一种基于射程的肿瘤内靶区生成方法和系统. CN: CN113018707A, 2021-06-25.

[5] 申国盛, 李强, 戴中颖, 刘新国, 金晓东, 贺鹏博. 一种图像引导放射治疗的摆位引导系统和方法. CN: CN112316318A, 2021-02-05.

[6] 戴天缘, 李强, 陈卫强, 刘新国, 戴中颖, 贺鹏博, 马圆圆, 申国盛, 张晖. 基于纳剂量学获得离子束辐照方案的方法. CN: CN110412639A, 2019-11-05.

[7] 贺鹏博, 陈卫强, 李强, 肖国青. 用于离子束放射治疗的磁共振图像引导装置. CN: CN108671418A, 2018-10-19.

[8] 申国盛, 李强, 陈卫强, 姬腾飞, 戴中颖, 刘新国, 马圆圆, 贺鹏博, 张晖. 一种用于放射治疗中患者摆位的实时验证装置及方法. CN: CN106880906A, 2017-06-23.

[9] 戴中颖, 李强, 刘新国, 申国盛, 马圆圆, 贺鹏博, 黄齐艳, 闫渊林. 重离子放射治疗多功能三维适形调强装置. CN: CN204745394U, 2015-11-11.

[10] 戴中颖, 李强, 马圆圆, 申国盛, 刘新国, 贺鹏博, 黄齐艳, 闫渊林. 三维剂量验证装置. CN: CN204723619U, 2015-10-28.

[11] 戴中颖, 李强, 马圆圆, 申国盛, 刘新国, 贺鹏博, 黄齐艳, 闫渊林. 基于水等效系数的离子束放射治疗剂量验证方法. CN: CN104888364A, 2015-09-09.

[12] 戴中颖, 李强, 马圆圆, 申国盛, 刘新国, 贺鹏博, 黄齐艳, 闫渊林. 三维剂量验证装置及其方法. CN: CN104857639A, 2015-08-26.

[13] 戴中颖, 李强, 刘新国, 申国盛, 马圆圆, 贺鹏博, 黄齐艳, 闫渊林. 重离子放射治疗多功能三维适形调强装置及方法. CN: CN104759038A, 2015-07-08.

[14] 刘新国, 李强, 贺鹏博, 戴中颖, 黄齐艳, 闫渊林, 马园园, 申国盛, 付廷岩, 肖国青. 快速获得免冲洗验证胶片剂量响应曲线的装置. CN: CN204314473U, 2015-05-06.

[15] 刘新国, 李强, 贺鹏博, 戴中颖, 黄齐艳, 闫渊林, 马园园, 申国盛, 付廷岩, 肖国青. 快速获得免冲洗验证胶片剂量响应曲线的装置和方法. CN: CN104502947A, 2015-04-08.

[16] 戴中颖, 李强, 贺鹏博, 刘新国, 申国盛, 马圆圆, 黄奇艳, 闫渊林, 肖国青. 一种模拟离子束射野的平行光野指示装置及方法. CN: CN104338245A, 2015-02-11.

[17] 贺鹏博, 李强, 戴中颖, 刘新国, 赵婷, 付廷岩, 申国盛, 马圆圆, 黄齐燕, 闫渊林. 离子束呼吸门控治疗中的呼吸引导装置及方法. CN: CN104274914A, 2015-01-14.

[18] 贺鹏博, 李强, 戴中颖, 刘新国, 申国盛. 放射治疗中动态肿瘤靶区的定位装置及其方法. CN: CN103691064A, 2014-04-02.

[19] 戴中颖, 李强, 刘新国, 贺鹏博, 黄齐艳, 申国盛. 三维点扫描束流配送中在线束流监测探测器的交叉标定方法. CN: CN103353605A, 2013-10-16.

出版信息

[1] Pengbo He, Shinichiro Mori, Takashi Ono, Akihiro Nomoto, Hitoshi Ishikawa. Impact of varying the number of irradiation fields on dose distribution: A four-dimensional scanned carbon-ion lung radiotherapy. Radiation Physics and Chemistry. 2023, 212:111183

[2] Xinyang Zhang, Hui Zhang, Jian Wang, Yuanyuan Ma, Xinguo Liu, Zhongying Dai, Rui He, Pengbo He*, Qiang Li. Deep learning-based fast denoising of Monte Carlo dose calculation in carbon ion radiotherapy. Medical Physics. 2023,16719 (通讯作者) 

[3] Pengbo He, Qiang Li. Impact of different synchrotron flattop operation modes on 4D dosimetric uncertainties for scanned carbon-ion beam delivery. Frontiers in Oncology. 2022,12:806742

[4] Pengbo He, Qiang Li. Motion management with variable cycle-based respiratory guidance method for carbon-ion pencil beam scanning treatment. Physica Medica. 2021,87:99-105

[5] Pengbo He*, Shinichiro Mori. Perturbation analysis of 4D dose distribution for scanned carbon-ion beam radiotherapy. Physica Medica. 2020, 74: 74-82

[6] Pengbo He, Qiang Li, Guoqing Xiao, Xiaohu Wang, Shuigen Ouyang, Ruifeng Liu. Effect of respiratory guidance on internal/external respiratory motion correlation for synchrotron-based pulsed heavy-ion radiotherapy. Australaslan Physical & Engineering Sciences in Medicine. 2018, 41:713-720

[7] Pengbo He, Qiang Li,Ting Zhao, Xinguo Liu, Zhongying Dai, Yuanyuan Ma. Effectiveness of respiratory-gated radiotherapy with audio-visual biofeedback for synchrotron-based scanned heavy-ion beam delivery. Physics in Medicine and Biology. 2016, 61:8541-8552

[8] Pengbo He, Qiang Li.Target motion compensation by means of adjustable heavy-ion beam slow extraction: simulations. International Journal of Particle Therapy.2015, 1(4):884-898

[9] Pengbo He, Qiang Li, Xinguo Liu, Zhongying Dai, Ting Zhao, Tingyan Fu, Guosheng Shen, Yuanyuan Ma, Qiyan Huang, Yuanlin Yan. Respiration motion management using audio-visaual biofeedback for respiratory-gated radiotherapy of synchrotron-based pulsed heavy-ion beam delivery. Medical Physics. 2014, 41(11):111708(1)-111708(11)

[10] HE Peng-Bo, LI Qiang, LIU Xin-Guo, YE Fei, DAI Zhong-Ying. Experimental measurement of the correlation between CT number and heavy ion range. Chinese Physics C. 2012, 36(10):954-957

发表论文
[1] He, Pengbo, Li, Qiang. Impact of Different Synchrotron Flattop Operation Modes on 4D Dosimetric Uncertainties for Scanned Carbon-Ion Beam Delivery. FRONTIERS IN ONCOLOGY[J]. 2022, 12: http://dx.doi.org/10.3389/fonc.2022.806742.
[2] 张新阳, 贺鹏博, 刘新国, 戴中颖, 马圆圆, 申国盛, 张晖, 陈卫强, 李强. 基于深度学习单投影的CT断层成像三维重建. 中国医学物理学杂志[J]. 2021, 38(10): 1223-1228, http://lib.cqvip.com/Qikan/Article/Detail?id=7105880990.
[3] He, Pengbo, Li, Qiang. Motion management with variable cycle-based respiratory guidance method for carbon-ion pencil beam scanning treatment. PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS[J]. 2021, 87: 99-105, http://dx.doi.org/10.1016/j.ejmp.2021.06.005.
[4] Shen, Guosheng, Dai, Zhongying, Chen, Weiqiang, Liu, Xinguo, Ma, Yanyuan, He, Pengbo, Xiao, Guoqing, Li, Qiang. A Method for Real-Time Patient Positioning Verification in Radiotherapy Using Multi-Angular Images with Conventional Video Cameras. JOURNAL OF MEDICAL IMAGING AND HEALTH INFORMATICS[J]. 2020, 10(2): 285-294, https://www.webofscience.com/wos/woscc/full-record/WOS:000496931800002.
[5] Kanai, Takayuki, Paz, Athena, Furuichi, Wataru, Liu, ChingSheng, He, Pengbo, Mori, Shinichiro. Four-dimensional carbon-ion pencil beam treatment planning comparison between robust optimization and range-adapted internal target volume for respiratory-gated liver and lung treatment. PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS[J]. 2020, 80: 277-287, http://dx.doi.org/10.1016/j.ejmp.2020.11.009.
[6] 金孙均, 王坤, 王志鹏, 范耀东, 杨小元, 张健, 贺鹏博, 申国盛, 戴天缘, 李强. 重离子束水吸收剂量的电离法实验研究. 原子能科学技术[J]. 2020, 54(9): 1722-1728, http://lib.cqvip.com/Qikan/Article/Detail?id=7102718561.
[7] Dai, Tianyuan, Zhang, Hui, Liu, Xinguo, Dai, Zhongying, He, Pengbo, Ma, Yuanyuan, Shen, Guosheng, Chen, Weiqiang, Li, Qiang. Nanodosimetric understanding to the dependence of the relationship between dose-averaged lineal energy on nanoscale and LET on ion species. PHYSICAL AND ENGINEERING SCIENCES IN MEDICINE[J]. 2020, 43(1): 239-246, https://www.webofscience.com/wos/woscc/full-record/WOS:000525685600024.
[8] He, Pengbo, Mori, Shinichiro. Perturbation analysis of 4D dose distribution for scanned carbon-ion beam radiotherapy. PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS[J]. 2020, 74: 74-82, http://dx.doi.org/10.1016/j.ejmp.2020.05.003.
[9] 戴天缘, 刘新国, 戴中颖, 贺鹏博, 马圆圆, 申国盛, 张晖, 陈卫强, 李强. TEPC壁对重离子束微剂量学测量及相对生物学效应计算的影响. 原子能科学技术[J]. 2019, 53(6): 1127-1134, http://lib.cqvip.com/Qikan/Article/Detail?id=7002128500.
[10] 戴天缘, 李强, 陈卫强, 刘新国, 戴中颖, 贺鹏博, 马圆圆, 申国盛, 张晖. 基于微剂量学蒙特卡罗模拟的重离子生物有效剂量精确计算方法. 中国医学物理学杂志[J]. 2019, 36(10): 1119-1124, http://lib.cqvip.com/Qikan/Article/Detail?id=7003021947.
[11] Zhang, Hui, Dai, Tianyuan, Liu, Xinguo, Chen, Weiqiang, Ma, Yuanyuan, He, Pengbo, Shen, Guosheng, Yuan, Ping, Dai, Zhongying, Li, Qiang. Dosimetric effect of the low dose envelope associated with different beam models for carbon-ion spot scanning beam delivery. ACTA ONCOLOGICAnull. 2019, 58(12): 1790-1793, http://dx.doi.org/10.1080/0284186X.2019.1648863.
[12] Zhang, Hui, Dai, Zhongying, Liu, Xinguo, Chen, Weiqiang, Ma, Yuanyuan, He, Pengbo, Dai, Tianyuan, Shen, Guosheng, Yuan, Ping, Li, Qiang. A novel pencil beam model for carbon-ion dose calculation derived from Monte Carlo simulations. PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS[J]. 2018, 55: 15-24, http://dx.doi.org/10.1016/j.ejmp.2018.10.014.
[13] He, Pengbo, Li, Qiang, Xiao, Guoqing, Wang, Xiaohu, Ouyang, Shuigen, Liu, Ruifeng. Effect of respiratory guidance on internal/external respiratory motion correlation for synchrotron-based pulsed heavy-ion radiotherapy. AUSTRALASIAN PHYSICAL & ENGINEERING SCIENCES IN MEDICINE[J]. 2018, 41(3): 713-720, https://www.webofscience.com/wos/woscc/full-record/WOS:000443027000015.
[14] Hui Zhang, Zhongying Dai, Xinguo Liu, Weiqiang Chen, Yuanyuan Ma, Pengbo He, Tianyuan Dai, Guosheng Shen, Ping Yuan, Qiang Li. A novel pencil beam model for carbon-ion dose calculation derived from Monte Carlo simulations. PHYSICA MEDICA. 2018, 55: 15-24, http://dx.doi.org/10.1016/j.ejmp.2018.10.014.
[15] Ma Yuanyuan, Liu Xinguo, Dai Zhongying, He Pengbo, Yan Yuanlin, Shen Guosheng, Yuan Ping, Li Qiang. Evaluation of mesh- and binary-based contour propagation methods in 4D thoracic radiotherapy treatments using patient 4D CT images. PHYSICA MEDICA[J]. 2017, 36: 46-53, http://dx.doi.org/10.1016/j.ejmp.2017.03.005.
[16] Ma, Yuanyuan, Liu, Xinguo, Dai, Zhongying, He, Pengbo, Yan, Yuanlin, Shen, Guosheng, Yuan, Ping, Li, Qiang. Evaluation of mesh- and binary-based contour propagation methods in 4D thoracic radiotherapy treatments using patient 4D CT images. PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS[J]. 2017, 36: 46-53, http://dx.doi.org/10.1016/j.ejmp.2017.03.005.
[17] Yan, YuanLin, Liu, XinGuo, Dai, ZhongYing, Ma, YuanYuan, He, PengBo, Shen, GuoSheng, Ji, TengFei, Zhang, Hui, Li, Qiang. Spot-scanning beam delivery with laterally-and longitudinally-mixed spot size pencil beams in heavy ion radiotherapy. CHINESE PHYSICS C[J]. 2017, 41(9): https://www.webofscience.com/wos/woscc/full-record/WOS:000412407200019.
[18] 贺鹏博. The Radiation Enhancement of 15nm Citrate-Capped Gold Nanoparticles Exposed to 70 keV/um Carbon Ions. Journal of Nanoscience and Nanotechnology. 2016, [19] 闫渊林, 刘新国, 付廷岩, 戴中颖, 马圆圆, 黄齐艳, 贺鹏博, 申国盛, 李强. HIRFL装置主动式点扫描束流配送系统的Monte Carlo模拟优化. 原子核物理评论[J]. 2016, 105-111, [20] He, Pengbo, Li, Qiang, Zhao, Ting, Liu, Xinguo, Dai, Zhongying, Ma, Yuanyuan. Effectiveness of respiratory-gated radiotherapy with audio-visual biofeedback for synchrotron-based scanned heavy-ion beam delivery. PHYSICS IN MEDICINE AND BIOLOGY[J]. 2016, 61(24): 8541-8552, https://www.webofscience.com/wos/woscc/full-record/WOS:000388688800008.
[21] Tian, Liheng, Li, Qiang, Liu, Xinguo, Dai, Zhongying, Fu, Tingyan, He, Pengbo, Yan, Yuanlin, Ma, Yuanyuan, Huang, Qiyan. Theoretical substantiation of biological efficacy enhancement for beta-delayed particle decay C-9 beam: A Monte Carlo study in combination with analysis with the local effect model approach. MEDICAL PHYSICS[J]. 2016, 43(3): 1200-1211, http://dx.doi.org/10.1118/1.4941310.
[22] Liu, Yan, Liu, Xi, Jin, Xiaodong, He, Pengbo, Zheng, Xiaogang, Ye, Fei, Chen, Weiqiang, Li, Qiang. The Radiation Enhancement of 15 nm Citrate-Capped Gold Nanoparticles Exposed to 70 keV/mu m Carbon Ions. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY[J]. 2016, 16(3): 2365-2370, [23] 姬腾飞, 刘新国, 戴中颖, 贺鹏博, 闫渊林, 黄齐艳, 李强. 重离子放射治疗双微小展宽峰组合照射方法. 原子核物理评论[J]. 2016, 33(3): 345-352, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5871406&detailType=1.
[24] 黄齐艳, 刘新国, 戴中颖, 贺鹏博, 申国盛, 马圆圆, 闫渊林, 付廷岩, 李强. 碳离子治疗中分野照射技术的Monte Carlo模拟. 原子核物理评论[J]. 2015, 32(1): 115-120, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5414872&detailType=1.
[25] 贺鹏博. 对癌症治疗的粒子束成像. 物理[J]. 2015, 44(10): 684-685, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5530758&detailType=1.
[26] Liu, Yan, Liu, Xi, Jin, Xiaodong, He, Pengbo, Zheng, Xiaogang, Dai, Zhongying, Ye, Fei, Zhao, Ting, Chen, Weiqiang, Li, Qiang. The dependence of radiation enhancement effect on the concentration of gold nanoparticles exposed to low- and high-LET radiations. PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS[J]. 2015, 31(3): 210-218, http://dx.doi.org/10.1016/j.ejmp.2015.01.006.
[27] Yan Liu, Xi Liu, Xiaodong Jin, Pengbo He, Xiaogang Zheng, Zhongying Dai, Fei Ye, Ting Zhao, Weiqiang Chen, Qiang Li. The dependence of radiation enhancement effect on the concentration of gold nanoparticles exposed to low- and high-LET radiations. PHYSICA MEDICA. 2015, 31(3): 210-218, http://dx.doi.org/10.1016/j.ejmp.2015.01.006.
[28] He, Pengbo, Li, Qiang, Liu, Xinguo, Dai, Zhongying, Zhao, Ting, Fu, Tingyan, Shen, Guosheng, Ma, Yuanyuan, Huang, Qiyan, Yan, Yuanlin. Respiratory motion management using audio-visual biofeedback for respiratory-gated radiotherapy of synchrotron-based pulsed heavy-ion beam delivery. MEDICAL PHYSICS[J]. 2014, 41(11): http://ir.impcas.ac.cn/handle/113462/18576.
[29] 贺鹏博. Respiratory motion management using audio-visual biofeedback. MEDICAL PHYSICS[J]. 2014, 41(11): 111708-1——111708, http://ir.impcas.ac.cn/handle/113462/12529.
[30] 赵婷, 叶飞, 贺鹏博, 刘雄雄, 李强. 辐照诱导人正常肝细胞系HL-7702细胞远后的微卫星不稳定性. 原子核物理评论[J]. 2013, 30(4): 494-502, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5024884&detailType=1.
[31] 贺鹏博, 李强. 离子束治疗中的靶区运动补偿方法. 原子核物理评论[J]. 2013, 30(2): 174-183, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=4874482&detailType=1.
[32] He PengBo, Li Qiang, Liu XinGuo, Ye Fei, Dai ZhongYing. Experimental measurement of the correlation between CT number and heavy ion range. CHINESE PHYSICS C[J]. 2012, 36(10): 954-957, http://ir.impcas.ac.cn/handle/113462/18585.
[33] He PengBo, Li Qiang, Liu XinGuo, Ye Fei, Dai ZhongYing. Experimental measurement of the correlation between CT number and heavy ion range. CHINESE PHYSICS C[J]. 2012, 36(10): 954-957, http://ir.impcas.ac.cn/handle/113462/18585.
[34] Tian Liheng, Li Qiang, Liu Xinguo, Dai Zhongying, Fu Tingyan, He Pengbo, Yan Yuanlin, Ma Yuanyuan, Huang Qiyan. Theoretical substantiation of biological efficacy enhancement for β‐delayed particle decay 9C beam: A Monte Carlo study in combination with analysis with the local effect model approach. MEDICAL PHYSICS[J]. http://dx.doi.org/10.1118/1.4941310.
发表著作
(1) 肿瘤粒子治疗工程技术, 中国科学技术出版社, 2022-03, 第 其他 作者

科研活动

   
科研项目
( 1 ) 运动靶区重离子放射治疗技术研究, 负责人, 其他国际合作项目, 2019-01--2022-12
( 2 ) 变周期呼吸引导的运动靶区重离子点扫描照射新方法研究, 负责人, 国家任务, 2018-01--2020-12
( 3 ) 重离子多次扫描联合呼吸门控对运动肿瘤靶区的适形照射治疗方法研究, 负责人, 地方任务, 2017-01--2018-12
( 4 ) 重离子呼吸门控治疗技术研究与开发, 负责人, 中国科学院计划, 2016-09--2019-06
( 5 ) 陇原青年创新创业人才(团队), 负责人, 地方任务, 2022-04--2023-12
( 6 ) 小型化重离子治疗装置研发, 参与, 国家任务, 2022-03--2026-11
( 7 ) 非预期靶区残余运动的重离子4D自适应优化跟踪放射治疗新方法, 负责人, 国家任务, 2024-01--2027-12
( 8 ) 陇原青年英才, 负责人, 地方任务, 2023-01--2025-12
( 9 ) 甘肃省杰出青年基金—基于肿瘤智能实时跟踪的快速重复扫描重离子照射治疗新方法, 负责人, 地方任务, 2022-10--2025-09

合作情况

日本国立放射线医学综合研究所(NIRS)